Cancers, Vol. 15, Pages 4748: Evaluation of Prognostic Parameters to Identify Aggressive Penile Carcinomas
Conclusion: Lymphatic involvement has the highest impact on prognosis in penile cancer, whereas HPV status alone is not suitable as a prognostic parameter. The pT1b stage, which includes grading, as well as lymphovascular and perineural invasion in the T stage, seems questionable; a revision of the TNM classification is therefore required. (Source: Cancers)
Source: Cancers - September 27, 2023 Category: Cancer & Oncology Authors: Jan Niklas Mink Oybek Khalmurzaev Alexey Pryalukhin Carol Immanuel Geppert Stefan Lohse Kristof Bende Jo ão Lobo Rui Henrique Hagen Loertzer Joachim Steffens Carmen Jer ónimo Heiko Wunderlich Julia Heinzelbecker Rainer M. Bohle Michael St öckle Vsevolo Tags: Article Source Type: research
Sentinel node biopsy in male genitourinary cancers: state of the art and future developments
ConclusionThe SLN procedures in penile, prostate and testicular cancers are reviewed. Current trends toward in development of hybrid technique and robot-assisted sentinel lymph node are also discussed. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - September 19, 2023 Category: Radiology Source Type: research
Incidence of urological tumors in Down ’s syndrome: a systematic review and meta-analysis
ConclusionThere was a very low incidence of urological tumors in people with Down ’s syndrome. Testis tumor was the most frequently described in all cohorts and within a normal distribution range. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - September 14, 2023 Category: Urology & Nephrology Source Type: research
Comorbidity in patients with Lichen sclerosus: a retrospective cohort study
This study confirmed the association between LS and vulvar cancer (OR = 17.4; 95% CI 12.1-25.3), penis cancer (OR = 9.1; 95% CI 4.3-18.9), prostate cancer (OR = 2.0; 95% CI 1.6-2.4) and breast cancer (OR = 1.6; 95% CI 1.4-1.8). LS was also associated with Crohn´s disease (OR = 2.0; 95% CI 1.6-2.6) and diabetes mellitus type 1 (OR = 1.9; 95% CI 1.6-2.1). The present study revealed novel important data regarding the association of LS with cancer and autoimmune diseases, emphasising the importance of sufficient treatment and follow-up of patients with LS. However, future studies are needed to confirm these results and the po...
Source: Cell Research - September 12, 2023 Category: Cytology Authors: Sandra Jerkovic Gulin Filippa Lundin Oliver Seifert Source Type: research
Acantholytic Squamous Cell Carcinoma: a Diagnostic Pitfall on Cytology
AbstractAcantholytic squamous cell carcinoma is an infrequent subtype of squamous cell carcinoma. This tumour variant being rare in itself has been rarely described at the penile location, thus leading to a limitation on information of pathological and immunohistochemical findings and prognosis. Clinical observations indicate an aggressive biologic behaviour. The cytological features on fine-needle aspiration cytology samples have rarely been described in literature. It is imperative for pathologists to be aware of the cytological features so as to allow the distinction of this variant from conventional squamous carcinoma....
Source: Indian Journal of Surgical Oncology - September 12, 2023 Category: Cancer & Oncology Source Type: research
Comorbidity in patients with Lichen sclerosus: a retrospective cohort study
This study confirmed the association between LS and vulvar cancer (OR = 17.4; 95% CI 12.1–25.3), penis cancer (OR = 9.1; 95% CI 4.3–18.9), prostate cancer (OR = 2.0; 95% CI 1.6–2.4) and breast cancer (OR = 1.6; 95% CI 1.4–1.8). LS was also associated with Crohn´s disease (OR = 2.0; 95% CI 1.6–2.6) and diabetes mellitus type 1 (OR = 1.9; 95% CI 1.6–2.1). The present study revealed novel important data regarding the association of LS with cancer and autoimmune diseases, emphasising the importance of sufficient t reatment and follow-up of patients with LS. However, future studies are neede...
