The Jerusalem tribune collapse incident: Challenges in the management of a pediatric mass casualty incident
CONCLUSION: Pediatric MCI management presents specific challenges. The lack of consistency in triage, registry, and management highlights the need for robust pediatric MCI training programs.PMID:38698513 | DOI:10.5055/ajdm.0479 (Source: American Journal of Disaster Medicine)
Source: American Journal of Disaster Medicine - May 3, 2024 Category: International Medicine & Public Health Authors: Naama Pines Saar Hashavya Miklosh Bala Kedar Asaf Lea Ohana-Sarna-Cahan Giora Weiser Bat El Shalem David Rekthman Shaden Salameh Source Type: research
Development and validation of a machine learning model to improve precision prediction for irrational prescriptions in orthopedic perioperative patients
CONCLUSION: The RF model showcased significantly high level of proficiency in predicting irrational prescriptions among orthopedic perioperative patients, outperforming other models by a considerable margin. It effectively enhanced the efficiency of pharmacist interventions, displaying outstanding performance in assisting pharmacists to intervene with irrational prescriptions.PMID:38698685 | DOI:10.1080/14740338.2024.2348569 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - May 3, 2024 Category: Drugs & Pharmacology Authors: Weipeng Li Nan Shang Zhiqi Zhang Yun Li Xianlin Li Xiaojun Zheng Source Type: research
Technology Behind Cell Therapy Augmentation of Fracture Healing: Concentrated Bone Marrow Aspirate
J Am Acad Orthop Surg. 2024 May 15;32(10):e476-e481. doi: 10.5435/JAAOS-D-24-00020.ABSTRACTWith an aging population, and an anticipated increase in overall fracture incidence, a sound understanding of bone healing and how technology can optimize this process is crucial. Concentrated bone marrow aspirate (cBMA) is a technology that capitalizes on skeletal stem and progenitor cells (SSPCs) to enhance the regenerative capacity of bone. This overview highlights the science behind cBMA, discusses the role of SSPCs in bone homeostasis and fracture repair, and briefly details the clinical evidence supporting the use of cBMA in fr...
Source: The Journal of the American Academy of Orthopaedic Surgeons - May 3, 2024 Category: Orthopaedics Authors: Philipp Leucht Devan Mehta Source Type: research
An in silico approach to elucidate the pathways leading to primary osteoporosis: age-related vs. postmenopausal
Biomech Model Mechanobiol. 2024 May 3. doi: 10.1007/s10237-024-01846-2. Online ahead of print.ABSTRACTNumerical models of bone remodelling have traditionally been used to perform in silico tests of bone loss in postmenopausal women and also to simulate the response to different drug treatments. These models simulate the menopausal oestrogen decline by altering certain signalling pathways. However, they do not consider the simultaneous effect that ageing can have on cell function and bone remodelling, and thus on bone loss. Considering ageing and oestrogen decline together is important for designing osteoporosis treatments ...
Source: Biomechanics and Modeling in Mechanobiology - May 3, 2024 Category: Biomedical Science Authors: Roc ío Ruiz-Lozano Jos é Luis Calvo-Gallego Peter Pivonka Michelle M McDonald Javier Mart ínez-Reina Source Type: research
Computer-simulated TOUCH prosthesis cup malposition and solutions
CONCLUSION: Our computer-based measurements suggested options for intraoperative cup revision depending on cup shape and size and on type of misalignment with resulting bone defects. These suggestions, however, need to be confirmed in anatomic specimens before introducing them into clinical practice.PMID:38701947 | DOI:10.1016/j.hansur.2024.101712 (Source: Hand Surgery)
Source: Hand Surgery - May 3, 2024 Category: Surgery Authors: Kevin Knappe Mareike Schonhoff Sebastian Jaeger Berthold Bickert Leila Harhaus Benjamin Panzram Source Type: research
Incidence and management of secondary deformities after megaendoprosthetic proximal femur replacement in skeletally immature bone sarcoma patients
CONCLUSIONS: Patients aged < 10 years were prone to develop secondary hip dysplasia and genu valgum following proximal femur replacement in this study. Management of secondary deformities should depend on remaining skeletal growth. Stress shielding was observed in almost all skeletally immature patients.PMID:38700674 | DOI:10.1007/s00402-024-05334-1 (Source: Hand Surgery)
Source: Hand Surgery - May 3, 2024 Category: Surgery Authors: Wiebke K Guder Nina M Engel Arne Streitb ürger Christina Polan Marcel Dudda Lars E Podleska Markus Nottrott Jendrik Hardes Source Type: research
Are current rates of uncemented fixation in total hip arthroplasty supported by the literature? An update on the uncemented paradox
Hip Int. 2024 May 3:11207000241249673. doi: 10.1177/11207000241249673. Online ahead of print.ABSTRACTThe optimal fixation method in total hip arthroplasty (THA) remains controversial. Initial concerns related to the long-term performance of cement fixation as well as cement disease led to the development of cementless implants, and registry data has indicated that the use of this type of fixation has increased in recent years. However, data from these same registries has not shown any improvement in outcomes when compared to cement fixation. On the contrary, while similar outcomes are seen when comparing these fixation typ...
Source: Hip International - May 3, 2024 Category: Orthopaedics Authors: Christopher M Scanlon Anthony C Gemayel Weston Buehring James D Slover Henrik Malchau Source Type: research
Assessment of Knowledge and Concern of People Living with HIV Regarding Human Mpox and Vaccination
CONCLUSION: The future study should focus on continuous education, promoting awareness through programs and establishing measures to successfully overcome identified variables that contribute to mpox pandemic understanding and attitudes. Applying the lessons learned from the COVID-19 pandemic will help the management of mpox virus.PMID:38698752 | DOI:10.2174/011570162X293673240427062123 (Source: Current HIV Research)
Source: Current HIV Research - May 3, 2024 Category: Infectious Diseases Authors: Deniz Borcak Yusuf Emre Özdemir Ye şilyurt Zuhal Esra Ensaro ğlu Samiha Akkaya Kadriye Kart Ya şar Source Type: research
Can therapeutic reassessment in ODF be based on management principles?
