Editorial
(Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - August 20, 2019 Category: Cardiology Source Type: research

Design and Computational Validation of a Novel Bioreactor for Conditioning Vascular Tissue to Time-Varying Multidirectional Fluid Shear Stress
ConclusionsA bioreactor capable of generating simultaneously desired time-varying WSS magnitude and directionality was designed and validated computationally. The ability to subject tissue toin vivo-like WSS will provide new insights into cardiovascular mechanobiology and disease. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - July 15, 2019 Category: Cardiology Source Type: research

On the Modeling of Patient-Specific Transcatheter Aortic Valve Replacement: A Fluid –Structure Interaction Approach
ConclusionIn conclusion, the development of realistic and accurate FSI patient-specific models can be used as a support for clinical decisions before the implantation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - July 15, 2019 Category: Cardiology Source Type: research

A Virtual Comparison of the eCLIPs Device and Conventional Flow-Diverters as Treatment for Cerebral Bifurcation Aneurysms
ConclusionsOur findings indicate that the eCLIPs device acts as a flow-diverter for bifurcation aneurysms, with somewhat diminished occlusion properties comparing to tubular flow diverters but without the jailing and diminished flow evident in a daughter vessel associated with use of conventional devices. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - July 8, 2019 Category: Cardiology Source Type: research

In-Vitro Pulsatile Flow Testing of Prosthetic Heart Valves: A Round-Robin Study by the ISO Cardiac Valves Working Group
ConclusionsThe study revealed the ambiguities in the current versions of the ISO 5840 series of standards and the shortcomings of some participating laboratories. This information has allowed the ISO Working Group to incorporate additional clarifying language into the ISO 5840-1, -2, and -3 standards that are currently under revision to improvein vitro assessments. The results presented here can also be used by the testing laboratories to benchmark pulse duplicator systems and to train and certify testing personnel. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 25, 2019 Category: Cardiology Source Type: research

High-Resolution Measurements of Leakage Flow Inside the Hinge of a Large-scale Bileaflet Mechanical Heart Valve Hinge Model
ConclusionsThe scale-up approach provided new insight into the nature of the hinge flow and enhanced understanding of its complexity. This study revealed flow features that may induce blood element damage. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 24, 2019 Category: Cardiology Source Type: research

Automatic Segmentation, Detection, and Diagnosis of Abdominal Aortic Aneurysm (AAA) Using Convolutional Neural Networks and Hough Circles Algorithm
ConclusionsAs a whole, a classifier using Convolutional Neural Network is designed and applied in order to detect AAA region among other abdominal regions. Then Hough Circles algorithm is applied to aorta patches for finding aorta border and measuring its diameter. Ultimately, the detected aortas will be categorized according to their diameters. All steps meet the expected results. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 19, 2019 Category: Cardiology Source Type: research

Optimization of a Transcatheter Heart Valve Frame Using Patient-Specific Computer Simulation
ConclusionsIn conclusion, patient-specific modelling and simulation could help to evaluate device performance prior to the actual first-in-human clinical study and, combined with device optimization, could help to develop better devices in a shorter period. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 13, 2019 Category: Cardiology Source Type: research

Preload Sensitivity with TORVAD Counterpulse Support Prevents Suction and Overpumping
ConclusionsCounterpulse support with the TORVAD preserves aortic valve flow and provides physiological sensitivity across all preload conditions. This should prevent overpumping and minimize the risk of suction. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 11, 2019 Category: Cardiology Source Type: research

Asymmetric Dynamics of the Native Aortic Annulus Evaluated by Force Transducer and Sonomicrometry in a Porcine Model
ConclusionsThis study is the first to describe detailed segmental dynamics and force distribution of the native aortic annulus in a porcine modelin vivo. The heterogenous behavior of the aortic annulus suggests that different segments demand different support for repair of the aortic root and valve. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - June 7, 2019 Category: Cardiology Source Type: research

Fabrication of Low-Cost Patient-Specific Vascular Models for Particle Image Velocimetry
ConclusionThis technique was successful to implement and test the use of PVA in a lost-core casting technique to create low-cost, patient-specificin vitro models for PIV experimentation. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - May 16, 2019 Category: Cardiology Source Type: research

