Association between Systemic Lupus Erythematosus and Periodontitis: A Systematic Review and Meta-analysis
Zoe Rutter-Locher, Toby O. Smith, Ian Giles, Nidhi Sofat (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - October 17, 2017 Category: Allergy & Immunology Source Type: research
The Use of Primary Prevention Statin Therapy in Those Predisposed to Atherosclerosis
AbstractPurpose of ReviewMany guidelines exist for the use of statins in the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Few have focused on disease specific states that predispose to ASCVD. This review is intended to focus on the recommendations and evidence in inflammatory diseases that predispose to an increased risk of ASCVD beyond what conventional cardiac risk scores would predict.Recent FindingsCertain autoimmune inflammatory diseases such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), and psoriasis/psoriatic arthritis have all been shown to increase the risk of ASCVD. Oth...
Source: Current Atherosclerosis Reports - October 17, 2017 Category: Cardiology Source Type: research
The Effectiveness of Mindfulness-based Cognitive Therapy on Psychological Symptoms and Quality of Life in Systemic Lupus Erythematosus Patients:
A Randomized Controlled Trial.
CONCLUSIONS: MBCT contributed to decreased psychological symptoms and improved QoL in patients with SLE with a stable effect on psychological symptoms and psychological components of QoL, but an unstable effect on physical components. PMID: 29026469 [PubMed] (Source: Oman Medical Journal)
Source: Oman Medical Journal - October 16, 2017 Category: Middle East Health Tags: Oman Med J Source Type: research
Defective Suppressor of Cytokine Signaling 1 Signaling Contributes to the Pathogenesis of Systemic Lupus Erythematosus
Huixia Wang, Jiaxing Wang, Yumin Xia (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - October 16, 2017 Category: Allergy & Immunology Source Type: research
Selective HDAC6 inhibition decreases early stage of lupus nephritis by down ‐regulating both innate and adaptive immune responses
Summary We have demonstrated previously that histone deacetylase (HDAC6) expression is increased in animal models of systemic lupus erythematosus (SLE) and that inhibition of HDAC6 decreased disease. In our current studies, we tested if an orally active selective HDAC6 inhibitor would decrease disease pathogenesis in a lupus mouse model with established early disease. Additionally, we sought to delineate the cellular and molecular mechanism(s) of action of a selective HDAC6 inhibitor in SLE. We treated 20‐week‐old (early‐disease) New Zealand Black (NZB)/White F1 female mice with two different doses of the selective H...
Source: Clinical and Experimental Immunology - October 16, 2017 Category: Allergy & Immunology Authors: J. Ren, X. Liao, M. D. Vieson, M. Chen, R. Scott, J. Kazmierczak, X. M. Luo, C. M. Reilly Tags: Original Article Source Type: research
The roles and applications of autoantibodies in progression, diagnosis, treatment and prognosis of human malignant tumours
Publication date: Available online 16 October 2017 Source:Autoimmunity Reviews Author(s): Jing Wu, Xiaobo Li, Wuqi Song, Yong Fang, Li Yu, Siyuan Liu, Leonid P. Churilov, Fengmin Zhang The existence of autoantibodies towards an individual's own proteins or nucleic acids has been established for more than 100years, and for a long period, these autoantibodies have been believed to be closely associated with autoimmune diseases. However, in recent years, researchers have become more interested in the role and application of autoantibodies in progression, diagnosis, treatment and prognosis of human malignant tumours. Over the...
Source: Autoimmunity Reviews - October 16, 2017 Category: Allergy & Immunology Source Type: research
Free-ranging dogs prefer petting over food in repeated interactions with unfamiliar humans [RESEARCH ARTICLE]
Debottam Bhattacharjee, Shubhra Sau, Jayjit Das, and Anindita Bhadra Dogs (Canis lupus familiaris) are the first species to have been domesticated, and unlike other domesticated species, they have developed a special bonding with their owners. The ability to respond to human gestures and language, and the hypersocial behaviours of dogs are considered key factors that have led them to become man's best friend. Free-ranging dogs provide an excellent model system for understanding the dog-human relationship in various social contexts. In India, free-ranging dogs occur in all possible human habitations. They scavenge among gar...
