IIG Seminar - Neuropsychiatric lupus: a nonresolving inflammation
Following a serendipitous finding that some anti-DNA antibodies cross react with the NMDA receptor on neurons, the Diamond laboratory developed a model of cognitive impairment in SLE that has many features in common with the cognitive impairment experienced by patients with neuropsychiatric lupus. A major feature is microglial activation and dendritic pruning of neurons. As patients report cognitive impairment to be one of three symptoms that most interfere with quality of life, an understanding of pathogenesis is critical.Air date: 4/10/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 21, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Evolution of pathogenic autoantibodies and B cell clones
Autoimmune disease presents a major clinical challenge due to limited treatment options and difficulties predicting adverse events like nephritis and lymphoma. Serum autoantibodies are unreliable prognosticators because they are often detected in patients with mild and severe disease alike. My research combines analysis of clinical samples and mouse models to understand how pathogenic autoantibodies develop and identify therapeutic targets specific to autoreactive B cells. We have developed a multi-omics single cell approach to longitudinally track autoreactive B cell clones harbouring lymphoma mutations in patients with S...
Source: Videocast - All Events - March 6, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG seminar - Neutrophils: acute responders in chronic inflammatory diseases
Dr. Kaplan's research has focused on identifying mechanisms of immune dysregulation, organ damage, and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity (in particular, type I interferons and myeloid cells) promote autoimmune responses and end-organ damage in systemic lupus erythematosus, rheumatoid arthritis, and other systemic autoimmune diseases. Recently, her research has focused on identifying abnormalities of neutrophil subsets, aberrant myeloid immunometabolism and the role of neutrophil extracellular traps (NETs) in systemic autoimmune disorders and chronic...
Source: Videocast - All Events - December 12, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The dark side of DNA - how the immune system senses DNA as a danger signal
Zhijian “ James ” Chen ’ s research into complex cellular biochemistry has led to the discovery of pathways and proteins that trigger immune and stress responses. Chen has identified proteins, such as the mitochondrial protein MAVS, that are crucial to the body ’ s defense against RNA viruses such as influenza and Ebola. Now, Chen and his team are dissecting a signaling pathway involving a novel DNA sensor – cyclic GMP-AMP (cGAMP) synthase, or cGAS – which activates an interferon response that may play a role in immune defense against pathogens and malignant cells, as well as in autoimmune diseases such as lupu...
Source: Videocast - All Events - July 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Casting the Net Wide: the Role of Neutrophils in Chronic Diseases
This is a rescheduled Mider Lecture. Speaker Mariana Kaplan, NIH NIAMS, focuses on identifying mechanisms of immune dysregulation, organ damage and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity (in particular, type I interferons and myeloid cells) promote end-organ damage in systemic lupus erythematosus, rheumatoid arthritis and other systemic autoimmune diseases.For more information go tohttps://oir.nih.gov/walsAir date: 6/9/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 11, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Protective and Pathogenic B Cell Responses: COVID-19 and Autoimmunity
Dr. Sanz's research interest is in understanding how the immune system goes awry in autoimmune diseases and ends up attacking our own tissues rather than concentrating on fighting infections. In particular, he is very interested in understanding the roles played in autoimmune diseases by B cells and their effector progeny, the plasma cells responsible for producing the autoantibodies that in many cases cause the disease. His research concentrates on systemic lupus erythematosus, but he is also investigating other autoimmune diseases such as Sjogren's syndrome, rheumatoid arthritis and type 1 diabetes. His work also has app...
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Premature Cardiovascular Disease in Systemic Autoimmunity: Lessons Learned from Lupus
.For more information go tohttps://cc.nih.gov/about/news/grcurrent.htmlAir date: 6/17/2020 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 20, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
2019 Demystifying Medicine Lecture- Autoimmunity: Basic and Clinical Advances and Challenges
Please join us for the next Demystifying Medicine lecture, " Autoimmunity: Basic and Clinical Advances and Challenges, " by Ronald Germain, M.D., Ph.D. (NIAID) and James Katz, M.D. (NIAMS) on April 23 from 4:00 p.m. to 5:30 p.m. in the Building 50 conference room, first floor. CME credit is available.
