Multiligament Knee Reconstruction With Suture Tape Augmentation: Patient-Reported Outcomes at Minimum 2-Year Follow-up
CONCLUSION: Patients who underwent MLKR with suture augmentation had satisfactory scores across all patient-reported outcome measurements. On the basis of these criteria, the average patient achieved an acceptable clinical outcome, demonstrating that MLKR with suture augmentation is a safe and efficacious surgical technique for the treatment of MLKI. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38690848 | DOI:10.3928/01477447-20240424-02 (Source: Orthopedics)
Source: Orthopedics - May 1, 2024 Category: Orthopaedics Authors: Brian Panish Jonathan J Lawson Seleem Elkadi Eliana Schaefer Gregory Perraut Evan H Argintar Source Type: research
Total Humeral Endoprosthetic Reconstruction: A Systematic Review
CONCLUSION: THER should be considered with a thorough knowledge of outcomes and potential complications to guide patient and clinician expectations. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38690850 | DOI:10.3928/01477447-20240424-01 (Source: Orthopedics)
Source: Orthopedics - May 1, 2024 Category: Orthopaedics Authors: Neil Jain Dominic Campano Caleb Gottlich Austin Yu George Brindley Alexandra Callan Alan Blank Source Type: research
Development of Transdermal Formulation Based on Nanotechnology and Elucidation of Its Drug Delivery Pathways
Yakugaku Zasshi. 2024;144(5):505-510. doi: 10.1248/yakushi.23-00178-1.ABSTRACTTransdermal drug delivery is a formulation in which the drug is absorbed through the skin for systemic action. Its advantages include avoidance of first-pass effects, sustained drug supply, and ease of administration and discontinuation. Drugs administered transdermally transfer into the blood circulation through the stratum corneum, epidermis, and dermis. The stratum corneum on the skin surface plays a barrier function in skin absorption. Therefore, developing of transdermal drug delivery systems requires innovations that overcome the barrier fu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Hiroko Otake Noriaki Nagai Source Type: research
Repurposing the multiple sclerosis drug Siponimod for osteoporosis treatment
Eur J Pharmacol. 2024 Apr 29:176630. doi: 10.1016/j.ejphar.2024.176630. Online ahead of print.ABSTRACTOsteoporosis is the most common bone disorder, in which an imbalance between osteoclastic bone resorption and osteoblastic bone formation disrupts bone homeostasis. Osteoporosis management using anti-osteoclastic agents is a promising strategy; however, this remains an unmet need. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) are essential for maintaining bone homeostasis. Here, we identified that Siponimod, a Food and Drug Administration-approved S1PR antagonist for the treatment of multiple sclerosis, shows pro...
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sitao Hu Yangyang Hu Zenglin Tan Chengyu Zhou Cheng Zhang Sheng Yin Xiaojun Chen Kai Chen Lu Wang Lei Chen Source Type: research
Effects of Empagliflozin on vascular and skeletal mineralization in Hyperlipidemic mice
Vascul Pharmacol. 2024 Apr 29:107376. doi: 10.1016/j.vph.2024.107376. Online ahead of print.ABSTRACTCardiovascular disease and osteoporosis, major causes of morbidity and mortality, are associated with hyperlipidemia. Recent studies show that empagliflozin (EMPA), an inhibitor of sodium-glucose cotransporter-2 (SGLT2), improves cardiovascular health. In preclinical animal studies, EMPA mitigates vascular calcification in the males but its effects in the females are not known. Thus, we used female mice to test the effects of EMPA on calcification in the artery wall, cardiac function, and skeletal bone. By serial in vivo mic...
