Peripheral Vascular Disease (PVD) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Analysis of tranexamic acid usage in adult spinal deformity patients with relative contraindications: does it increase the risk of complications?
CONCLUSIONS: Administration of intravenous TXA during the correction procedure did not change rates of thromboembolic events, acute MI, or stroke in this cohort of adult spinal deformity surgery patients.PMID:38457792 | DOI:10.3171/2024.1.SPINE231098 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - March 8, 2024 Category: Neurosurgery Authors: Jeffrey P Mullin Mohamed A R Soliman Justin S Smith Michael P Kelly Thomas J Buell Bassel Diebo Justin K Scheer Breton Line Virginie Lafage Renaud Lafage Eric Klineberg Han Jo Kim Peter G Passias Jeffrey L Gum Khaled Kebaish Robert K Eastlack Alan H Danie Source Type: research

Peripheral artery disease: an underdiagnosed condition in familial hypercholesterolemia? A systematic review
ConclusionThis systematic review sheds light on the limited number of studies on PAD in FH patients. Particularly, considering the potential positive effects of newly available lipid-lowering strategies on PAD outcomes, addressing this research gap is pivotal for a more comprehensive understanding of peripheral vascular manifestations in FH patients and for optimal management of this population. (Source: Endocrine)
Source: Endocrine - March 8, 2024 Category: Endocrinology Source Type: research

Aiming for precision: CYP2C19 gene polymorphism and clopidogrel resistance in patients with peripheral artery disease
Antiplatelet therapy with aspirin and/or one of the P2Y12 inhibitors (e.g., clopidogrel, prasugrel, and ticagrelor) is the cornerstone of medical therapy to mitigate the risk of ischemic events in patients with atherosclerotic cardiovascular diseases (ASCVD) [1]. Moreover, dual antiplatelet therapy (DAPT) is the standard of care following percutaneous revascularization of coronary, lower extremity and carotid arteries [2 –4]. Clopidogrel is the most widely used P2Y12 inhibitor but requires hepatic activation by the cytochrome P450 (CYP) 2C19 enzyme [5]. (Source: Thrombosis Research)
Source: Thrombosis Research - March 8, 2024 Category: Hematology Authors: Sina Rashedi, Parham Sadeghipour, Junyang Lou Source Type: research

Factors associated with Ninety-day Reintervention following Lower Extremity Revascularization
Peripheral artery disease (PAD) represents a high volume, high-cost burden on the healthcare system. The Centers for Medicare and Medicaid Services (CMS) has developed the Bundled Payments for Care Improvement-Advanced program, in which a single payment is provided for all services administered in a postsurgical 90-day episode of care. Factors associated with 30- and 90-day reinterventions after PAD interventions would represent useful data for both payors and stake holders. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - March 7, 2024 Category: Surgery Authors: Olamide Alabi, Jessica L. Harding, Nader Massarweh, Xinyan Zheng, Luke Brewster, Jialin Mao, Yazan Duwayri Source Type: research

Optimizing platelet inhibition in peripheral artery disease: A comparison of mono-antiplatelet therapy and dual-antiplatelet therapy using thromboelastography
CONCLUSIONS: Patients on DAPT showed a significant increase in platelet inhibition when compared to initial aspirin MAPT. A significant difference in AA %platelet inhibition was shown for patients on DAPT when compared to initial clopidogrel MAPT. The results show that patients may benefit from DAPT post-revascularization. Personalizing antiplatelet therapy with objective viscoelastic testing to confirm adequate treatment may be the next step in optimizing patient outcomes to reduce thrombosis in PAD patients.PMID:38441042 | DOI:10.1177/17085381241237005 (Source: Vascular)
Source: Vascular - March 5, 2024 Category: Surgery Authors: Ivy Lee Sasha Suarez Ryan Hall Monica Majumdar Tiffany Bellomo Samuel Jessula Kathryn Nuzzolo Douglas M Jefferson Nikolaos Zacharias Anahita Dua Source Type: research

Gut microbiota ’s causative relationship with peripheral artery disease: a Mendelian randomization study
ConclusionOur findings hint at a causative association between certain gut microbiota and PAD, introducing new avenues for understanding PAD’s etiology and developing effective treatments. The observed associations now warrant further validation in varied populations and detailed exploration at finer taxonomic levels. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 5, 2024 Category: Microbiology Source Type: research

Case Report: Multiple atherosclerotic plaques at its extreme in synchrony
F1000Res. 2024 Jan 24;12:738. doi: 10.12688/f1000research.135416.3. eCollection 2023.ABSTRACTPeripheral artery (PAD) disease in association with renal artery stenosis is an important association which predicts the severity of the disease. An increase in the number of vessels affected by peripheral artery disease increases the chances of renal artery stenosis. In our case, the patient had primarily presented with anginal chest pain with complaints of claudication which on further investigation was diagnosed to be a triple vessel coronary artery disease along with bilateral subclavian and bilateral renal stenosis. On detaile...
Source: Atherosclerosis - March 4, 2024 Category: Cardiology Authors: Saket Toshniwal Isha Sahai Benumadhab Ghosh Anuj Chaturvedi Gajendra Agrawal Sourya Acharya Sunil Kumar Satish Khadse Kashish Khurana Source Type: research

Advances in secondary prevention mechanisms of macrovascular complications in type 2 diabetes mellitus patients: a comprehensive review
AbstractType 2 diabetes mellitus (T2DM) poses a significant global health burden. This is particularly due to its macrovascular complications, such as coronary artery disease, peripheral vascular disease, and cerebrovascular disease, which have emerged as leading contributors to morbidity and mortality. This review comprehensively explores the pathophysiological mechanisms underlying these complications, protective strategies, and both existing and emerging secondary preventive measures. Furthermore, we delve into the applications of experimental models and methodologies in foundational research while also highlighting cur...
Source: European Journal of Medical Research - March 4, 2024 Category: Research Source Type: research

Association of prognostic nutritional index with peripheral artery disease in US adults: a cross-sectional study
The objective of this study was to investigate the relationship between the prognostic nutritional index (PNI) and peripheral artery disease (PAD). (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - March 2, 2024 Category: Cardiology Authors: Dikang Pan, Julong Guo, Zhixiang Su, Wenzhuo Meng, Jingyu Wang, Jianming Guo and Yongquan Gu Tags: Research Source Type: research

Mind the Gap Between Clinical Trials and Real World Data: Learning From Patients Revascularised for Peripheral Artery Disease in France
Eur J Vasc Endovasc Surg. 2024 Feb 28:S1078-5884(24)00198-9. doi: 10.1016/j.ejvs.2024.02.038. Online ahead of print.NO ABSTRACTPMID:38428667 | DOI:10.1016/j.ejvs.2024.02.038 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - March 1, 2024 Category: Surgery Authors: Fabien Lareyre Juliette Raffort Source Type: research