Thyroid stimulating receptor autoantibodies
This article provides a comprehensive review of TRAb, encompassing its clinical assays along with its significance in the clinical setting.PMID:38697458 | DOI:10.1016/j.cca.2024.119700 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - May 2, 2024 Category: Chemistry Authors: Yumeng Gao Ling Qiu Songlin Yu Xinqi Cheng Source Type: research
Investigational bispecific antibodies for the treatment of rheumatoid arthritis
Expert Opin Investig Drugs. 2024 May 2. doi: 10.1080/13543784.2024.2351507. Online ahead of print.ABSTRACTINTRODUCTION: Rheumatoid arthritis (RA) is an autoimmune disorder with a characteristic chronic inflammation of the synovium that may lead to the destruction of the joints in untreated patients. Interestingly, despite the availability of several effective treatments, many patients do not achieve remission or low disease activity or may experience disease relapse.Following the above unmet needs, bispecific antibodies (BsAbs) have emerged as a new approach to improve the disease's treatment. BsAbs are designed to simulta...
Source: Expert Opinion on Investigational Drugs - May 2, 2024 Category: Drugs & Pharmacology Authors: Aliki I Venetsanopoulou Paraskevi V Voulgari Alexandros A Drosos Source Type: research
From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes
Expert Rev Endocrinol Metab. 2024 May 1:1-11. doi: 10.1080/17446651.2024.2347263. Online ahead of print.ABSTRACTINTRODUCTION: Type 1 diabetes (T1D) mellitus is an autoimmune disease in which immune cells, predominantly effector T cells, destroy insulin-secreting beta-cells. Beta-cell destruction led to various consequences ranging from retinopathy and nephropathy to neuropathy. Different strategies have been developed to achieve normoglycemia, including exogenous glucose compensation, whole pancreas transplantation, islet transplantation, and beta-cell replacement.AREAS COVERED: The last two decades of experience have show...
Source: Expert Review of Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Asef Azad Hasan Ali Altunbas Ayse Esra Manguoglu Source Type: research
Assessment of serum inflammatory parameters in RRMS and SPMS patients
DISCUSSION: Significant differences were found in BAFF, gp130, MMP-2 and osteopontin levels between RRMS and SPMS patients. Serum IL-32 levels were statistically lower in RRMS patients treated with disease-modifying therapy than in treatment-naïve patients.PMID:38697017 | DOI:10.1080/01616412.2024.2337503 (Source: Neurological Research)
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Maria Nowak-Kiczmer Natalia Niedziela Zenon P Czuba Pawe ł Sowa Krzysztof Wierzbicki Micha ł Lubczyński Monika Adamczyk-Sowa Source Type: research
From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes
Expert Rev Endocrinol Metab. 2024 May 1:1-11. doi: 10.1080/17446651.2024.2347263. Online ahead of print.ABSTRACTINTRODUCTION: Type 1 diabetes (T1D) mellitus is an autoimmune disease in which immune cells, predominantly effector T cells, destroy insulin-secreting beta-cells. Beta-cell destruction led to various consequences ranging from retinopathy and nephropathy to neuropathy. Different strategies have been developed to achieve normoglycemia, including exogenous glucose compensation, whole pancreas transplantation, islet transplantation, and beta-cell replacement.AREAS COVERED: The last two decades of experience have show...
Source: Expert Review of Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Asef Azad Hasan Ali Altunbas Ayse Esra Manguoglu Source Type: research
Assessment of serum inflammatory parameters in RRMS and SPMS patients
DISCUSSION: Significant differences were found in BAFF, gp130, MMP-2 and osteopontin levels between RRMS and SPMS patients. Serum IL-32 levels were statistically lower in RRMS patients treated with disease-modifying therapy than in treatment-naïve patients.PMID:38697017 | DOI:10.1080/01616412.2024.2337503 (Source: Neurological Research)
Source: Neurological Research - May 2, 2024 Category: Neurology Authors: Maria Nowak-Kiczmer Natalia Niedziela Zenon P Czuba Pawe ł Sowa Krzysztof Wierzbicki Micha ł Lubczyński Monika Adamczyk-Sowa Source Type: research
Association Between HLA-DRB1 Alleles and Graves ʼ Disease in Asian
Populations: A Meta-Analysis
Horm Metab Res DOI: 10.1055/a-2298-4366Graves’ disease (GD) is an autoimmune disease that primarily affects the thyroid
gland. It is the most common cause of hyperthyroidism. Genetic studies have
shown that human leukocyte antigen (HLA) plays an important role in the
development of GD. In this article, we performed a meta-analysis determined to
evaluate the relationship between HLA-DRB1 alleles and GD. This meta-analysis
included 9 studies (3582 cases in the case group and 23070 cases in the control
group) and 27 alleles was performed. The combined results showe...
Source: Hormone and Metabolic Research - May 2, 2024 Category: Endocrinology Authors: Li, Wenyi Ke, Tingyu Wang, Jia Zhu, Fangling Chi, Yan Tags: Original Article: Endocrine Care Source Type: research
SGLT-2 inhibitors May Decrease Recurrent Gout Flares in Patients with Type 2 diabetes
Dr. Bernal
Clinical question: Do SGLT-2 inhibitors decrease gout flares in patients with type 2 diabetes and a known history of gout?
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT-2 inhibitors) are known to decrease serum urate levels and the risk of incident gout. However, their role in secondary prevention of gout flares is unknown.
Study design: Propensity score–matched, new-user cohort study
Setting: British Columbia, Canada
Synopsis: Using a group of population-based, linked, administrative databases, the population of British Columbia was studied. 15,067 patients with gout and type 2 diabetes had f...
