Rapid and sustained improvements in itch and quality of life with upadacitinib plus topical corticosteroids in adults and adolescents with atopic dermatitis: 52-week outcomes from the phase 3 AD Up study
Conclusions: Upadacitinib + TCS results in rapid, sustained improvements in burdensome AD symptoms and QoL.PMID:38697950 | DOI:10.1080/09546634.2024.2344589 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 2, 2024 Category: Dermatology Authors: Nina Magnolo Michael C Cameron Mona Shahriari Bob Geng Brian M Calimlim Henrique Teixeira Xiaofei Hu Yang Yang Yingyi Liu Shiyu Zhang Cristina Sancho Sanchez Katherine Altman Richard G Langley Source Type: research
GABA transporter mGat4 is involved in multiple neural functions in mice
Biochim Biophys Acta Mol Cell Res. 2024 Apr 30:119740. doi: 10.1016/j.bbamcr.2024.119740. Online ahead of print.ABSTRACTγ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. The termination of GABA transmission is through the action of GABA transporters (GATs). mGAT4 (encoded by Slc6a11) is another GAT besides GAT1 (encoded by Slc6a1) that functions in GABA reuptake in CNS. Research on the function of mGAT4 is still in its infancy. We developed an mGat4 knockout mouse model (mGat4-/- mice) and performed a series of behavioral analyses for the first time to study the effect of m...
Source: Biochimica et Biophysica Acta - May 2, 2024 Category: Biochemistry Authors: Yue Ying Weitong Liu Haoyue Wang Jiahao Shi Zhugang Wang Jian Fei Source Type: research
Lead poisoning of raptors: state of the science and cross-discipline mitigation options for a global problem
Biol Rev Camb Philos Soc. 2024 May 2. doi: 10.1111/brv.13087. Online ahead of print.ABSTRACTLead poisoning is an important global conservation problem for many species of wildlife, especially raptors. Despite the increasing number of individual studies and regional reviews of lead poisoning of raptors, it has been over a decade since this information has been compiled into a comprehensive global review. Here, we summarize the state of knowledge of lead poisoning of raptors, we review developments in manufacturing of non-lead ammunition, the use of which can reduce the most pervasive source of lead these birds encounter, an...
Source: Biological Reviews of the Cambridge Philosophical Society - May 2, 2024 Category: Biology Authors: Todd E Katzner Deborah J Pain Michael McTee Leland Brown Sandra Cuadros Mark Pokras Vincent A Slabe Richard T Watson Guillermo Wiemeyer Bryan Bedrosian Jordan O Hampton Chris N Parish James M Pay Keisuke Saito John H Schulz Source Type: research
Deciphering the Pharmacological Mechanisms of Wen-Jing-Zhi-Tong Decoction in Treating Primary Dysmenorrhea by UPLC-Q-ExactiveOrbitrap-MS/MS with GC-MS and Network Pharmacology
CONCLUSION: This study provides the first comprehensive analysis of the key compounds, targets, and pathways of WJZTD, laying a solid foundation for future pharmacological studies on PDM. The anti-nociceptive and anti-inflammatory effect may be attributed to the downregulation of the BDNF/TrkB/ERK/CREB signaling pathway.PMID:38693741 | DOI:10.2174/0113862073308798240425115006 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - May 2, 2024 Category: Chemistry Authors: Xiaotian Yang Yajie Qin Huifang Zhou Source Type: research
Lower Limb Proprioception in Low Back Pain and Its Relationship With Voluntary Postural Control
This study aimed to investigate whether patients with low back pain (LBP) had impaired lower limb proprioception and its association with somatosensory acuity. Thirty patients with LBP and 30 asymptomatic people volunteered, using Sway Discrimination Apparatus tests to assess somatosensory acuity during voluntary anteroposterior and mediolateral postural sway. Results showed significantly reduced somatosensory acuity in mediolateral sway in LBP patients (p = 0.005) with ankle, knee, and hip proprioception showing significantly impairment compared to asymptomatic controls (all p ≤ 0.012). Regression analysis showed that a...
