Mind the Gap Between Clinical Trials and Real World Data: Learning From Patients Revascularised for Peripheral Artery Disease in France
Eur J Vasc Endovasc Surg. 2024 Feb 28:S1078-5884(24)00198-9. doi: 10.1016/j.ejvs.2024.02.038. Online ahead of print.NO ABSTRACTPMID:38428667 | DOI:10.1016/j.ejvs.2024.02.038 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - March 1, 2024 Category: Surgery Authors: Fabien Lareyre Juliette Raffort Source Type: research

Mind the Gap Between Clinical Trials and Real World Data: Learning From Patients Revascularised for Peripheral Artery Disease in France
Eur J Vasc Endovasc Surg. 2024 Feb 28:S1078-5884(24)00198-9. doi: 10.1016/j.ejvs.2024.02.038. Online ahead of print.NO ABSTRACTPMID:38428667 | DOI:10.1016/j.ejvs.2024.02.038 (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - March 1, 2024 Category: Surgery Authors: Fabien Lareyre Juliette Raffort Source Type: research

Effect of a Home Based Exercise Programme and a Smartphone app: WalkingPad Randomised Clinical Trial
Objective: Home based exercise therapy (HBET) for patients with peripheral artery disease (PAD) and intermittent claudication (IC) is a low cost, low risk, and effective therapeutic measure to improve walking distances, walking performance, and quality of life (QoL). However, adherence is low due to a lack of supervision and intrinsic motivation. The aim was to investigate whether HBET programmes with a behaviour change intervention, supported and unsupported by a smartphone application (app), is effective in improving walking distances and performance, as well as QoL over six months. (Source: European Journal of Vascular ...
Source: European Journal of Vascular and Endovascular Surgery - March 1, 2024 Category: Surgery Authors: Ivone Silva, Carlos Veiga, Hugo Paredes, Celia Moreira, Susana Pedras Source Type: research

Editor's Choice -- Exercise Therapy for Chronic Symptomatic Peripheral Artery Disease: A  Clinical Consensus Document of the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases in Collaboration With the European Society of Vascular Medicine and the European Society for Vascular Surgery
All guidelines worldwide strongly recommend exercise as a pillar in the management of patients affected by lower extremity peripheral artery disease (PAD). Exercise therapy in this setting presents different modalities, and a structured programme provides optimal results. This clinical consensus paper is intended to promote and assist the set up of comprehensive exercise programmes and best advice for patients with symptomatic chronic PAD. Different exercise training protocols specific for patients with PAD are presented. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - March 1, 2024 Category: Surgery Authors: Lucia Mazzolai, Jill Belch, Maarit Venermo, Victor Aboyans, Marianne Brodmann, Alessandra Bura-Rivi ère, Sebastien Debus, Christine Espinola-Klein, Amy E. Harwood, John A. Hawley, Stefano Lanzi, Juraj Madarič, Guillaume Mahé, Davide Malatesta, Oliver S Tags: Clinical Practice Guideline Document Source Type: research

Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases
Conclusion: Our research suggested new evidence of the relationship between identified metabolites and 6 age-related diseases, which may hold promise as valuable biomarkers.PMID:38415056 | PMC:PMC10897029 | DOI:10.3389/fgene.2024.1353908 (Source: Atherosclerosis)
Source: Atherosclerosis - February 28, 2024 Category: Cardiology Authors: Zonghao Qian Yuzhen Huang Yucong Zhang Ni Yang Ziwei Fang Cuntai Zhang Le Zhang Source Type: research

Short-term outcomes of endovascular management of acute limb ischemia using aspiration mechanical thrombectomy
CONCLUSIONS: Short-term amputation-free survival rates of endovascular management of acute limb ischemia are adequate across all modalities. However, aspiration mechanical thrombectomy was associated with significantly worse amputation-free survival compared to other endovascular adjuncts alone (i.e., pharmacomechanical thrombolysis). Severe limb ischemia (Rutherford ALI Stage 2B) and prior supra-inguinal bypass were associated with worse amputation-free survival regardless of the choice of endovascular intervention.PMID:38415647 | DOI:10.1177/17085381241236923 (Source: Vascular)
Source: Vascular - February 28, 2024 Category: Surgery Authors: Matthew E Auda Molly Ratner Michael Pezold Caron Rockman Mikel Sadek Glenn Jacobowitz Todd Berland Jeffrey J Siracuse Katherine Teter William Johnson Karan Garg Source Type: research

Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases
Conclusion: Our research suggested new evidence of the relationship between identified metabolites and 6 age-related diseases, which may hold promise as valuable biomarkers.PMID:38415056 | PMC:PMC10897029 | DOI:10.3389/fgene.2024.1353908 (Source: Atherosclerosis)
Source: Atherosclerosis - February 28, 2024 Category: Cardiology Authors: Zonghao Qian Yuzhen Huang Yucong Zhang Ni Yang Ziwei Fang Cuntai Zhang Le Zhang Source Type: research

