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Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus
Background A major systemic lupus erythematosus (SLE) susceptibility locus lies within a common inversion polymorphism region (encompassing 3.8 – 4.5 Mb) located at 8p23. Initially implicated genes included FAM167A-BLK and XKR6, of which BLK received major attention due to its known role in B-cell biology. Recently, additional SLE risk carried in non-inverted background was also reported. Objective and methods In this case –control study, we further investigated the ‘extended’ 8p23 locus (~ 4 Mb) where we observed multiple SLE signals and assessed these signals for their relation to the inversion a...
Source: Journal of Medical Genetics - May 26, 2017 Category: Genetics & Stem Cells Authors: Demirci, F. Y., Wang, X., Morris, D. L., Feingold, E., Bernatsky, S., Pineau, C., Clarke, A., Ramsey-Goldman, R., Manzi, S., Vyse, T. J., Ilyas Kamboh, M. Tags: Complex traits Source Type: research

Description of Malignancy Rates in Childhood- and Adult-Onset Systemic Lupus Erythematous by Proportional Meta-analysis
Objective: Describe malignancy rates in childhood onset and adult onset systemic lupus erythematous (SLE) by proportional meta-analysis. Methods: Two reviewers screened data from PubMed (1966–2015), EMBASE (1980–2015), and LILACS (1982–2015) for SLE-associated malignancy. Proportional meta-analysis with a random-effects model and 95% confidence intervals (CIs) were calculated according to SLE onset age and mean follow-up time. Statistical difference was defined by 95% CI overlap. Results: Overall the malignancy rate reported in 30 case series with 96,578 subjects was 3.4% (95% CI, 0.0260–0.0442; I...
Source: JCR: Journal of Clinical Rheumatology - May 25, 2017 Category: Rheumatology Tags: Original Articles Source Type: research

Prevalence of Pulmonary Embolism Among Systemic Lupus Erythematosus Discharges: A Decade of Analysis of the National Hospital Discharge Survey
Conclusions: Significant association exists between SLE and PE regardless of sex, race, age, and associated comorbidities. Females had an overall higher prevalence of SLE-related PE (1.67%) compared with males (1.29%). Stratified according to sex, race, and age groups, the association is highest for females, blacks, and age group 35 to 44 years, respectively. (Source: JCR: Journal of Clinical Rheumatology)
Source: JCR: Journal of Clinical Rheumatology - May 25, 2017 Category: Rheumatology Tags: Original Articles Source Type: research

Hashimoto thyroiditis, anti ‐thyroid antibodies and systemic lupus erythematosus
ConclusionThere is a two‐fold increased risk of HT in SLE patients. Anti‐Sm antibodies favor this association and also double antibody positivity. Disease activity and cumulative damage are not related to HT or with autoantibodies. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - May 25, 2017 Category: Rheumatology Authors: Rayana T. Posselt, Vin ícius N. Coelho, Thelma L. Skare Tags: Original Article Source Type: research

Obesity and the Risk of Systemic Lupus Erythematosus among Women in the Nurses ′ Health Studies
Obesity is increasingly prevalent and related to increased risk of several autoimmune diseases, likely via generation of inflammatory adipokines. Prior studies have not evaluated obesity in relation to systemic lupus erythematosus (SLE) risk. We prospectively evaluated whether obesity was associated with increased SLE risk among women in the U.S. Nurses ′ Health Study cohorts. (Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - May 25, 2017 Category: Rheumatology Authors: Sara K. Tedeschi, Medha Barbhaiya, Susan Malspeis, Bing Lu, Jeffrey A. Sparks, Elizabeth W. Karlson, Walter Willett, Karen H. Costenbader Source Type: research

