T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activity
Systemic lupus erythematosus (SLE) is distinguished by an extensive range of clinical heterogeneity with unpredictable disease flares and organ damage. This research investigates the potential of aberrant sign... (Source: Journal of Biomedical Science)
Source: Journal of Biomedical Science - April 22, 2024 Category: Biomedical Science Authors: Chin-Man Wang, Yeong-Jian Jan Wu, Jian-Wen Zheng, Li Yu Huang, Keng Poo Tan and Ji-Yih Chen Tags: Research Source Type: research
Multi-omics study reveals different pathogenesis of the generation of skin lesions in SLE and IDLE patients
J Autoimmun. 2024 Apr 20;146:103203. doi: 10.1016/j.jaut.2024.103203. Online ahead of print.ABSTRACTLupus erythematosus (LE) is a heterogeneous, antibody-mediated autoimmune disease. Isolate discoid LE (IDLE) and systematic LE (SLE) are traditionally regarded as the two ends of the spectrum, ranging from skin-limited damage to life-threatening multi-organ involvement. Both belong to LE, but IDLE and SLE differ in appearance of skin lesions, autoantibody panels, pathological changes, treatments, and immunopathogenesis. Is discoid lupus truly a form of LE or is it a completely separate entity? This question has not been full...
Source: Journal of Autoimmunity - April 21, 2024 Category: Allergy & Immunology Authors: Qianwen Li Chen Jia Wenjing Pan Hongmei Liu Congli Tang Daniel Weber Kaili Chen Hai Long Miranda L Byrne-Steele Jian Han Nongyue He Rong Xiao Ming Zhao Nan Che Qing Guo Guangji Gui Shanshan Li Henan Si Shuping Guo Hongye Liu Gang Wang Guannan Zhu Bin Yang Source Type: research
UHRF1P contributes to IL-17A-mediated systemic lupus erythematosus via UHRF1-MAP4K3 axis
J Autoimmun. 2024 Apr 20;146:103221. doi: 10.1016/j.jaut.2024.103221. Online ahead of print.ABSTRACTInflammatory T cells contribute to the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Analysis of the T-cell transcriptomics data of two independent SLE patient cohorts by three machine learning models revealed the pseudogene UHRF1P as a novel SLE biomarker. The pseudogene-encoded UHRF1P protein was overexpressed in peripheral blood T cells of SLE patients. The UHRF1P protein lacks the amino-terminus of its parental UHRF1 protein, resulting in missing the proteasome-binding ubiquitin-like (Ub...
Source: Journal of Autoimmunity - April 21, 2024 Category: Allergy & Immunology Authors: Huai-Chia Chuang Kuei-Yuan Lan Pu-Ming Hsu Ming-Han Chen Yi-Ming Chen Jeng-Hsien Yen Ben-Yang Liao Tse-Hua Tan Source Type: research
Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8 < sup > + < /sup > T cells via suppressing IL-15/STAT3 pathway
Biomed Pharmacother. 2024 Apr 20;174:116597. doi: 10.1016/j.biopha.2024.116597. Online ahead of print.ABSTRACTZhen-Wu-Tang (ZWT), a conventional herbal mixture, has been recommended for treating lupus nephritis (LN) in clinic. However, its mechanisms of action remain unknown. Here we aimed to define the immunological mechanisms underlying the effects of ZWT on LN and to determine whether it affects renal tissue-resident memory T (TRM) cells. Murine LN was induced by a single injection of pristane, while in vitro TRM cells differentiated with IL-15/TGF-β. We found that ZWT or mycophenolate mofetil treatment significantly a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Chun-Ling Liang Yu-Yan Wei Yi Chen Yini Luo Fenglian Qin Yuchao Chen Huazhen Liu Feifei Qiu Junbiao Wu Bin Yang Yuntao Liu Zhenhua Dai Source Type: research
New method to differentiate between lupus anticoagulants, progressive coagulation inhibitors and coagulation factor deficiencies in the mixing tests
CONCLUSIONS: ALD50 and WaS showed acceptable sensitivity and specificity to LA and progressive coagulation factor inhibitor, respectively. These indexes would be useful for the differentiation between LA, factor deficiency, and progressive coagulation factor inhibitor in the mixing tests.PMID:38644054 | DOI:10.1111/ijlh.14289 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 21, 2024 Category: Hematology Authors: Daiki Shimomura Osamu Kumano Kaori Ueda Keisuke Kitano Nobuo Arai Masashi Shimada Mikio Kamioka Source Type: research