Source: Journal of Experimental Biology - October 16, 2017 Category: Biology Authors: Bhattacharjee, D., Sau, S., Das, J., Bhadra, A. Tags: RESEARCH ARTICLE Source Type: research
Cell-bound complement activation products as lupus biomarkers: diagnosis, monitoring and stratification.
Authors: Ahearn JM, Liu CC, Manzi S Abstract INTRODUCTION: Cell-bound complement activation products (CB-CAPs) were first reported in 2004, since which time multiple laboratories have demonstrated their value as biomarkers for diagnosis, monitoring, and stratification of patients with systemic lupus erythematosus. Areas Covered: This review summarizes the highlights of these 14 years of CB-CAPs discovery and validation, concluding with a view toward their future potential for precision medicine. Expert Commentary: The practice of medicine is both art and science and each physician can be considered both artist and ...
Source: Expert Review of Clinical Immunology - October 15, 2017 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
GSE102728 IgG immunocomplexes sensitize human monocytes for inflammatory hyperactivity via transcriptomic and epigenetic reprogramming in autoimmune disease
We present here evidence that IgG ICs precipitated from RA sera sensitized human monocytes for a long-lasting inflammatory functional state characterized by a strong TNF α response to cellular proteins representing damage-associated molecular patterns (DAMPs) and microbe-derived pathogen-associated molecular patterns (PAMPs). Importantly, plate-coated human IgG (cIgG, a mimic of deposited IC without antigen restriction) exhibited similarly robust ability of monocyt e sensitization in vitro. The cIgG-induced functional programming is through FcγRIIa/Syk signaling and accompanied by characteristic phenotypic chan...
Source: GEO: Gene Expression Omnibus - October 15, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Autoimmune comorbidity in chronic spontaneous urticaria: a systematic review
Conclusions CSU patients have an increased risk of AIDs, especially adult female patients with a positive family history and a genetic predisposition for AIDs, who should be screened for signs and symptoms of AIDs. (Source: Autoimmunity Reviews)
Source: Autoimmunity Reviews - October 15, 2017 Category: Allergy & Immunology Source Type: research
Rheumatic diseases and autoimmune vascular dementia
Publication date: Available online 14 October 2017 Source:Autoimmunity Reviews Author(s): Fabiola Atzeni, Nicolò Pipitone, Luca Iaccarino, Ignazio Francesco Masala, Ronen Weiss, Alessandra Alciati, Andrea Doria, Joab Chapmanand, Piercarlo Sarzi-Puttini Vascular dementia (VD) comes second after Alzheimer’s disease (AD) as a cause of impaired cognition. VD is not a specific nosological entity, but rather a syndrome encompassing a number of diseases caused by impaired supply of blood to the brain. Systemic autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis and antiphospho...
Source: Autoimmunity Reviews - October 15, 2017 Category: Allergy & Immunology Source Type: research
Phalangeal Microgeodic Syndrome in a Patient with Systemic Lupus Erythematosus.
Authors: Kurushima S, Horai Y, Takatani A, Nishino A, Kawashiri SY, Ichinose K, Nakamura H, Kawakami A Abstract We herein report a woman in her 50s with systemic lupus erythematosus (SLE) who developed swelling and pain in her fingers; the symptoms were more prominent in winter. Magnetic resonance imaging (MRI) revealed bone edema in the phalanges of both hands, which was compatible with phalangeal microgeodic syndrome (PMS). This is the first reported case of PMS in a patient with SLE and suggests that performing MRI should be considered for patients with SLE in order to assess the nature of finger symptoms and si...
Source: Internal Medicine - October 14, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research
Effect of vitamin D supplementation on patients with systemic lupus erythematosus: a systematic review
The objective of this systematic review was to analyze clinical trials carried out for the investigation of the effect of vitamin D supplementation on systemic lupus erythematosus. The research was performed from August to September 2016, without limits regarding year of publication, restriction of gender, age, and ethnicity. For the guiding question, the PICO strategy was employed. To evaluate the quality of the publications the PRISMA protocol and Jadad scale were used. The risk of bias analysis of the clinical trials was performed using the Cochrane collaboration tool. After the process of article selection and removal ...
