Transplantation of Human Embryonic Stem Cell –Derived Pericyte-Like Cells Transduced with Basic Fibroblast Growth Factor Promotes Angiogenic Recovery in Mice with Severe Chronic Hindlimb Ischemia
AbstractCritical limb ischemia (CLI) is a state of severe peripheral artery disease, with no effective treatment. Cell therapy has been investigated as a therapeutic tool for CLI, and pericytes are promising therapeutic candidates based on their angiogenic properties. We firstly generated highly proliferative and immunosuppressive pericyte-like cells from embryonic stem (ES) cells. In order to enhance the angiogenic potential, we transduced the basic fibroblast growth factor (bFGF) gene into the pericyte-like cells and found a significant enhancement of angiogenesis in a Matrigel plug assay. Furthermore, we evaluated the b...
Source: Journal of Cardiovascular Translational Research - February 20, 2024 Category: Cardiology Source Type: research

Diabetic Foot Ulcers: A Review of Debridement Techniques
Surg Technol Int. 2024 Feb 15;44:sti44/1718. Online ahead of print.ABSTRACTDiabetic foot ulcers (DFUs) are a prevalent complication of diabetes mellitus (DM) and lead to significant morbidity and mortality. Patients with DM have a lifetime risk of DFUs as high as 34%. The pathogenesis of DFUs is multifactorial, and the most common underlying causes are poor glycemic control, peripheral neuropathy, peripheral vascular disease, foot deformity, and poor foot care. Diabetic lower-extremity complications are also a significant burden in terms of healthcare costs. In the United States alone, the direct cost of diabetic foot care...
Source: Surgical Technology International - February 19, 2024 Category: Surgery Authors: Brianna C Sa Narges Maskan Bermudez Stephanie V Shimon Robert S Kirsner Source Type: research

Spectrophotometric resolution for quantitative analysis of aspirin and rivaroxaban combination therapy in biological fluids using simple and eco-friendly procedure
Patients diagnosed with symptomatic peripheral artery disease (PAD) in the lower extremities have a higher likelihood of suffering from major vascular events. Recently, FDA has approved the combination therapy... (Source: Chemistry Central Journal)
Source: Chemistry Central Journal - February 19, 2024 Category: Chemistry Authors: Heba M. Mohamed and Hebatallah M. Essam Tags: Research Source Type: research

Hepatitis C virus infection associated with coronary and thoracic aortic atherosclerosis
CONCLUSIONS: HCV infection with metabolic syndrome, liver fibrosis and elevated anti-HCV S/CO ratio was associated with atherosclerosis.PMID:38368945 | DOI:10.1016/j.amjms.2024.02.004 (Source: Atherosclerosis)
Source: Atherosclerosis - February 18, 2024 Category: Cardiology Authors: Chih-Wen Wang Chung-Feng Huang Ming-Lun Yeh Szu-Chia Chen Chih-Hsing Hung Chao-Hung Kuo Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Ming Lung-Yu Source Type: research

Hepatitis C virus infection associated with coronary and thoracic aortic atherosclerosis
CONCLUSIONS: HCV infection with metabolic syndrome, liver fibrosis and elevated anti-HCV S/CO ratio was associated with atherosclerosis.PMID:38368945 | DOI:10.1016/j.amjms.2024.02.004 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - February 18, 2024 Category: General Medicine Authors: Chih-Wen Wang Chung-Feng Huang Ming-Lun Yeh Szu-Chia Chen Chih-Hsing Hung Chao-Hung Kuo Jee-Fu Huang Chia-Yen Dai Wan-Long Chuang Ming Lung-Yu Source Type: research