Acute myocardial infarction due to spontaneous coronary artery dissection in a young male with systemic lupus erythematosus: A case report
Exp Ther Med. 2024 Apr 9;27(6):246. doi: 10.3892/etm.2024.12534. eCollection 2024 Jun.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disease which typically presents in young women. Patients with SLE exhibit features of accelerated atherosclerosis. Here, the present study reported a rare case of acute myocardial infarction (AMI) in a male patient diagnosed with SLE. A 29-year-old male with no cardiovascular history was diagnosed with AMI and underwent coronary angiography, which showed a long-extended spiral-shaped dissection of the right coronary artery (RCA). The patient's autoimmune panel tested positive fo...
Source: Experimental and Therapeutic Medicine - April 24, 2024 Category: General Medicine Authors: Yunyi Li Quan Zhou Xiao Meng Source Type: research
Induction treatment for lupus nephritis at a high-complexity hospital in Chile
CONCLUSION: This study did not find significant differences in the clinical response to IVC or MMF at 6 months. Future prospective studies are required to determine the optimal induction therapy for LN, especially in Latin populations.PMID:38652826 | DOI:10.1177/09612033241249574 (Source: Lupus)
Source: Lupus - April 23, 2024 Category: Rheumatology Authors: Paulina Ramirez Andres Giglio Jorge Verdugo Francisco Gutierrez Source Type: research
GSE264393 Multiscale topology classifies and quantifies cell types in subcellular spatial transcriptomics [human snRNA-seq]
Contributors : Katherine Benjamin ; Aneesha Bhandari ; Jessica D Kepple ; Rui Qi ; Zhouchun Shang ; Yanan Xing ; Yanru An ; Nannan Zhang ; Yong Hou ; Tanya L Crockford ; Oliver MacCallion ; Fadi Issa ; Joanna Hester ; Ulrike Tillmann ; Heather A Harrington ; Katherine R BullSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSpatial transcriptomics has the potential to transform our understanding of RNA expression in tissues. Classical array-based technologies produce multiple-cell-scale measurements requiring deconvolution to recover single cell information. However, rapid a...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE264334 Multiscale topology classifies and quantifies cell types in subcellular spatial transcriptomics [Xenium]
Contributors : Katherine Benjamin ; Aneesha Bhandari ; Jessica D Kepple ; Rui Qi ; Zhouchun Shang ; Yanan Xing ; Yanru An ; Nannan Zhang ; Yong Hou ; Tanya L Crockford ; Oliver MacCallion ; Fadi Issa ; Joanna Hester ; Ulrike Tillmann ; Heather A Harrington ; Katherine R BullSeries Type : OtherOrganism : Homo sapiensSpatial transcriptomics has the potential to transform our understanding of RNA expression in tissues. Classical array-based technologies produce multiple-cell-scale measurements requiring deconvolution to recover single cell information. However, rapid advances in subcellular measurement of RNA exp...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE264321 Multiscale topology classifies and quantifies cell types in subcellular spatial transcriptomics [stereo-seq]
Contributors : Katherine Benjamin ; Aneesha Bhandari ; Jessica D Kepple ; Rui Qi ; Zhouchun Shang ; Yanan Xing ; Yanru An ; Nannan Zhang ; Yong Hou ; Tanya L Crockford ; Oliver MacCallion ; Fadi Issa ; Joanna Hester ; Ulrike Tillmann ; Heather A Harrington ; Katherine R BullSeries Type : OtherOrganism : Mus musculusSpatial transcriptomics has the potential to transform our understanding of RNA expression in tissues. Classical array-based technologies produce multiple-cell-scale measurements requiring deconvolution to recover single cell information. However, rapid advances in subcellular measurement of RNA exp...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
Targeting T-bet expressing B cells for therapeutic interventions in autoimmunity
Clin Exp Immunol. 2024 Apr 22:uxae036. doi: 10.1093/cei/uxae036. Online ahead of print.ABSTRACTApart from serving as a Th1 lineage commitment regulator, transcription factor T-bet is also expressed in other immune cell types and thus orchestrates their functions. In case of B cells, more specifically, T-bet is responsible for their isotype switching to specific IgG sub-classes (IgG2a/c in mice and IgG1/3 in humans). In various autoimmune disorders, such as systemic lupus erythematosus and/or rheumatoid arthritis, subsets of T-bet expressing B cells, known as age-associated B cells (CD19+CD11c+CD21-T-bet+) and/or double-neg...
