Characterization of T cell receptor repertoire in penile cancer
AbstractTumor-infiltrating lymphocytes (TILs) play a key role in regulating the host immune response and shaping tumor microenvironment. It has been previously shown that T cell infiltration in penile tumors was associated with clinical outcomes. However, few studies have reported the T cell receptor (TCR) repertoire in patients with penile cancer. In the present study, we evaluated the TCR repertoires in tumor and adjacent normal tissues from 22 patients with penile squamous cell carcinoma (PSCC). Analysis of the T cell receptor beta-variable (TRBV) and joining (TRBJ) genes usage and analysis of complementarity determinin...
Source: Cancer Immunology, Immunotherapy - January 27, 2024 Category: Cancer & Oncology Source Type: research
Viruses, Vol. 16, Pages 162: Vaccine and Non-Vaccine HPV Types Presence in Adolescents with Vertically Acquired HIV Five Years Post Gardasil Quadrivalent Vaccination: The Zimgard Cohort
Conclusion: The Gardasil quadrivalent HPV vaccine (4vHPV) was expected to protect against infection with HPV types 16, 18, 6, and 11. We demonstrated a possible waning of immunity to HPV18 in 17% of the participants, and an associated loss in cross-protection against HPV45. We observed a relatively high prevalence of ‘opportunistic non-vaccine HPV types’ or ‘ecological niche occupiers’ in this cohort, and suggest further research on the involvement of these types in cervical and other genital cancers. Our study is one of the few, if not the first, to report on HPV vac...
Source: Viruses - January 22, 2024 Category: Virology Authors: Alltalents T. Murahwa Tinashe Mudzviti Racheal S. Dube Mandishora Takudzwa Chatindo Peace Chanetsa Margaret Pascoe Tinei Shamu Wisdom Basera Ruedi Luethy Anna-Lise Williamson Tags: Article Source Type: research
Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection
Volume 19, Issue 1, December 2024 . (Source: Epigenetics)
Source: Epigenetics - January 21, 2024 Category: Genetics & Stem Cells Authors: Renan da Silva SantosDaniel Pascoalino PinheiroCarlos Gustavo HirthMaria J úlia Barbosa BezerraIsabelle Joyce de Lima Silva-FernandesFrancisca Andréa da Silva OliveiraMaisa Viana de Holanda BarrosEster Silveira RamosArlindo A. MouraOdorico de Moraes Man Source Type: research
Authors ’ Reply: To Letter to the Editor by Dr Pettaway
We express our gratitude to Dr Pettaway for highlighting important considerations. As Dr Pettaway articulated, our study encompassed a heterogeneous cohort of penile cancer patients, including those who were cancer-na ïve and those with one or more prior recurrences, all of whom underwent treatment with thulium–yttrium–aluminum–garnet (Tm:YAG) laser. Given the rarity of penile cancer, we consciously chose not to confine our study to a singular subgroup to avert potential statistical power loss. (Source: Urology)
Source: Urology - January 16, 2024 Category: Urology & Nephrology Authors: Stefano Luzzago, Gennaro Musi Source Type: research
Editorial Comment
The authors report their experience using the thulium-yttrium-aluminum-garnet (TM:YAG) laser in treating a cohort of 65 patients with ≤cT1,N0 penile squamous carcinoma from 2013 to 2022. The authors used high-power contact mode to resect the tumor sending deep and peripheral margins of the specimen for pathologic analysis. An additional 3 mm periphery around the tumor was ablated using lower power settings as margin. (Source: Urology)
Source: Urology - January 16, 2024 Category: Urology & Nephrology Authors: Curtis A. Pettaway Source Type: research
New EAU/ASCO guideline recommendations on sentinel node biopsy for penile cancer and remaining challenges from a nuclear medicine perspective
ConclusionOver the years, DSNB has evolved significantly, related to the dedicated efforts and innovations in nuclear medicine and subsequent clinical studies validating its efficacy. It is now strongly recommended for surgical staging among selected penile cancer patients. To optimise DSNB further, multidisciplinary collaborative research is required to improve SN identification for better diagnostic accuracy and fewer complications. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - January 13, 2024 Category: Nuclear Medicine Source Type: research
Geographic variation of HPV-associated cancer incidence in Kentucky using spatial scan statistics
ConclusionOverlapping clusters of HPV-associated cancers were identified at the county-level and included both urban and rural counties of Kentucky. Findings can assist in the design of public health interventions to increase screenings, promote vaccination, and recruit physicians in these regions to improve prevention, diagnosis, and early treatment of HPV-associated cancers. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - January 12, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 303: Multiplex Immunofluorescence Captures Progressive Immune Exhaustion with Advancing Penile Squamous Cell Cancer Stage
Keerthi Gullapalli
Gabriel Roman Souza
Hiroko Miyagi
Brandon J. Manley
Philippe E. Spiess
Jad Chahoud
Penile squamous cell carcinoma (PSCC) is a rare and deadly malignancy. Therapeutic advances have been stifled by a poor understanding of disease biology. Specifically, the immune microenvironment is an underexplored component in PSCC and the activity of immune checkpoint inhibitors observed in a subset of patients suggests immune escape may play an important role in tumorigenesis. Herein, we explored for the first time the immune microenvironment of 57 men with PSCC and how it varies with the presence of hu...
