Cardiovascular risk and inflammation in a population with autoimmune diseases: a narrative review
Juvenile Systemic Connective Tissue Diseases (JSCTD) are a heterogeneous group of chronic autoimmune diseases, associated with dyslipidemia and increased cardiovascular risk are related. Studies from the last 10 years, from 2013 to 2022, on lipid profiles in JSCTD were collected. Different studies on lipid profiles in children affected by JSCTD were selected, because the aim is to analyze the cardiovascular risk and the possibility of atherosclerosis in these patients in whom, sometimes, corticosteroid therapies and immunosuppressants increase the state of dyslipidemia. Several studies have shown that autoimmune diseases w...
Source: Frontiers in Immunology - March 28, 2024 Category: Allergy & Immunology Source Type: research

Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic
Biomimetics (Basel). 2024 Feb 23;9(3):135. doi: 10.3390/biomimetics9030135.ABSTRACTAtherosclerosis represents the etiologic source of several cardiovascular events, including myocardial infarction, cerebrovascular accidents, and peripheral artery disease, which remain the leading cause of mortality in the world. Numerous strategies are being delineated to revert the non-optimal projections of the World Health Organization, by both designing new diagnostic and therapeutic approaches or improving the interventional procedures performed by physicians. Deeply understanding the pathological process of atherosclerosis is, theref...
Source: Atherosclerosis - March 27, 2024 Category: Cardiology Authors: Joana Henriques Ana M Amaro Ana P Piedade Source Type: research

Validation of the OAC3-PAD Bleeding Risk Score in Patients with Peripheral Artery Disease after Endovascular Treatment
(Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - March 26, 2024 Category: Surgery Authors: Vinko Boc, Kevin Pelicon, Klemen Petek, Anja Boc, Nata ša Kejžar, Aleš Blinc Tags: Research Letter Source Type: research

Enhancing walking performance in patients with peripheral arterial disease: An intervention with ankle-foot orthosis
This study aimed to employ advanced biomechanical gait analysis to evaluate the impact of AFO intervention on gait performance among patients with PAD. Patients with claudication had hip, knee, and ankle joint kinetics and kinematics assessed using a cross-over intervention design. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - March 23, 2024 Category: Cardiology Authors: Farahnaz Fallahtafti, Kaeli Samson, Zahra Salamifar, Jason Johanning, Iraklis Pipinos, Sara A. Myers Source Type: research

Clinical Physiology: The Crucial Role of MRI in Evaluation of Peripheral Artery Disease
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00533.2023. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a common vascular disease that primarily affects the lower limbs and is defined by the constriction or blockage of peripheral arteries and may involve microvascular dysfunction and tissue injury. Patients with diabetes have more prominent disease of microcirculation and develop peripheral neuropathy, autonomic dysfunction, and medial vascular calcification. Early and accurate diagnosis of PAD and disease characterization are essential for personalized management and therapy planni...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Nahla M H Elsaid Dana C Peters Gigi Galiana Albert J Sinusas Source Type: research

Clinical Physiology: The Crucial Role of MRI in Evaluation of Peripheral Artery Disease
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00533.2023. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a common vascular disease that primarily affects the lower limbs and is defined by the constriction or blockage of peripheral arteries and may involve microvascular dysfunction and tissue injury. Patients with diabetes have more prominent disease of microcirculation and develop peripheral neuropathy, autonomic dysfunction, and medial vascular calcification. Early and accurate diagnosis of PAD and disease characterization are essential for personalized management and therapy planni...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Nahla M H Elsaid Dana C Peters Gigi Galiana Albert J Sinusas Source Type: research

Clinical Physiology: The Crucial Role of MRI in Evaluation of Peripheral Artery Disease
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00533.2023. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a common vascular disease that primarily affects the lower limbs and is defined by the constriction or blockage of peripheral arteries and may involve microvascular dysfunction and tissue injury. Patients with diabetes have more prominent disease of microcirculation and develop peripheral neuropathy, autonomic dysfunction, and medial vascular calcification. Early and accurate diagnosis of PAD and disease characterization are essential for personalized management and therapy planni...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Nahla M H Elsaid Dana C Peters Gigi Galiana Albert J Sinusas Source Type: research

Clinical Physiology: The Crucial Role of MRI in Evaluation of Peripheral Artery Disease
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00533.2023. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a common vascular disease that primarily affects the lower limbs and is defined by the constriction or blockage of peripheral arteries and may involve microvascular dysfunction and tissue injury. Patients with diabetes have more prominent disease of microcirculation and develop peripheral neuropathy, autonomic dysfunction, and medial vascular calcification. Early and accurate diagnosis of PAD and disease characterization are essential for personalized management and therapy planni...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Nahla M H Elsaid Dana C Peters Gigi Galiana Albert J Sinusas Source Type: research