Source: Clinical and Developmental Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Athanasios Sachinidis Malamatenia Lamprinou Theodoros Dimitroulas Alexandros Garyfallos Source Type: research
A Case of Palmoplantar Keratoderma in the Constellation of Connective Tissue Diseases
Cureus. 2024 Mar 20;16(3):e56531. doi: 10.7759/cureus.56531. eCollection 2024 Mar.ABSTRACTOverlap syndrome is a clinical challenge and brings together a wide range of treatment options for the treating physician. Addressing each and every complaint of the patient is crucial. A 50-year-old female patient presented with skin thickening, blackening, and hyperkeratosis; dysphagia; joint pain; features of myopathy; Raynaud's phenomenon; and dry mouth. Inflammatory markers were raised along with a positive antinuclear antibody (ANA) with Golgi apparatus pattern, anti-Sjögren's-syndrome-related antigen A (anti-SSA)/Ro60 3+, anti...
Source: Pain Physician - April 22, 2024 Category: Anesthesiology Authors: Ishan Verma Amol H Dube Sunita Kumbhalkar Keshao Nagpure Gitesh Sawatkar Sachin R Chuadhari Ashwini Umredkar Source Type: research
Potential therapies targeting metabolic pathways in systemic lupus erythematosus
Clin Immunol. 2024 Apr 20:110224. doi: 10.1016/j.clim.2024.110224. Online ahead of print.ABSTRACTThe pathophysiology of systemic lupus erythematosus (SLE) is multifactorial and involves alterations in metabolic pathways, including glycolysis, lipid metabolism, amino acid metabolism, and mitochondrial dysfunction. Increased glycolysis in SLE T cells, which is associated with elevated glucose transporter 1 expression, suggests targeting glucose transporters and hexokinase as potential treatments. Abnormalities in lipid metabolism, particularly in lipid rafts and enzymes, present new therapeutic targets. This review discusses...
Source: Clinical Immunology - April 22, 2024 Category: Allergy & Immunology Authors: Ryo Hisada Michihito Kono Source Type: research
A panel of tetranucleotide STR markers as an alternative approach to forensic DNA identification of wolf and dog
Anim Genet. 2024 Apr 21. doi: 10.1111/age.13428. Online ahead of print.ABSTRACTCommercial panels of microsatellite (STR) loci are focused on the use of DNA of the domestic dog (Canis lupus familiaris) and are often inapplicable for genotyping the DNA of the gray wolf (Canis lupus lupus). We propose a CPlex test system, including one hexa- and 12 tetranucleotide autosomal STR loci, as well as two sex loci, that is equally efficient in DNA identification of biological samples of the wolf and the dog. Analysis of molecular variance between samples revealed significant differentiation values (FST = 0.0784, p < 0.001), which...
Source: Animal Genetics - April 22, 2024 Category: Genetics & Stem Cells Authors: Aliaksandra E Hrebianchuk Nastassia S Parfionava Tatsiana V Zabauskaya Iosif S Tsybovsky Source Type: research
Structural basis for the recognition of IFNAR1 by the humanized therapeutic monoclonal antibody QX006N for the treatment of systemic lupus erythematosus
Int J Biol Macromol. 2024 Apr 20:131721. doi: 10.1016/j.ijbiomac.2024.131721. Online ahead of print.ABSTRACTInterferon (IFN) alpha/beta receptor 1 (IFNAR1) is indispensable for antiviral responses and the immune regulation. Dysregulation of the IFNAR1-mediaetd signaling pathways leads to deleterious autoimmune diseases such as systemic lupus erythematosus (SLE). QX006N, a humanized therapeutic monoclonal antibody, specifically targets human IFNAR1 and is in the clinical trial phase for treating SLE, but the molecular mechanism underlying the QX006N-mediated recognition of IFNAR1 remains unclear. Here, we report the high ne...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Xiaorong Chen Huimin Ke Wei Li Lu Yin Wei Chen Tao Chen Yiliang Wu Jiwan Qiu Wei Feng Source Type: research
T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activity
Systemic lupus erythematosus (SLE) is distinguished by an extensive range of clinical heterogeneity with unpredictable disease flares and organ damage. This research investigates the potential of aberrant sign... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 22, 2024 Category: Biomedical Science Authors: Chin-Man Wang, Yeong-Jian Jan Wu, Jian-Wen Zheng, Li Yu Huang, Keng Poo Tan and Ji-Yih Chen Tags: Research Source Type: research
Multi-omics study reveals different pathogenesis of the generation of skin lesions in SLE and IDLE patients
J Autoimmun. 2024 Apr 20;146:103203. doi: 10.1016/j.jaut.2024.103203. Online ahead of print.ABSTRACTLupus erythematosus (LE) is a heterogeneous, antibody-mediated autoimmune disease. Isolate discoid LE (IDLE) and systematic LE (SLE) are traditionally regarded as the two ends of the spectrum, ranging from skin-limited damage to life-threatening multi-organ involvement. Both belong to LE, but IDLE and SLE differ in appearance of skin lesions, autoantibody panels, pathological changes, treatments, and immunopathogenesis. Is discoid lupus truly a form of LE or is it a completely separate entity? This question has not been full...