Source: European Journal of Medical Research - September 11, 2023 Category: Research Source Type: research
Thursday, June 22, 20234:30 PM - 5:30 PMPP01 Presentation Time: 4:30 PM
To report results for 89 patients with penile cancer treated with high-dose-rate brachytherapy (HDR-BT) at a single institution. Six (6.7%) were treated with superficial mold brachytherapy and 83 (93.3%) received interstitial therapy. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Sylwia Kellas-Sleczka, Wojcieszek Piotr, Stankiewicz Magdalena, Szlag Marta, Cholewka Agnieszka, Lelek Piotr, Sleczka Maciej, Pruefer Agnieszka, Marek Fijalkowski, Andrejczuk Andrzej Tags: Scientific Session: Miscellaneous Proffered Papers I Source Type: research
Viruses, Vol. 15, Pages 1857: Burden of HPV-Related Hospitalization in Germany from 2000 to 2021
Conclusion: Our study provides a comprehensive analysis of the trends in HPV-related hospitalizations over the past two decades. The decline in hospitalization rates for cervical cancer and dysplasia suggests the potential efficacy of the HPV vaccination and screening programs. (Source: Viruses)
Source: Viruses - August 31, 2023 Category: Virology Authors: Georgios Tampakoudis Olympia E. Anastasiou Tags: Communication Source Type: research
Treatment of penoscrotal basal cell carcinoma – an institutional retrospective review
We examined all penoscrotal BCC at a single institution over an 18-year period. A total of 7 cases were identified, 5 scrotal and 2 penile. Four cases (57%) were treated with Mohs micrographic surgery (MMS) and 3 cases (43%) with conventional excision. A prior retrospective review of vulvar BCC at our institution during the same time period showed that MMS was utilized in 4 (11%) of 35 cases. Functional preservation is vital when performing surgery on the genitals and tissue-sparing MMS provides optimal tumor clearance and outcomes for both males and females. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - August 28, 2023 Category: Dermatology Source Type: research
Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients
CONCLUSIONS: Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.PMID:37639681 | DOI:10.1093/ajcp/aqad107 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 28, 2023 Category: Pathology Authors: Anandi Lobo Sourav K Mishra Shilpy Jha Ankit Tiwari Rahul Kapoor Shivani Sharma Seema Kaushal N Sri Kiranmai M Rakshitha Das Kamal P Peddinti Shailendra K Sharma Nitin Bhardwaj Samriti Arora Deepika Jain Ekta Jain Gauri Munjal Sayali Shinde Vipra Malik He Source Type: research
Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients
CONCLUSIONS: Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.PMID:37639681 | DOI:10.1093/ajcp/aqad107 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 28, 2023 Category: Pathology Authors: Anandi Lobo Sourav K Mishra Shilpy Jha Ankit Tiwari Rahul Kapoor Shivani Sharma Seema Kaushal N Sri Kiranmai M Rakshitha Das Kamal P Peddinti Shailendra K Sharma Nitin Bhardwaj Samriti Arora Deepika Jain Ekta Jain Gauri Munjal Sayali Shinde Vipra Malik He Source Type: research
Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients
CONCLUSIONS: Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.PMID:37639681 | DOI:10.1093/ajcp/aqad107 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 28, 2023 Category: Pathology Authors: Anandi Lobo Sourav K Mishra Shilpy Jha Ankit Tiwari Rahul Kapoor Shivani Sharma Seema Kaushal N Sri Kiranmai M Rakshitha Das Kamal P Peddinti Shailendra K Sharma Nitin Bhardwaj Samriti Arora Deepika Jain Ekta Jain Gauri Munjal Sayali Shinde Vipra Malik He Source Type: research
Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients
CONCLUSIONS: Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.PMID:37639681 | DOI:10.1093/ajcp/aqad107 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 28, 2023 Category: Pathology Authors: Anandi Lobo Sourav K Mishra Shilpy Jha Ankit Tiwari Rahul Kapoor Shivani Sharma Seema Kaushal N Sri Kiranmai M Rakshitha Das Kamal P Peddinti Shailendra K Sharma Nitin Bhardwaj Samriti Arora Deepika Jain Ekta Jain Gauri Munjal Sayali Shinde Vipra Malik He Source Type: research
Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients
CONCLUSIONS: Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.PMID:37639681 | DOI:10.1093/ajcp/aqad107 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - August 28, 2023 Category: Pathology Authors: Anandi Lobo Sourav K Mishra Shilpy Jha Ankit Tiwari Rahul Kapoor Shivani Sharma Seema Kaushal N Sri Kiranmai M Rakshitha Das Kamal P Peddinti Shailendra K Sharma Nitin Bhardwaj Samriti Arora Deepika Jain Ekta Jain Gauri Munjal Sayali Shinde Vipra Malik He Source Type: research
Cancers, Vol. 15, Pages 4261: Long-Term Periodic and Conditional Survival Trends in Prostate, Testicular, and Penile Cancers in the Nordic Countries, Marking Timing of Improvements
Hemminki
Survival studies are important tools for cancer control, but long-term survival data on high-quality cancer registries are lacking for all cancers, including prostate (PC), testicular (TC), and penile cancers. Using generalized additive models and data from the NORDCAN database, we analyzed 1- and 5-year relative survival for these cancers in Denmark (DK), Finland (FI), Norway (NO), and Sweden (SE) over a 50-year period (1971–2020). We additionally estimated conditional 5/1-year survival for patients who survived the 1st year after diagnosis. Survival improved early for TC, and 5-year survival re...
Source: Cancers - August 25, 2023 Category: Cancer & Oncology Authors: Filip Tichanek Asta F örsti Akseli Hemminki Otto Hemminki Kari Hemminki Tags: Article Source Type: research