Significance of immunoglobulins synthesis with central nervous system involvement in Neuro-Beh çet's disease
CONCLUSIONS: IgA index acts as a potential diagnostic indicator in differentiating NBD from NIND and CNS-IIDD. Excessive immunoglobulin production induced by CNS inflammation and demyelination might be latent immunopathogenesis of NBD.PMID:38643816 | DOI:10.1016/j.cca.2024.119681 (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - April 21, 2024 Category: Chemistry Authors: Haoting Zhan Linlin Cheng Yeling Liu Honglin Xu Xinxin Feng Yongmei Liu Haolong Li Zhan Li Siyu Wang Haiqiang Jin Wenjie Zheng Hongjun Hao Yongzhe Li Source Type: research
Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8 < sup > + < /sup > T cells via suppressing IL-15/STAT3 pathway
Biomed Pharmacother. 2024 Apr 20;174:116597. doi: 10.1016/j.biopha.2024.116597. Online ahead of print.ABSTRACTZhen-Wu-Tang (ZWT), a conventional herbal mixture, has been recommended for treating lupus nephritis (LN) in clinic. However, its mechanisms of action remain unknown. Here we aimed to define the immunological mechanisms underlying the effects of ZWT on LN and to determine whether it affects renal tissue-resident memory T (TRM) cells. Murine LN was induced by a single injection of pristane, while in vitro TRM cells differentiated with IL-15/TGF-β. We found that ZWT or mycophenolate mofetil treatment significantly a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 21, 2024 Category: Drugs & Pharmacology Authors: Chun-Ling Liang Yu-Yan Wei Yi Chen Yini Luo Fenglian Qin Yuchao Chen Huazhen Liu Feifei Qiu Junbiao Wu Bin Yang Yuntao Liu Zhenhua Dai Source Type: research
Disrupting B and T cell Collaboration in Autoimmune Disease: T cell engagers versus CAR T cell therapy?
Clin Exp Immunol. 2024 Apr 20:uxae031. doi: 10.1093/cei/uxae031. Online ahead of print.ABSTRACTB and T cells collaborate to drive autoimmune disease (AID). Historically, B and T cell (B-T cell) co-interaction was targeted through different pathways such as alemtuzumab, abatacept, and dapirolizumab with variable impact on B cell depletion (BCD), whereas the majority of patients with AID including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and organ transplantation benefit from targeted BCD with anti-CD20 monoclonal antibodies such as rituximab, ocrelizumab or ofatumumab. Refractory AID is a signi...
Source: Clinical and Developmental Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Kavina Shah Maria Leandro Mark Cragg Florian Kollert Franz Schuler Christian Klein Venkat Reddy Source Type: research
Anti-U1RNP antibodies are associated with a distinct clinical phenotype and a worse survival in patients with systemic sclerosis
CONCLUSIONS: In SSc patients, anti-U1RNP antibodies are associated with a higher incidence of overlap syndrome, a distinct clinical phenotype, and poorer survival compared to SSc-RNP- and MCTD patients. Our study suggests that SSc-RNP+ patients should be separated from MCTD patients and may constitute an enriched population for progressive lung disease.PMID:38642508 | DOI:10.1016/j.jaut.2024.103220 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - April 20, 2024 Category: Allergy & Immunology Authors: Kevin Chevalier Guillaume Chassagnon Sarah Leonard-Louis Pascal Cohen Bertrand Dunogue Alexis Regent Benjamin Thoreau Luc Mouthon Benjamin Chaigne Source Type: research
Relevance of acquired T cell molecular defects in the immunopathogenesis of SLE
Clin Immunol. 2024 Apr 18:110225. doi: 10.1016/j.clim.2024.110225. Online ahead of print.ABSTRACTSystemic lupus erythematosus (SLE) and other autoimmune diseases are thought to develop in genetically predisposed individuals when triggered by environmental factors. This paradigm does not fully explain disease development, as it fails to consider the delay between birth and disease expression. In this review, we discuss observations described in T cells from patients with SLE that are not related to hereditary factors and have therefore been considered secondary to the disease process itself. Here, we contextualize some of t...
Source: Clinical Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Florencia Rosetti Iris K Madera-Salcedo Jos é C Crispín Source Type: research
