Structured Literature Review to Identify Human Papillomavirus ’s Natural History Parameters for Dynamic Population Models of Vaccine Impacts
This study aimed to identify and synthesize data needed to parametrize DTMs on the natural history of HPV infection and related diseases. Parameters describing data of interest were grouped by their anatomical location (genital warts, recurrent respiratory papillomatosis, and cervical, anal, vaginal, vulvar, head and neck, and penile cancers), and natural history (progression, regression, death, cure, recurrence, detection), and were identified through a systematic literature review (SLR) and complementary targeted literature reviews (TLRs). The extracted data were then synthesized by pooling parameter values across public...
Source: Infectious Diseases and Therapy - April 8, 2024 Category: Infectious Diseases Source Type: research
Novel erectile analyses revealed augmentable penile Lyve-1, the lymphatic marker, expression
CONCLUSIONS: The current in vivo system will potentially contribute to the assessment of penile pathology from a novel viewpoint. In addition, current analyses revealed inducible Lyve-1 expression for LPS injection and the erection state, which requires further analyses on penile lymphatic system.PMID:38566911 | PMC:PMC10985380 | DOI:10.1002/rmb2.12570 (Source: Reproductive Biology)
Source: Reproductive Biology - April 3, 2024 Category: Reproduction Medicine Authors: Kota Fujimoto Daiki Hashimoto Sang Woon Kim Yong Seung Lee Takuya Suzuki Masanori Nakata Shinji Kumegawa Shinichi Asamura Gen Yamada Source Type: research
Novel erectile analyses revealed augmentable penile Lyve-1, the lymphatic marker, expression
CONCLUSIONS: The current in vivo system will potentially contribute to the assessment of penile pathology from a novel viewpoint. In addition, current analyses revealed inducible Lyve-1 expression for LPS injection and the erection state, which requires further analyses on penile lymphatic system.PMID:38566911 | PMC:PMC10985380 | DOI:10.1002/rmb2.12570 (Source: Reproductive Biology)
Source: Reproductive Biology - April 3, 2024 Category: Reproduction Medicine Authors: Kota Fujimoto Daiki Hashimoto Sang Woon Kim Yong Seung Lee Takuya Suzuki Masanori Nakata Shinji Kumegawa Shinichi Asamura Gen Yamada Source Type: research
Developing and validating a nomogram for penile cancer survival: A comprehensive study based on SEER and Chinese data
ConclusionPenile cancer, often overlooked in research, has lacked detailed investigative focus and guidelines. This study stands as the first to validate penile cancer prognosis using extensive data from the SEER database, supplemented by data from our own institution. Our findings equip surgeons with an essential tool to predict the prognosis of penile cancer better suited than TNM, thereby enhancing clinical decision-making processes. (Source: Cancer Medicine)
Source: Cancer Medicine - April 3, 2024 Category: Cancer & Oncology Authors: Jiawen Luo,
Jintao Hu,
Yelisudan Mulati,
Zhikai Wu,
Cong Lai,
Degeng Kong,
Cheng Liu,
Kewei Xu Tags: RESEARCH ARTICLE Source Type: research
A diagnosis of syphilis following a radical circumcision for suspected penile cancer
We present a case of a 70-year-old gentleman who was referred to our tertiary 2-week-wait penile cancer clinic with a penile mass that was ulcerated, painful and discharging. This was suspicious for penile cancer and a radical circumcision was performed to remove the diseased foreskin en bloc with the lesion that was arising from the inner foreskin. Histopathology did not reveal cancer; however, we identified spirochaetes in keeping with syphilis. This was confirmed on serology. The patient was referred to the genitourinary medicine team and treated with antibiotics. This case demonstrates a rare presentation of genital sy...
Source: Annals of the Royal College of Surgeons of England - April 2, 2024 Category: Surgery Authors: K H Pang A Haider A Freeman P Hadway C Bunker A Muneer H M Alnajjar Source Type: research
A diagnosis of syphilis following a radical circumcision for suspected penile cancer
We present a case of a 70-year-old gentleman who was referred to our tertiary 2-week-wait penile cancer clinic with a penile mass that was ulcerated, painful and discharging. This was suspicious for penile cancer and a radical circumcision was performed to remove the diseased foreskin en bloc with the lesion that was arising from the inner foreskin. Histopathology did not reveal cancer; however, we identified spirochaetes in keeping with syphilis. This was confirmed on serology. The patient was referred to the genitourinary medicine team and treated with antibiotics. This case demonstrates a rare presentation of genital sy...