Hepatitis B Vaccine Non Response: A Predictor of Latent Autoimmunity?
Unresponsiveness to Hepatitis B virus (HBV) vaccine has been associated with interleukins involved with Th1 functioning including Interleukin-8 (IL-18) and Interferon- γ (IFN-γ). IL-18 and IFN-γ have also been implicated in the onset of different types of immune-mediate inflammatory conditions such as Type 1 Diabetes (T1D), Celiac disease (CD), rheumatoid arthritis (RA), obesity and systemic lupus erythematosus (SLE). Taking into account that HBV vaccination is provided in the 1st year of life worldwide, I propose that all babies should be tested for anti-HBs response after completion of the vaccine serie...
Source: Medical Hypotheses - May 25, 2017 Category: Biomedical Science Authors: M.D. Raffaella Mormile Source Type: research

Two separate effects contribute to regulatory T ‐cell defect in SLE patients and their unaffected relatives
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - May 24, 2017 Category: Allergy & Immunology Authors: Nuno Costa, Oriana Marques, Sandra I. Godinho, Cl áudia Carvalho, Barbara Leal, Ana M. Figueiredo, Carlos Vasconcelos, António Marinho, Maria F. Moraes‐Fontes, António Gomes da Costa, Cristina Ponte, Raquel Campanilho‐Marques, Telma Cóias, Ana R. Tags: Original Article Source Type: research

Anti-nucleosome antibodies in systemic lupus erythematosus patients: Relation to anti-double stranded deoxyribonucleic acid and disease activity
Conclusion Anti-NCS antibodies could play a role in the pathogenesis of SLE and is related to disease activity. Its association with anti-dsDNA antibodies and its presence in those with negative anti-ds DNA may aid in the diagnosis of SLE. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - May 24, 2017 Category: Rheumatology Source Type: research

Exhaled nitric oxide, pulmonary function, and disease activity in children with systemic lupus erythematosus
ConclusionDecreased TLC and high FENO were common in SLE children who had no respiratory symptoms and correlated with disease activity. FENO should be considered as an additional pulmonary function to evaluate disease activity in children with SLE. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 23, 2017 Category: Respiratory Medicine Authors: Jitladda Deerojanawong, Pitchaya Leartphichalak, Ankanee Chanakul, Suchada Sritippayawan, Rujipat Samransamruajkit Tags: ORIGINAL ARTICLE: OUTCOMES Source Type: research

Suicidal death of erythrocytes in cancer and its chemotherapy: A potential target in the treatment of tumor ‐associated anemia
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - May 23, 2017 Category: Cancer & Oncology Authors: Elisabeth Lang, Rosi Bissinger, Syed M. Qadri, Florian Lang Tags: Mini Review Source Type: research

Development of Improved Dosing Regimens for Mycophenolate Mofetil Based on Population Pharmacokinetic Analyses in Adults with Lupus Nephritis
ConclusionA ‘tiered’ dosing approach considering patient renal function and CsA co-therapy, rather than a ‘one dose fits all’ approach, would help individualize MMF therapy in adult lupus nephritis patients to ensure more patients have optimal MPA exposure. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - May 23, 2017 Category: Drugs & Pharmacology Source Type: research

Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis
Conclusion NLRP3 inflammasomes were activated in podocytes of both LN patients and in lupus‐prone mice. Activation of NLRP3 is involved in the pathogenesis of podocyte injuries and the development of proteinuria in LN. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - May 23, 2017 Category: Rheumatology Authors: Rong Fu, Chaohuan Guo, Shuang Wang, Yuefang Huang, Ou Jin, Haoqiang Hu, Jingxian Chen, Bihua Xu, Mianjing Zhou, Jijun Zhao, Sun ‐sang J. Sung, Hongyang Wang, Felicia Gaskin, Niansheng Yang, Shu‐Man Fu Tags: Full Length Source Type: research

Podocytes as active participants in lupus nephritis
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - May 23, 2017 Category: Rheumatology Authors: Ian R. Rifkin, Ramon G. Bonegio Tags: Editorial Source Type: research

