An acute phase reaction from zoledronate mimicking symptoms seen in opioid withdrawal: a case report

CONCLUSION: Zoledronate, well known for causing acute phase reactions, was likely the cause of withdrawal-like symptoms. Acute phase reactions with bisphosphonates mostly occur in the first infusion, and the incidence decreases with subsequent infusions. Symptoms typically occur 24-72 h post-infusion, and last at most for 72 h. Cognitive bias led the primary team to be concerned with opioid withdrawal rather than investigating other causes for the patient's presentation. Therefore, providers should thoroughly investigate potential etiologies and rule them out accordingly to provide the best care. Health care providers should also be aware of the implicit biases that potentially impact the quality of care they provide to patients.PMID:38693547 | DOI:10.1186/s13722-024-00464-8
Source: Addiction Science and Clinical Practice - Category: Addiction Authors: Source Type: research