Time Savings and Safety of EMS Administration of Antibiotics for Open Fractures
CONCLUSIONS: EMS clinicians were able to safely administer antibiotics to patients with open fractures a median of 15 minutes before arrival at the hospital, and 99 percent of the patients receiving antibiotics had them administered within one hour of EMS dispatch. EMS administration of antibiotics may be a safe way to increase compliance with recommendations for early antibiotic administration for open fractures.PMID:38661320 | DOI:10.1080/10903127.2024.2347291 (Source: Rural Remote Health)
Source: Rural Remote Health - April 25, 2024 Category: Rural Health Authors: Alexander D Muniz Dominic J Gregorio Scott A Studebaker Aaron M Peth Cole G Camacho Bilie Williams Douglas F Kupas Lawrence H Brown Source Type: research
Time Savings and Safety of EMS Administration of Antibiotics for Open Fractures
CONCLUSIONS: EMS clinicians were able to safely administer antibiotics to patients with open fractures a median of 15 minutes before arrival at the hospital, and 99 percent of the patients receiving antibiotics had them administered within one hour of EMS dispatch. EMS administration of antibiotics may be a safe way to increase compliance with recommendations for early antibiotic administration for open fractures.PMID:38661320 | DOI:10.1080/10903127.2024.2347291 (Source: Prehospital Emergency Care)
Source: Prehospital Emergency Care - April 25, 2024 Category: Endocrinology Authors: Alexander D Muniz Dominic J Gregorio Scott A Studebaker Aaron M Peth Cole G Camacho Bilie Williams Douglas F Kupas Lawrence H Brown Source Type: research
Exploring the anti-osteoporosis potential of Petroselinum crispum (Mill.) fuss extract employing experimentally ovariectomized rat model and network pharmacology approach
Fitoterapia. 2024 Apr 23:105971. doi: 10.1016/j.fitote.2024.105971. Online ahead of print.ABSTRACTOne of the most prevalent secondary osteoporosis is ovariectomy-induced osteoporosis. Parsley (Petroselinum crispum) has potent estrogenic and antioxidant properties and was used traditionally in the treatment of amenorrhea and dysmenorrhea. The present study aimed to characterize parsley leaf extract (PLE) employing RP-HPLC-MS-MS/MS-based method and possible protective effect in ovariectomized (OVX)-induced osteoporosis in rats was assessed. Rats were randomly assigned into SHAM group, OVX group, PLE + OVX group (150 mg/kg/da...
Source: Fitoterapia - April 25, 2024 Category: Biochemistry Authors: Noha M Saeed Laila A Ramadan Walaa A El-Sabbagh Mohamed A Said Hanaa M Abdel-Rahman Reham Hassan Mekky Source Type: research
Angiopoietin 1 Relieves Osteolysis by Promoting Macrophage Mitophagy Through the TBK1-SQSTM1 Pathway to Inhibit AIM2 Inflammasome-Mediated Pyroptosis
This study aimed to explore the molecular mechanism by which Angiopoietin (Ang-1) inhibits osteoclast activation to alleviate osteolysis. RAW264.7 mouse macrophages were stimulated with LPS or RANKL to induce osteoclast formation. Additionally, titanium (Ti) particles (50 mg) were subperiosteally implanted around the cranial suture of mice to establish a calvarial osteolysis model. Ang-1, a member of the pro-angiogenic factor protein family and an important inflammatory regulator molecule, was utilized in this model. TRAP staining was utilized to detect osteoclast activation, while a western blot was conducted to identify ...
Source: Applied Biochemistry and Biotechnology - April 25, 2024 Category: Biochemistry Authors: Jian Yin Peng Lai Libo Zhu Jinzhong Ma Source Type: research
Return to Sports After Anterior Cruciate Ligament Reconstruction
Perm J. 2024 Apr 25:1-7. doi: 10.7812/TPP/23.132. Online ahead of print.ABSTRACTAnterior cruciate ligament (ACL) tears are one of the most common orthopedic injuries among athletes. Although a small proportion of patients with isolated tears can return to sports after completing a nonsurgical rehabilitation program, ACL reconstruction is frequently recommended for young athletes, especially those with concomitant knee injuries or symptomatic knee instability. Alongside emerging evidence for the effect of prehabilitation, the current standard of care for postoperative ACL physical therapy includes pain control, range of mot...
Source: The Permanente journal - April 25, 2024 Category: General Medicine Authors: Aditya Manoharan Andrew Fithian Virginia Xie Kurt Hartman William Schairer Najeeb Khan Source Type: research
Reply to letter to the Editor regarding “Does the interfacing angle between pedicle screws and support rods affect clinical outcomes after posterior thoracolumbar fusion? A retrospective clinical study”
We thank the authors of the Letter to the Editor, Y üzügüldü and Erşen, regarding our article “Does the interfacing angle between pedicle screws and support rods affect clinical outcomes after posterior thoracolumbar fusion? A retrospective clinical study” for their detailed considerations and interested questions on this topic. Putting our study results in context with further recent research findings on the relationship between the risk of revision surgery and instrumentation is a valuable point that we were happy to pursue. (Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Authors: David C. Noriega Tags: Letters to the Editor Source Type: research
Editorial Board
(Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Source Type: research
Table of Contents
(Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Source Type: research
Meetings Calendar
(Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Source Type: research
Letter to the editor regarding “Does the interfacing angle between pedicle screws and support rods affect clinical outcomes after posterior thoracolumbar fusion? A retrospective clinical study” by Noriega et al.
