Age-related differences in functional connectivity associated with pain modulation
Neurobiol Aging. 2024 Apr 25;140:1-11. doi: 10.1016/j.neurobiolaging.2024.04.008. Online ahead of print.ABSTRACTGrowing evidence suggests that aging is associated with impaired endogenous pain modulation, and that this likely underlies the increased transition from acute to chronic pain in older individuals. Resting-state functional connectivity (rsFC) offers a valuable tool to examine the neural mechanisms behind these age-related changes in pain modulation. RsFC studies generally observe decreased within-network connectivity due to aging, but its relevance for pain modulation remains unknown. We compared rsFC within a se...
Source: Neurobiology of Aging - May 1, 2024 Category: Geriatrics Authors: Marian van der Meulen Katharina M Rischer Ana Mar ía González Roldán Juan Lorenzo Terrasa Pedro Montoya Fernand Anton Source Type: research
Chitin-glucan improves important pathophysiological features of irritable bowel syndrome
CONCLUSION: CG decreased visceral perception and intestinal inflammation through master gene regulation and direct binding of microbial products, suggesting that CG may constitute a new therapeutic strategy for patients with IBS or IBS-like symptoms.PMID:38690023 | PMC:PMC11056916 | DOI:10.3748/wjg.v30.i16.2258 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - May 1, 2024 Category: Gastroenterology Authors: Caroline Valibouze Caroline Dubuquoy Philippe Chavatte Micha ël Genin Veronique Maquet Salvatore Modica Pierre Desreumaux Christel Rousseaux Source Type: research
Ultrasound-guided erector spinae nerve block for relief of chest pain from pneumonia in the emergency department
We present the case of a 58-year-old male presenting to the ED with chest pain from pneumonia which remained unmanageable after acetaminophen, NSAID, and opioid administration. An ultrasound-guided erector spinae plane block was performed in the ED and the patient had a significant reduction in his chest pain.PMID:38693022 | DOI:10.1016/j.ajem.2024.04.026 (Source: Herpes)
Source: Herpes - May 1, 2024 Category: Infectious Diseases Authors: Robert Stenberg Laine Goff Erin L Simon Source Type: research
Quality of life and support needs in children, adolescents, and young adults with facioscapulohumeral dystrophy, a mixed-method study
DISCUSSION: Quality of life in childhood FSHD is diminished caused by their physical limitations, altered appearance, fear of social rejection, and uncertainty of the disease progression in the future. A fear of social rejection most likely contributes to striving for normality regardless of physical discomfort. Support should be focused on acceptance and coping with hurtful comments. It should preferably be individualized, easily accessible and not offered as therapy but rather as tutoring for children.PMID:38692157 | DOI:10.1016/j.ejpn.2024.04.006 (Source: European Journal of Paediatric Neurology)
Source: European Journal of Paediatric Neurology - May 1, 2024 Category: Neurology Authors: Jildou N Dijkstra Nathani ël B Rasing Helena T M Boon Sandra Altena-Rensen Edith H C Cup Anke Lanser Ietske J Siemann Baziel G van Engelen Corrie E Erasmus Nicol C Voermans Source Type: research
Chitin-glucan improves important pathophysiological features of irritable bowel syndrome
CONCLUSION: CG decreased visceral perception and intestinal inflammation through master gene regulation and direct binding of microbial products, suggesting that CG may constitute a new therapeutic strategy for patients with IBS or IBS-like symptoms.PMID:38690023 | PMC:PMC11056916 | DOI:10.3748/wjg.v30.i16.2258 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - May 1, 2024 Category: Gastroenterology Authors: Caroline Valibouze Caroline Dubuquoy Philippe Chavatte Micha ël Genin Veronique Maquet Salvatore Modica Pierre Desreumaux Christel Rousseaux Source Type: research
Characterizing 1991 Gulf War women veterans from the Boston Biorepository and Integrative Network for Gulf War Illness: demographics, exposures, neuroimaging and cognitive outcomes
