Serum long non-coding Ribonucleic Acid H19 serves as a biomarker for systemic lupus erythematosus and participates in the disease progression
CONCLUSIONS: The expression of H19 is upregulated in patients with SLE and plays a role in cell function and inflammation by targeting miR-19b in PBMCs, which may be one of the pathological mechanisms of SLE.PMID:38634475 | DOI:10.1177/09612033241243175 (Source: Lupus)
Source: Lupus - April 18, 2024 Category: Rheumatology Authors: Hongyu Yang Shuping Wang Fei Wang Xuemei Bai Juan Ren Source Type: research
The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases
Crit Rev Microbiol. 2024 Apr 18:1-21. doi: 10.1080/1040841X.2024.2344114. Online ahead of print.ABSTRACTEpstein-Barr Virus (EBV), a dsDNA herpesvirus, is believed to play a significant role in exacerbating and potentially triggering autoimmune and autoinflammatory maladies. Around 90% of the world is infected with the virus, which establishes latency within lymphocytes. EBV is also known to cause infectious mononucleosis, a self-limited flu-like illness, in adolescents. EBV is often reactivated and it employs several mechanisms of evading the host immune system. It has also been implicated in inducing host immune dysfuncti...
Source: Critical Reviews in Microbiology - April 18, 2024 Category: Microbiology Authors: Abdul Hamid Borghol Elio R Bitar Aya Hanna Georges Naim Elias A Rahal Source Type: research
The abnormal signaling of the B cell receptor and co-receptors of lupus B cells
Clin Immunol. 2024 Apr 16;263:110222. doi: 10.1016/j.clim.2024.110222. Online ahead of print.ABSTRACTIt is easily understood that studying the physiology and pathophysiology of the BCRtriggered cascade is of importance, particularly in such diseases as systemic lupus erythematosus (SLE) that are considered by many as a "B cell disease". Even though B cells are not considered as the only players in lupus pathogenesis, and other immune and non-immune cells are certainly involved, it is the success of recent B cell-targeting treatment strategies that ascribe a critical role to the lupus B cell.PMID:38636889 | DOI:10.1016/j.cl...
Source: Clinical Immunology - April 18, 2024 Category: Allergy & Immunology Authors: Stamatis-Nick C Liossis Source Type: research
Serum long non-coding Ribonucleic Acid H19 serves as a biomarker for systemic lupus erythematosus and participates in the disease progression
CONCLUSIONS: The expression of H19 is upregulated in patients with SLE and plays a role in cell function and inflammation by targeting miR-19b in PBMCs, which may be one of the pathological mechanisms of SLE.PMID:38634475 | DOI:10.1177/09612033241243175 (Source: Lupus)
Source: Lupus - April 18, 2024 Category: Rheumatology Authors: Hongyu Yang Shuping Wang Fei Wang Xuemei Bai Juan Ren Source Type: research
The role of Epstein-Barr virus in autoimmune and autoinflammatory diseases
Crit Rev Microbiol. 2024 Apr 18:1-21. doi: 10.1080/1040841X.2024.2344114. Online ahead of print.ABSTRACTEpstein-Barr Virus (EBV), a dsDNA herpesvirus, is believed to play a significant role in exacerbating and potentially triggering autoimmune and autoinflammatory maladies. Around 90% of the world is infected with the virus, which establishes latency within lymphocytes. EBV is also known to cause infectious mononucleosis, a self-limited flu-like illness, in adolescents. EBV is often reactivated and it employs several mechanisms of evading the host immune system. It has also been implicated in inducing host immune dysfuncti...
Source: Critical Reviews in Microbiology - April 18, 2024 Category: Microbiology Authors: Abdul Hamid Borghol Elio R Bitar Aya Hanna Georges Naim Elias A Rahal Source Type: research
From Castleman disease histopathological features to idiopathic multicentric Castleman disease: a multiparametric approach to exclude potential iMCD histopathological mimickers
Conclusions
HHV-8+ MCD and PCN/POEMS-related CD are the major mimickers of iMCD in lymph node biopsies. Grading of the five histopathological features for CD might be useful to, in conjunction with complete ancillary testing, suggest for specific disease entities. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Rodriguez Merino, L., Pomares, A. A., Arce, J. R., Montes-Moreno, S. Tags: Original research Source Type: research
Canonical and noncanonical functions of complement in systemic lupus erythematosus
Eur J Immunol. 2024 Apr 17:e2350918. doi: 10.1002/eji.202350918. Online ahead of print.ABSTRACTFor many years complement activation in systemic lupus erythematosus (SLE) was viewed as a major cause of tissue injury. However, human and murine studies showed that complement plays a protective as well as a proinflammatory role in tissue damage. A hierarchy is apparent with early classical pathway components, particularly C1q, exerting the greatest influence. Understanding the mechanisms underlying the protective function(s) of complement remains an important challenge for the future and has implications for the use of complem...
