A challenging diagnosis of chronic osteomyelitis in a child with congenital insensitivity to pain: a case report
CONCLUSION: This case highlights the challenges faced in diagnosing osteomyelitis among CIP patients and emphasizes the need for other diagnostic criteria apart from pain.PMID:38694364 | PMC:PMC11060246 | DOI:10.1097/MS9.0000000000001971 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Hazem Kamil Riffa Alassri Douaa Albelal Abu Baker Alassri Nafiza Martini Jaber Mahmod Source Type: research
Short-term cervical spinal cord stimulation for central post-stroke pain: a case report and literature review
CONCLUSION: A potential role of spinal cord stimulation in the treatment of post-stroke pain is proposed in combined with traditional medication or other neuromodulation strategies, to achieve better control of pain in the future.PMID:38694358 | PMC:PMC11060234 | DOI:10.1097/MS9.0000000000002025 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Xu Zhang Xuebin Yan Yuzhao Huang Haocheng Zhou Source Type: research
All available diagnostic and therapeutic options should be fully exploited in order to quickly identify and optimally treat neuropathic pain in long-COVID
Eur Arch Psychiatry Clin Neurosci. 2024 May 2. doi: 10.1007/s00406-024-01820-0. Online ahead of print.NO ABSTRACTPMID:38695877 | DOI:10.1007/s00406-024-01820-0 (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - May 2, 2024 Category: Psychiatry Authors: Josef Finsterer Source Type: research
Knowledge of female genital schistosomiasis and urinary schistosomiasis among final-year midwifery students in the Volta Region of Ghana
CONCLUSION: Awareness of FGS was limited among the study participants. The high prevalence of knowledge of some FGS symptoms related to the genitalia needs cautious interpretation. Health care training institutions must make deliberate efforts to highlight FGS in the training of midwives as the condition has diagnostic and management implications for some sexual and reproductive health conditions.PMID:38696499 | DOI:10.1371/journal.pone.0302554 (Source: Pain Physician)
Source: Pain Physician - May 2, 2024 Category: Anesthesiology Authors: Wisdom Klutse Azanu Joseph Osarfo Gideon Appiah Yvonne Sefadzi Godonu Gifty Dufie Ampofo Verner Orish Michael Amoh Evans Kofi Agbeno Emmanuel Senanu Komla Morhe Margaret Gyapong Source Type: research
Avoiding pain during propofol injection in pediatric anesthesia: Hypnoanalgesia of the hand versus intravenous lidocaine
CONCLUSIONS: Our results suggest that hypnoanalgesia of the hand alone is effective to prevent the pain related to propofol injection in children. No significant difference was found in comparison with lidocaine admixture nor for pain or satisfaction.PMID:38693886 | DOI:10.1111/pan.14909 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - May 2, 2024 Category: Anesthesiology Authors: Marie-Madeleine Polomeni Thomas Huguet Maryline Mariotti Claire Larcher Fran çois Delort Vincent Minville Delphine Kern Source Type: research
Effectiveness of implementing a standardized perioperative pain management protocol in children undergoing tonsillectomy: A quality improvement project
CONCLUSION: The quality improvement project highlighted notable improvements in the intervention group for whom a standardized perioperative pain management protocol was used, including reduced opioid medication administration, lower incidence of respiratory interventions, and high adherence to the pain management protocol. These findings underscore the effectiveness and feasibility of standardized protocols in enhancing patient outcomes.PMID:38695104 | DOI:10.1111/pan.14917 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - May 2, 2024 Category: Anesthesiology Authors: Lauren Freedman Anna Varughese Binu Koirala Vinciya Pandian Source Type: research
GABA transporter mGat4 is involved in multiple neural functions in mice
Biochim Biophys Acta Mol Cell Res. 2024 Apr 30:119740. doi: 10.1016/j.bbamcr.2024.119740. Online ahead of print.ABSTRACTγ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. The termination of GABA transmission is through the action of GABA transporters (GATs). mGAT4 (encoded by Slc6a11) is another GAT besides GAT1 (encoded by Slc6a1) that functions in GABA reuptake in CNS. Research on the function of mGAT4 is still in its infancy. We developed an mGat4 knockout mouse model (mGat4-/- mice) and performed a series of behavioral analyses for the first time to study the effect of m...
Source: Cell Research - May 2, 2024 Category: Cytology Authors: Yue Ying Weitong Liu Haoyue Wang Jiahao Shi Zhugang Wang Jian Fei Source Type: research
Sensitivity to change and responsiveness of provocative load tests among athletes with patellar tendinopathy
CONCLUSION: This study found moderate to high sensitivity to change and established MCID values for the SLDS and KE test in athletes with patellar tendinopathy before and after rehabilitation. Both tests may be useful as pain on loading outcomes as athletes progress with their rehabilitation, but the KE test results in higher floor effects and has lower sensitivity to change.PMID:38696973 | DOI:10.1016/j.bjpt.2024.101064 (Source: Physical Therapy)
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: Diego Ruffino Mat ías Alfonso Vilma Campana Peter Malliaras Source Type: research
Prognostic Factors and Treatment Effect Modifiers for Physical Health, Opioid Prescription, and Health Care Utilization in Patients With Musculoskeletal Disorders in Primary Care: Exploratory Secondary Analysis of the STEMS Randomized Trial of Direct Access to Physical Therapist-Led Care
CONCLUSIONS: Patients with musculoskeletal conditions with lower levels of pain self-efficacy, higher pain severity, and presenting with low back pain have less favorable clinical and health care outcomes in primary care. Prespecified characteristics did not modify the treatment effect of the offer of a direct-access physical therapist-led pathway compared to GP-led care.IMPACT: Patients with musculoskeletal conditions receiving primary care in the form of direct-access physical therapist-led or GP-led care who have lower levels of self-efficacy, higher pain severity, and low back pain are likely to have a less favorable p...