Source: Revista Brasileira de Reumatologia - October 14, 2017 Category: Rheumatology Source Type: research
Treat to target, remission and low disease activity in SLE
Publication date: Available online 13 October 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): Eric F. Morand, Marta Mosca Despite improvements in survival, outcomes of contemporary treatment of systemic lupus erythematosus (SLE) are unacceptable. Unlike in many diseases, treat-to-target (T2T) approaches have not been adopted in SLE, owing to a lack of validated targets to treat towards. Therefore, it is a key goal to validate target state definitions such as low disease activity and remission, and test their implementation in clinical practice and clinical trials. In this article, we review r...
Source: Best Practice and Research Clinical Rheumatology - October 14, 2017 Category: Rheumatology Source Type: research
Association of TNFSF4 Polymorphisms with Neuromyelitis Optica Spectrum Disorders in a Chinese Population
This study demonstrates an association betweenTNFSF4 polymorphisms and susceptibility for the development of NMOSD in the Chinese population. (Source: Journal of Molecular Neuroscience)
Source: Journal of Molecular Neuroscience - October 14, 2017 Category: Neuroscience Source Type: research
Usefulness of neutrophil-to-lymphocyte ratio as a biomarker for diagnosing infections in patients with systemic lupus erythematosus
AbstractNeutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) have been investigated as disease activity markers for systemic lupus erythematosus (SLE). Hence, we investigated the clinical significance of these parameters in diagnosing infection in patients with SLE. In total, 120 patients with SLE, who were admitted to hospital due to disease flares or infection, were recruited for the study. Of the 120 patients, 60 had a concurrent infection (SLE with infection), while the remaining 60 patients were admitted with a flare without any evidence of infection (SLE wit...
Source: Clinical Rheumatology - October 13, 2017 Category: Rheumatology Source Type: research
Bilateral Hemorrhagic Retinopathy with Roth Spots in Pediatric-Onset Systemic Lupus Erythematosus and Associated Thrombocytopenia: A Case Report and Review of Literature.
Authors: Zhang J, Chen Y, Yu Z, Liu L PMID: 29020480 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 13, 2017 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Acquired factor XI deficiency and therapeutic plasma exchange
We report a case of acquired FXI deficiency in a pregnant woman with lupus. We proved that the inhibitor was an IgG, therefore potentially capable of crossing the placenta. While immune suppression eliminated detectable circulating inhibitor, the woman's FXI remained quite low. A multi‐disciplinary team was formed and therapeutic plasma exchange with 100% plasma replacement was performed when the patient went into labor, to acutely raise her FXI level and remove any potential non‐neutralizing inhibitor. The mother had a controllable level of bleeding during post‐TPE cesarean section; the baby had no bleeding and the ...
Source: Journal of Clinical Apheresis - October 13, 2017 Category: Hematology Authors: Geoffrey D. Wool, Angela Treml, Jonathan L. Miller Tags: CASE REPORT Source Type: research
Lupus ‐like cutaneous reaction following pembrolizumab: an immune‐related adverse event associated with anti‐PD‐1 therapy
In this report, we describe a patient who developed a lupus‐like cutaneous reaction in the setting of pembrolizumab therapy for metastatic melanoma, adding to the spectrum of reactions which may be observed in association with PD‐1 inhibitor therapy. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - October 13, 2017 Category: Pathology Authors: Kimberly Shao, Suzanne McGettigan, Rosalie Elenitsas, Emily Y. Chu Tags: CASE REPORT Source Type: research
Effects of age and gender on reference levels of biomarkers comprising the pediatric Renal Activity Index for Lupus Nephritis (p-RAIL)
Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease that disproportionately effects women and children of minorities. Renal involvement (lupus nephritis, or LN) occurs in up to 80% of childr... (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - October 13, 2017 Category: Rheumatology Authors: Michael R. Bennett, Qing Ma, Jun Ying, Prasad Devarajan and Hermine Brunner Tags: Research article Source Type: research
Olfactory eavesdropping: The odor of feathers is detectable to mammalian predators and competitors
Abstract The role of olfactory eavesdropping in interactions between mammalian predator and prey species is well established. Bird plumage can be odorous and consequently nest predators could use odor to identify and locate avian prey, and nest competitors could use odor to assess occupancy of nest cavities by birds. However, despite extensive research on avian nest predation and competition, the costs of olfactory eavesdropping on plumage odor by nest predators or competitors remain largely unknown. We used two experiments to investigate whether feather odor is detected by marsupial species which are competitors for nest ...
