Preliminary Study: 3D Nailing for Intertrochanteric Femur Fractures
CONCLUSION: In both static compression and fatigue tests, 3DPFN exhibits significant biomechanical advantages over PFNA. This suggests that 3DPFN may be an excellent choice for the treatment of intertrochanteric fractures of the femur and holds further research value for development. Future studies may involve clinical trials to validate and refine the 3DPFN design based on the observed results and promote the advancement of orthopedic implant technology.PMID:38687858 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Weibin Li Lishan Sun Yasen Cao Source Type: research
Construction and Validation Study of a Model for Predicting the Risk of Pulmonary Complications in Elderly Patients with Multiple Rib Fractures
CONCLUSIONS: The column-line diagram model of pulmonary complications in patients with MRF constructed in this study showed good discriminative and calibration performance in both internal and external validation, which is helpful for clinicians to identify individuals at high risk of pulmonary complications as early as possible, and thus can be recommended for clinical use.PMID:38687856 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Chenchen Yang Hengfa Ge Aifeng Gong Source Type: research
Safflower Yellow Combined with Low Molecular Weight Heparin in Preventing Deep Vein Thrombosis After Orthopaedic Surgery: A Meta-Analysis and Literature Review
CONCLUSION: Safflower yellow combined with LMWH can reduce postoperative blood hypercoagulability and prevent DVT formation in lower extremities in orthopedic patients, and achieves better outcomes than LMWH alone in terms of postoperative bleeding tendency.PMID:38687854 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 30, 2024 Category: Complementary Medicine Authors: Yanbin Sun Houling Zhao Zhen Gao Lei Li Source Type: research
Epstein-barr virus infections induce aberrant osteoclastogenesis in immune system-humanized NOD/Shi-scid/IL-2R γC < sup > null < /sup > mice
Biochem Biophys Res Commun. 2024 Apr 23;715:149984. doi: 10.1016/j.bbrc.2024.149984. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV) and other viral infections are possible triggers of autoimmune diseases, such as rheumatoid arthritis (RA). To analyze the causative relationship between EBV infections and RA development, we performed experiment on humanized NOD/Shi-scid/IL-2RγCnull (hu-NOG) mice reconstituted human immune system components and infected with EBV. In EBV-infected hu-NOG mice, breakdown of knee joint bones was found to be accompanied by the accumulation of receptor activator of nuclear factor-κB (NF-Î...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yasuko Nagatsuka Mitsuhiro Iwata Yosuke Nagasawa Hiroshi Tsuzuki Noboru Kitamura Atsushi Komatsu Kei Kawana Ryoji Ito Shigeyoshi Fujiwara Hideki Nakamura Masami Takei Source Type: research
Epstein-barr virus infections induce aberrant osteoclastogenesis in immune system-humanized NOD/Shi-scid/IL-2R γC < sup > null < /sup > mice
Biochem Biophys Res Commun. 2024 Apr 23;715:149984. doi: 10.1016/j.bbrc.2024.149984. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV) and other viral infections are possible triggers of autoimmune diseases, such as rheumatoid arthritis (RA). To analyze the causative relationship between EBV infections and RA development, we performed experiment on humanized NOD/Shi-scid/IL-2RγCnull (hu-NOG) mice reconstituted human immune system components and infected with EBV. In EBV-infected hu-NOG mice, breakdown of knee joint bones was found to be accompanied by the accumulation of receptor activator of nuclear factor-κB (NF-Î...
Source: Biochemical and Biophysical Research communications - April 30, 2024 Category: Biochemistry Authors: Yasuko Nagatsuka Mitsuhiro Iwata Yosuke Nagasawa Hiroshi Tsuzuki Noboru Kitamura Atsushi Komatsu Kei Kawana Ryoji Ito Shigeyoshi Fujiwara Hideki Nakamura Masami Takei Source Type: research
Associations between back pain incidence, and physical activity and sedentary behaviours: A prospective cohort study with data from over 365,000 participants
CONCLUSION: Physical activity was related to a reduced risk of back pain incidence (except over-high vigorous physical activity). Substituting sedentary behaviours with physical activities reduced the risk of future back pain.PMID:38687159 | DOI:10.2519/jospt.2024.12338 (Source: Health Physics)
Source: Health Physics - April 30, 2024 Category: Physics Authors: Yong-Hui Zhang Hao-Ran Xu Qi-Hao Yang Shu-Hao Du Xuan Su Yi-Li Zheng Meng-Si Peng Xue-Qiang Wang Source Type: research
Boosting treatment outcomes via the patient-practitioner relationship, treatment-beliefs or therapeutic setting. A systematic review with meta-analysis of contextual effects in chronic musculoskeletal pain
CONCLUSION: Whilst evidence gaps exist, per current evidence it may not be possible to achieve meaningful benefit for patients with chronic musculoskeletal pain by manipulating the context of non-pharmacological and non-surgical treatments. TRIAL REGISTRATION: This systematic review was prospectively registered in PROSPERO (registration number: CRD42023391601).PMID:38687160 | DOI:10.2519/jospt.2024.12259 (Source: Health Physics)