Deficiency of Complement 1r subcomponent in early ‐onset SLE: Role for disease‐modifying alleles in a monogenic disease
Conclusion: We report a novel high‐penetrance mutation in C1R as the cause of monogenic SLE. Disease expressivity in this family appears to be influenced by additional common and rare genetic variants. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - May 23, 2017 Category: Rheumatology Authors: Erkan Demirkaya, Qing Zhou, Carolyne K. Smith, Michael J. Ombrello, Natalie Deuitch, Wanxia L. Tsai, Patrycja Hoffmann, Elaine F. Remmers, Masaki Takeuchi, Yong Hwan Park, JaeJin Chae, Kenan Barut, Dogan Simsek, Amra Adrovic, Sezgin Sahin, Salim Caliskan, Tags: Brief Report Source Type: research

Depression Risk in Young Adults with Childhood ‐ and Adult‐Onset Lupus: 12 Years of Follow‐up
Conclusion. Young adults with SLE, particularly those with childhood‐onset disease, are at high risk for major depression, which is associated with increased disease activity, poorer physical functioning, and lower educational attainment. Early depression intervention in young adults with SLE has the potential to improve both medical and psychosocial outcomes. This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - May 23, 2017 Category: Rheumatology Authors: Andrea M. Knight, Laura Trupin, Patricia Katz, Edward Yelin, Erica F. Lawson Tags: Brief Report Source Type: research

Delays to care in pediatric lupus patients from the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry
ABSTRACT Objectives. Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation among pediatric lupus patients, we examined differences in demographic and clinical characteristics of lupus patients within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry with regards to time between symptom onset and presentation to a pediatric rheumatologist. Methods. We analyzed data from 598 CARRA Legacy Registry participants...
Source: Arthritis Care and Research - May 23, 2017 Category: Rheumatology Authors: Tamar B Rubinstein, Wenzhu B Mowrey, Norman T Ilowite, Dawn M Wahezi, Tags: Original Article Source Type: research

Clinicopathological features of multiple mononeuropathy associated with systemic lupus  erythematosus: a multicenter study
AbstractMultiple mononeuropathy (MM) occurs rarely during systemic lupus erythematosus (SLE) but may lead to major disability. The aim of this study was to investigate the clinic-pathological presentations of MM during SLE, as well as long-term outcomes. We conducted a multicentric retrospective study that included patients receiving a diagnosis of MM during SLE. Ten patients were included (8 women and 2 men, median age at MM diagnosis: 40.4  years). SLE was diagnosed before MM in 9/10 patients (median time 8.2 years). When MM occurred, the SLEDAI score was ≥6 for 6/9 patients. Presenting symptoms consisted of...
Source: Journal of Neurology - May 23, 2017 Category: Neurology Source Type: research

Lupus panniculitis of the scalp presenting with linear alopecia along the lines of Blaschko
(Source: Clinical And Experimental Dermatology)
Source: Clinical And Experimental Dermatology - May 22, 2017 Category: Dermatology Authors: S. Lueangarun, U. Subpayasarn, P. Chakavittumrong, T. Tempark, W. Suthiwartnarueput Tags: CPD ● A memorable patient Source Type: research

Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis.
Abstract Autoimmunity involves immune responses directed against self, which are a result of defective self/foreign distinction of the immune system, leading to proliferation of self-reactive lymphocytes, and is characterized by systemic, as well as tissue-specific, inflammation. Numerous mechanisms operate to ensure the immune tolerance to self-antigens. However, monogenetic defects or genetic variants that weaken immune tolerance render susceptibility to the loss of immune tolerance, which is further triggered by environmental factors. In this review, we discuss the phenomenon of immune tolerance, genetic and en...
Source: International Review of Cell and Molecular Biology - May 21, 2017 Category: Cytology Authors: Devarapu SK, Lorenz G, Kulkarni OP, Anders HJ, Mulay SR Tags: Int Rev Cell Mol Biol Source Type: research

Association of polymorphic variants of PTPN22, TNF and VDR genes in children with lupus nephritis: A study in Colombian family triads.
CONCLUSION: These findings showed an association between the PTPN22 rs2476601 polymorphism and pediatric lupus nephritis due to its overtransmission in the group of families studied. PMID: 28527290 [PubMed - in process] (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - May 21, 2017 Category: International Medicine & Public Health Tags: Biomedica Source Type: research

