This MoCo biotech just raised another $20M to get its superbug-killing therapy through the clinic
Gaithersburg ’s Adaptive Phage Therapeutics Inc. has raised another $20 million in funding, less than a year after securing nearly $41 million to advance its therapy for superbugs. The new funding brings the Series B total to $61 million, allowing the company to accelerate clinical trials for two programs: pr osthetic joint infection and diabetic foot osteomyelitis, in which soft tissue infections can spread to the bone and require amputation. Adaptive Phage is now enrolling patients in both studies… (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - April 4, 2022 Category: Health Management Authors: Sara Gilgore Source Type: news

First-Year Follow-up of Chronic Nonbacterial Osteomyelitis First-Year Follow-up of Chronic Nonbacterial Osteomyelitis
What have we learned about the disease course of pediatric patients with chronic nonbacterial osteomyelitis?Arthritis Research & Therapy (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - January 19, 2022 Category: Orthopaedics Tags: Pediatrics Journal Article Source Type: news

What is the Difference Between a Paronychia and a Felon?
Discussion The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations. Due to their important interactions in ...
Source: PediatricEducation.org - December 6, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What Is In That Ear?
Discussion The external auditory canal mainly derives from the ectoderm however it abuts other structures which arise from mesodermal or endodermal tissues. The lateral 1/3 is primarily cartilaginous with the inner 2/3rd being bony with the tympanic, temporal and mastoid bone forming various parts. The canal is lined with squamous epithelium and has various structures such as sebaceous glands, hair follicles and of course ceruminous glands. It is not surprising that this structure is subject to obstruction given its small size. Cerumen, hair and other cellular debris may become impacted if they are not regularly expelled f...
Source: PediatricEducation.org - October 11, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Fluorescence-Guided Debridement of Chronic Osteomyelitis Fluorescence-Guided Debridement of Chronic Osteomyelitis
In this article, the authors describe a technique for fluorescence-guided bone debridement with the preoperative administration of doxycycline.Current Orthopaedic Practice (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 17, 2021 Category: Consumer Health News Tags: Orthopaedics Journal Article Source Type: news

Procalcitonin in Diagnosing Diabetic Foot Osteomyelitis Procalcitonin in Diagnosing Diabetic Foot Osteomyelitis
Could measurements of serum procalcitonin levels help determine the presence of diabetic foot osteomyelitis?Wounds (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 10, 2021 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news

Calcium Sulfate With Antibiotics for DFUs With Osteomyelitis Calcium Sulfate With Antibiotics for DFUs With Osteomyelitis
In this case series, the authors describe a novel strategy for the local delivery of antibiotics to diabetic foot ulcers complicated by osteomyelitis.Wounds (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 5, 2021 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news

How Are Iliac Fractures Treated?
Discussion Avulsion fractures of the pelvis are more commonly seen in adults and teenage athletes. Currently they are more common in male athletes but with the increased number of females in sports, more are also being seen in females. Soccer and track and field are common sports where these injuries occur. The injuries are felt to be caused by a repetitive traction on the apophysis or more commonly due to a ‘sudden, forceful, or unbalanced contraction of an attached musculotendinous unit while engaged in a sporting event…. Skeletal maturity has a direct effect on the incidence of the injury.” They can oc...
Source: PediatricEducation.org - April 19, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What Are Toxin-Mediated Diseases?
Discussion A poison is a generic term for “a substance with an inherent property that tends to destroy life or impair health.” A toxin is more specific and is “any poison produced by an organism, characterized by antigenicity in certain animals and high molecular weight, and including the bacterial toxins that are the causative agents of tetanus, diphtheria, etc., and such plant and animal toxins as ricin and snake venom.” A toxin does not include those substances that are made synthetically produced. Venom is also a toxin that is used by animals and insects for predation or defense which can cause ...
Source: PediatricEducation.org - April 12, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Who Gets Pott ’ s Puffy Tumor?
Discussion Pott’s puffy tumor (PPT) was first described by Sir Percivall Pott in 1775 and who also described other orthopaedic and oncological diseases subsequently named for him. “It is a subperiosteal abscess of the anterior wall of the frontal sinus associated with underlying frontal osteomyelitis.” The tender edema and swelling of the forehead is the sign of PPT. Associated fever, headache, and rhinorrhea along with similar problems such as postnasal drip or nasal congestion are common. Associated ophthalmological problems include peri-orbital or eyelid edema and/or preseptal cellulitis. Ptosis and di...
Source: PediatricEducation.org - March 1, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

How Common Are Bone Spurs in Young Athletes?
Discussion The terminology of abnormal calcification of soft tissues and uses of the terms is often muddied. Especially as the causes may be similar and multiple adjacent tissues may be involved. An exostosis is an abnormal proliferation of bone from the joint. They can appear in various forms and in many locations. An osteophyte is also known as a bone spur and is type of exostosis. Osteophytes are thought to be periosteal or synovial mesenchymal stems cells that become calcified. They usually have a more narrow or pointed projection from the joint. Osteophytes are a very common feature of osteoarthritis. Enthesophytes a...
Source: PediatricEducation.org - November 30, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Vertebral Osteomyelitis After Spine Surgery Vertebral Osteomyelitis After Spine Surgery
Learn how the presentation and outcomes of postoperative vertebral osteomyelitis can differ from that of native cases.Spine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 19, 2020 Category: Consumer Health News Tags: Orthopaedics Journal Article Source Type: news

What Causes Joint Pain?
DiscussionMusculoskeletal problems are common problems in pediatric practice with up to 15% of acute care visits being for this problem. Joint pain is a common concern for families but the differential diagnosis is extensive and needs thoughtful consideration. History is a key to discerning the potential diagnosis but also in guiding the physical examination and laboratory examination. Family history especially for systemic diseases should be considered. On physical examination all joints should be examined include sacroiliac and temporomandibular joints. Is this arthritis or arthralgia? Distinction between inflammatory...
Source: PediatricEducation.org - October 26, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

A Review of Diabetic Foot Wounds and Osteomyelitis A Review of Diabetic Foot Wounds and Osteomyelitis
A new review provides an overview of the etiology, diagnosis, and treatment options for diabetic foot ulcers for the practicing orthopedist.Current Orthopaedic Practice (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 16, 2020 Category: Consumer Health News Tags: Orthopaedics Journal Article Source Type: news

Coupling antibiotics with stem cells to fight off bone infections
(Kanazawa University) Researchers from Kanazawa University investigated the effects of adipose-derived stem cells (ADSCs) loaded with the antibiotic ciprofloxacin on osteomyelitis caused by implants. By administering ADSC-loaded ciprofloxacin to the site of bone infection in rats, the researchers found a significant improvement of the infection, as shown by reduced soft tissue swelling, abscess formation, and bone degradation. These findings suggest a potential new therapy for implant-related bone infections that have traditionally been difficult to treat with antibiotics. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 1, 2020 Category: Infectious Diseases Source Type: news