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: James Zouch Nazim Bhimani Andr é Bussières Manuela Ferreira Nadine E Foster Paulo Ferreira Source Type: research
Kinesiophysiological analysis associated with changes in subjective intensities in belt electrode-skeletal muscle electrical stimulation: a prospective exploratory study
Conclusion] These findings show that objective intensities of >3 METs, as recommended in rehabilitation prescriptions, can be achieved when the subjective intensity is set at strong or maximum tolerated. Treatment with B-SES may provide a viable alternative to therapeutic exercise.PMID:38694009 | PMC:PMC11060770 | DOI:10.1589/jpts.36.284 (Source: Physical Therapy)
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: Norikazu Hishikawa Koshiro Sawada Motonori Kubo Mari Kakita Takashi Kawasaki Suzuyo Ohashi Yasuo Mikami Source Type: research
Efficacy of ultrasound therapy with neck retraction exercises vs. ultrasound therapy with deep cervical flexor training for excessive screen time users: a pilot randomized controlled study
Conclusion] Ultrasound therapy with neck retraction exercises could have a more positive effect on pain, forward head posture, and strength of the deep cervical flexor muscles in comparison to ultrasound therapy with deep cervical flexor training for excessive screen time users.PMID:38694008 | PMC:PMC11060765 | DOI:10.1589/jpts.36.303 (Source: Physical Therapy)
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: Monthinee Watthanasuwakul Panida Hanphitakphong Somruthai Poomsalood Source Type: research
Emerging technology has a brilliant future: the CRISPR-Cas system for senescence, inflammation, and cartilage repair in osteoarthritis
Cell Mol Biol Lett. 2024 May 2;29(1):64. doi: 10.1186/s11658-024-00581-x.ABSTRACTOsteoarthritis (OA), known as one of the most common types of aseptic inflammation of the musculoskeletal system, is characterized by chronic pain and whole-joint lesions. With cellular and molecular changes including senescence, inflammatory alterations, and subsequent cartilage defects, OA eventually leads to a series of adverse outcomes such as pain and disability. CRISPR-Cas-related technology has been proposed and explored as a gene therapy, offering potential gene-editing tools that are in the spotlight. Considering the genetic and multi...
Source: Cellular and Molecular Biology Letters - May 2, 2024 Category: Biochemistry Authors: Shicheng Jia Rongji Liang Jiayou Chen Shuai Liao Jianjing Lin Wei Li Source Type: research
Bilateral pyogranulomatous otitis externa with putative cartilage destruction in a dog: A severe case of auricular chondritis?
Vet Dermatol. 2024 May 2. doi: 10.1111/vde.13252. Online ahead of print.ABSTRACTAuricular chondritis of unknown cause was suspected in a 10-year-old male Bolognese dog with a five-month history of painful bilateral nodular and ulcerative pyogranulomatous dermatitis of the pinnae with putative auricular cartilage destruction. Pain and lesions resolved with immunosuppressive doses of prednisolone, yet the condition resulted in deformity of both pinnae and external canals.PMID:38695235 | DOI:10.1111/vde.13252 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - May 2, 2024 Category: Veterinary Research Authors: Michela De Lucia Carolina Mendes Giovanna Bertolini Source Type: research
Prolonged Opioid Use Is Associated With Poor Pain Alleviation After Orthopaedic Surgery
CONCLUSION: Our findings demonstrated an overall high rate of COU. The known risk factors of COU were evident in our study population, particularly the modifiable risk factor of acute postsurgical PPA. Better management of postsurgical pain in orthopaedic patients may lead to a decrease in the rates of COU in this group.PMID:38696825 | DOI:10.5435/JAAOS-D-24-00044 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - May 2, 2024 Category: Orthopaedics Authors: Meir T Marmor Stephanie Hu Varun Mahadevan Alexander Floren Belen Perez Solans Rada Savic Source Type: research
Cervical Disk Replacement Versus Anterior Cervical Diskectomy and Fusion: Effect of Procedural Variant on Patients With a Prolonged Preoperative Duration of Symptoms From Disk Herniation
CONCLUSION: Patients with prolonged PSD due to cervical DH demonstrated notable improvements in physical function, disability, pain, and mental health regardless of fusion versus arthroplasty techniques. Accounting for demographic variations, patients undergoing CDA demonstrated a greater magnitude of improvement and superior scores in physical function at the first postoperative follow-up. Rates of clinically tangible improvements in PROMs did not markedly vary by surgical procedure. Patients undergoing CDA may perceive greater early improvements to physical function compared with patients undergoing ACDF for prolonged PS...
Source: The Journal of the American Academy of Orthopaedic Surgeons - May 2, 2024 Category: Orthopaedics Authors: Timothy J Hartman James W Nie Ishan Khosla Omolabake O Oyetayo Keith R MacGregor Eileen Zheng Fatima N Anwar Andrea M Roca Alexandra C Loya Srinath S Medakkar Vincent P Federico Dustin H Massel Arash J Sayari Gregory D Lopez Kern Singh Source Type: research
