Prescriber decision-making on antithrombotic therapy after endovascular intervention for peripheral artery disease: a protocol for a discrete choice experiment
Introduction Peripheral artery disease (PAD) is a major risk factor for cardiovascular morbidity and mortality, despite surgical and endovascular treatments. Emerging evidence supports the use of immediate antithrombotic medications after endovascular intervention for PAD, however, there is a lack of consensus regarding choice and duration of antithrombotic therapy. Prescriber decision-making is a complex process, with prior studies demonstrating patient factors can influence variability in antithrombotic therapy for PAD. However, it remains unclear the relative contribution of these factors. This paper describes a planned...
Source: BMJ Open - March 20, 2024 Category: General Medicine Authors: Zhu, A., Tang, R., Rajendran, S., Hajian, H., Aitken, S. J. Tags: Open access, Cardiovascular medicine Source Type: research

Sex differences in the purinergic 2 receptor mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00010.2024. Online ahead of print.ABSTRACTWe investigated the role played by ATP sensitive purinergic 2 (P2) receptors in evoking the pressor response to treadmill exercise in male and female rats with and without femoral arteries that were ligated for ~72 hours to induce simulated peripheral artery disease (PAD). We hypothesized that PPADS (P2 receptor antagonist, 10 mg i.v.) would reduce the pressor response to four minutes of treadmill exercise (15 m×min-1, 1° incline) and steady-state exercise plasma norepinephrine (NE) values in male and femal...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Alec L E Butenas Joseph S Flax Raimi J Carroll C Shane Chuwonganant Ashley M Baranczuk Steven W Copp Source Type: research

Pulmonary edema in a young male with severe uncontrolled cardiovascular risk factors and pan-vascular atherosclerosis: a case report
Monaldi Arch Chest Dis. 2024 Mar 12. doi: 10.4081/monaldi.2024.2862. Online ahead of print.ABSTRACTCardiovascular risk factors are the cause of atherosclerotic disease, which can involve all the elastic and muscolo-elastic arteries. The etiopathogenesis of atherosclerosis is multifactorial since genetics, lifestyle, and comorbidities can be simultaneously involved. Clinical manifestations can be heterogeneous and include myocardial infarction, stroke, aortic aneurysms, renal artery stenosis, renal insufficiency, peripheral artery disease, etc. Currently, 70% of clinical events cannot be prevented with available drug therap...
Source: Atherosclerosis - March 18, 2024 Category: Cardiology Authors: Andrea Palomba Francesco Pelizzo Mattia Canevari Olga Vriz Source Type: research

Pulmonary edema in a young male with severe uncontrolled cardiovascular risk factors and pan-vascular atherosclerosis: a case report
Monaldi Arch Chest Dis. 2024 Mar 12. doi: 10.4081/monaldi.2024.2862. Online ahead of print.ABSTRACTCardiovascular risk factors are the cause of atherosclerotic disease, which can involve all the elastic and muscolo-elastic arteries. The etiopathogenesis of atherosclerosis is multifactorial since genetics, lifestyle, and comorbidities can be simultaneously involved. Clinical manifestations can be heterogeneous and include myocardial infarction, stroke, aortic aneurysms, renal artery stenosis, renal insufficiency, peripheral artery disease, etc. Currently, 70% of clinical events cannot be prevented with available drug therap...
Source: Monaldi Archives for Chest Disease - March 18, 2024 Category: Respiratory Medicine Authors: Andrea Palomba Francesco Pelizzo Mattia Canevari Olga Vriz Source Type: research

Sex differences in the purinergic 2 receptor mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00010.2024. Online ahead of print.ABSTRACTWe investigated the role played by ATP sensitive purinergic 2 (P2) receptors in evoking the pressor response to treadmill exercise in male and female rats with and without femoral arteries that were ligated for ~72 hours to induce simulated peripheral artery disease (PAD). We hypothesized that PPADS (P2 receptor antagonist, 10 mg i.v.) would reduce the pressor response to four minutes of treadmill exercise (15 m×min-1, 1° incline) and steady-state exercise plasma norepinephrine (NE) values in male and femal...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Alec L E Butenas Joseph S Flax Raimi J Carroll C Shane Chuwonganant Ashley M Baranczuk Steven W Copp Source Type: research

Pulmonary edema in a young male with severe uncontrolled cardiovascular risk factors and pan-vascular atherosclerosis: a case report
Monaldi Arch Chest Dis. 2024 Mar 12. doi: 10.4081/monaldi.2024.2862. Online ahead of print.ABSTRACTCardiovascular risk factors are the cause of atherosclerotic disease, which can involve all the elastic and muscolo-elastic arteries. The etiopathogenesis of atherosclerosis is multifactorial since genetics, lifestyle, and comorbidities can be simultaneously involved. Clinical manifestations can be heterogeneous and include myocardial infarction, stroke, aortic aneurysms, renal artery stenosis, renal insufficiency, peripheral artery disease, etc. Currently, 70% of clinical events cannot be prevented with available drug therap...
Source: Monaldi Archives for Chest Disease - March 18, 2024 Category: Respiratory Medicine Authors: Andrea Palomba Francesco Pelizzo Mattia Canevari Olga Vriz Source Type: research