Source: Vascular Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sophia Kalanski Stuti Pradhan Andy Hon Yuxuan Xia Nora Safvati Juan Carlos Rivera Mimi Lu Linda L Demer Yin Tintut Source Type: research
An acute phase reaction from zoledronate mimicking symptoms seen in opioid withdrawal: a case report
CONCLUSION: Zoledronate, well known for causing acute phase reactions, was likely the cause of withdrawal-like symptoms. Acute phase reactions with bisphosphonates mostly occur in the first infusion, and the incidence decreases with subsequent infusions. Symptoms typically occur 24-72 h post-infusion, and last at most for 72 h. Cognitive bias led the primary team to be concerned with opioid withdrawal rather than investigating other causes for the patient's presentation. Therefore, providers should thoroughly investigate potential etiologies and rule them out accordingly to provide the best care. Health care providers shou...
Source: Addiction Science and Clinical Practice - May 1, 2024 Category: Addiction Authors: Pankti P Acharya Crystal Joseph Source Type: research
Establishment of a Rabbit Model of Adjacent Intervertebral Disk Degeneration After Lumbar Fusion and Fixation and Evaluation of Autophagy Factor Expression in Nucleus Pulposus Cells
CONCLUSION: After posterolateral lumbar fusion in rabbits, the animal ASD model showed gradual deterioration of adjacent intervertebral disks with prolonged follow-up. The findings indicate the important role of autophagy in the apoptosis of nucleus pulposus cells in adjacent intervertebral disks. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38690847 | DOI:10.3928/01477447-20240424-04 (Source: Orthopedics)
Source: Orthopedics - May 1, 2024 Category: Orthopaedics Authors: Jiawen Sun Fuyu Chen Xiaodong Wei Yufu Ou Source Type: research
Geographic Access to Pediatric Orthopedic Surgeons in the United States: An Analysis of Sociodemographic Factors
CONCLUSION: Pediatric orthopedic surgeons are not equally distributed in the United States, and many counties are not optimally served. Additional studies are needed to identify the relationship between travel distances and patient outcomes and how geographic inequalities can be minimized. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38690849 | DOI:10.3928/01477447-20240424-03 (Source: Orthopedics)
Source: Orthopedics - May 1, 2024 Category: Orthopaedics Authors: Daniel Farivar Nicholas J Peterman Paal K Nilssen Kenneth D Illingworth Teryl K Nuckols David L Skaggs Source Type: research
Total Humeral Endoprosthetic Reconstruction: A Systematic Review
CONCLUSION: THER should be considered with a thorough knowledge of outcomes and potential complications to guide patient and clinician expectations. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38690850 | DOI:10.3928/01477447-20240424-01 (Source: Orthopedics)
Source: Orthopedics - May 1, 2024 Category: Orthopaedics Authors: Neil Jain Dominic Campano Caleb Gottlich Austin Yu George Brindley Alexandra Callan Alan Blank Source Type: research
Multiligament Knee Reconstruction With Suture Tape Augmentation: Patient-Reported Outcomes at Minimum 2-Year Follow-up
CONCLUSION: Patients who underwent MLKR with suture augmentation had satisfactory scores across all patient-reported outcome measurements. On the basis of these criteria, the average patient achieved an acceptable clinical outcome, demonstrating that MLKR with suture augmentation is a safe and efficacious surgical technique for the treatment of MLKI. [Orthopedics. 202x;4x(x):xx-xx.].PMID:38690848 | DOI:10.3928/01477447-20240424-02 (Source: Orthopedics)
Source: Orthopedics - May 1, 2024 Category: Orthopaedics Authors: Brian Panish Jonathan J Lawson Seleem Elkadi Eliana Schaefer Gregory Perraut Evan H Argintar Source Type: research
Development of Transdermal Formulation Based on Nanotechnology and Elucidation of Its Drug Delivery Pathways
Yakugaku Zasshi. 2024;144(5):505-510. doi: 10.1248/yakushi.23-00178-1.ABSTRACTTransdermal drug delivery is a formulation in which the drug is absorbed through the skin for systemic action. Its advantages include avoidance of first-pass effects, sustained drug supply, and ease of administration and discontinuation. Drugs administered transdermally transfer into the blood circulation through the stratum corneum, epidermis, and dermis. The stratum corneum on the skin surface plays a barrier function in skin absorption. Therefore, developing of transdermal drug delivery systems requires innovations that overcome the barrier fu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Hiroko Otake Noriaki Nagai Source Type: research
Repurposing the multiple sclerosis drug Siponimod for osteoporosis treatment
Eur J Pharmacol. 2024 Apr 29:176630. doi: 10.1016/j.ejphar.2024.176630. Online ahead of print.ABSTRACTOsteoporosis is the most common bone disorder, in which an imbalance between osteoclastic bone resorption and osteoblastic bone formation disrupts bone homeostasis. Osteoporosis management using anti-osteoclastic agents is a promising strategy; however, this remains an unmet need. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) are essential for maintaining bone homeostasis. Here, we identified that Siponimod, a Food and Drug Administration-approved S1PR antagonist for the treatment of multiple sclerosis, shows pro...