Large variability of the activity and chronicity indexes within and between histological classes of lupus nephritis.
Authors: Azoicăi T, Belibou IM, Lozneanu L, Giuşcă SE, Cojocaru E, Căruntu ID Abstract Systemic lupus erythematosus (SLE) is characterized by a multifaceted pathogenesis and a heterogeneous clinical expression. The kidney involvement is almost unavoidable in all forms of SLE with chronic evolution, 75% of patients developing renal lesions defined as lupus nephritis (LN) - a glomerulonephritis with an extremely diverse lesion spectrum. The present study aimed to reevaluate a series of cases diagnosed as LN, focusing on the histological features in correlation with the level of activity and chronicity. The study ...
Source: Romanian Journal of Morphology and Embryology - May 21, 2017 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry IX: Clinical Features and Survival of Childhood-Onset Systemic Lupus Erythematosus in China.
Abstract BACKGROUND: Approximately 15-20% cases of systemic lupus erythematosus (SLE) are diagnosed in children. There have been a few studies reporting the epidemiological data of pediatric-onset SLE (cSLE) in China, neither comparing the differences between cSLE and adult-onset SLE (aSLE). The aim of this study was to describe the impact of age of onset on clinical features and survival in cSLE patients in China based on the Chinese SLE Treatment and Research group (CSTAR) database. METHODS: We made a prospective study of 225 cSLE patients (aged Results: The mean age of cSLE patients was 12.16 ± 2.92...
Source: Chinese Medical Journal - May 21, 2017 Category: General Medicine Authors: Wu CY, Li CF, Wu QJ, Xu JH, Jiang LD, Gong L, Wu FQ, Gu JR, Zhao JL, Li MT, Zhao Y, Zeng XF, CSTAR Co-authors Tags: Chin Med J (Engl) Source Type: research

Vitamin D3 alters the expression of Toll ‐like receptors in peripheral blood mononuclear cells of patients with systemic lupus erythematosus
This article is protected by copyright. All rights reserved (Source: Journal of Cellular Biochemistry)
Source: Journal of Cellular Biochemistry - May 20, 2017 Category: Biochemistry Authors: Esmaeil Yazdanpanah, Mahmoud Mahmoudi, Maryam Sahebari, Zahra Rezaieyazdi, Seyed ‐Alireza Esmaeili, Nafiseh Tabasi, Soheila Jaberi, Amirhossein Sahebkar, Maryam Rastin Tags: Article Source Type: research

IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors.
In this study, we identified that HDACi trichostatin A (TSA) and histone acetyltransferase (HAT)-p300 downregulated IRF5 promoter activity, mRNA expression, and protein level, whereas the HAT-p300/CBP-associated factor had no effect. Moreover, TSA inhibited the production of TNF-α and IL-6 in differentiated THP-1cells. Furthermore, chromatin immunoprecipitation assays revealed that TSA inhibited DNA binding of Sp1, RNA polymerase II, HDAC3, and p300 to the core promoter region of IRF5. Our results suggest that HDACi may have therapeutic potential in patients with autoimmune diseases such as SLE through repression of ...
Source: Oncotarget - May 20, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The association between systemic lupus erythematosus and bipolar disorder  - a big data analysis.
The objective of this study was to investigate the association between SLE and BD using big data analysis methods. METHODS: Patients with SLE were compared with age- and sex-matched controls regarding the prevalence of BD in a cross-sectional study. Chi-square and t-tests were used for univariate analysis and a logistic regression model was used for multivariate analysis, adjusting for confounders. The study was performed utilizing the chronic disease registry of Clalit Health Services medical database. RESULTS: The study included 5018 SLE patients and 25,090 matched controls. BD was found in a higher prevalence am...
Source: Journal of the Association of European Psychiatrists - May 20, 2017 Category: Psychiatry Tags: Eur Psychiatry Source Type: research