Short-term outcomes of endovascular management of acute limb ischemia using aspiration mechanical thrombectomy
CONCLUSIONS: Short-term amputation-free survival rates of endovascular management of acute limb ischemia are adequate across all modalities. However, aspiration mechanical thrombectomy was associated with significantly worse amputation-free survival compared to other endovascular adjuncts alone (i.e., pharmacomechanical thrombolysis). Severe limb ischemia (Rutherford ALI Stage 2B) and prior supra-inguinal bypass were associated with worse amputation-free survival regardless of the choice of endovascular intervention.PMID:38415647 | DOI:10.1177/17085381241236923 (Source: Vascular)
Source: Vascular - February 28, 2024 Category: Surgery Authors: Matthew E Auda Molly Ratner Michael Pezold Caron Rockman Mikel Sadek Glenn Jacobowitz Todd Berland Jeffrey J Siracuse Katherine Teter William Johnson Karan Garg Source Type: research

Predictive model and risk analysis for peripheral vascular disease in type 2 diabetes mellitus patients using machine learning and shapley additive explanation
ConclusionThe machine learning approach successfully developed a PVD risk prediction model with good performance. The model identified the factors associated with PVD and offered physicians an intuitive understanding on the impact of key features in the model. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 28, 2024 Category: Endocrinology Source Type: research

Mind the Gap Between Clinical Trials and Real World Data: Learning From Patients Revascularised for Peripheral Artery Disease in France
(Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - February 28, 2024 Category: Surgery Authors: Fabien Lareyre, Juliette Raffort Tags: Invited Commentary Source Type: research

The prevalent causes of death in patients with peripheral artery disease undergoing revascularisation or amputation
CONCLUSION: Whilst cardiovascular COD are the most prevalent reasons for mortality in patients with PAD, the proportion of patients dying from neoplasia and respiratory disease is high. Improved reporting standards for COD in studies examining PAD are needed.PMID:38411009 | DOI:10.1177/17085381241236562 (Source: Vascular)
Source: Vascular - February 27, 2024 Category: Surgery Authors: Stacey Telianidis Sarah Joy Aitken Source Type: research

Classification of anatomic patterns of peripheral artery disease with automated machine learning (AutoML)
CONCLUSION: After a brief training period with a limited dataset, AutoML has demonstrated its potential in identifying and classifying the anatomical patterns of PAD, operating unhindered by the factors that can affect human analysts, such as fatigue or lack of experience. This technology bears the potential to revolutionize outcome prediction and standardize evidence-based revascularization strategies for patients with PAD, leveraging its adaptability and ability to continuously improve with additional data. The pursuit of further research in AutoML within the field of vascular medicine is both promising and warranted. Ho...
Source: Vascular - February 26, 2024 Category: Surgery Authors: Yury Rusinovich Volha Rusinovich Aliaksei Buhayenka Vitalii Liashko Arsen Sabanov David J F Holstein Samer Aldmour Markus Doss Daniela Branzan Source Type: research

Postoperative Pyoderma Gangrenosum in a Patient Presenting with Acute Peripheral Artery Disease Secondary to Antiphospholipid Syndrome: A Case Report
We report a 53-year-old febrile male patient with acute peripheral arterial disease who underwent transtibial amputation after failed thrombolysis. Five days after amputation, an ulcer developed around the cannulation site of the right internal jugular vein that was indicative of pathergy. The patient's fever did not improve after surgery, and purpuric discoloration and punctate ulcers of the skin near the amputation site became apparent, leading to re-debridement. Finally, consultation with a dermatologist raised the possibility of postoperative PG, and additional laboratory tests revealed positive anticardiolipin autoant...
Source: Clinical, Cosmetic and Investigational Dermatology - February 26, 2024 Category: Dermatology Authors: Haijun Wei Ke Wang Wei Huang Yang Liu Source Type: research

Classification of anatomic patterns of peripheral artery disease with automated machine learning (AutoML)
CONCLUSION: After a brief training period with a limited dataset, AutoML has demonstrated its potential in identifying and classifying the anatomical patterns of PAD, operating unhindered by the factors that can affect human analysts, such as fatigue or lack of experience. This technology bears the potential to revolutionize outcome prediction and standardize evidence-based revascularization strategies for patients with PAD, leveraging its adaptability and ability to continuously improve with additional data. The pursuit of further research in AutoML within the field of vascular medicine is both promising and warranted. Ho...
Source: Vascular - February 26, 2024 Category: Surgery Authors: Yury Rusinovich Volha Rusinovich Aliaksei Buhayenka Vitalii Liashko Arsen Sabanov David J F Holstein Samer Aldmour Markus Doss Daniela Branzan Source Type: research

Postoperative Pyoderma Gangrenosum in a Patient Presenting with Acute Peripheral Artery Disease Secondary to Antiphospholipid Syndrome: A Case Report
We report a 53-year-old febrile male patient with acute peripheral arterial disease who underwent transtibial amputation after failed thrombolysis. Five days after amputation, an ulcer developed around the cannulation site of the right internal jugular vein that was indicative of pathergy. The patient's fever did not improve after surgery, and purpuric discoloration and punctate ulcers of the skin near the amputation site became apparent, leading to re-debridement. Finally, consultation with a dermatologist raised the possibility of postoperative PG, and additional laboratory tests revealed positive anticardiolipin autoant...
Source: Clinical, Cosmetic and Investigational Dermatology - February 26, 2024 Category: Dermatology Authors: Haijun Wei Ke Wang Wei Huang Yang Liu Source Type: research