Source: Health Physics - April 30, 2024 Category: Physics Authors: Tobias Saueressig Patrick J Owen Hugo Pedder Nitin Kumar Arora Marieke Simons Svenja Kaczorowski Clint T Miller Lars Donath Daniel L Belavy Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
An Overlooked Disease: Minimal Autonomous Cortisol Secretion (MACS). A Narrative Review
CONCLUSION: MACS is no longer considered an asymptomatic disorder; repeated hormonal and functional tests are crucial to prevent multiorgan damage.PMID:38686896 | DOI:10.2174/0118715303266569231129101847 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 30, 2024 Category: Drugs & Pharmacology Authors: Stephanie Farah Leah Nasr Jocelyne Eid Fares Source Type: research
Boosting treatment outcomes via the patient-practitioner relationship, treatment-beliefs or therapeutic setting. A systematic review with meta-analysis of contextual effects in chronic musculoskeletal pain
CONCLUSION: Whilst evidence gaps exist, per current evidence it may not be possible to achieve meaningful benefit for patients with chronic musculoskeletal pain by manipulating the context of non-pharmacological and non-surgical treatments. TRIAL REGISTRATION: This systematic review was prospectively registered in PROSPERO (registration number: CRD42023391601).PMID:38687160 | DOI:10.2519/jospt.2024.12259 (Source: Physical Therapy)
Source: Physical Therapy - April 30, 2024 Category: Physiotherapy Authors: Tobias Saueressig Patrick J Owen Hugo Pedder Nitin Kumar Arora Marieke Simons Svenja Kaczorowski Clint T Miller Lars Donath Daniel L Belavy Source Type: research
Associations between back pain incidence, and physical activity and sedentary behaviours: A prospective cohort study with data from over 365,000 participants
CONCLUSION: Physical activity was related to a reduced risk of back pain incidence (except over-high vigorous physical activity). Substituting sedentary behaviours with physical activities reduced the risk of future back pain.PMID:38687159 | DOI:10.2519/jospt.2024.12338 (Source: Physical Therapy)
Source: Physical Therapy - April 30, 2024 Category: Physiotherapy Authors: Yong-Hui Zhang Hao-Ran Xu Qi-Hao Yang Shu-Hao Du Xuan Su Yi-Li Zheng Meng-Si Peng Xue-Qiang Wang Source Type: research
Long non-coding RNA H19 mediates osteogenic differentiation of bone marrow mesenchymal stem cells through the miR-29b-3p/DKK1 axis
This study aimed to explore the molecular mechanism of long non-coding RNA H19 in osteoporosis after SCI and provide new research directions for existing prevention strategies. We used small interfering RNA to knockdown H19 expression and regulated miR-29b-2p expression using miR-29b-3p mimetics and inhibitors. Western blotting, real-time fluorescence quantitative PCR, Alizarin red staining, alkaline phosphatase staining and double-luciferase reporter gene assays were used to assess gene expression, osteogenic ability and binding sites. lncRNA H19 was upregulated in BMSCs from the osteoporosis group, whereas miR-29b-3p was...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Sen Qin Da Liu Source Type: research
Effect of Low Protein Diet on Bone Structure of Young Wistar Mice
Conclusion:</b> A low protein diet decreased the body weight of the rats, also causing impaired bone growth characterized by decreasing femur weight. The low protein diet also caused osteoporosis in the bones.PMID:38686732 | DOI:10.3923/pjbs.2024.113.118 (Source: Pakistan Journal of Biological Sciences: PJBS)
Source: Pakistan Journal of Biological Sciences: PJBS - April 30, 2024 Category: Biomedical Science Authors: Faysal Kastella Filiani Natalia Salim Hanna Goenawan Ronny Lesmana Rita Maliza Rahimi Syaidah Aziiz Mardanarian Rosdianto Vita Murniati Tarawan None Setiawan Source Type: research
Implementation of a day-stay joint replacement pathway in an Australian regional public hospital: A descriptive study
CONCLUSION: The day-stay joint replacement surgery pathway was feasible to implement, safe and acceptable to patients. Day-stay pathways have potential patient and system-level efficiency benefits.PMID:38686659 | DOI:10.1111/ajr.13127 (Source: The Australian Journal of Rural Health)
Source: The Australian Journal of Rural Health - April 30, 2024 Category: Rural Health Authors: Amanda Tutty Sam Martin Corey Scholes Michel Genon Jane Linton Simon Davidson Christopher Williams Source Type: research
Preoperative handgrip strength can predict early postoperative shoulder function in patients undergoing arthroscopic rotator cuff repair
CONCLUSIONS: Higher baseline grip strength predicts more favorable postoperative shoulder function following ARCR. A preoperative grip strength test in orthopedic clinics may serve as a predictor for postoperative shoulder functional recovery in patients undergoing ARCR.PMID:38689328 | DOI:10.1186/s13018-024-04750-8 (Source: Hand Surgery)
Source: Hand Surgery - April 30, 2024 Category: Surgery Authors: Yu-Cheng Liu Shu-Wei Huang Christopher R Adams Chung-Ying Lin Yu-Pin Chen Yi-Jie Kuo Tai-Yuan Chuang Source Type: research