Source: Ethology - October 12, 2017 Category: Zoology Authors: Milla Mihailova, Mathew L. Berg, Katherine L. Buchanan, Andrew T. D. Bennett Tags: RESEARCH PAPER Source Type: research
Association of Trauma and Posttraumatic Stress Disorder With Incident Systemic Lupus Erythematosus in a Longitudinal Cohort of Women
We examined the association of trauma exposure and PTSD symptoms with SLE incidence over 24 years of follow‐up in a US longitudinal cohort of women (n = 54,763). Incident SLE in women meeting ≥4 American College of Rheumatology criteria was ascertained by self‐report and confirmed by medical record review. PTSD and trauma exposure were assessed with the Short Screening Scale for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition PTSD and the Brief Trauma Questionnaire, respectively. Women were categorized as having no trauma, trauma and no PTSD symptoms, subclinical PTSD (1–3 symptoms), or p...
Source: Arthritis and Rheumatism - October 12, 2017 Category: Rheumatology Authors: Andrea L. Roberts, Susan Malspeis, Laura D. Kubzansky, Candace H. Feldman, Shun ‐Chiao Chang, Karestan C. Koenen, Karen H. Costenbader Tags: Original Article Source Type: research
Calcineurin inhibitors in systemic lupus erythematosus
Publication date: Available online 11 October 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): Chi Chiu Mok The calcineurin inhibitors (CNIs) belong to a group of immunosuppressive agents that block T-cell activation through the suppression of the calcium/calcimodulin-dependent phosphatase calcineurin. Agents such as cyclosporine A (CSA) and tacrolimus (TAC) have long been used in patients with systemic lupus erythematosus (SLE). TAC is preferred to CSA in SLE because of the lower frequency of cosmetic, hypertensive and dyslipidemic adverse effects. Recent randomised controlled trials have dem...
Source: Best Practice and Research Clinical Rheumatology - October 12, 2017 Category: Rheumatology Source Type: research
Pregnancy in systemic lupus erythematosus and antiphospholipid syndrome
Publication date: Available online 11 October 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): Rebecca Fischer-Betz, Christof Specker Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with a high prevalence in females of childbearing age. Pregnancy in SLE nowadays has favorable outcomes for the majority of women. However, flares of disease activity, preeclampsia, fetal loss, and preterm birth are well-known risks in such pregnancies. Anti-SS-A(Ro)/SS-B(La) antibodies put fetuses at risk for congenital heart block and neonatal lupus. Several risk factors for advers...
Source: Best Practice and Research Clinical Rheumatology - October 12, 2017 Category: Rheumatology Source Type: research
Identification of key genes for diabetic kidney disease using biological informatics methods.
Authors: Ma F, Sun T, Wu M, Wang W, Xu Z Abstract Diabetic kidney disease (DKD) is a common complication of diabetes, which is characterized by albuminuria, impaired glomerular filtration rate or a combination of the two. The aim of the present study was to identify the potential key genes involved in DKD progression and to subsequently investigate the underlying mechanism involved in DKD development. The array data of GSE30528 including 9 DKD and 13 control samples was downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) in DKD glomerular and tubular kidney biopsy ti...
Source: Molecular Medicine Reports - October 11, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
PTPN22 1858C > T polymorphism and susceptibility to systemic lupus erythematosus: a meta-analysis update.