Source: Journal of Autoimmunity - April 21, 2024 Category: Allergy & Immunology Authors: Qianwen Li Chen Jia Wenjing Pan Hongmei Liu Congli Tang Daniel Weber Kaili Chen Hai Long Miranda L Byrne-Steele Jian Han Nongyue He Rong Xiao Ming Zhao Nan Che Qing Guo Guangji Gui Shanshan Li Henan Si Shuping Guo Hongye Liu Gang Wang Guannan Zhu Bin Yang Source Type: research
UHRF1P contributes to IL-17A-mediated systemic lupus erythematosus via UHRF1-MAP4K3 axis
J Autoimmun. 2024 Apr 20;146:103221. doi: 10.1016/j.jaut.2024.103221. Online ahead of print.ABSTRACTInflammatory T cells contribute to the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Analysis of the T-cell transcriptomics data of two independent SLE patient cohorts by three machine learning models revealed the pseudogene UHRF1P as a novel SLE biomarker. The pseudogene-encoded UHRF1P protein was overexpressed in peripheral blood T cells of SLE patients. The UHRF1P protein lacks the amino-terminus of its parental UHRF1 protein, resulting in missing the proteasome-binding ubiquitin-like (Ub...
Source: Journal of Autoimmunity - April 21, 2024 Category: Allergy & Immunology Authors: Huai-Chia Chuang Kuei-Yuan Lan Pu-Ming Hsu Ming-Han Chen Yi-Ming Chen Jeng-Hsien Yen Ben-Yang Liao Tse-Hua Tan Source Type: research
Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8 < sup > + < /sup > T cells via suppressing IL-15/STAT3 pathway
Biomed Pharmacother. 2024 Apr 20;174:116597. doi: 10.1016/j.biopha.2024.116597. Online ahead of print.ABSTRACTZhen-Wu-Tang (ZWT), a conventional herbal mixture, has been recommended for treating lupus nephritis (LN) in clinic. However, its mechanisms of action remain unknown. Here we aimed to define the immunological mechanisms underlying the effects of ZWT on LN and to determine whether it affects renal tissue-resident memory T (TRM) cells. Murine LN was induced by a single injection of pristane, while in vitro TRM cells differentiated with IL-15/TGF-β. We found that ZWT or mycophenolate mofetil treatment significantly a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Chun-Ling Liang Yu-Yan Wei Yi Chen Yini Luo Fenglian Qin Yuchao Chen Huazhen Liu Feifei Qiu Junbiao Wu Bin Yang Yuntao Liu Zhenhua Dai Source Type: research
New method to differentiate between lupus anticoagulants, progressive coagulation inhibitors and coagulation factor deficiencies in the mixing tests
CONCLUSIONS: ALD50 and WaS showed acceptable sensitivity and specificity to LA and progressive coagulation factor inhibitor, respectively. These indexes would be useful for the differentiation between LA, factor deficiency, and progressive coagulation factor inhibitor in the mixing tests.PMID:38644054 | DOI:10.1111/ijlh.14289 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 21, 2024 Category: Hematology Authors: Daiki Shimomura Osamu Kumano Kaori Ueda Keisuke Kitano Nobuo Arai Masashi Shimada Mikio Kamioka Source Type: research