Evaluating the Performance of Cardiac Pulse Duplicators Through the Concept of Fidelity
AbstractIntroductionThe advanced design techniques used in modern prosthetic heart valve (PHV) development require accurate replication of the entire cardiac cycle. While cardiac pulse duplicator (CPD) design has a direct impact on the PHV test data generated, no clear guidelines exist to evaluate the CPD ’s performance. In response to this, we present a method to quantitatively assess CPD performance.Materials and MethodsA method to establish the fidelity of CPDs was formulated based on the pressure/time relationship and the error related to this relationship ’s target. This method was applied to assess the pe...
Source: Cardiovascular Engineering and Technology - April 30, 2019 Category: Cardiology Source Type: research

Novel T-wave Detection Technique with Minimal Processing and RR-Interval Based Enhanced Efficiency
ConclusionsA T-wave detection technique requiring minimal pre-processing and with simple decision rule has been designed. The noticeably high positive predictivity rate of the proposed technique shows its efficiency to detect T-wave peak. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 16, 2019 Category: Cardiology Source Type: research

Locating Atrial Fibrillation Rotor and Focal Sources Using Iterative Navigation of Multipole Diagnostic Catheters
ConclusionsThe algorithm could play a critical role in clinical electrophysiology laboratories for mapping patient-specific ablation of AF sources located outside the pulmonary veins and improving the procedure success. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 15, 2019 Category: Cardiology Source Type: research

Image-Based Flow Simulations of Pre- and Post-left Atrial Appendage Closure in the Left Atrium
ConclusionsThis framework successfully predicted patient-specific outcome of a LAA closure procedure for one patient with atrial fibrillation. It can be further developed into a useful tool for pre-procedural planning and candidate selection. More patient data are necessary for further validation studies. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 5, 2019 Category: Cardiology Source Type: research

Mechanics of Atherosclerotic Plaques: Effect of Heart Rate
ConclusionsThe results of current study may provide a better understanding on the mechanics of vulnerable atherosclerotic plaques and that any experimental methods assessing the viscoelasticity of plaque composition during progression are highly desirable. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 4, 2019 Category: Cardiology Source Type: research

High-Frequency Fluctuations in Post-stenotic Patient Specific Carotid Stenosis Fluid Dynamics: A Computational Fluid Dynamics Strategy Study
ConclusionsThe Sigma model was the best combination between accuracy and cost for simulating the pulsatile post-stenotic flow field, whereas for the constant flow rate, the under-resolved DNS approach was better. These results can be used as a reference for future studies investigating high-frequent flow features. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - April 1, 2019 Category: Cardiology Source Type: research

Development of a Two-Way Coupled Eulerian –Lagrangian Computational Magnetic Nanoparticle Targeting Model for Pulsatile Flow in a Patient-Specific Diseased Left Carotid Bifurcation Artery
ConclusionThe simulation results presented in the present work have shown to yield favorable capture efficiencies for micron range particles and a potential for enhancing capture efficiency of superparamagnetic particles in smaller arteries and/or using magnetized implants such as cardiovascular stents. The present work presents results for justifying further investigation of MDT as a treatment technique for cardiovascular disease. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 29, 2019 Category: Cardiology Source Type: research

The Length Versus Diameter Relationship and Radial Force Properties of the Amplatzer ™ Vascular Plug Type IV: Observations for Oversizing
ConclusionsThe AVP IV device has a reliable length for diameter relationship. A counterintuitive property of the AVP IV with regards to radial force for device size was found. The 5  mm AVPIV was found to exert the highest radial force and stiffness compared to the other devices. The 7 and 8 mm AVPIV devices were consistently found to exert less radial force. This property suggests that oversizing an AVP IV could be safe and effective, potentially decreasing total devices use d, cost, and overall procedure time. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 21, 2019 Category: Cardiology Source Type: research

Assessing the Thrombogenic Potential of Heart Valve Prostheses: An Approach for a Standardized In - Vitro Method
ConclusionThe THIA 3 has proven its suitability for valid, reproducible evaluation of thrombogenic potential of heart valves in a short period of time. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - March 6, 2019 Category: Cardiology Source Type: research

Experimental Insight into the Hemodynamics and Perfusion of Radiological Contrast in Patent and Non-patent Aortic Dissection Models
ConclusionsBlood velocities in the TL and FL were highly sensitive to the exact dissection configuration. Geometric case A1R, which had its proximal entry tear located further downstream along the aortic arch, and had its entry and reentry tears sufficiently sized, exhibited the highest FL flow velocity among the tested models, and it was also higher than in the TL, which suggest that this configuration had elevated hemodynamic loading and risk for tearing. In contrast-enhanced diagnostic imaging, a time-delayed acquisition protocol is recommended to improve the detection of suspected cases with a non-patent FL. (Source: C...
Source: Cardiovascular Engineering and Technology - February 25, 2019 Category: Cardiology Source Type: research