Diagnosis of catastrophic anti-phospholipid syndrome in a patient tested negative for conventional tests.
Authors: Conti F, Priori R, Alessandri C, Misasi R, Capozzi A, Pendolino M, Truglia S, Frisenda S, Sorice M, Valesini G Abstract Catastrophic antiphospholipid syndrome (CAPS) is a severe variant of APS, characterised by clinical evidence of multiple organ involvement developing over a very short period of time, histopathological evidence of multiple small vessel occlusions and laboratory confirmation of the presence of aPL (lupus anticoagulant and/or anticardiolipin antibodies and/or anti-Beta2-glcyoprotein I antibodies). Here we report a case of a 39-year-old woman patient who developed a CAPS which was negative t...
Source: Clinical and Experimental Rheumatology - May 20, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

The relevance of cluster analyses to stratify systemic lupus erythematosus: increased mortality with heavier treatment.
Authors: De Marchi G, Quartuccio L, Zuliani F, Bond M, De Vita S Abstract ****************************************************************************. PMID: 28516870 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 20, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Myeloid Populations in Systemic Autoimmune Diseases
AbstractSystemic autoimmune diseases (SADs) encompass a wide spectrum of clinical signs as a reflection of their complex physiopathology. A variety of mechanisms related with the innate immune system are in the origin of the loss of self-tolerance in these diseases, and for most of them, the myeloid leukocytes are key actors. Monocytes, macrophages, dendritic cells, and neutrophils are first-line immune effectors located in the interface between innate and adaptive immunity. They are crucial in the organization of the local and systemic responses to damage-associated molecular patterns (DAMPs) and determine the intensity, ...
Source: Clinical Reviews in Allergy and Immunology - May 20, 2017 Category: Allergy & Immunology Source Type: research

Associations between PTPN22 and TLR9 polymorphisms and systemic lupus erythematosus: a comprehensive meta-analysis
AbstractPrevious studies have explored the relationship of PTPN22 and TLR9 polymorphisms with systemic lupus erythematosus (SLE). In consideration of the population stratification, conflicting results and updating data, we conducted a comprehensive meta-analysis, which consists of a total of 17 research articles (9120 cases and 11,724 controls) for PTPN22 and 20 articles (including up to 2808 cases and 3386 controls) for TLR9. Significant association was verified between PTPN22 rs2476601 and SLE in the overall population (OR  = 1.511 per T allele, 95% CI 1.338–1.706,P = 2.931 ×&nbs...
Source: Archives of Dermatological Research - May 20, 2017 Category: Dermatology Source Type: research

Pneumococcal infection in patients with systemic lupus erythematosus
Conclusion SLE is a disease of high susceptibility for invasive pneumococcal infections. Our study points to the need for vaccination against Streptococcus pneumoniae in SLE. (Source: Joint Bone Spine)
Source: Joint Bone Spine - May 19, 2017 Category: Orthopaedics Source Type: research

Unraveling the expression of microRNA ‐27a* & NKG2D in peripheral blood mononuclear cells and natural killer cells of pediatric systemic lupus erythematosus patients
ConclusionThe altered expression of the triad, miR‐27a* as well as NKG2D and ULBP2, is thought to be characteristic for NK cells in SLE patients. Hence, the ability of miR‐27a* to alter the expression of NKG2D may provide a new groundwork for understanding the role of miRNAs in NK cells of SLE patients. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - May 19, 2017 Category: Rheumatology Authors: Shady K. Sourour, Heba R. Aboelenein, Noha M. Elemam, Amira K. Abdelhamid, Samia Salah, Ahmed I. Abdelaziz Tags: Original Article Source Type: research

The Effects of Indirect- and Direct-Acting Anticoagulants on Lupus Anticoagulant Assays: A Large, Retrospective Study at a Coagulation Reference Laboratory.
Abstract Objectives: To investigate the effects of indirect- and direct-acting anticoagulants on the interpretation of lupus anticoagulant (LAC) assays. Methods: A retrospective database review was performed to identify all LAC panels from November 2012 to November 2015. The positivity rates for three LAC tests were compared among various anticoagulant medications. Results: This analysis included 7,721 LAC panels. Direct oral anticoagulants, warfarin, and unfractionated heparin (UFH) were associated with higher LAC positivity rates compared with patients not receiving documented anticoagulation (83% for ...
Source: American Journal of Clinical Pathology - May 19, 2017 Category: Pathology Authors: Seheult JN, Meyer MP, Bontempo FA, Chibisov I Tags: Am J Clin Pathol Source Type: research