Source: Annals of the Royal College of Surgeons of England - April 2, 2024 Category: Surgery Authors: K H Pang A Haider A Freeman P Hadway C Bunker A Muneer H M Alnajjar Source Type: research
A diagnosis of syphilis following a radical circumcision for suspected penile cancer
We present a case of a 70-year-old gentleman who was referred to our tertiary 2-week-wait penile cancer clinic with a penile mass that was ulcerated, painful and discharging. This was suspicious for penile cancer and a radical circumcision was performed to remove the diseased foreskin en bloc with the lesion that was arising from the inner foreskin. Histopathology did not reveal cancer; however, we identified spirochaetes in keeping with syphilis. This was confirmed on serology. The patient was referred to the genitourinary medicine team and treated with antibiotics. This case demonstrates a rare presentation of genital sy...
Source: Annals of the Royal College of Surgeons of England - April 2, 2024 Category: Surgery Authors: K H Pang A Haider A Freeman P Hadway C Bunker A Muneer H M Alnajjar Source Type: research
Near-infrared fluorescence-assisted superficial inguinal lymph-node excision for low-risk penile cancer
ConclusionNear-infrared fluorescence-assisted superficial inguinal lymph-node dissection in penile carcinoma is accurate and effective, and could reduce surgical complications. (Source: World Journal of Urology)
Source: World Journal of Urology - April 1, 2024 Category: Urology & Nephrology Source Type: research
Case report and literature review of penile metastasis of bladder cancer
Asian J Surg. 2024 Mar 29:S1015-9584(24)00529-3. doi: 10.1016/j.asjsur.2024.03.095. Online ahead of print.NO ABSTRACTPMID:38555212 | DOI:10.1016/j.asjsur.2024.03.095 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 30, 2024 Category: Surgery Authors: Xinru Feng ZhengJun Chen Source Type: research
Case report and literature review of penile metastasis of bladder cancer
Asian J Surg. 2024 Mar 29:S1015-9584(24)00529-3. doi: 10.1016/j.asjsur.2024.03.095. Online ahead of print.NO ABSTRACTPMID:38555212 | DOI:10.1016/j.asjsur.2024.03.095 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 30, 2024 Category: Surgery Authors: Xinru Feng ZhengJun Chen Source Type: research
Case report and literature review of penile metastasis of bladder cancer
Asian J Surg. 2024 Mar 29:S1015-9584(24)00529-3. doi: 10.1016/j.asjsur.2024.03.095. Online ahead of print.NO ABSTRACTPMID:38555212 | DOI:10.1016/j.asjsur.2024.03.095 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 30, 2024 Category: Surgery Authors: Xinru Feng ZhengJun Chen Source Type: research
Case report and literature review of penile metastasis of bladder cancer
Asian J Surg. 2024 Mar 29:S1015-9584(24)00529-3. doi: 10.1016/j.asjsur.2024.03.095. Online ahead of print.NO ABSTRACTPMID:38555212 | DOI:10.1016/j.asjsur.2024.03.095 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - March 30, 2024 Category: Surgery Authors: Xinru Feng ZhengJun Chen Source Type: research
Insights into the management of penile squamous cell carcinoma: from conventional approaches to emerging novel therapies
Expert Opin Pharmacother. 2024 Mar 29. doi: 10.1080/14656566.2024.2337244. Online ahead of print.ABSTRACTINTRODUCTION: Penile squamous cell carcinoma (PSCC), a rare genitourinary cancer, is associated with poor outcomes due to limited treatment effectiveness, especially in advanced stages.AREAS COVERED: While chemotherapy and/or surgery remain the standard of care, emerging therapies like immunotherapy, targeted therapy, and human papillomavirus (HPV) directed therapies show promise. Key to advancing treatment is understanding the immune microenvironment to gain insights into tumor resistance mechanisms and potential thera...
Source: Expert Opinion on Pharmacotherapy - March 29, 2024 Category: Drugs & Pharmacology Authors: Houssein Safa Chiara Mercinelli Philippe E Spiess Andrea Necchi Jad Chahoud Source Type: research