Quantitative Characterization of Aortic Valve Endothelial Cell Viability and Morphology In Situ Under Cyclic Stretch
In conclusion,in vitro application of physiological levels of cyclic strain to tissue engineered heart valves seeded with autologous endothelial cells would be advantageous. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 22, 2019 Category: Cardiology Source Type: research

Current Challenges and Emergent Technologies for Manufacturing Artificial Right Ventricle to Pulmonary Artery (RV-PA) Cardiac Conduits
AbstractDespite advances in modern surgery, congenital heart disease remains a medical challenge and major cause of infant mortality. Valved conduits are routinely used to surgically correct blood flow in hearts with congenital malformations by connecting the right ventricle to the pulmonary artery (RV-PA). This review explores the current range of RV-PA conduits and describes their strengths and disadvantages. Homografts and xenografts are currently the primary treatment modalities, however both graft types have limited biocompatibility and durability, and present a disease transmission risk. Structural deterioration of a...
Source: Cardiovascular Engineering and Technology - February 14, 2019 Category: Cardiology Source Type: research

Tricuspid Valve Annular Mechanics: Interactions with and Implications for Transcatheter Devices
AbstractIn the interventional treatment of tricuspid valve regurgitation, the majority of prosthetic devices interact with or are implanted to the tricuspid valve annulus. For new transcatheter technologies, there exists a growing body of clinical experience, literature, and professional discourse related to the difficulties in delivering, securing, and sustaining the function of these devices within the dynamic tricuspid annulus. Many of the difficulties arise from circumstances not encountered in open-heart surgery, namely; a non-arrested heart, indirect visualization, and a reliance on non-suture-based methods. These ch...
Source: Cardiovascular Engineering and Technology - February 12, 2019 Category: Cardiology Source Type: research

Cyclosporin A Protected Cardiomyocytes Against Oxidative Stress Injury by Inhibition of NF- κ B Signaling Pathway
ConclusionsCsA protected cardiomyocytes against H2O2-induced cell injury. Hence, CsA may be developed as a candidate drug to prevent or treat myocardial ischemia reperfusion injury. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 6, 2019 Category: Cardiology Source Type: research

The Impact of the Right Coronary Artery Geometric Parameters on Hemodynamic Performance
ConclusionsLow values of tortuosity, smaller cross-sectional area and higher angle of the right-ventricular branch leads to a hemodynamic behavior more propitious to atherosclerosis formation, within the study cases. The right-ventricular branch seems to have the highest influence in the hemodynamic behavior of the right coronary artery. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 6, 2019 Category: Cardiology Source Type: research

A Tunable Resonance Cantilever for Cardiac Energy Harvesting
ConclusionsThe prototype device can harvest sufficient energy to sustain implantable cardiac devices such as a leadless pacemaker. The system in this paper has the potential to eliminate batteries in certain implantable cardiac devices and thereby improve overall patient monitoring and treatment. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - February 1, 2019 Category: Cardiology Source Type: research

MRI and Blood Flow in Human Arteries: Are There Any Adverse Effects?
ConclusionsOur results suggest that the clinical consequences are to be carefully considered before exposing human beings to ultra high field MRI. It may not be appropriate to conclude anything about the effect of magnetic field on blood flow in human beings based on experimental studies on animals, which is one of the reasons for the contradicting reports found in the literature. A slip condition at the wall which is appropriate to hemodynamics is yet to be developed. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 28, 2019 Category: Cardiology Source Type: research

Multi-Objective Optimization Design of Balloon-Expandable Coronary Stent
ConclusionsThe obtained results showed that the multi-objective optimization method is efficient in predicting an optimal stent design. The method presented in this paper can be useful in optimizing stent design and improving the comprehensive mechanical properties of stents. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 23, 2019 Category: Cardiology Source Type: research

Technical Feasibility and Design of a Shape Memory Alloy Support Device to Increase Ejection Fraction in Patients with Heart Failure
ConclusionsThis study demonstrated the feasibility of volume displacement in a static heart model by activation of SMA-wires. Configuration, duty cycle, frequency, pulse intervals and diameter were identified as important factors affecting the activation of SMA-wires on volume displacement. Future research should include the use of parallel SMA-wires, prototype testing in dynamic orex vivo bench models. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - January 9, 2019 Category: Cardiology Source Type: research