Relapsed Hydroxychloroquine Induced Thrombocytopenia in Systemic Lupus Erythematosus Patient
We present one case of severe thrombocytopenia occurring in a patient with SLE undergoing treatment with Hydroxychloroquine. (Source: Reumatologia Clinica)
Source: Reumatologia Clinica - May 18, 2017 Category: Rheumatology Source Type: research

Thrombophilia risk is not increased in children after perinatal stroke
Perinatal stroke causes cerebral palsy and lifelong disability. Specific diseases are definable, but mechanisms are poorly understood. Evidence suggests possible associations between arterial perinatal stroke and prothrombotic disorders, but population-based, controlled, disease-specific studies are limited. Understanding thrombophilia in perinatal stroke informs pathogenesis models and clinical management. We conducted a population-based, prospective, case-control study to determine the association of specific perinatal stroke diseases with known thrombophilias. Children with idiopathic magnetic resonance imaging–cl...
Source: Blood - May 18, 2017 Category: Hematology Authors: Curtis, C., Mineyko, A., Massicotte, P., Leaker, M., Jiang, X. Y., Floer, A., Kirton, A. Tags: Pediatric Hematology, Free Research Articles, Thrombosis and Hemostasis, Vascular Biology, CME article Source Type: research

Pregnancy and Glomerular Disease: A Systematic Review of the Literature with Management Guidelines.
Abstract During pregnancy, CKD increases both maternal and fetal risk. Adverse maternal outcomes include progression of underlying renal dysfunction, worsening of urine protein, and hypertension, whereas adverse fetal outcomes include fetal loss, intrauterine growth restriction, and preterm delivery. As such, pregnancy in young women with CKD is anxiety provoking for both the patient and the clinician providing care, and because the heterogeneous group of glomerular diseases often affects young women, this is an area of heightened concern. In this invited review, we discuss pregnancy outcomes in young women with g...
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 18, 2017 Category: Urology & Nephrology Authors: Blom K, Odutayo A, Bramham K, Hladunewich MA Tags: Clin J Am Soc Nephrol Source Type: research

