Organ-preserving treatment as the most important option in the treatment of primary penile cancer
Aktuelle Urol. 2023 Aug;54(4):299-303. doi: 10.1055/a-2109-9836. Epub 2023 Aug 4.ABSTRACTThe treatment of patients with penile cancer presents a significant challenge for therapists and patients alike. In this context, the focus must not only be on surgical techniques but rather on patient education and collaborative treatment planning. Consistent information about potential organ preservation and its consequences is essential. Following clinical examination and histological confirmation of the diagnosis, an organ-preserving and stage-adapted surgical procedure should be used in almost all cases. Intraoperatively, the aim ...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Chris Protzel Richard Kutschke Marie-Luise Eckert Source Type: research
Systemic treatment of penile cancer: New concepts? New achievements?
Aktuelle Urol. 2023 Aug;54(4):304-312. doi: 10.1055/a-2104-1418. Epub 2023 Aug 4.ABSTRACTSystemic chemotherapy has been in use for metastatic penile carcinoma for years, but its success is limited. Its significance is largely associated with its role in multimodal treatment for lymphatic metastasis in the context of radical lymph node surgery. In cases of limited lymph node involvement, the combination of surgical treatment plus cisplatin- and taxane-based triple combinations may be curative. Advances in the understanding of molecular changes in penile cancer and the search for potential therapy targets have led to numerou...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Oliver Hakenberg Desiree Louise Dr äger Source Type: research
Importance of HPV status and p16 for the prognosis of penile carcinoma
CONCLUSION: HPV status alone seems to be lacking prognostic relevance. In contrast, p16 status was confirmed as an independent prognostic factor. Thus, the expression of p16INK4a is associated with a significantly better MFS. Especially in HPV-negative tumours, the p16 status should be evaluated with regard to the prognostic value and thus also with a view to the treatment decision.PMID:37541236 | DOI:10.1055/a-2104-1270 (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Jan Niklas Mink Oybek Khalmurzaev Alexey Pryalukhin Sebastian H ölters Carol Geppert Stefan Lohse Kristof Bende Jo ão Lobo Rui Henrique Hagen Loertzer Joachim Steffens Carmen Jer ónimo Heiko Wunderlich Julia Heinzelbecker Rainer Bohle Michael St öckle Source Type: research
Organ-preserving treatment as the most important option in the treatment of primary penile cancer
Aktuelle Urol. 2023 Aug;54(4):299-303. doi: 10.1055/a-2109-9836. Epub 2023 Aug 4.ABSTRACTThe treatment of patients with penile cancer presents a significant challenge for therapists and patients alike. In this context, the focus must not only be on surgical techniques but rather on patient education and collaborative treatment planning. Consistent information about potential organ preservation and its consequences is essential. Following clinical examination and histological confirmation of the diagnosis, an organ-preserving and stage-adapted surgical procedure should be used in almost all cases. Intraoperatively, the aim ...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Chris Protzel Richard Kutschke Marie-Luise Eckert Source Type: research
Systemic treatment of penile cancer: New concepts? New achievements?
Aktuelle Urol. 2023 Aug;54(4):304-312. doi: 10.1055/a-2104-1418. Epub 2023 Aug 4.ABSTRACTSystemic chemotherapy has been in use for metastatic penile carcinoma for years, but its success is limited. Its significance is largely associated with its role in multimodal treatment for lymphatic metastasis in the context of radical lymph node surgery. In cases of limited lymph node involvement, the combination of surgical treatment plus cisplatin- and taxane-based triple combinations may be curative. Advances in the understanding of molecular changes in penile cancer and the search for potential therapy targets have led to numerou...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Oliver Hakenberg Desiree Louise Dr äger Source Type: research
Importance of HPV status and p16 for the prognosis of penile carcinoma
CONCLUSION: HPV status alone seems to be lacking prognostic relevance. In contrast, p16 status was confirmed as an independent prognostic factor. Thus, the expression of p16INK4a is associated with a significantly better MFS. Especially in HPV-negative tumours, the p16 status should be evaluated with regard to the prognostic value and thus also with a view to the treatment decision.PMID:37541236 | DOI:10.1055/a-2104-1270 (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Jan Niklas Mink Oybek Khalmurzaev Alexey Pryalukhin Sebastian H ölters Carol Geppert Stefan Lohse Kristof Bende Jo ão Lobo Rui Henrique Hagen Loertzer Joachim Steffens Carmen Jer ónimo Heiko Wunderlich Julia Heinzelbecker Rainer Bohle Michael St öckle Source Type: research
Organ-preserving treatment as the most important option in the treatment of primary penile cancer
Aktuelle Urol. 2023 Aug;54(4):299-303. doi: 10.1055/a-2109-9836. Epub 2023 Aug 4.ABSTRACTThe treatment of patients with penile cancer presents a significant challenge for therapists and patients alike. In this context, the focus must not only be on surgical techniques but rather on patient education and collaborative treatment planning. Consistent information about potential organ preservation and its consequences is essential. Following clinical examination and histological confirmation of the diagnosis, an organ-preserving and stage-adapted surgical procedure should be used in almost all cases. Intraoperatively, the aim ...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Chris Protzel Richard Kutschke Marie-Luise Eckert Source Type: research
Systemic treatment of penile cancer: New concepts? New achievements?