In conclusion, present meta-analysis update confirms that T allele and T/T genotype in PTPN22 1858 C > T polymorphism confers SLE susceptibility, particular in Caucasian and Latin groups, suggesting PTPN22 1858 C > T as a potential genetic marker in SLE susceptibility. PMID: 28990435 [PubMed - as supplied by publisher] (Source: Autoimmunity)
Source: Autoimmunity - October 11, 2017 Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Association of anti-CLIC2 and anti-HMGB1 autoantibodies with higher disease activity in systemic lupus erythematosus patients
Conclusion: Our findings support the potential of using anti-CLIC2 autoantibodies as a novel biomarker for SLE patients. Both anti-CLIC2 and anti-HMGB1 autoantibody levels demonstrated potential in monitoring SLE disease activity. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - October 11, 2017 Category: Internal Medicine Authors: CS Syahidatulamali WG Wan Syamimee Y Nor Azwany KK Wong CH Che Maraina Source Type: research
Mortality from systemic lupus erythematosus in Brazil: evaluation of causes according to the government health database
Conclusions This study identified a need for greater control of risk factors for cardiovascular diseases and a better understanding of the pathogenesis of atherosclerosis in SLE. Infectious causes are still frequent, and management should be improved, especially in the early stages of the disease. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - October 10, 2017 Category: Rheumatology Source Type: research
Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles
s Dichi & Andréa Name Colado Simão (Source: Immunology and Cell Biology)
Source: Immunology and Cell Biology - October 10, 2017 Category: Allergy & Immunology Authors: Poliana Macedo Guimar ães Bruna Miglioranza Scavuzzi Nicole Perugini Stadtlober Lorena Flor da Rosa Franchi Santos Marcell Alysson Batisti Lozovoy Tatiana Mayumi Veiga Iriyoda Neide Tomimura Costa Edna Maria Vissoci Reiche Michael Maes Isaias Dichi Andr Source Type: research
Reports of three cases with the initial presentation of mesenteric vasculitis in children with system lupus erythematous
AbstractWe reviewed three cases of systemic lupus erythematosus (SLE) in children with mesenteric vasculitis (LMV) as initial presentation and analysed their clinical characteristics to improve the understanding of this disease. Three patients with SLE were admitted to our hospital and initially presented with gastrointestinal symptoms. We retrospectively analysed their clinical data, including clinical presentations, laboratory results, images and short- and long-term treatment outcomes. (1) All three children were school-age girls. The patients were presented to our hospital with vomiting and abdominal pain as initial sy...
Source: Clinical Rheumatology - October 10, 2017 Category: Rheumatology Source Type: research
CD4+ T helper cells and regulatory T cells in active lupus nephritis: an imbalance towards a predominant Th1 response?
In conclusion, the inverse association between Th1 cells from PBMC and urinary/renal tissue indicate a role for Th1 in LN pathophysiology. Urinary Th17 cells were associated with less severe LN, and Th17 increased in PBMC during therapy. Urinary CD4+ T cells were not different between LN and DC. The expression of the transcription factor Tbet in the glomerulus from a patient with active lupus nephritis. Th1 cells in peripheral blood are inversely correlated with urinary Th1 cells and with Tbet expression in renal tissue of patients with active lupus nephritis, whereas the Th17 response in urine is associated with a less s...
Source: Clinical and Experimental Immunology - October 10, 2017 Category: Allergy & Immunology Authors: D. Mesquita, G. Mastroianni Kirsztajn, M. F. Franco, L. A. Reis, S. F. Perazzio, F. V. Mesquita, V. da Silva Ferreira, L. E. Coelho Andrade, A. W. Silva de Souza Tags: Original Article Source Type: research
Vitamin D and the Skin: An Update for Dermatologists
AbstractVitamin D plays a key role in skeletal and cardiovascular disorders, cancers, central nervous system diseases, reproductive diseases, infections, and autoimmune and dermatological disorders. The two main sources of vitamin D are sun exposure and oral intake, including vitamin D supplementation and dietary intake. Multiple factors are linked to vitamin D status, such as Fitzpatrick skin type, sex, body mass index, physical activity, alcohol intake, and vitamin D receptor polymorphisms. Patients with photosensitive disorders tend to avoid sun exposure, and this practice, along with photoprotection, can put this categ...