Linear cutaneous lupus erythematosus/discoid lupus erythematosus in an adult.
Authors: Mao QX, Zhang WL, Wang Q, Xiao XM, Chen H, Shao XB, Jia H, Feng SY, Wu JB, Li CR PMID: 28507499 [PubMed - in process] (Source: Advances in Dermatology and Allergology)
Source: Advances in Dermatology and Allergology - May 17, 2017 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Successful treatment of a 20-year nonhealing venous leg ulcer in a patient with systemic lupus erythematosus.
Authors: Yildiz CE, Conkbayir C, Tolgay HE, Ceviker K, Canikoglu M, Sayin OA, Ugurlucan M PMID: 28507589 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Henoch-Sch önlein purpura in a pediatric patient with lupus.
Henoch-Schönlein purpura in a pediatric patient with lupus. Arch Med Sci. 2017 Apr 01;13(3):689-690 Authors: Hu P, Huang BY, Zhang DD, Jiang GM, Liu SY, Xia X, Cai J PMID: 28507588 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Longterm Hydroxychloroquine Therapy and Low-dose Aspirin May Have an Additive Effectiveness in the Primary Prevention of Cardiovascular Events in Patients with Systemic Lupus Erythematosus.
Authors: Fasano S, Pierro L, Pantano I, Iudici M, Valentini G Abstract OBJECTIVE: Systemic lupus erythematosus (SLE) is associated with an increased risk of cardiovascular disease (CVD). Thromboprophylaxis with low-dose aspirin (ASA) and hydroxychloroquine (HCQ) seems promising in SLE. We investigated the effects of HCQ cumulative dosages (c-HCQ) and the possible synergistic efficacy of ASA and HCQ in preventing a first CV event (CVE) in patients with SLE. METHODS: Patients consecutively admitted to our center who, at admission, satisfied the 1997 American College of Rheumatology and/or 2012 Systemic Lupus Coll...
Source: Journal of Rheumatology - May 17, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Intractable Cutaneous Nontuberculous Mycobacteriosis (Mycobacterium abscessus) during Treatment for Systemic Lupus Erythematosus.
Authors: Kishida D, Sato M, Kobayashi C, Ueno KI, Kinoshita T, Kodaira M, Shimojima Y, Ishii W, Ushiki A, Ikeda SI Abstract Mycobacterium abscessus infection tends to occur in patients with an advanced immunocompromised status. We encountered a case of intractable cutaneous M. abscessus infection that developed in a patient with systemic lupus erythematosus (SLE) during maintenance therapy. A 28-year-old woman developed a fever and redness of the skin on her buttocks. General antibacterial therapy was ineffective, and acid-fast bacteria were detected in the biopsy that was conducted to differentiate the dermal symp...
Source: Internal Medicine - May 17, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Brain Biopsy Is More Reliable than the DNA test for JC Virus in Cerebrospinal Fluid for the Diagnosis of Progressive Multifocal Leukoencephalopathy.
Authors: Ikeda J, Matsushima A, Ishii W, Goto T, Takahashi K, Nakamichi K, Saijo M, Sekijima Y, Ikeda SI Abstract The current standard diagnostic approach for progressive multifocal leukoencephalopathy (PML) is to perform a DNA test to identify the presence of the JC virus in cerebrospinal fluid (CSF). A 32-year-old woman with a 5-year history of systemic lupus erythematosus developed right hemiplegia and motor aphasia. MRI revealed a large white matter lesion in the left frontal lobe. JC virus DNA was undetectable in the CSF, but a brain biopsy showed typical histopathology and a high DNA load of the JC virus. The...
Source: Internal Medicine - May 17, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Successful Treatment of Catastrophic Antiphospholipid Antibody Syndrome Associated with MALT Lymphoma by Autologous Hematopoietic Stem Cell Transplantation.
Authors: Oka S, Ono K, Nohgawa M Abstract A 37-year-old woman with extranodal marginal-zone lymphoma was admitted with a fever, hemiplegia, and severe dyspnea after chemotherapy. Catastrophic antiphospholipid antibody syndrome (CAPS) was suspected based on the histopathological confirmation of small-pulmonary vessel occlusion, evidence of the involvement of three organs, and elevated lupus anticoagulant assay results in a short time span. The patient responded to the initial treatment. One month later, the CAPS and lymphoma relapsed, and the patient underwent autologous hematopoietic stem cell transplantation. Comp...
Source: Internal Medicine - May 17, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Longitudinal quasi-static stability predicts changes in dog gait on rough terrain [RESEARCH ARTICLE]
Simon Wilshin, Michelle A. Reeve, G. Clark Haynes, Shai Revzen, Daniel E. Koditschek, and Andrew J. Spence Legged animals utilize gait selection to move effectively and must recover from environmental perturbations. We show that on rough terrain, domestic dogs, Canis lupus familiaris, spend more time in longitudinal quasi-statically stable patterns of movement. Here, longitudinal refers to the rostro-caudal axis. We used an existing model in the literature to quantify the longitudinal quasi-static stability of gaits neighbouring the walk, and found that trot-like gaits are more stable. We thus hypothesized that when pertu...
Source: Journal of Experimental Biology - May 17, 2017 Category: Biology Authors: Wilshin, S., Reeve, M. A., Haynes, G. C., Revzen, S., Koditschek, D. E., Spence, A. J. Tags: RESEARCH ARTICLE Source Type: research

Assessment of condyle, masseter and temporal muscles volumes in patients with juvenile systemic lupus erythematosus: A cross-sectional study
Conclusion This study suggested that volume of the target structures has no correlation with cumulative corticosteroid dose, disease activity, and malocclusion. (Source: Journal of Oral Biology and Craniofacial Research)
Source: Journal of Oral Biology and Craniofacial Research - May 17, 2017 Category: Dentistry Source Type: research

