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A Novel Human Interleukin ‐23A Overexpressing Mouse Model of Systemic Lupus Erythematosus
ConclusionWe have generated and characterized a novel genetic mouse model of SLE, providing proof-of-concept for the etiopathogenic role of human IL-23A. This new model has a normal life span and integrates several characteristics of the human disease's complexity and chronicity, making it an attractive preclinical tool for studying IL-23 –dependent pathogenic mechanisms and assessing the efficacy of anti–human IL-23A or modeled disease-related therapeutics. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 3, 2024 Category: Rheumatology Authors: Eleni Christodoulou ‐Vafeiadou, Christina Geka, Lida Iliopoulou, Lydia Ntari, Maria C. Denis, Niki Karagianni, George Kollias Tags: Full Length Source Type: research

GSE247355 Targeting Osteosarcoma with Canine B7-H3 CAR T Cells and Impact of CXCR2 Co-Expression on Functional Activity
Contributors : Jennifer W Cao ; Jessica Lake ; Renata Impastato ; Lyndah Chow ; Luisanny Perez ; Laura Chubb ; Jade Kurihara ; Michael R Verneris ; Steven DowSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisAbstract. The use of large animal spontaneous models of solid cancers, such as dogs with osteosarcoma (OS), can help develop new cancer immunotherapy approaches, including chimeric antigen receptor (CAR) T cells. Therefore, the goal of the present study was to generate canine CAR T cells targeting the B7-H3 (CD276) co-stimulatory molecule overexpressed by several so...
Source: GEO: Gene Expression Omnibus - April 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Canis lupus familiaris Source Type: research

GSE237690 Lupus dermal fibroblasts hyper-respond to inflammatory cytokines and exhibit a pro-fibrotic phenotype to TGF- β in patients with scarring skin disease
Contributors : J M Kahlenberg ; Suzanne K Shoffner-Beck ; Lisa Abernathy-Close ; Johann E Gudjonsson ; Lam C TsoiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienswe examined responses to cytokines in dermal fibroblasts from the skin of SLE patients with CLE and healthy control volunteers to identify the inflammatory phenotype and gene expression profile associated with SLE and scarring CLE lesions. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Analysis of m6A-regulated genes and subtype classification in lupus nephritis
Lupus nephritis (LN) is the most common and severe clinical manifestation of systemic lupus erythematosus (SLE). N6-methyladenosine (m6A) is a reversible RNA modification and has been implicated in various bio... (Source: BMC Nephrology)
Source: BMC Nephrology - April 3, 2024 Category: Urology & Nephrology Authors: Diangeng Li, Yanchun Li, Kaiyi Zhu, Yuqing Yuan, Zheng He, Qianmei Sun and Meiling Jin Tags: Research Source Type: research

Risk factors for initial and recurrent severe infections in first hospitalized patients with systemic lupus erythematosus: A retrospective study of a Chinese cohort
ConclusionIn this cohort of SLE, patients with severe infection had a higher risk of reinfection, and low immunoglobulin, anti-dsDNA antibody positivity, and cyclophosphamide use were independent risk factors for recurrent severe infection. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - April 2, 2024 Category: Rheumatology Authors: Ying Zhu, Kexin Zhu, Xueyi Zhang, Zhijie Qian, Qingqing Guo, Xuefeng Xu, Genhong Yao, Xiaojun Tang, Dandan Wang, Huayong Zhang, Xuebing Feng, Ziyi Jin, Lingyun Sun Tags: ORIGINAL ARTICLE Source Type: research

Combined rituximab and belimumab to treat recalcitrant epidermolysis bullosa aquisita associated with systemic lupus erythematosus
Br J Dermatol. 2024 Apr 2:ljae141. doi: 10.1093/bjd/ljae141. Online ahead of print.NO ABSTRACTPMID:38561894 | DOI:10.1093/bjd/ljae141 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 2, 2024 Category: Dermatology Authors: Thomas J Tull Emma C Benton Kristina Semkova Natalie A Watson John B Mee Begona Lopez Jane Setterfield Barbara Carey Sajjad Ajmad Scott J Robbie Richard W Groves Giovanni Sanna David P D'Cruz Source Type: research

The impact of Libman-sacks endocarditis on inpatient outcomes with systemic lupus erythematosus: A retrospective study
This study aimed to explore the characteristics and prognosis of SLE patients with LSE and the impact of LSE in patients with SLE on inpatient outcomes including inpatient mortality, length of stay, acute heart failure, atrial fibrillation, and cerebrovascular accidents (CVA).METHODS: This study included adult patients who were hospitalized with SLE between the years 2019 and 2020, using the National Inpatient Sample (NIS) database. The total number of patients with a diagnosis of SLE in the years 2019 and 2020 in the NIS database was 150,411. Of those, 349 had a diagnosis of LSE. The study population was divided into two ...
Source: Lupus - April 2, 2024 Category: Rheumatology Authors: Halah Alfatlawi Abdulmajeed Alharbi Momin Shah Yusuf Nawras Nezam Altorok Source Type: research

Investigation of Factors Associated with Subclinical Infections of Giardia duodenalis and Cryptosporidium canis in Kennel-Housed Dogs ( Canis lupus familiaris )
Comp Med. 2024 Apr 2. doi: 10.30802/AALAS-CM-24-000007. Online ahead of print.ABSTRACTGiardia duodenalis and Cryptosporidium spp. are zoonotic protozoal pathogens, spread by a fecal-oral route, which can infect a wide range of hosts including but not limited to dogs and humans. Giardia was recently estimated to be present in 37% to 50% of kennel-housed dogs. Cryptosporidium infections in kennel-housed dogs have been reported in 7% to 21% of the population. The goal of this study was to define demographic factors and fecal scores associated with positive screening test cases of Giardia and Cryptosporidium in kennel-housed l...
Source: Comparative Medicine - April 2, 2024 Category: Zoology Authors: Loni A Taylor Meriam N Saleh Eric C Kneese Tracy H Vemulapalli Christine M Budke Guilherme G Verocai Source Type: research

A predictive model for premature atherosclerosis in systemic lupus erythematosus based on clinical characteristics
CONCLUSIONS: The comprehensive nomogram constructed in this study serves as a useful and convenient tool for evaluating the risk of premature atherosclerosis in SLE patients. It is helpful for clinicians to early identify SLE patients with premature atherosclerosis and facilitates the implementation of more effective preventive measures. Key Points • SLE patients are at a significantly higher risk of developing premature atherosclerosis compared to the general population, and this risk persists even in cases with low disease activity. Traditional models used to evaluate and predict premature atherosclerosis in SLE patien...
Source: Atherosclerosis - April 2, 2024 Category: Cardiology Authors: Ruyu Liang Haojie Xu Ranran Yao Wenwen Pei Ziye Wang Renge Liang Xiao Han Yunshan Zhou Yuan An Yin Su Source Type: research

Laboratory assessment of antiphospholipid syndrome: Laboratory data
CONCLUSION: We found several issues with the laboratory workup of APS. This indicates a need for increased awareness of comprehensive laboratory assessment of possible APS as well as a closer collaboration between the laboratory and clinicians.PMID:38563299 | DOI:10.1111/ijlh.14273 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 2, 2024 Category: Hematology Authors: Camilla J Kobylecki Signe Vedel-Krogh Shoaib Afzal Jens P Goetze Source Type: research