CONCLUSIONS: Management is unsuitable for eliminating the need for therapeutic re-evaluation because, through the deployment of the organizational mode which is consubstantial with it, it is opposed to the institutional order of which any therapeutic approach is a part.PMID:38699911 | DOI:10.1684/orthodfr.2024.144 (Source: L' Orthodontie Francaise)
Source: L' Orthodontie Francaise - May 3, 2024 Category: Dentistry Authors: Aymeric Philibert Source Type: research
Milk-Alkali Syndrome: A Century-old Cause of Hypercalcemia Requires the Addition of Venous Blood Gas in Hypercalcemia Workup
J Assoc Physicians India. 2023 Sep;71(9):104-105. doi: 10.59556/japi.71.0330.ABSTRACTThe Milk-Alkali syndrome (MAS) is identified by the triad of high serum levels of calcium, metabolic alkalosis, and acute kidney injury, usually caused by consuming excessive amounts of calcium and absorbable alkali. If not treated promptly, the syndrome can result in rapid hypercalcemia, acute renal failure, and metastatic calcification. Notably, an increasing number of cases of MAS have been observed, potentially due to the rampant use of calcium-based over-the-counter supplements for the prevention and treatment of osteoporosis in postm...
Source: Journal of the Association of Physicians of India - May 3, 2024 Category: General Medicine Authors: Utsav Sahu Tamal Trivedi Rajesh Gupta Source Type: research
Opioid use and disposal at 2 weeks post-surgery: Brief communication regarding excess opioids and disposal habits
CONCLUSION: Two-thirds of the patients reported having excess opioids, highlighting the issue of an overabundance of unused prescription opioids in America. Utilization of opioid-free pain management strategies and drug disposal kits should be explored to reduce the number of unused and improperly disposed opioids.PMID:38700391 | DOI:10.5055/jom.0854 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - May 3, 2024 Category: Addiction Authors: Henry Kuechly Sarah Kurkowski John Bonamer Brian Newyear Brian Johnson Brian Grawe Source Type: research
Opioid prescribing patterns for distal radius fractures in the ambulatory setting: A 10-year retrospective study
CONCLUSIONS: Prescriptions of both opioid and nonopioid analgesic medications for DRF have been steadily increasing over time in the nonoperative ambulatory setting, with middle-aged adults most likely to receive an opioid prescription. Opioid prescription rates differ significantly between patients utilizing workers' compensation and patients receiving services under charity care, suggesting that socioeconomic factors play a role in prescribing patterns.PMID:38700392 | DOI:10.5055/jom.0862 (Source: Journal of Opioid Management)
Source: Journal of Opioid Management - May 3, 2024 Category: Addiction Authors: Brian Pettitt-Schieber Robert P Lesko Fei Wang Jinesh Shah Joseph A Ricci Source Type: research
Correlation of serum matrix metalloproteinase 3 with osteoporosis in patients of postmenopausal rheumatoid arthritis
Hum Immunol. 2024 May 2;85(3):110807. doi: 10.1016/j.humimm.2024.110807. Online ahead of print.ABSTRACTOsteoporosis (OP) is a common complication of postmenopausal women with rheumatoid arthritis (RA). Herein, the objective of our study was to explore the correlation between serum matrix metalloproteinase 3 (MMP3) and OP among postmenopausal women with RA to foster better diagnosis and treatment. A total of 208 elderly postmenopausal women with RA were included in this study, with 83 patients diagnosed with OP after RA diagnosis and 125 patients without OP. Serum MMP3 levels and bone mineral density (BMD) were measured and...
Source: Human Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Rong Ji Lei Yang Guoxun Shi Jianming Sun Pei Cao Source Type: research
An in silico approach to elucidate the pathways leading to primary osteoporosis: age-related vs. postmenopausal
Biomech Model Mechanobiol. 2024 May 3. doi: 10.1007/s10237-024-01846-2. Online ahead of print.ABSTRACTNumerical models of bone remodelling have traditionally been used to perform in silico tests of bone loss in postmenopausal women and also to simulate the response to different drug treatments. These models simulate the menopausal oestrogen decline by altering certain signalling pathways. However, they do not consider the simultaneous effect that ageing can have on cell function and bone remodelling, and thus on bone loss. Considering ageing and oestrogen decline together is important for designing osteoporosis treatments ...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Roc ío Ruiz-Lozano Jos é Luis Calvo-Gallego Peter Pivonka Michelle M McDonald Javier Mart ínez-Reina Source Type: research
Fracture haematoma proteomics
CONCLUSION: The early fxH proteome of the ETC group was characterized by the expression of immunomodulatory, mainly pro-inflammatory, proteins, whereas the early fxH proteome of the DCO group was more regenerative and osteogenic in nature. These findings match clinical observations, in which enhanced surgical trauma after multiple trauma causes dysbalanced inflammation, potentially leading to reduced tissue regeneration, and gained insights into regulatory mechanisms of fracture healing after severe trauma.PMID:38699779 | DOI:10.1302/2046-3758.135.BJR-2023-0323.R1 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Rald V M Groven Christel Kuik Johannes Greven Ümit Mert Freek G Bouwman Martijn Poeze Taco J Blokhuis Markus Huber-Lang Frank Hildebrand Berta Cillero-Pastor Martijn van Griensven Source Type: research