Source: European Journal of Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sitao Hu Yangyang Hu Zenglin Tan Chengyu Zhou Cheng Zhang Sheng Yin Xiaojun Chen Kai Chen Lu Wang Lei Chen Source Type: research
Effects of Empagliflozin on vascular and skeletal mineralization in Hyperlipidemic mice
Vascul Pharmacol. 2024 Apr 29:107376. doi: 10.1016/j.vph.2024.107376. Online ahead of print.ABSTRACTCardiovascular disease and osteoporosis, major causes of morbidity and mortality, are associated with hyperlipidemia. Recent studies show that empagliflozin (EMPA), an inhibitor of sodium-glucose cotransporter-2 (SGLT2), improves cardiovascular health. In preclinical animal studies, EMPA mitigates vascular calcification in the males but its effects in the females are not known. Thus, we used female mice to test the effects of EMPA on calcification in the artery wall, cardiac function, and skeletal bone. By serial in vivo mic...
Source: Vascular Pharmacology - May 1, 2024 Category: Drugs & Pharmacology Authors: Sophia Kalanski Stuti Pradhan Andy Hon Yuxuan Xia Nora Safvati Juan Carlos Rivera Mimi Lu Linda L Demer Yin Tintut Source Type: research
An acute phase reaction from zoledronate mimicking symptoms seen in opioid withdrawal: a case report
CONCLUSION: Zoledronate, well known for causing acute phase reactions, was likely the cause of withdrawal-like symptoms. Acute phase reactions with bisphosphonates mostly occur in the first infusion, and the incidence decreases with subsequent infusions. Symptoms typically occur 24-72 h post-infusion, and last at most for 72 h. Cognitive bias led the primary team to be concerned with opioid withdrawal rather than investigating other causes for the patient's presentation. Therefore, providers should thoroughly investigate potential etiologies and rule them out accordingly to provide the best care. Health care providers shou...
Source: Addiction Science and Clinical Practice - May 1, 2024 Category: Addiction Authors: Pankti P Acharya Crystal Joseph Source Type: research
Absorbing oxygen carriers promotes phosphorus recovery from sludge via the microwave thermal conversion process
This study aims to apply the Absorbing oxygen carriers (AOCs) to induce the migration and transformation of phosphorus compounds during the microwave thermal conversion of sludge so the hard-to-extract organic phosphorus (OP) can be converted to easy-to-extract inorganic phosphorus (IP) and be enriched onto the sludge char. The AOCs were recycled by screen separation from the IP-rich sludge char, with the latter being a renewable phosphorus source from sludge. The AOCs in this novel process enhanced the conversion efficiency of OP into non-apatite inorganic phosphorus (NAlP), which was further converted to apatite inorgani...
Source: Bioresource Technology - May 1, 2024 Category: Biotechnology Authors: Xiaoyu Yan Shuheng Zhao Jianjun Hu Jiatao Dang Sen Yao Junmeng Cai Sureewan Sittijunda Wei Wang Duu-Jong Lee Panbo Yang Source Type: research