Aktuelle Urol. 2023 Aug;54(4):304-312. doi: 10.1055/a-2104-1418. Epub 2023 Aug 4.ABSTRACTSystemic chemotherapy has been in use for metastatic penile carcinoma for years, but its success is limited. Its significance is largely associated with its role in multimodal treatment for lymphatic metastasis in the context of radical lymph node surgery. In cases of limited lymph node involvement, the combination of surgical treatment plus cisplatin- and taxane-based triple combinations may be curative. Advances in the understanding of molecular changes in penile cancer and the search for potential therapy targets have led to numerou...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Oliver Hakenberg Desiree Louise Dr äger Source Type: research
Importance of HPV status and p16 for the prognosis of penile carcinoma
CONCLUSION: HPV status alone seems to be lacking prognostic relevance. In contrast, p16 status was confirmed as an independent prognostic factor. Thus, the expression of p16INK4a is associated with a significantly better MFS. Especially in HPV-negative tumours, the p16 status should be evaluated with regard to the prognostic value and thus also with a view to the treatment decision.PMID:37541236 | DOI:10.1055/a-2104-1270 (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Jan Niklas Mink Oybek Khalmurzaev Alexey Pryalukhin Sebastian H ölters Carol Geppert Stefan Lohse Kristof Bende Jo ão Lobo Rui Henrique Hagen Loertzer Joachim Steffens Carmen Jer ónimo Heiko Wunderlich Julia Heinzelbecker Rainer Bohle Michael St öckle Source Type: research
Organ-preserving treatment as the most important option in the treatment of primary penile cancer
Aktuelle Urol. 2023 Aug;54(4):299-303. doi: 10.1055/a-2109-9836. Epub 2023 Aug 4.ABSTRACTThe treatment of patients with penile cancer presents a significant challenge for therapists and patients alike. In this context, the focus must not only be on surgical techniques but rather on patient education and collaborative treatment planning. Consistent information about potential organ preservation and its consequences is essential. Following clinical examination and histological confirmation of the diagnosis, an organ-preserving and stage-adapted surgical procedure should be used in almost all cases. Intraoperatively, the aim ...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Chris Protzel Richard Kutschke Marie-Luise Eckert Source Type: research
Systemic treatment of penile cancer: New concepts? New achievements?
Aktuelle Urol. 2023 Aug;54(4):304-312. doi: 10.1055/a-2104-1418. Epub 2023 Aug 4.ABSTRACTSystemic chemotherapy has been in use for metastatic penile carcinoma for years, but its success is limited. Its significance is largely associated with its role in multimodal treatment for lymphatic metastasis in the context of radical lymph node surgery. In cases of limited lymph node involvement, the combination of surgical treatment plus cisplatin- and taxane-based triple combinations may be curative. Advances in the understanding of molecular changes in penile cancer and the search for potential therapy targets have led to numerou...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Oliver Hakenberg Desiree Louise Dr äger Source Type: research
Importance of HPV status and p16 for the prognosis of penile carcinoma
CONCLUSION: HPV status alone seems to be lacking prognostic relevance. In contrast, p16 status was confirmed as an independent prognostic factor. Thus, the expression of p16INK4a is associated with a significantly better MFS. Especially in HPV-negative tumours, the p16 status should be evaluated with regard to the prognostic value and thus also with a view to the treatment decision.PMID:37541236 | DOI:10.1055/a-2104-1270 (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Jan Niklas Mink Oybek Khalmurzaev Alexey Pryalukhin Sebastian H ölters Carol Geppert Stefan Lohse Kristof Bende Jo ão Lobo Rui Henrique Hagen Loertzer Joachim Steffens Carmen Jer ónimo Heiko Wunderlich Julia Heinzelbecker Rainer Bohle Michael St öckle Source Type: research
Organ-preserving treatment as the most important option in the treatment of primary penile cancer
Aktuelle Urol. 2023 Aug;54(4):299-303. doi: 10.1055/a-2109-9836. Epub 2023 Aug 4.ABSTRACTThe treatment of patients with penile cancer presents a significant challenge for therapists and patients alike. In this context, the focus must not only be on surgical techniques but rather on patient education and collaborative treatment planning. Consistent information about potential organ preservation and its consequences is essential. Following clinical examination and histological confirmation of the diagnosis, an organ-preserving and stage-adapted surgical procedure should be used in almost all cases. Intraoperatively, the aim ...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Chris Protzel Richard Kutschke Marie-Luise Eckert Source Type: research
Systemic treatment of penile cancer: New concepts? New achievements?
Aktuelle Urol. 2023 Aug;54(4):304-312. doi: 10.1055/a-2104-1418. Epub 2023 Aug 4.ABSTRACTSystemic chemotherapy has been in use for metastatic penile carcinoma for years, but its success is limited. Its significance is largely associated with its role in multimodal treatment for lymphatic metastasis in the context of radical lymph node surgery. In cases of limited lymph node involvement, the combination of surgical treatment plus cisplatin- and taxane-based triple combinations may be curative. Advances in the understanding of molecular changes in penile cancer and the search for potential therapy targets have led to numerou...
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Oliver Hakenberg Desiree Louise Dr äger Source Type: research
Importance of HPV status and p16 for the prognosis of penile carcinoma
CONCLUSION: HPV status alone seems to be lacking prognostic relevance. In contrast, p16 status was confirmed as an independent prognostic factor. Thus, the expression of p16INK4a is associated with a significantly better MFS. Especially in HPV-negative tumours, the p16 status should be evaluated with regard to the prognostic value and thus also with a view to the treatment decision.PMID:37541236 | DOI:10.1055/a-2104-1270 (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - August 4, 2023 Category: Urology & Nephrology Authors: Jan Niklas Mink Oybek Khalmurzaev Alexey Pryalukhin Sebastian H ölters Carol Geppert Stefan Lohse Kristof Bende Jo ão Lobo Rui Henrique Hagen Loertzer Joachim Steffens Carmen Jer ónimo Heiko Wunderlich Julia Heinzelbecker Rainer Bohle Michael St öckle Source Type: research
