Preventive Care for Men Who Have Sex With Men
Am Fam Physician. 2024 Apr;109(4):324-332.ABSTRACTMen who have sex with men (MSM) is an inclusive term used to refer to phenotypic males who have insertive or receptive sex (penile-anal or penile-oral) with other phenotypic males, including people who are transgender or have other gender identities. MSM may report their sexual orientation as homosexual, bisexual, heterosexual, or something else, but this stated sexual orientation may not align with their sexual attraction or behaviors. Several health conditions disproportionately affect MSM compared with age-matched heterosexual men, including HIV infection, anal cancer, s...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Stephen McMullan Therese Anderson Nadine Elhage Source Type: research
The indirect costs of human papillomavirus-related cancer in Central and Eastern Europe: years of life lost and productivity costs
CONCLUSIONS: There is a high disease burden of HPV-related cancer-related deaths in the CEE region, with a large economic impact to society due to substantial productivity losses. It is critical to implement and reinforce public health measures with the aim to reduce the incidence of HPV-related diseases, and the subsequent premature cancer deaths. Improving HPV screening and increasing vaccination programs, in both male and female populations, could help reduce this burden.PMID:38638098 | DOI:10.1080/13696998.2024.2341572 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 19, 2024 Category: Health Management Authors: Ugne Sabale Eugenia Karamousouli Lazar Popovic Zo árd Tibor Krasznai Daniel Harrop Anne Meiwald Robert Hughes Georgie Weston Goran Bencina Source Type: research
Young men with penile cancer fare as poorly as elder patients: clinical implications
International Journal of Impotence Research, Published online: 18 April 2024; doi:10.1038/s41443-024-00889-4Young men with penile cancer fare as poorly as elder patients: clinical implications (Source: International Journal of Impotence Research)
Source: International Journal of Impotence Research - April 18, 2024 Category: Urology & Nephrology Authors: K. Vandermaesen M. Albersen Source Type: research
Human malignancies associated with persistent HPV infection
Oncologist. 2024 Apr 17:oyae071. doi: 10.1093/oncolo/oyae071. Online ahead of print.ABSTRACTHuman papillomavirus (HPV)-associated malignancies account for ~5% of human cancers worldwide. Thirteen, or more, HPV types are oncogenic, but infection with these viruses is common and usually cleared within 2 years. Only infections that become persistent are associated with the development of cancer, often occurring several decades later. These cancers mostly arise in 6 different anatomical regions: 5 are anogenital (anus, cervix, penis, vagina, and vulva) and the sixth is the oropharynx. Oncogenic HPVs promote cellular proliferat...
Source: The Oncologist - April 17, 2024 Category: Cancer & Oncology Authors: Alison A McBride Source Type: research
Human malignancies associated with persistent HPV infection
Oncologist. 2024 Apr 17:oyae071. doi: 10.1093/oncolo/oyae071. Online ahead of print.ABSTRACTHuman papillomavirus (HPV)-associated malignancies account for ~5% of human cancers worldwide. Thirteen, or more, HPV types are oncogenic, but infection with these viruses is common and usually cleared within 2 years. Only infections that become persistent are associated with the development of cancer, often occurring several decades later. These cancers mostly arise in 6 different anatomical regions: 5 are anogenital (anus, cervix, penis, vagina, and vulva) and the sixth is the oropharynx. Oncogenic HPVs promote cellular proliferat...
Source: The Oncologist - April 17, 2024 Category: Cancer & Oncology Authors: Alison A McBride Source Type: research
Immune-based Therapies for Penile Cancer
This article reviews penile squamous cell carcinoma (PSCC), a rare genitourinary cancer that has been increasing in prevalence. It discusses emerging therapies, focusing on immunotherapy, vaccine therapy, and cell-based treatments, especially in the context of human papillomavirus-related PSCC. Factors influencing these therapies are discussed. These include the immune microenvironment, programmed cell death ligand-1 expression, and tumor immune cell infiltration. This article also highlights immune checkpoint inhibitors and related clinical trials. This review supports the use of personalized medicine in treating PSCC. It...