A Valveless Pulsatile Pump for the Treatment of Heart Failure with Preserved Ejection Fraction: A Simulation Study
ConclusionsIn this simulation study, the valveless pulsatile device improves hemodynamics in HFpEF patients by increasing the total stroke volume. The hemodynamic benefits are achieved with a small device volume comparable to implantable rotary blood pumps. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 10, 2018 Category: Cardiology Source Type: research

A Computational Study of Mechanical Performance of Bioresorbable Polymeric Stents with Design Variations
ConclusionThe structural behaviour of bioresorbable polymeric stent is strongly affected by its design, in terms of expansion, dogboning, recoiling and stress distribution during the deployment process. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 10, 2018 Category: Cardiology Source Type: research

Patient-Specific Multi-Scale Model Analysis of Hemodynamics Following the Hybrid Norwood Procedure for Hypoplastic Left Heart Syndrome: Effects of Reverse Blalock –Taussig Shunt Diameter
ConclusionAmong the three graft sizes, the best option seems to be the 3.5  mm RBTS which provides a more organized flow similar to that of the 3.0 mm configuration with lower levels of wall shear stress. As such, in the setting of this study and for comparable HN physiologies our results suggest that: (1) the 4.0 mm shunt is a generous shunt diameter choice that may be problematic particularly when implemented prophylactically in the absence of stenosis, and (2) the 3.5 mm shunt may be a more suitable alternative since it exhibits more favorable hemodynamics at lower levels of wall shear stress. (Sourc...
Source: Cardiovascular Engineering and Technology - December 4, 2018 Category: Cardiology Source Type: research

Study on the Accuracy of Structural and FSI Heart Valves Simulations
ConclusionIn this regard, our results indicate the quadrangular shell with reduced integration and viscous hourglass control to be the best choice to model heart valves. If a solid discretization is required, quadratic hexahedral elements with full integration are also acceptable. Finally, our results show that the damping coefficient needs to be carefully selected in order to smooth out the high frequency modes of the structure without introducing excessive numerical artificial viscosity. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 1, 2018 Category: Cardiology Source Type: research

Uncertainty Quantification of a Multiscale Model for In-Stent Restenosis
ConclusionThe model output contains a moderate quantity of uncertainty, and the model precision can be increased by obtaining a more certain value on the endothelium regeneration time. We conclude that the quasi-Monte Carlo UQ and the Sobol SA are reliable methods for estimating uncertainties in the response of complicated multiscale cardiovascular models. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - December 1, 2018 Category: Cardiology Source Type: research

A Novel Pulse Damper for Endothelial Cell Flow Bioreactors
ConclusionsFlow pulsatility from PP causes EC distress at low flow and cell detachment at high flow. Elevated temporal shear stress gradient combined with elevated shear stress magnitude at high flow are believed to be the cause of cell detachment and death. The proposed PD design was effective at minimizing the hemodynamic stressors in the pump ’s output, demonstrably reducing cell distress. Adoption of the proposed PD design in flow bioreactors should improve experimental protocols. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 28, 2018 Category: Cardiology Source Type: research

Objective Uniaxial Identification of Transition Points in Non-Linear Materials: Sample Application to Porcine Coronary Arteries and the Dependency of Their Pre- and Post-Transitional Moduli with Position
This study aimed to develop an objective method for the elastic characterisation of pre- and post-transitional moduli of left anterior descending (LAD) porcine coronary arteries.MethodsEight coronary arteries were divided into proximal, middle and distal test specimens. Specimens underwent uniaxial extension up to 3  mm. Force–displacement measurements were used to determine the induced true stress and stretch for each specimen. A local maximum of the stretch-true stress data was used to identify a transition point. Pre- and post-transitional moduli were calculated up to and from this point, respectively.Results...
Source: Cardiovascular Engineering and Technology - November 28, 2018 Category: Cardiology Source Type: research

Steady Flow in a Patient-Averaged Inferior Vena Cava —Part II: Computational Fluid Dynamics Verification and Validation
ConclusionsOverall, the study demonstrates mesh-convergent CFD simulations that predict IVC flow patterns that agree reasonably well with PIV data, even at exercise conditions where the flow in the IVC is extremely complex. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 16, 2018 Category: Cardiology Source Type: research

Steady Flow in a Patient-Averaged Inferior Vena Cava: Part II —Computational Fluid Dynamics Verification and Validation
ConclusionsOverall, the study demonstrates mesh-convergent CFD simulations that predict IVC flow patterns that agree reasonably well with PIV data, even at exercise conditions where the flow in the IVC is extremely complex. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 16, 2018 Category: Cardiology Source Type: research