Conclusions: Although subtle and limited findings were present in this group of women veterans, it suggests that continued follow-up of GW women veterans is warranted. Future research should continue to evaluate differences between men and women in GW veteran samples. The BBRAIN women sub-repository is recruiting and these data are available to the research community for studies of women veterans.PMID:38692856 | DOI:10.1080/13854046.2024.2344263 (Source: The Clinical Neuropsychologist)
Source: The Clinical Neuropsychologist - May 1, 2024 Category: Psychiatry & Psychology Authors: Maxine Krengel Dylan Keating Linda Chao Julianne Dugas BangBon Koo Timothy Heeren Emily Quinn Rosemary Toomey Lea Steele Nancy Klimas Francis Samonte Laila Abdullah Kimberly Sullivan Source Type: research
Multiligament Knee Reconstruction With Suture Tape Augmentation: Patient-Reported Outcomes at Minimum 2-Year Follow-up
CONCLUSION: Patients who underwent MLKR with suture augmentation had satisfactory scores across all patient-reported outcome measurements. On the basis of these criteria, the average patient achieved an acceptable clinical outcome, demonstrating that MLKR with suture augmentation is a safe and efficacious surgical technique for the treatment of MLKI. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38690848 | DOI:10.3928/01477447-20240424-02 (Source: Orthopedics)
Source: Orthopedics - May 1, 2024 Category: Orthopaedics Authors: Brian Panish Jonathan J Lawson Seleem Elkadi Eliana Schaefer Gregory Perraut Evan H Argintar Source Type: research
Neurologic Approach to Radiculopathy, Back Pain, and Neck Pain
Prim Care. 2024 Jun;51(2):345-358. doi: 10.1016/j.pop.2024.02.003. Epub 2024 Mar 11.ABSTRACTBack pain and neck pain are common in clinical practice, but significant challenges and pitfalls exist in their diagnosis, treatment, and management. From the neurologic standpoint, cervical radiculopathy and lumbosacral radiculopathy are characterized by neck pain or back pain accompanied by sensory and motor symptoms in an arm or leg. The basic neurologic examination is vital, but testing like electromyography and MRI is often needed especially in cases that fail conservative management. Oral medications, injection-based therapies...
Source: Primary Care - May 1, 2024 Category: Primary Care Authors: Canaan Coker Jade Park Ryan D Jacobson Source Type: research
Recognizing Myopathy in Patients with Muscle Weakness or Pain
Prim Care. 2024 Jun;51(2):311-326. doi: 10.1016/j.pop.2024.02.005. Epub 2024 Mar 19.ABSTRACTMuscle weakness and pain can be seen in orthopedic, rheumatologic, cardiac, and musculoskeletal conditions in addition to neurologic disorders. Myopathy, which describes a heterogenous group of hereditary and acquired disorders that affect muscle channels, structure, and metabolism, is one possible cause. This review focuses on essential information to support primary care providers as they assess patients with muscle weakness and pain for myopathy. As with most neurologic disorders, a thorough clinical history and physical examinat...
Source: Primary Care - May 1, 2024 Category: Primary Care Authors: Melissa A Elafros Arjun Seth Source Type: research
Long-term results of arthroscopic capsulolabral revision repair for failed anterior shoulder instability repair using suture anchors at a minimum of 10 years follow-up
CONCLUSION: Long-term follow-up after ACRR shows predictable results, with a high degree of patient satisfaction, good to excellent patient-reported outcome scores and minimal radiological degenerative changes. However, with an average recurrence rate of 19.3% after 11.86 years, the redislocation rate appears high. With careful patient selection, recurrence rates can be significantly reduced.PMID:38693287 | DOI:10.1007/s00402-024-05304-7 (Source: Hand Surgery)
Source: Hand Surgery - May 1, 2024 Category: Surgery Authors: Mohamed Aboalata Johannes Plath Hani Eltair Stephan Vogt Andreas B Imhoff Source Type: research
Mindfulness-based stress reduction (MBSR) for fibromyalgia patients: The role of pain cognitions as mechanisms of change