Clinical Physiology: The Crucial Role of MRI in Evaluation of Peripheral Artery Disease
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00533.2023. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a common vascular disease that primarily affects the lower limbs and is defined by the constriction or blockage of peripheral arteries and may involve microvascular dysfunction and tissue injury. Patients with diabetes have more prominent disease of microcirculation and develop peripheral neuropathy, autonomic dysfunction, and medial vascular calcification. Early and accurate diagnosis of PAD and disease characterization are essential for personalized management and therapy planni...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Nahla M H Elsaid Dana C Peters Gigi Galiana Albert J Sinusas Source Type: research

Clinical Physiology: The Crucial Role of MRI in Evaluation of Peripheral Artery Disease
Am J Physiol Heart Circ Physiol. 2024 Mar 22. doi: 10.1152/ajpheart.00533.2023. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a common vascular disease that primarily affects the lower limbs and is defined by the constriction or blockage of peripheral arteries and may involve microvascular dysfunction and tissue injury. Patients with diabetes have more prominent disease of microcirculation and develop peripheral neuropathy, autonomic dysfunction, and medial vascular calcification. Early and accurate diagnosis of PAD and disease characterization are essential for personalized management and therapy planni...
Source: American Journal of Physiology. Heart and Circulatory Physiology - March 22, 2024 Category: Physiology Authors: Nahla M H Elsaid Dana C Peters Gigi Galiana Albert J Sinusas Source Type: research

Chinese expert consensus on antithrombotic therapy of panvascular diseases (2024 edition)
Zhonghua Yi Xue Za Zhi. 2024 Mar 26;104(12):906-923. doi: 10.3760/cma.j.cn112137-20231101-00959.ABSTRACTPanvascular disease is a systemic condition with vascular lesions (95% of which are atherosclerosis) as the common pathological feature, which can be manifested as coronary artery disease, cerebrovascular disease, peripheral artery disease, etc., or a combination of two or more vascular bed diseases that is called multivascular disease. The burden of panvascular diseases in China is heavy, and improvement of patient prognosis is urgently needed. Although the management of panvascular diseases belongs to different discipl...
Source: Atherosclerosis - March 21, 2024 Category: Cardiology Authors: Chinese College of Cardiovascular Physicians Source Type: research

Remnant Cholesterol, Not LDL Cholesterol, Explains Peripheral Artery Disease Risk Conferred by apoB: A Cohort Study
CONCLUSIONS: PAD risk conferred by elevated apoB-containing lipoproteins was explained mainly by elevated remnants, while myocardial infarction risk was explained by both elevated remnants and LDL.PMID:38511326 | DOI:10.1161/ATVBAHA.123.320175 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Benjamin N Wadstr öm Kasper M Pedersen Anders B Wulff B ørge G Nordestgaard Source Type: research

Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis in Mice
CONCLUSIONS: Our study provides a novel mechanism with which GLP-1(32-36) acts in modulating metabolic reprogramming toward glycolytic flux in partnership with GLP-1R for improved angiogenesis in high glucose-exposed EPCs and T1DM murine models. We propose that GLP-1(32-36) could be used as a monotherapy or add-on therapy with existing treatments for peripheral artery disease.REGISTRATION: URL: www.ebi.ac.uk/metabolights/; Unique identifier: MTBLS9543.PMID:38511325 | DOI:10.1161/ATVBAHA.124.320714 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Yikai Zhang Shengyao Wang Qiao Zhou Yi Xie Yepeng Hu Weihuan Fang Changxin Yang Zhe Wang Shu Ye Xinyi Wang Chao Zheng Source Type: research

Chinese expert consensus on antithrombotic therapy of panvascular diseases (2024 edition)
Zhonghua Yi Xue Za Zhi. 2024 Mar 26;104(12):906-923. doi: 10.3760/cma.j.cn112137-20231101-00959.ABSTRACTPanvascular disease is a systemic condition with vascular lesions (95% of which are atherosclerosis) as the common pathological feature, which can be manifested as coronary artery disease, cerebrovascular disease, peripheral artery disease, etc., or a combination of two or more vascular bed diseases that is called multivascular disease. The burden of panvascular diseases in China is heavy, and improvement of patient prognosis is urgently needed. Although the management of panvascular diseases belongs to different discipl...
Source: Atherosclerosis - March 21, 2024 Category: Cardiology Authors: Chinese College of Cardiovascular Physicians Source Type: research

Remnant Cholesterol, Not LDL Cholesterol, Explains Peripheral Artery Disease Risk Conferred by apoB: A Cohort Study
CONCLUSIONS: PAD risk conferred by elevated apoB-containing lipoproteins was explained mainly by elevated remnants, while myocardial infarction risk was explained by both elevated remnants and LDL.PMID:38511326 | DOI:10.1161/ATVBAHA.123.320175 (Source: Arteriosclerosis, Thrombosis and Vascular Biology)
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 21, 2024 Category: Cardiology Authors: Benjamin N Wadstr öm Kasper M Pedersen Anders B Wulff B ørge G Nordestgaard Source Type: research