Source: Journal of Motor Behavior - May 2, 2024 Category: Neurology Authors: Zhengquan Chen Oren Tirosh Jia Han Roger Adams Doa El-Ansary Adrian Pranata Source Type: research
Overview of long COVID in Brazil: a preliminary analysis of a survey to think about health policies
Cad Saude Publica. 2024 Apr 29;40(4):e00094623. doi: 10.1590/0102-311XPT094623. eCollection 2024.ABSTRACTCharacterized by symptoms that remain or appear for the first time within three months of SARS-CoV-2 infection, long COVID can manifest itself in different ways, including in non-hospitalized or asymptomatic cases. Thus, this study offers an overview of long COVID in Brazil, especially of its diagnosis, symptoms, and challenges for new health management. Data from a study that investigated long COVID in people affected by COVID-19 were used. These original data stem from a survey with adult Brazilians (aged 18 years or ...
Source: Cadernos de Saude Publica - May 2, 2024 Category: International Medicine & Public Health Authors: Karina Barros Calife Batista Michelle Vieira Fernandez Lorena Guadalupe Barberia Erica Tatiane da Silva Vaneide Daciane Pedi B árbara Maia Lima Madeira Pontes Gui Araujo Rafael da Silveira Moreira Marcos Pedrosa Mariana Pastorello Verotti Claudio Maierov Source Type: research
Beyond the modified dot-probe task: A meta-analysis of the efficacy of alternate attention bias modification tasks across domains
Clin Psychol Rev. 2024 Apr 27;110:102436. doi: 10.1016/j.cpr.2024.102436. Online ahead of print.ABSTRACTAttention biases towards disease-relevant cues have been implicated in numerous disorders and health conditions, such as anxiety, cancer, drug-use disorders, and chronic pain. Attention bias modification (ABM) has shown that changing attention biases can change related emotional processes. ABM most commonly uses a modified dot-probe task, which has received increasing criticism regarding its reliability and inconsistent findings. The purpose of the present review was thus to systematically review and meta-analyse alterna...
Source: Clinical Psychology Review - May 2, 2024 Category: Psychiatry & Psychology Authors: Tessa Rooney Louise Sharpe Jemma Todd Stefan Carlo Michalski Dimitri Van Ryckeghem Geert Crombez Ben Colagiuri Source Type: research
Acupuncture for pediatric chronic pain: a systematic review
CONCLUSION: The analyzed studies showed important clinical results such as the reduction of pain intensity, and improvement in school attendance and social life. However, there are many limitations in study design and sample size. Therefore, there is weak evidence to support the use of acupuncture in the context of pediatric chronic pain, but the positive results reinforce the need for further investigation of the topic with the conduct of larger and well-designed studies, to obtain more data and greater scientific conviction of the findings.PMID:38697213 | DOI:10.1016/j.jped.2024.03.013 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - May 2, 2024 Category: Pediatrics Authors: Jo ão Roberto Bissoto Jos é Udevanier Rebouças da Silva Júnior Gabrielle Pignol Alvares Fl ávia H Santos Claudio Arnaldo Len Source Type: research
Health Care Utilization by Patients With Chronic Pelvic Pain
CONCLUSION: Patients with chronic pelvic pain have higher rates of chronic overlapping pain conditions and undergo more ED visits, imaging tests, and hysterectomies than patients without chronic pelvic pain. Improving access to multidisciplinary care, increasing utilization of interventions such as PT and psychological or behavioral therapy, and reducing ED utilization may be possible targets to help reduce overall health care costs and improve patient care.PMID:38696811 | DOI:10.1097/AOG.0000000000005595 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - May 2, 2024 Category: OBGYN Authors: Isabel Green Morgan Briggs Diana Encalada Soto Kristin Cole Jenna Wygant Tatnai Burnett Xuan Zhu Innie Chen Lindsey R Sangaralingam Viengneesee Thao Source Type: research
Spinopelvic interactions in total hip arthroplasty: 295 patients followed for a minimum follow-up of 10 years
CONCLUSIONS: Concurrent spinal pathology influences THA outcomes at a minimum follow-up of 10 years. Sex, age, and associated lumbar degeneration can affect clinical and radiological changes over time. A decrease in SFP angle values over time was found in patients sustaining late dislocation.PMID:38695378 | DOI:10.1177/11207000241248074 (Source: Hip International)
Source: Hip International - May 2, 2024 Category: Orthopaedics Authors: Eduardo Garc ía-Rey Laura Salda ña Source Type: research
Effects of additional exercise therapy after a successful vascular intervention for people with symptomatic peripheral arterial disease
CONCLUSIONS: There is very uncertain evidence that additional exercise therapy after successful lower limb revascularisation may improve absolute maximal walking distance at the end of follow-up compared to standard care. Evidence is also very uncertain about the effects of exercise on pain-free walking distance, six-minute walk test distance, quality of life, ankle-brachial index, mortality, and reintervention rates. Although it is not possible to confirm the effectiveness of supervised exercise compared to standard care for all outcomes, studies did not report any harm to participants from this intervention after lower l...