Source: The Hospitalist - May 1, 2024 Category: Hospital Management Authors: Ronda Whitaker Tags: Autoimmune Diseases In the Literature Pharmacology Rheumatology Source Type: research
Abnormal energy metabolism in the pathogenesis of systemic lupus erythematosus
Int Immunopharmacol. 2024 Apr 30;134:112149. doi: 10.1016/j.intimp.2024.112149. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) is a severe autoimmune disease with significant socioeconomic impact worldwide. Orderly energy metabolism is essential for normal immune function, and disordered energy metabolism is increasingly recognized as an important contributor to the pathogenesis of SLE. Disorders of energy metabolism are characterized by increased reactive oxygen species, ATP deficiency, and abnormal metabolic pathways. Oxygen and mitochondria are critical for the production of ATP, and both mitochondrial...
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Shumei Cao Jiao Jiang Haoyuan Yin Lai Wang Qianjin Lu Source Type: research
Roles of blood metabolites in mediating the relationship between vitiligo and autoimmune diseases: Evidence from a Mendelian randomization study
CONCLUSIONS: We substantiated vitiligo's influence on susceptibility to seven autoimmune diseases and conducted a thorough investigation of serum metabolites correlated with vitiligo. Histidine and pyruvate are potential mediators of vitiligo associated with autoimmune diseases.By combining metabolomics with genomics, we provide new perspectives on the etiology of vitiligo and its immune comorbidities.PMID:38691918 | DOI:10.1016/j.intimp.2024.112132 (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 1, 2024 Category: Allergy & Immunology Authors: Siyu Yang Xinglin Hu Puyu Zou Zhuotong Zeng Yibo Hu Rong Xiao Source Type: research
Circulating immune profile in granulomatosis with polyangiitis reveals distinct patterns related to disease activity
In this study, we examined circulating immune profiles in GPA patients during active and remission disease states to identify potential immune patterns associated with disease activity. The distribution and phenotypic characteristics of major circulating immune cells, and the profiles of circulating cytokines/chemokines, were studied on cryopreserved peripheral blood mononuclear cells from GPA patients (active, n = 20; remission, n = 20) and healthy controls (n = 20) leveraging a 40-color optimized multicolor immunofluorescence panel (OMIP-69) and in serum using a 46-plex Luminex multiplex assay, respectively. Deep phenoty...
Source: Journal of Autoimmunity - May 1, 2024 Category: Allergy & Immunology Authors: C G Bonasia N Inrueangsri T Bijma K P Mennega R Wilbrink S Arends W H Abdulahad N A Bos A Rutgers P Heeringa Source Type: research
Autoimmune diseases and the risk of bladder cancer: A Mendelian randomization analysis
CONCLUSION: This study provides evidence of a causal relationship between AIDs and BC risk at the genetic level, confirming a causal relationship between RA and MS in increasing the risk of BC.PMID:38692170 | DOI:10.1016/j.jaut.2024.103231 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - May 1, 2024 Category: Allergy & Immunology Authors: Jun Li Cui Cheng Jiajun Zhang Source Type: research
A body-brain circuit that regulates body inflammatory responses
Nature. 2024 May 1. doi: 10.1038/s41586-024-07469-y. Online ahead of print.ABSTRACTThe body-brain axis is emerging as a principal conductor of organismal physiology. It senses and controls organ function1,2, metabolism3 and nutritional state4-6. Here, we show that a peripheral immune insult powerfully activates the body-brain axis to regulate immune responses. We demonstrate that pro- and anti-inflammatory cytokines communicate with distinct populations of vagal neurons to inform the brain of an emerging inflammatory response. In turn, the brain tightly modulates the course of the peripheral immune response. Genetic silenc...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Hao Jin Mengtong Li Eric Jeong Felipe Castro-Martinez Charles S Zuker Source Type: research
Voltage-gated potassium channel 1.3: A promising molecular target in multiple disease therapy
Biomed Pharmacother. 2024 Apr 30;175:116651. doi: 10.1016/j.biopha.2024.116651. Online ahead of print.ABSTRACTVoltage-gated potassium channel 1.3 (Kv1.3) has emerged as a pivotal player in numerous biological processes and pathological conditions, sparking considerable interest as a potential therapeutic target across various diseases. In this review, we present a comprehensive examination of Kv1.3 channels, highlighting their fundamental characteristics and recent advancements in utilizing Kv1.3 inhibitors for treating autoimmune disorders, neuroinflammation, and cancers. Notably, Kv1.3 is prominently expressed in immune ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Sixuan Cheng Dawei Jiang Xiaoli Lan Kun Liu Cheng Fan Source Type: research
Genome-wide analysis of two different regions of brain reveals the molecular changes of fertility related genes in rln3a < sup > -/- < /sup > mutants in male Nile tilapia (Oreochromis niloticus)
Gen Comp Endocrinol. 2024 Apr 29:114543. doi: 10.1016/j.ygcen.2024.114543. Online ahead of print.ABSTRACTRelaxin3 (rln3) has been associated with various emotional and cognitive processes, including stress, anxiety, learning, memory, motivational behavior, and circadian rhythm. Notably, previous report revealed that Rln3a played an indispensable role in testicular development and male fertility in Nile tilapia (Oreochromis niloticus). However, the underlying molecular mechanisms remain largely unknown. We found that Rln3a is expressed exclusively in the diencephalon* (Di*) of the brain. Deficiency of Rln3a resulted in a si...
Source: General and Comparative Endocrinology - May 1, 2024 Category: Endocrinology Authors: Tengfei Wu You Wu Yanlong Li Yiyun Du Saining Feng Deshou Wang Linyan Zhou Source Type: research