Source: American Journal of Clinical Dermatology - October 9, 2017 Category: Dermatology Source Type: research
Discordance of the Framingham cardiovascular risk score and the 2013 American College of Cardiology/American Heart Association risk score in systemic lupus erythematosus and rheumatoid arthritis
AbstractDespite the increasing use of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cardiovascular (CV) risk score in clinical practice, few studies have compared this score to the Framingham risk score among rheumatologic patients. We calculated Framingham and 2013 ACC/AHA risk scores in subjects with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and assessed demographic, CV, and rheumatologic characteristics associated with discordant scores (high-risk ACC/AHA scores but low-risk Framingham scores). SLE and RA subjects drawn from two population-based cohort studies were a...
Source: Clinical Rheumatology - October 9, 2017 Category: Rheumatology Source Type: research
Cardiopulmonary Manifestations of Collagen Vascular Diseases
AbstractPurpose of ReviewThe study aimed to illustrate the cardiopulmonary findings of the following collagen vascular diseases on cross-sectional imaging: rheumatoid arthritis, scleroderma (progressive systemic sclerosis), systemic lupus erythematosus, the inflammatory myopathies (polymyositis/dermatomyositis), and Sj ögren’s syndrome.Recent FindingsAlthough collagen vascular diseases can affect any part of the body, interstitial lung disease and pulmonary hypertension are the two most important cardiopulmonary complications and are responsible for the majority of morbidity and mortality in this patient populat...
Source: Current Rheumatology Reports - October 9, 2017 Category: Rheumatology Source Type: research
A Rapid Evaluation of Activity in Lupus (LFA ‐REAL™) Correlates with More Complex Disease Activity Instruments Whether Evaluated by Clinical Investigators or Real‐World Clinicians
Abstract Lupus disease measures such as the SLE Disease Activity Index (SLEDAI) and the British Isles Lupus Assessment Group (BILAG) Index are challenging to interpret. The Lupus Foundation of America–Rapid Evaluation of Activity in Lupus (LFA‐REAL) is intended to provide an efficient application of anchored visual analogue scores, each representing the individual severity of active symptoms, with the sum of individual scores deriving an overall disease activity assessment. ObjectivesTo compare the performance of LFA‐REAL to SLE disease activity assessments and compare scores between trained lupus clinical invest...
Source: Arthritis Care and Research - October 9, 2017 Category: Rheumatology Authors: Anca D Askanase, Samantha C Nguyen, Karen Costenbader, S Sam Lim, Diane Kamen, Cynthia Aranow, Jennifer Grossman, Teja M Kapoor, DeAnna Baker ‐Frost, Teresa Aberle, Aikaterini Thanou‐Stavraki, Leslie M Hanrahan, Mimi Kim, Joan T Merrill Tags: Original Article Source Type: research
Neonatal lupus erythematosus presenting as Stevens-Johnson syndrome
Publication date: Available online 9 October 2017 Source:Dermatologica Sinica Author(s): Ren-Feng Liu, Wen-Hung Chung, Chin-Yi Yang, Fang-Ying Wang, Chun-Bing Chen Neonatal lupus erythematosus (NLE) is a rare acquired condition caused by the transplacental passage of maternal autoantibodies. It is characterized by cutaneous, cardiac, hepatobiliary, hematological and neurological involvement. Cutaneous findings of NLE are variable, but few reports in the literature describe the presence of erosions or epidermal loss in NLE. Herein, we describe the case of an infant with NLE presenting as Stevens-Johnson syndrome (SJS), wit...
Source: Dermatologica Sinica - October 9, 2017 Category: Dermatology Source Type: research
Low level of circulating basophil counts in biopsy-proven active lupus nephritis
AbstractBasophils have been shown to be important players in promoting lupus nephritis (LN). However, the relationship between circulating basophil counts and renal pathology activity of LN remains unclear. In this retrospective study, 159 clinical and pathology samples from patients with biopsy-proven LN were analyzed. The renal activity and classification were evaluated according to renal pathology. The correlations between circulating basophil counts and renal pathology activity index were assessed. Overall, circulating basophil counts correlated with total systemic lupus erythematosus disease activity index (SLEDAI) sc...
Source: Clinical Rheumatology - October 8, 2017 Category: Rheumatology Source Type: research
Bioinformatics analysis of fibroblasts exposed to TGF ‑β at the early proliferation phase of wound repair.