Belimumab in the management of systemic lupus erythematosus – an update
. (Source: Expert Opinion on Biological Therapy)
Source: Expert Opinion on Biological Therapy - May 16, 2017 Category: Drugs & Pharmacology Authors: Vladimir Tesar Zdenka Hruskova Source Type: research

Malignancy as a comorbidity in rheumatic diseases: a retrospective hospital-based study
AbstractPatients with Rheumatic diseases (RDs) are at an increased risk of malignancies compared with the general population. The aim of this study was to examine the relative frequency of several cancers in a single homogeneous cohort of patients with different RDs. Patients diagnosed with rheumatoid arthritis (RA), Ankylosing spondylitis (AS), Sj ögren’s syndrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis (DM), or polymyositis were included. Out of 3982 adult residents admitted to the division of rheumatology, 61 malignancies were observed. The 2009 National Central Can...
Source: Clinical Rheumatology - May 16, 2017 Category: Rheumatology Source Type: research

Erratum for the Research Article: "Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus" by I. A. Buskiewicz, T. Montgomery, E. C. Yasewicz, S. A. Huber, M. P. Murphy, R. C. Hartley, R. Kelly, M. K. Crow, A. Perl, R. C. Budd, A. Koenig.
Erratum for the Research Article: "Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus" by I. A. Buskiewicz, T. Montgomery, E. C. Yasewicz, S. A. Huber, M. P. Murphy, R. C. Hartley, R. Kelly, M. K. Crow, A. Perl, R. C. Budd, A. Koenig. Sci Signal. 2017 May 16;10(479): Authors: PMID: 28512148 [PubMed - in process] (Source: Science Signaling)
Source: Science Signaling - May 16, 2017 Category: Biomedical Science Tags: Sci Signal Source Type: research

Novel enzyme immunoassay system for simultaneous detection of six subclasses of antiphospholipid antibodies for differential diagnosis of antiphospholipid syndrome
Antiphospholipid syndrome, which often complicates systemic lupus erythematosus (SLE), features high occurrence of arterial and/or venous thrombosis and recurrent fetal loss. However, which antibody subclass contributes to which clinical event remains uncertain. We newly developed an up-to-date enzyme immunoassay system using the AcuStar automated analyzer (Instrumentation Laboratory, Bedford, Massachusetts, USA) for parallel detection of six subclasses of antiphospholipid antibodies (aPLs): anticardiolipin antibodies (aCL) of IgG, IgM, and IgA and anti-β2-glycoprotein I antibodies (aβ2GPI) of IgG, IgM, and IgA. ...
Source: Blood Coagulation and Fibrinolysis - May 15, 2017 Category: Hematology Tags: Original Articles Source Type: research

Fc Gamma Receptor IIB Deficient Mice: A Lupus Model with Increased Endotoxin Tolerance-Related Sepsis Susceptibility
In conclusion, repeated-LPS administrations induced quantitatively greater endotoxin-tolerance responses in FcGRIIb−/− mice both in vivo and in vitro. Endotoxin-tolerance in vivo was associated with more severe sepsis, at least in part, due to macrophage-dysfunction. (Source: Shock)
Source: Shock - May 15, 2017 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Incidence of Vertebral Fractures in Women with Systemic Lupus Erythematosus After 8 Years of Follow-Up
AbstractThe aim of this study was to evaluate possible associations between potential risk factors and the occurrence of established vertebral fractures (VF) in Mexican patients with systemic lupus erythematosus (SLE). Consecutive patients with SLE were enrolled in a prospective, observational study from 2006 to 2015. Information on potential risk factors, including demographics, clinical data, and bone mineral density (BMD) at the lumbar spine and hip on dual-energy X-ray absorptiometry was collected at baseline and follow-up. Semiquantitative analysis was used to determine incident VF on lateral thoracic and lumbar radio...
Source: Calcified Tissue International - May 15, 2017 Category: Orthopaedics Source Type: research