Peripheral Vascular Disease (PVD) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach
CONCLUSIONS: PAD interventionalists practicing at an academic health system recognize the heterogenous response of their patients to clopidogrel therapy but are unsure when to leverage genetic testing to improve outcomes for their patients. Our study identified gaps regarding PAD interventionalists' knowledge, perceived barriers, and attitudes toward CYP2C19 testing in PAD. This information highlights the need for randomized data on genetic testing for clopidogrel responsiveness in peripheral vascular disease following intervention to help guide antiplatelet management.PMID:38669051 | DOI:10.1177/17085381241246318 (Source: Vascular)
Source: Vascular - April 26, 2024 Category: Surgery Authors: Christopher Regan Lindsey E Scierka Alan Dardik Britt Tonnessen Cassius Iyad Ochoa Chaar Costin Ionescu Edouard Aboian Jonathan Cardella Naiem Nassiri Raul Guzman Robert Attaran Sameer Nagpal Samit Shah Kim G Smolderen Carlos Mena-Hurtado Source Type: research

Unused potential of lipid-lowering therapy in very high-risk patients with atherosclerotic cardiovascular disease. A retrospective data analysis
CONCLUSION: Switch to high-intensity statins and use of ezetimibe and PCSK9i was low in chronic ASCVD patients. Even though statin intake was high in high-risk patients, target levels were still not reached.PMID:38664125 | DOI:10.1016/j.numecd.2024.03.007 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Sarah B Pohl Christiane Engelbertz Holger Reinecke Nasser M Malyar Matthias Meyborg Tobias J Brix Julian Varghese Katrin Gebauer Source Type: research

Are Barriers to Physical Activity Associated With Changing Physical Activity Levels and Sedentary Time in Patients With Peripheral Arterial Disease? A Longitudinal Study
J Aging Phys Act. 2024 Apr 24:1-7. doi: 10.1123/japa.2023-0120. Online ahead of print.ABSTRACTThe aims of the current study were to analyze the association between the barriers to and changes in physical activity levels and sedentary behavior, as well as to examine whether these barriers change over time in patients with peripheral artery disease. In this longitudinal study, we assessed 72 patients (68% men; 65.7 ± 9.2 years). Physical activity was measured over a 7-day period using an accelerometer, and data were collected on time spent in sedentary activities, low-light physical activities, and moderate-to-vigorous phys...
Source: Journal of Aging and Physical Activity - April 25, 2024 Category: Geriatrics Authors: Juliane Carolina da Silva Santos Raphael Mendes Ritti-Dias Gabriel Grizzo Cucato Nelson Wolosker Marilia de Almeida Correia Breno Quintella Farah Source Type: research

Limb Outcomes With Ticagrelor Plus Aspirin in Patients With Diabetes Mellitus and Atherosclerosis
CONCLUSIONS: Patients with T2DM and atherosclerosis are at high risk of limb events. Ticagrelor decreased this risk, but increased bleeding. Future trials evaluating the combination of ticagrelor and aspirin would further elucidate the benefit/risk of such therapy in patients with PAD, including those without coronary artery disease. (A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus [THEMIS]: NCT01991795).PMID:38658101 | DOI:10.1016/j.jacc.2024.03.377 (Source: Atherosclerosis)
Source: Atherosclerosis - April 24, 2024 Category: Cardiology Authors: Marc P Bonaca Deepak L Bhatt Tabassome Simon Kim Michael Fox Shamir Mehta Robert A Harrington Lawrence A Leiter Warren H Capell Claes Held Anders Himmelmann Wilhelm Ridderstr åle Jersey Chen Jane J Lee Yang Song Marielle Andersson Jayne Prats Mikhail Kos Source Type: research

Establishing a Critical Limb Ischemia Outpatient Center: Separating Facts from Myth
This article discusses critical limb ischemia center creation from the perspective of critical limb ischemia therapists working in an outpatient setting. (Source: Techniques in Vascular and Interventional Radiology)
Source: Techniques in Vascular and Interventional Radiology - April 24, 2024 Category: Radiology Authors: Fadi Saab, Bret N. Wiechmann Source Type: research

Brief report: Effect of cardiac multi-morbidity on COVID hospitalization outcomes
by Fouad Chouairi, Edward Jaffe, Abdul Mannan Khan Minhas, Marat Fudim BackgroundThe COVID-19 pandemic has stretched healthcare resources thin and led to significant morbidity and mortality. There have been no studies utilizing national data to investigate the role of cardiac risk factors on outcomes of COVID hospitalizations. The aim of this study was to examine the effect of cardiac multimorbidity on healthcare utilization and outcomes among COVID hospitalizations during the first year of the pandemic. MethodsUsing the national inpatient sample (NIS), we identified all adult hospital admissions with a primary diagnosis o...
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Fouad Chouairi Source Type: research

Smoking as a risk factor for lower extremity peripheral artery disease in women compared to men: A systematic review and meta-analysis
DiscussionsFurther research is required to elucidate sex differences in the relationships between smoking and PAD, as the current evidence is limited and mixed. Tobacco-control programs should consider both sexes. (Source: PLoS One)
Source: PLoS One - April 24, 2024 Category: Biomedical Science Authors: Ying Xu Source Type: research

Prosthetic Outcomes after Amputation and the Impact of Mobility Level on Survival
Lower extremity amputation continues to be necessary in a significant number of patients with peripheral vascular disease. The 5 year survival following lower limb loss is markedly reduced. Many of these patients are never fitted with a prosthesis and there is a dearth of knowledge regarding the barriers to prosthetic attainment. The goal of this study was to identify the risk factors for not receiving a prosthesis and the effect of mobility level on survival following major amputation. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 23, 2024 Category: Surgery Authors: William Shutze, Dennis Gable, Gerald Ogola, John Eidt Source Type: research

Enabling Non-invasive Tracking of Vascular Endothelial Cells Derived from Induced Pluripotent Stem Cells Using Nuclear Imaging
ConclusionsThis study establishes an optimized cell modification and imaging protocol for tracking transplanted cells. Future efforts will focus on enhancing cell survival and integration via improved delivery systems, thereby advancing the potential of cell-based therapies for PAD.Graphical AbstractIn this study, we present an optimized approach for non-invasive tracking of transplanted vascular endothelial cells (HiPSC-ECs) using a combination of lentiviral transduction with hNIS and eGFP genes and single-photon emission computed tomography (SPECT) imaging. Our methodology allows real-time monitoring of HiPSC-ECs in vivo...
Source: Cardiovascular Engineering and Technology - April 23, 2024 Category: Cardiology Source Type: research

Scout Vein Graft – An intraoperative technique to assess the suitability of atherosclerotic donor arteries for free flap reconstruction
Free flap reconstruction of diabetic foot and its salvage is becoming more common. The combination of diabetes mellitus, post-infective lower extremity wounds, and peripheral vascular disease leads to a confluence of perilous factors, putting both limb and life at risk.1 The initial step in microvascular reconstruction is to assess the suitability of the donor artery, which is done clinically by palpating peripheral pulses, preoperatively with vascular imaging, and intraoperatively by examining the vessel characteristics and pulsatility of the donor artery. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - April 20, 2024 Category: Cosmetic Surgery Authors: Madhu Periasamy, Vamseedharan Muthukumar, Hari Venkatramani, S Raja Sabapathy Source Type: research