Bioinformatics analysis of fibroblasts exposed to TGF‑β at the early proliferation phase of wound repair. Mol Med Rep. 2017 Sep 26;: Authors: Mi B, Liu G, Zhou W, Lv H, Zha K, Liu Y, Wu Q, Liu J Abstract The aim of the current study was to identify gene signatures during the early proliferation stage of wound repair and the effect of TGF‑β on fibroblasts and reveal their potential mechanisms. The gene expression profiles of GSE79621 and GSE27165 were obtained from GEO database. Differentially expressed genes (DEGs) were identified using Morpheus and co‑expressed DEGs were selected using...
Source: Molecular Medicine Reports - October 7, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Diagnosis of systemic inflammatory diseases among patients admitted for acute pericarditis with pericardial effusion
Aims: Acute pericarditis may be the heralding manifestation of various systemic inflammatory diseases (SIDs). The aim of this study was to identify clinical indicators for SIDs in patients admitted for acute pericarditis with pericardial effusion. Methods: All consecutive adult patients hospitalized in a Department of Internal Medicine over a 10-year period for acute pericarditis with pericardial effusion were retrospectively reviewed. Patients with cancer and tuberculosis were excluded. A structured clinical panel for extra-cardiac symptoms of SIDs was applied. SIDs were classified using current international criteria. ...
Source: Journal of Cardiovascular Medicine - October 7, 2017 Category: Cardiology Tags: Research articles: Pericarditis and myocarditis Source Type: research
Two Case Reports: Using Simulated Re-Attachment to Treat Persistent Complex Bereavement Disorder and PTSD
Publication date: Available online 6 October 2017 Source:EXPLORE: The Journal of Science and Healing Author(s): Mark Rider These case reports focus on a rapid treatment for persistent complex bereavement disorder and PTSD which appears to activate the mirror neuron network. Simulated Re-Attachment is a technique which has been found to repair phantom limb pain in just a few sessions. The same neuroplasticity that accomplishes phantom pain relief has been found to occur in the treatment of complicated grief and PTSD using similar methods. The Simulated Re-Attachment for the client in Case 1 was found to significantly reduc...
Source: EXPLORE: The Journal of Science and Healing - October 7, 2017 Category: Complementary Medicine Source Type: research
Systemic lupus erythematosus following meningococcal vaccination
A previously healthy, 17-year-old Asian female presented to our emergency department 15days after receiving the Menveo ® (Meningococcal groups A, C, Y and W-135, oligosaccharide diphtheria CRM197 conjugate) vaccine. The evening after she received the vaccination, she began to feel ill and subsequently experienced 14days of fever and fatigue; 5days prior to the ED visit she developed a progressive, erythematous, non -pruritic, non-painful facial rash. She received 2days of cefadroxil prior to presentation; there was no improvement in her symptoms. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - October 7, 2017 Category: Emergency Medicine Authors: Alexandria D. Holmes, Osman Z. Abbasi, Jeanne L. Jacoby Source Type: research
Interspecies transmission of emotional information via chemosignals: from humans to dogs (Canis lupus familiaris).
We report a study examining interspecies emotion transfer via body odors (chemosignals). Do human body odors (chemosignals) produced under emotional conditions of happiness and fear provide information that is detectable by pet dogs (Labrador and Golden retrievers)? The odor samples were collected from the axilla of male donors not involved in the main experiment. The experimental setup involved the co-presence of the dog's owner, a stranger and the odor dispenser in a space where the dogs could move freely. There were three odor conditions [fear, happiness, and control (no sweat)] to which the dogs were assigned randomly....
Source: Animal Cognition - October 7, 2017 Category: Zoology Authors: D'Aniello B, Semin GR, Alterisio A, Aria M, Scandurra A Tags: Anim Cogn Source Type: research
Association of interleukin 13 gene polymorphisms and plasma IL 13 level with risk of systemic lupus erythematosus.