CONCLUSIONS: These results reveal the significant therapeutic potential of MBSR for FM patients, due to the emphasis on non-judging and acceptance of negative inner states. Furthermore, this research identified two important pain-related cognitions as mechanisms of change, suggesting that MBSR contributes to cognitive change, which enables the reduction of physical and psychological distress.TRIAL REGISTRATION NUMBER: NCT04304664.PMID:38692113 | DOI:10.1016/j.ctcp.2024.101860 (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - May 1, 2024 Category: Complementary Medicine Authors: Renen Taub Nancy Agmon-Levin Lee Frumer Inbal Samuel-Magal Ittai Glick Danny Horesh Source Type: research
Safety and immunogenicity of a polyvalent DNA-protein HIV vaccine with matched Env immunogens delivered as a prime-boost regimen or coadministered in HIV-uninfected adults in the USA (HVTN 124): a phase 1, placebo-controlled, double-blind randomised controlled trial
Lancet HIV. 2024 May;11(5):e285-e299. doi: 10.1016/S2352-3018(24)00036-5.ABSTRACTBACKGROUND: An effective HIV vaccine will most likely need to have potent immunogenicity and broad cross-subtype coverage. The aim of the HIV Vaccine Trials Network (HVTN) 124 was to evaluate safety and immunogenicity of a unique polyvalent DNA-protein HIV vaccine with matching envelope (Env) immunogens.METHODS: HVTN 124 was a randomised, phase 1, placebo-controlled, double-blind study, including participants who were HIV seronegative and aged 18-50 years at low risk for infection. The DNA vaccine comprised five plasmids: four copies expressin...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Ian Frank Shuying S Li Nicole Grunenberg Edgar T Overton Samuel T Robinson Hua Zheng Kelly E Seaton Jack R Heptinstall Mary A Allen Kenneth H Mayer Daniel A Culver Michael C Keefer Sri Edupuganti Michael N Pensiero Vijay L Mehra Stephen C De Rosa Daryl E Source Type: research
Evaluating the effect of a mobile-based symptom monitoring system for improving physical function in patients with cancer during chemotherapy: study protocol for a multicentre randomised controlled trial
This study is a multicentre, open-label, parallel-group, randomised controlled trial. We will recruit 372 patients at three tertiary hospitals located in Seoul, South Korea. Study participants will be randomly assigned to either an intervention group receiving the ePRO-CTCAE app and a control group receiving routine clinical practice only. The primary outcome is changes in physical function from commencement to completion of planned chemotherapy. A linear mixed model will be performed under the intention-to-treat principle. The secondary outcomes include physical activity level; changes in pain interference; changes in dep...
Source: Cancer Control - May 1, 2024 Category: Cancer & Oncology Authors: Mangyeong Lee Danbee Kang Yesol Um Bokyung Jo Jeong Rhue Sehhoon Park Yoo-Young Lee Joseph J Noh Yun-Gyoo Lee Dong-Hoe Koo Kyong-Hwa Park Soohyeon Lee Jin Seok Ahn Dongryul Oh Juhee Cho Source Type: research
Long-acting transdermal drug delivery formulations: Current developments and innovative pharmaceutical approaches
Adv Drug Deliv Rev. 2024 Apr 29:115326. doi: 10.1016/j.addr.2024.115326. Online ahead of print.ABSTRACTTransdermal administration remains an active research and development area as an alternative route for long-acting drug delivery. It avoids major drawbacks of conventional oral (gastrointestinal side effects, low bioavailability, and multiple dosing) or parenteral routes (invasiveness, pain, and psychological stress and bio-hazardous waste generated from needles), thereby increasing patient appeal and compliance. This review focuses on the current state of long-acting transdermal drug delivery, including adhesive patches,...
Source: Advanced Drug Delivery Reviews - May 1, 2024 Category: Drugs & Pharmacology Authors: Tanvi Karve Amruta Dandekar Vivek Agrahari M Melissa Peet Ajay K Banga Gustavo F Doncel Source Type: research
Arthroscopy for the Treatment of Temporomandibular Disorders
J Contemp Dent Pract. 2024 Mar 19;25(3):197-198. doi: 10.5005/jp-journals-10024-3646.ABSTRACTHow to cite this article: Mosaddad SA. Arthroscopy for the Treatment of Temporomandibular Disorders. J Contemp Dent Pract 2024;25(3):197-198. Keywords: Arthroscopy, Facial pain, Temporomandibular joint, Temporomandibular joint disorders.PMID:38690689 | DOI:10.5005/jp-journals-10024-3646 (Source: J Contemp Dent Pract)
Source: J Contemp Dent Pract - May 1, 2024 Category: Dentistry Authors: Ali Seyed Mosaddad Source Type: research