Sex differences in the purinergic 2 receptor mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00010.2024. Online ahead of print.ABSTRACTWe investigated the role played by ATP sensitive purinergic 2 (P2) receptors in evoking the pressor response to treadmill exercise in male and female rats with and without femoral arteries that were ligated for ~72 hours to induce simulated peripheral artery disease (PAD). We hypothesized that PPADS (P2 receptor antagonist, 10 mg i.v.) would reduce the pressor response to four minutes of treadmill exercise (15 m×min-1, 1° incline) and steady-state exercise plasma norepinephrine (NE) values in male and femal...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Alec L E Butenas Joseph S Flax Raimi J Carroll C Shane Chuwonganant Ashley M Baranczuk Steven W Copp Source Type: research

Sex differences in the purinergic 2 receptor mediated blood pressure response to treadmill exercise in rats with simulated peripheral artery disease
Am J Physiol Regul Integr Comp Physiol. 2024 Mar 18. doi: 10.1152/ajpregu.00010.2024. Online ahead of print.ABSTRACTWe investigated the role played by ATP sensitive purinergic 2 (P2) receptors in evoking the pressor response to treadmill exercise in male and female rats with and without femoral arteries that were ligated for ~72 hours to induce simulated peripheral artery disease (PAD). We hypothesized that PPADS (P2 receptor antagonist, 10 mg i.v.) would reduce the pressor response to four minutes of treadmill exercise (15 m×min-1, 1° incline) and steady-state exercise plasma norepinephrine (NE) values in male and femal...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 18, 2024 Category: Physiology Authors: Alec L E Butenas Joseph S Flax Raimi J Carroll C Shane Chuwonganant Ashley M Baranczuk Steven W Copp Source Type: research

Periprocedural Risk Predictors Affecting Long-Term Prognosis in Patients With Chronic Obstructive Pulmonary Disease Undergoing Coronary Artery Bypass Grafting
CONCLUSION: Patients with COPD undergoing isolated CABG had a significantly higher incidence of all-cause death than those without COPD. Herein, risk predictors are provided for all-cause death in patients undergoing isolated CABG.PMID:38494437 | DOI:10.14503/THIJ-23-8199 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 17, 2024 Category: Cardiology Authors: Aleksander Dokollari Serge Sicouri Leila Hosseinian Ozgun Erten Basel Ramlawi Gianluigi Bisleri Massimo Bonacchi Noah Sicouri Gianluca Torregrossa Francis P Sutter Source Type: research

Periprocedural Risk Predictors Affecting Long-Term Prognosis in Patients With Chronic Obstructive Pulmonary Disease Undergoing Coronary Artery Bypass Grafting
CONCLUSION: Patients with COPD undergoing isolated CABG had a significantly higher incidence of all-cause death than those without COPD. Herein, risk predictors are provided for all-cause death in patients undergoing isolated CABG.PMID:38494437 | DOI:10.14503/THIJ-23-8199 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 17, 2024 Category: Cardiology Authors: Aleksander Dokollari Serge Sicouri Leila Hosseinian Ozgun Erten Basel Ramlawi Gianluigi Bisleri Massimo Bonacchi Noah Sicouri Gianluca Torregrossa Francis P Sutter Source Type: research

Periprocedural Risk Predictors Affecting Long-Term Prognosis in Patients With Chronic Obstructive Pulmonary Disease Undergoing Coronary Artery Bypass Grafting
CONCLUSION: Patients with COPD undergoing isolated CABG had a significantly higher incidence of all-cause death than those without COPD. Herein, risk predictors are provided for all-cause death in patients undergoing isolated CABG.PMID:38494437 | DOI:10.14503/THIJ-23-8199 (Source: Texas Heart Institute Journal)
Source: Texas Heart Institute Journal - March 17, 2024 Category: Cardiology Authors: Aleksander Dokollari Serge Sicouri Leila Hosseinian Ozgun Erten Basel Ramlawi Gianluigi Bisleri Massimo Bonacchi Noah Sicouri Gianluca Torregrossa Francis P Sutter Source Type: research

The Effect of Induction Therapy on Antibody-Mediated Rejection in Kidney Transplantation: A Network Meta-Analysis Using Recent Data
CONCLUSION: ATG is widely used in KT induction regimens. Our results showed that ATG reduced the risk of AMR in KT recipients when compared with other induction drugs; therefore, it appears to be an efficient choice of induction regimen to reduce AMR after KT.PMID:38490831 | DOI:10.1016/j.transproceed.2024.01.021 (Source: Herpes)
Source: Herpes - March 15, 2024 Category: Infectious Diseases Authors: Jin Ho Lee Heeryong Lee Kipyo Kim Seoung Woo Lee Joon Ho Song Seun Deuk Hwang Source Type: research