We read with great interest the article by Noriega et al. [1] investigating one of the causes of revision surgery. Revision surgeries or repetitious revisions are one of the biggest nightmares of spine surgeons and we must do our best to avoid revisions. The authors defined pedicle screw/rod interfacing angle mismatch as any deviation from 90 ˚ formed by the axes between the rod and the pedicle screw head. Mismatch found to be associated with a higher risk of revision surgery by causing increased mechanical stress on the construct. (Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Authors: U ğur Yüzügüldü, Ömer Erşen Tags: Letters to the Editor Source Type: research
Letter to the editor regarding “Associations between paraspinal muscle characteristics and spinal curvature in conservatively treated adolescent idiopathic scoliosis: a systematic review” by Chan et al.
We read with high interest the study by Chan and colleagues about the muscle characteristics in scoliosis and their relationships with the curve features. The authors conducted a systematic review and found that the paraspinal muscles on the concavity presented different important alterations [1]. The results of this work are very important, especially for supporting the studies about rehabilitation in scoliosis. The application of quantitative measures, like the ones mentioned in the review, deserves a lot of attention because they allow precise calculations able to sustain valid reasonings. (Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Authors: Daniele Coraci, Maria Chiara Maccarone, Giorgio Simioni, Lisa Ragazzo, Stefano Masiero Tags: Letters to the Editor Source Type: research
Letter to the editor regarding “Electrophysiological evaluation in scoliosis. What a multiperspective literature analysis displays” by Coraci et al.
We read an interesting sectorial literature analysis conducted by Coraci et al [1] to summarize the characteristics of outcome measures reported in peer-reviewed articles related to rehabilitation and AIS over the last decade. Out of 127 relevant papers identified from PubMed, the most frequently used outcome measure was Cobb angles from radiographs. Other commonly assessed outcomes included health-related quality of life, surface volume, respiration, muscular function, and electrophysiological assessments. (Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Authors: Winnie WY Chan, Eric C. Parent, Arnold YL Wong Tags: Letters to the Editor Source Type: research
Response to letter to the editor regarding, “MRI-based endplate Bone Quality score independently predicts cage subsidence following transforaminal lumbar interbody fusion”
We would like to express our gratitude to Mochizuki et al. [1] for their critical review and valuable comments on our study entitled, “MRI-based Endplate Bone Quality score independently predicts cage subsidence following transforaminal lumbar interbody fusion.” Concern was raised regarding variables that can be potential confounding factors for cage subsidence, such as details of the surgical techniques, cage surface coating (eg, titanium-coated), cage shape (eg, boomerang versus bullet), cage's position, and the use of antiosteoporosis drugs (eg, bisphosphonate and teriparatide). (Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Authors: Youwei Ai, Qian Chen, Ce Zhu, Limin Liu Tags: Letters to the Editor Source Type: research
Letter to the editor regarding “MRI-based endplate bone quality score independently predicts cage subsidence following transforaminal lumbar interbody fusion” by Chen et al.
We read with great interest the article by Chen et al [1] that used the MRI-based Endplate Bone Quality (EBQ) score as an independent predictor of cage subsidence in patients after transforaminal lumbar interbody fusion (TLIF) surgery. This retrospective study was conducted on 280 adult patients who underwent single-segment TLIF for degenerative lumbar spine disease and aimed to investigate the predictive value of MRI-based EBQ scores for cage subsidence. The study found that cage subsidence, observed in 42 patients, was associated with visibly reduced bone density as measured by quantitative computed tomography, and the m...
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Authors: Hidetaka Mochizuki, Masatsugu Tsukamoto, Tadatsugu Morimoto, Hirohito Hirata, Tomohito Yoshihara, Masaaki Mawatari Tags: Letters to the Editor Source Type: research
“May the odds be ever in your favor”: modulating risk and surgical selection in the treatment of spinal epidural abscess
In the dystopian series The Hunger Games, the phrase “May the odds be ever in your favor” appears quite frequently as a catch phrase, well wish or quotidian blessing depending on which character is speaking. In healthcare today, and especially in surgery, we are always trying to ensure that odds are always in favor of a positive outcome at the ins titutional level, the provider level and most importantly—the patient level. That is really what risk modeling in surgical decision-making boils down to; ensuring the odds of the best result possible are maximized while those of an adverse event are minimized. (Source: The Spine Journal)
Source: The Spine Journal - April 25, 2024 Category: Orthopaedics Authors: Andrew J. Schoenfeld Tags: Commentary Source Type: research