Autoimmunity refers to a system of immune responses gone awry, tantamount to an attack against the body's own healthy cells and tissues with painful and often fatal consequences. This enemy within manifests itself in myriad ways, from targeted attacks (e.g., rheumatoid arthritis leading to debilitating joint damage) to multi...
Source: Videocast - All Events - April 19, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Autoantigens and autoimmunity: a bedside to bench and back again story
NIH Director's Wednesday Afternoon Lecture Series
Noncoding RNAs play critical roles in the metabolism of all cells. The Wolin laboratory studies how noncoding RNAs function, how cells recognize and degrade defective noncoding RNAs, and how failure to degrade these RNAs affects cell function and contributes to human disease. Their studies revealed new mechanisms by which defective RNAs are targeted for degradation and new classes of noncoding RNAs. Most recently, their work has contributed to a novel theory for how the autoimmune disease systemic lupus erythematosus may be triggered in genetically susceptible individuals.A...
Source: Videocast - All Events - February 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Michelle A Petri, MD, MPH - Improving the Diagnosis and Treatment of Lupus: Practical Guidance for the Primary Care Physician
Improving the Diagnosis and Treatment of Lupus: Practical Guidance for the Primary Care Physician (Source: Peerview CME/CE Video Podcast - Internal Medicine International)
Source: Peerview CME/CE Video Podcast - Internal Medicine International - June 29, 2018 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: video
High-throughput quantitative proteomics
ProtIG Lecture Series
The ability to rapidly identify functional proteins with post translation modifications (PTMs) is a crucial element in understanding cellular function. Protein PTMs have emerged in the post-genomic era critical features in regulating and diversifying protein biological activity, but identifying specific proteoforms with PTMs and understanding their function on individual proteins is currently limited by the lack of effective and accessible analytical methods. Therefore, there is a crucial need to develop a high-throughput approach to functionally characterize intact proteins and their modified proteof...
Source: Videocast - All Events - April 24, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
B cells in Autoimmune diseases: Focus on Sj ö gren's Syndrome
NIDCR Clinical Research Fellowship Grand Rounds
B cells play a complex role in the development of systemic autoimmune diseases, especially in primary Sj ö gren's syndrome, a progressive condition that damages saliva and tear glands and leads to dry mouth, dry eyes, and other symptoms. Dr. Jacques-Olivier Pers will outline growing evidence that regulatory B lymphocytes (Breg) may blunt the pathogenesis of systemic autoimmune disease, and thus may be potential targets for treatment. Studies of distinct B cell subsets that play differing roles in autoimmune diseases are providing new insights into Breg development and immune...
Source: Videocast - All Events - April 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Development and Function of Dendritic Cells
Immunonology IG Seminar
Dr. Reizis did his thesis research in immunology with Irun R. Cohen at the Weizmann Institute, and trained as a postdoc with Philip Leder at Harvard Medical School. In late 2003, he started his lab at Columbia University, where he became a tenured Associate Professor in 2010 and a Professor in 2014. In 2015, he joined New York University School of Medicine (NYUSoM) as a Professor in the departments of Pathology and Medicine. Boris is the director of NYUSoM Immunology and Inflammation Training programand the co-Director of the Colton Center for Autoimmunity. In 2016, he has been awarded the inaugural...
Source: Videocast - All Events - January 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
NETting the web in systemic autoimmunity
Immunology Interest Group Seminar Series
Mariana Kaplan, M.D. is Senior Investigator and Chief of the Systemic Autoimmunity Branch at NIAMS/NIH. Prior to her appointment, she was Professor of Medicine in the Division of Rheumatology at the University of Michigan. Dr. Kaplan obtained her medical degree at the National Autonomous University of Mexico and did her Internal Medicine Residency at the National Institute of Medical Sciences and Nutrition in Mexico City. Dr. Kaplan did her Rheumatology Fellowship and postdoctoral training at the University of Michigan, where she was a member of the faculty for 15 years, and an acti...
Source: Videocast - All Events - June 19, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