Source: Cochrane Database of Systematic Reviews - May 2, 2024 Category: General Medicine Authors: Gabriel Cucato Paulo Pl Longano Daniel Perren Raphael M Ritti-Dias John M Saxton Source Type: research
Early versus delayed appendicectomy for appendiceal phlegmon or abscess
CONCLUSIONS: For the comparison of early versus delayed open or laparoscopic appendicectomy for paediatric and adult participants with appendiceal phlegmon, very low-certainty evidence suggests that early appendicectomy may reduce the abdominal abscess rate. The evidence is very uncertain whether early appendicectomy prevents overall morbidity or other complications. Early appendicectomy may reduce the total length of hospital stay and increase the time away from normal activities, but the evidence is very uncertain. For the comparison of early versus delayed laparoscopic appendicectomy for paediatric participants with app...
Source: Cochrane Database of Systematic Reviews - May 2, 2024 Category: General Medicine Authors: Shiyi Zhou Yao Cheng Nansheng Cheng Jianping Gong Bing Tu Source Type: research
Anticoagulation and vascular anomalies
Res Pract Thromb Haemost. 2024 Apr 3;8(3):102402. doi: 10.1016/j.rpth.2024.102402. eCollection 2024 Mar.ABSTRACTA State of the Art lecture titled "Anticoagulation and Vascular Anomalies" was presented at the International Society on Thrombosis and Haemostasis (ISTH) Congress in 2023. Vascular anomalies have been classified by the International Society for the Study of Vascular Anomalies into vascular tumors and vascular malformations. Although some vascular tumors, such as tufted angioma and kaposiform hemangioendothelioma, and other vascular malformations can present with coagulation aberrancies, these are not generally m...
Source: Thrombosis and Haemostasis - May 2, 2024 Category: Hematology Authors: Shelley E Crary Joana M Mack Source Type: research
Plantar vein thrombosis: 17-year longitudinal study of consecutive patients from a Swiss academic center
CONCLUSION: We provided initial information on the clinical characteristics, treatment, and course of PVT, which partly resembles that of distal deep vein thrombosis.PMID:38694839 | PMC:PMC11061322 | DOI:10.1016/j.rpth.2024.102396 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - May 2, 2024 Category: Hematology Authors: Margarita Serifi Philippe A Kaufmann Riccardo M Fumagalli Adrian Kobe Nils Kucher Stefano Barco Source Type: research
Comparison of Short ‑Term Outcomes and 3-Year Overall Survival between Robotic and Laparoscopic Gastrectomy for Gastric Cancer: A Propensity Score Matching Analysis
Conclusion: Our findings suggest that RG may offer advantages in terms of blood loss, surgical complications, recovery time, and pain management compared to LG while maintaining similar overall survival rates. However, RG is associated with higher hospital costs, potentially limiting its wider adoption. Further research, including large, multi-center randomized controlled trials with longer patient follow-up, particularly for advanced gastric cancer, is needed to confirm these findings.PMID:38693890 | DOI:10.1080/00015458.2024.2348256 (Source: Acta Chirurgica Belgica)
Source: Acta Chirurgica Belgica - May 2, 2024 Category: Surgery Authors: Li Zhang Jingli Cui Mingzhi Cai Bin Li Gang Ma Xuejun Wang Yong Liu Jingyu Deng Rupeng Zhang Han Liang Jilong Yang Source Type: research