Editorial: Special Issue on Verification, Validation, and Uncertainty Quantification of Cardiovascular Models: Towards Effective VVUQ for Translating Cardiovascular Modelling to Clinical Utility
(Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 12, 2018 Category: Cardiology Source Type: research

Steady Flow in a Patient-Averaged Inferior Vena Cava —Part I: Particle Image Velocimetry Measurements at Rest and Exercise Conditions
ConclusionsThe IVC geometry, boundary conditions, and infrarenal velocity measurements are provided for download on a free and publicly accessible repository  athttps://doi.org/10.6084/m9.figshare.7198703. These data will facilitate future CFD validation studies of idealized,in vitro IVC hemodynamics and of similar laminar flows in vascular geometries. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 8, 2018 Category: Cardiology Source Type: research

Validation and Extension of a Fluid –Structure Interaction Model of the Healthy Aortic Valve
ConclusionsThe study suggests a new operating mechanism for the healthy aortic valve leaflets considerably different from what reported in the literature to date and largely more efficient in terms of hydrodynamic performance. This work also confirms the crucial role that numerical approaches, complemented with experimental findings, can play in overcoming some of the limitations inherent in experimental techniques, supporting the full understanding of complex physiological phenomena. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - November 7, 2018 Category: Cardiology Source Type: research

Uncertainty Quantification and Sensitivity Analysis for Computational FFR Estimation in Stable Coronary Artery Disease
ConclusionModel errors related to solving a simplified reduced-order model rather than a full 3D problem were small compared with uncertainty related to input data. Improved measurement of coronary blood flow has the potential to reduce uncertainty in computational FFR predictions significantly. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 31, 2018 Category: Cardiology Source Type: research

Validation of Numerical Simulations of Thoracic Aorta Hemodynamics: Comparison with In Vivo Measurements and Stochastic Sensitivity Analysis
ConclusionsIn summary, a successful integration of hemodynamic simulations and of MRI data for a patient-specific simulation has been shown. The wall compliance seems to have a significant impact on the numerical predictions; a larger wall elasticity generally improves the agreement with experimental data. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 24, 2018 Category: Cardiology Source Type: research

Estimation of Biomechanical Properties of Normal and Atherosclerotic Common Carotid Arteries
ConclusionPresent study can be an indicative of the general state of the vascular system and be used for discriminating atherosclerotic from healthy arteries. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 24, 2018 Category: Cardiology Source Type: research

Evaluation of Peak Wall Stress in an Ascending Thoracic Aortic Aneurysm Using FSI Simulations: Effects of Aortic Stiffness and Peripheral Resistance
ConclusionsThis is the first time that the risk of rupture of an aTAA is quantified in case of the combined effects of hypertension and aortic stiffness increase. Our findings suggest that a stiffer TAA may have the most altered distribution of wall stress and an acute change of peripheral vascular resistance could significantly increase the risk of rupture for a stiffer aneurysm. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 19, 2018 Category: Cardiology Source Type: research

Coronary Stent Fracture: Clinical Evidence Vs. the Testing Paradigm
ConclusionsThe full scale of stent fracture is most likely under-reported and its assessment is dependent on detection time and detection resolution. Within the event of SF it is not necessarily consequential; further research is warranted to distinguish when the event negatively impacts the patient. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 19, 2018 Category: Cardiology Source Type: research

A New Method for Simulating Embolic Coils as Heterogeneous Porous Media
ConclusionsThese results indicate that the benefits of the porous medium assumption can be retained if a heterogeneous approach is applied. Implementation of the presented method led to a substantial reduction in the total number of mesh elements compared to the conventional method, and greater accuracy was enabled by considering heterogeneity compared to the homogenous approach. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 18, 2018 Category: Cardiology Source Type: research

Reversed Auxiliary Flow to Reduce Embolism Risk During TAVI: A Computational Simulation and Experimental Study
ConclusionsThe present study confirms that the integration ofin vitro experiments and in silico analyses allows designing and benchmarking novel solutions for cerebral embolic protection during TAVI such as the proposed embo-deviation technique based on an auxiliary retrograde flow from the right subclavian artery. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 16, 2018 Category: Cardiology Source Type: research

Cardiac Valve Bioreactor for Physiological Conditioning and Hydrodynamic Performance Assessment
ConclusionsWe have developed a single bioreactor system that allows for step-wise conditioning protocols to be developed for each unique TEHV design as well as allows for hydrodynamic performance assessment. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - October 11, 2018 Category: Cardiology Source Type: research