This study aims to explore the potential association of IL-13 polymorphisms with the risk of SLE. We genotyped IL-13 rs20541, rs848 and rs1295686 using Snapshot SNP genotyping assays. Plasma IL-13 level was determined by enzyme-linked immunosorbent assay (ELISA). We found that rs20541 was associated with increased risk of SLE (CT vs. CC: adjusted OR=1.43, 95%CI, 1.04-1.99, P=.030; TT vs. CC: adjusted OR=1.73, 95%CI, 1.10-2.73, P=.018; CT/TT vs. CC: adjusted OR=1.50, 95%CI, 1.10-2.04, P=.010; T vs. C adjusted OR=1.34, 95%CI, 1.08-1.93, P=.031). CT and TT genotypes in rs20541 were associated with increased risk of renal diso...
Source: Cytokine - October 7, 2017 Category: Molecular Biology Authors: Wang R, Lu YL, Huang HT, Qin HM, Lan Y, Wang JL, Wang CF, Wei YS Tags: Cytokine Source Type: research
B cell tolerance to epidermal ribonuclear ‐associated neo‐autoantigen in vivo
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - October 6, 2017 Category: Allergy & Immunology Authors: S øren E. Degn, Elisabeth Alicot, Michael C. Carroll Tags: Original Article Source Type: research
[World Report] Lupus research centre fosters collaboration
The Hospital for Special Surgery (HSS), New York, USA, has been a leader for decades in the study and treatment of rheumatological diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. (Source: LANCET)
Source: LANCET - October 6, 2017 Category: General Medicine Authors: Rita Rubin Tags: World Report Source Type: research
[Perspectives] Mary Crow: leader in research on systemic lupus erythematosus
Mary “Peggy” Crow was not one of those people who always wanted to be a doctor. “I absolutely was not on a track toward either medicine or research”, Crow, Physician-in-Chief at the Hospital for Special Surgery (HSS), New York City, USA, and a past President of the American College of Rheumatolog y, told The Lancet. She took biology in 7th grade and loved it, Crow says, but at her private high school in Westchester County, NY, girls didn't get to take science—she “was not even offered science courses”, recalls Crow. (Source: LANCET)
Source: LANCET - October 6, 2017 Category: General Medicine Authors: Rita Rubin Tags: Perspectives Source Type: research
Antimalarial drug toxicities in patients with cutaneous lupus and dermatomyositis: a retrospective cohort study
Antimalarials are effective for rheumatic skin diseases, but have been associated with retinopathy.We investigated the toxicity risk of antimalarials alone and in combination.Antimalarials were generally well tolerated and had similar risk profiles. Risk of retinopathy seems to be lowest for quinacrine, then hydroxychloroquine, and highest for chloroquine. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - October 6, 2017 Category: Dermatology Authors: Lavanya Mittal, Lingqiao Zhang, Rui Feng, Victoria P. Werth Source Type: research
Efficacy and tolerance profile of thalidomide in cutaneous lupus erythematosus: a systematic review and meta-analysis
Thalidomide has shown excellent results for severe cutaneous lupus Erythematosus (CLE) but its prescription is limited by potentially severe adverse events. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - October 6, 2017 Category: Dermatology Authors: Fran çois Chasset, Toufik Tounsi, Elise Cesbron, Annick Barbaud, Camille Francès, Laurent Arnaud Source Type: research
B cell tolerance to epidermal ribonuclear-associated neo-autoantigen in vivo.
This article is protected by copyright. All rights reserved. PMID: 28984923 [PubMed - as supplied by publisher] (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - October 6, 2017 Category: Allergy & Immunology Authors: Degn SE, Alicot E, Carroll MC Tags: Clin Exp Immunol Source Type: research
Updates in Lupus Genetics
AbstractPurpose of ReviewOur understanding on genetic basis of SLE has been advanced through genome-wide association studies. We review recent progress in lupus genetics with a focus on SLE-associated loci that have been functionally characterized, and discuss the potential for clinical translation of genetics data.Recent FindingsOver 100 loci have been confirmed to show robust association with SLE and many share with other immune-mediated diseases. Although causative variants captured at these established loci are limited, they guide biological studies of gene targets for functional characterization which highlight the im...
Source: Current Rheumatology Reports - October 5, 2017 Category: Rheumatology Source Type: research