Source: Urologic Clinics of North America - April 16, 2024 Category: Urology & Nephrology Authors: Majd Al Assaad, Houssein Safa, Chiara Mercinelli, Philippe E. Spiess, Andrea Necchi, Jad Chahoud Source Type: research
Psychosocial Impact of Penile Cancer
Penile cancer is a rare cancer, where patients not only need to deal with the anxiety around a cancer diagnosis, but also manage the consequences of treatment on their self-esteem, body image, and intimate relationships. Many find it embarrassing and difficult to talk to family and friends. Due to this, changes in urination and other physical effects of treatment, many will withdraw from social activities too. Patients need psychosocial support and more needs to be done to address this unmet need. Holistic and multidisciplinary approaches in clinic, with access to counseling, may help patients adjust to their new situation...
Source: Urologic Clinics of North America - April 16, 2024 Category: Urology & Nephrology Authors: Benjamin E. Ayres Source Type: research
The case for centralization of care in penile cancer — respecting geographical needs
Nature Reviews Urology, Published online: 15 April 2024; doi:10.1038/s41585-024-00879-7Centralization of care for penile cancer has been underscored in the 2023 updated EAU–ASCO guidelines. Expertise consolidation enhances patient care, addressing penile cancer complexities from diagnosis to treatment. Centralization initiatives, like the European Reference Networks, and dedicated scientific societies have crucial roles in guiding centralized care pathways to ultimately improve patient outcomes. (Source: Nature Reviews Urology)
Source: Nature Reviews Urology - April 15, 2024 Category: Urology & Nephrology Authors: Giuseppe Basile Andrea Necchi Gagan Prakash Karima Oualla Philippe E. Spiess Peter A. S. Johnstone Source Type: research
Does MRI Have a Role in the Preoperative Staging of Penile Cancer?
Conclusions The use of MRI as a preoperative modality for staging penile cancer performs best for identifying tumour involvement of the cavernosal bodies. Performing the MRI with the penis erect with the use of an intra-cavernosal injection did not offer any additional benefit in accurately staging penile cancer.PMID:38606225 | PMC:PMC11008335 | DOI:10.7759/cureus.56016 (Source: Cancer Control)
Source: Cancer Control - April 12, 2024 Category: Cancer & Oncology Authors: Muhammad Iqbal Mostafa Shendy Anna McClune Wail Mohamed Anthony Shanahan Balan Palaniappan Gareth Brown Source Type: research
Pathology of Squamous Cell Carcinoma of the Penis: Back to Square One
The landscape of squamous cell carcinoma of the penis (SCC-P) has undergone a significant transformation since the new World Health Organization classification of genitourinary cancers and recent European Association of Urology/American Association of Clinical Oncology guidelines. These changes emphasize the necessity to categorize SCC-P into 2 groups based on its association with human papillomavirus (HPV) infection. This shift has major implications, considering that prior knowledge was derived from a mix of both groups. Given the distinct prognosis, treatment options, and staging systems observed for HPV-associated tumo...
Source: Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Diego F. Sanchez, Pedro Oliveira Source Type: research
Forthcoming Issues
Advances in Penile and Testicular Cancer (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 11, 2024 Category: Urology & Nephrology Source Type: research
Erectile function preservation after radiotherapy using a dose-optimization approach on sexual structures for localized prostate cancer
CONCLUSION: This approach with dose-optimization on sexual structures for localized prostate cancer found excellent results on erectile function preservation after radiotherapy, with 78% of the patients with no or mild erectile dysfunction at 2 years.PMID:38599939 | DOI:10.1016/j.canrad.2023.08.010 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 10, 2024 Category: Cancer & Oncology Authors: A Chardon C Udrescu A Beneux A Ruffion S Horn A Lapierre O Chapet Source Type: research
Penile cancer with perineural invasion is more prone to postoperative recurrence
CONCLUSION: Penile cancer with perineural invasion is more prone to and perineural invasion is an independent risk factor for postoperative recurrence of the malignancy.PMID:38598218 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Yue-Fu Han Xin-Hua Yao Ji-Wang Deng Bin Lai Yong-Mao Zeng Lian Peng Zi-Jian Tang Chen Wang Jun-Wei Li Source Type: research
Erectile function preservation after radiotherapy using a dose-optimization approach on sexual structures for localized prostate cancer
CONCLUSION: This approach with dose-optimization on sexual structures for localized prostate cancer found excellent results on erectile function preservation after radiotherapy, with 78% of the patients with no or mild erectile dysfunction at 2 years.PMID:38599939 | DOI:10.1016/j.canrad.2023.08.010 (Source: Cancer Radiotherapie)
Source: Cancer Radiotherapie - April 10, 2024 Category: Cancer & Oncology Authors: A Chardon C Udrescu A Beneux A Ruffion S Horn A Lapierre O Chapet Source Type: research