Source: European Journal of Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Matthew C Pickering Marina Botto Source Type: research
Receipt of rheumatology care and lupus-specific labs among young adults with systemic lupus erythematosus: A US Medicare retention in care cohort study
CONCLUSION: Disparities in care, measured by rheumatology visits and serology testing, exist by neighborhood disadvantage, race and ethnicity, and region among young adults with lupus, despite uniform Medicare coverage. Findings support evaluating lupus care quality measures and their impact on US lupus outcomes.PMID:38631342 | DOI:10.1177/09612033241247905 (Source: Lupus)
Source: Lupus - April 17, 2024 Category: Rheumatology Authors: Maria Schletzbaum W Ryan Powell Shivani Garg Joseph Kramer Brad C Astor Andrea Gilmore-Bykovskyi Amy J Kind Christie M Bartels Source Type: research
Canonical and noncanonical functions of complement in systemic lupus erythematosus
Eur J Immunol. 2024 Apr 17:e2350918. doi: 10.1002/eji.202350918. Online ahead of print.ABSTRACTFor many years complement activation in systemic lupus erythematosus (SLE) was viewed as a major cause of tissue injury. However, human and murine studies showed that complement plays a protective as well as a proinflammatory role in tissue damage. A hierarchy is apparent with early classical pathway components, particularly C1q, exerting the greatest influence. Understanding the mechanisms underlying the protective function(s) of complement remains an important challenge for the future and has implications for the use of complem...
Source: European Journal of Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Matthew C Pickering Marina Botto Source Type: research
Phosphatidic Acid Promoting the Generation of Interleukin ‐17A Producing Double‐Negative T Cells by Enhancing mTORC1 Signaling in Lupus
ConclusionThe accumulation of PA in T cells could activate the mTORC1 pathway, promoting DNT cell expansion and IL-17A secretion, resulting in GCB cell abnormalities in lupus. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2024 Category: Rheumatology Authors: Wenjing Li,
Xiaojun Tang,
Yuanyuan Zheng,
Xuefeng Xu,
Nan Zhao,
Betty P. Tsao,
Xuebing Feng,
Lingyun Sun Tags: Full Length Source Type: research
The role of thymic stromal lymphopoietin in cutaneous disorders
AbstractThymic Stromal Lymphopoietin (TSLP) is an important cytokine that invokes early immune responses. TSLP, an IL-7-like cytokine encoded by theTSLP gene, activates JAK1 and JAK2 signaling pathways, stimulating dendritic cells to induce inflammatory Th2 cells. This cytokine is associated with pruritus in various cutaneous disorders, particularly atopic dermatitis. Varying levels of the cytokine TSLP have been demonstrated in studies of different cutaneous disorders. Pharmacological treatment targeting TSLP has been explored recently, particularly in the realm of atopic dermatitis.This review explores the relation of TS...
Source: Archives of Dermatological Research - April 17, 2024 Category: Dermatology Source Type: research
Identification of EPSTI1 as a new potential biomarker for SLE based on GEO database
ConclusionTogether,EPSTI1 was found to be a potential biomarker for SLE, closely related to T cell immune imbalance.Key Points• EPSTI1 expression was significantly increased in PBMCs of SLE patients.• EPSTI1 was positively correlated with disease activity and T cell activation- or differentiation-associated genes in SLE patients.• EPSTI1 might have a good diagnostic value for SLE. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
A retrospective cohort study of Epstein-Barr virus infection status and systemic lupus erythematosus
ConclusionsPatients with SLE with lytic EBV infection have higher disease activity and take longer to achieve remission. Our study furthers our understanding of the relationship between SLE and EBV infection and may inform better treatment practices in the future. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
The immunoregulatory effects of total glucosides of paeony in autoimmune diseases
J Leukoc Biol. 2024 Apr 16:qiae095. doi: 10.1093/jleuko/qiae095. Online ahead of print.ABSTRACTTotal glucoside of paeonia (TGP) and its main active ingredient paeoniflorin, extracted from the Chinese herb Paeonia Lactiflora Pallas, exhibit potent immunomodulatory effects. TGP has been shown to inhibit inflammatory responses and disease progression in experimental models of multiple autoimmune diseases (AIDs), including rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome, psoriasis, etc. TGP shows broad immunomodulatory effects on many immune cells such as T cells, macrophages, and dendritic cells, by reg...
Source: Journal of Leukocyte Biology - April 16, 2024 Category: Hematology Authors: Mengna Zhao Na Peng Yingbo Zhou Yuan Qu Meng Cao Qinghua Zou Qinghong Yu Liwei Lu Fan Xiao Source Type: research