Source: Cancers - January 11, 2024 Category: Cancer & Oncology Authors: Filip Ionescu Jonathan Nguyen Carlos Moran Segura Mahati Paravathaneni G. Daniel Grass Peter Johnstone Niki M. Zacharias Curtis A. Pettaway Xin Lu Youngchul Kim Junmin Whiting Jasreman Dhillon Steven A. Eschrich Juskaran Chadha Keerthi Gullapalli Gabriel Tags: Article Source Type: research
Cancers, Vol. 16, Pages 330: The Role of Proton Therapy for Prostate Cancer in the Setting of Hip Prosthesis
Conclusions: PT for treatment of prostate cancer patients with hip prosthesis is feasible and equivalent or potentially superior to VMAT in quality in some cases. The choice of radiotherapy regimen can be personalized based on patient characteristics to achieve the best treatment outcome. (Source: Cancers)
Source: Cancers - January 11, 2024 Category: Cancer & Oncology Authors: Maryam Moteabbed Mislav Bobi ć Harald Paganetti Jason A. Efstathiou Tags: Article Source Type: research
The landscape of penile cancer research in Germany and Austria: a survey among professors in academic centers holding chair positions and results of a literature search
ConclusionsGiven the lack of centralization in G + A, this analysis highlights the need for research coordination within multicenter PeCa-projects. The decline in basic/fundamental research should be effectively addressed by the allocation of funded research projects. (Source: World Journal of Urology)
Source: World Journal of Urology - January 8, 2024 Category: Urology & Nephrology Source Type: research
Invasive penile glans Squamous Cell Carcinoma (peSCC) and Reflectance Confocal Microscopy (RCM): is it a valuable alternative to histopathology?
Skin Res Technol. 2024 Jan;30(1):e13564. doi: 10.1111/srt.13564.NO ABSTRACTPMID:38174773 | DOI:10.1111/srt.13564 (Source: Cell Research)
Source: Cell Research - January 4, 2024 Category: Cytology Authors: Luca Rapparini Aurora Alessandrini Biagio Scotti Emi Dika Source Type: research
Human Papilloma Virus-Infected Cells
Subcell Biochem. 2023;106:213-226. doi: 10.1007/978-3-031-40086-5_8.ABSTRACTHuman papillomavirus (HPV) is associated with infection of different tissues, such as the cervix, anus, vagina, penis, vulva, oropharynx, throat, tonsils, back of the tongue, skin, the lungs, among other tissues. HPV infection may or may not be associated with the development of cancer, where HPVs not related to cancer are defined as low-risk HPVs and are associated with papillomatosis disease. In contrast, high-risk HPVs (HR-HPVs) are associated with developing cancers in areas that HR-HPV infects, such as the cervix. In general, infection of HPV ...
Source: Sub-Cellular Biochemistry - December 30, 2023 Category: Biochemistry Authors: Alfredo Cruz-Gregorio Ana Karina Aranda-Rivera Source Type: research
Human Papilloma Virus-Infected Cells
Subcell Biochem. 2023;106:213-226. doi: 10.1007/978-3-031-40086-5_8.ABSTRACTHuman papillomavirus (HPV) is associated with infection of different tissues, such as the cervix, anus, vagina, penis, vulva, oropharynx, throat, tonsils, back of the tongue, skin, the lungs, among other tissues. HPV infection may or may not be associated with the development of cancer, where HPVs not related to cancer are defined as low-risk HPVs and are associated with papillomatosis disease. In contrast, high-risk HPVs (HR-HPVs) are associated with developing cancers in areas that HR-HPV infects, such as the cervix. In general, infection of HPV ...
Source: Sub-Cellular Biochemistry - December 30, 2023 Category: Biochemistry Authors: Alfredo Cruz-Gregorio Ana Karina Aranda-Rivera Source Type: research
Human Papilloma Virus-Infected Cells
Subcell Biochem. 2023;106:213-226. doi: 10.1007/978-3-031-40086-5_8.ABSTRACTHuman papillomavirus (HPV) is associated with infection of different tissues, such as the cervix, anus, vagina, penis, vulva, oropharynx, throat, tonsils, back of the tongue, skin, the lungs, among other tissues. HPV infection may or may not be associated with the development of cancer, where HPVs not related to cancer are defined as low-risk HPVs and are associated with papillomatosis disease. In contrast, high-risk HPVs (HR-HPVs) are associated with developing cancers in areas that HR-HPV infects, such as the cervix. In general, infection of HPV ...
Source: Sub-Cellular Biochemistry - December 30, 2023 Category: Biochemistry Authors: Alfredo Cruz-Gregorio Ana Karina Aranda-Rivera Source Type: research
