Correction: Lupus low disease activity state attainment in the phase 3 TULIP trials of anifrolumab in active systemic lupus erythematosus
Morand EF, Abreu G, Furie RA, et al. Lupus low disease activity state attainment in the phase 3 TULIP trials of anifrolumab in active systemic lupus erythematosus. Annals of the Rheumatic Diseases 2023;82:639-645. This note aims to correct an error in the DORIS (Definition of Remission in SLE) data in the Morand E, et al. (2023) article. In the version of this article initially published, analyses of DORIS remission excluded all laboratory parameters in the calculation of clinical SLEDAI-2K (cSLEDAI-2K), consistent with the cSLEDAI-2K definition in the TULIP protocols. The updated analysis aligns with the published DORIS r...
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Tags: ARD Correction Source Type: research
Single-cell profiling reveals kidney CD163+ dendritic cell participation in human lupus nephritis
Conclusion
The intricate interplay involving DC3s, T cells and tubular epithelial cells within kidneys may substantially contribute to LN pathogenesis. The enumeration of renal DC3 holds potential as a valuable stratification feature for guiding LN patient treatment decisions in clinical practice. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - April 11, 2024 Category: Rheumatology Authors: Chen, W., Jin, B., Cheng, C., Peng, H., Zhang, X., Tan, W., Tang, R., Lian, X., Diao, H., Luo, N., Li, X., Fan, J., Shi, J., Yin, C., Wang, J., Peng, S., Yu, L., Li, J., Wu, R.-Q., Kuang, D.-M., Shi, G.-P., Zhou, Y., Wang, F., Jiang, X. Tags: ARD, Autoimmunity Source Type: research
SARS-CoV-2 Mu variant in dogs visiting veterinary clinics during the third pandemic peak in Eastern Colombia
Vet Res Commun. 2024 Apr 10. doi: 10.1007/s11259-024-10374-4. Online ahead of print.ABSTRACTThe global presence of SARS-CoV-2 in household pets is acknowledged, yet documentation remains scarce, leaving many regions unexplored. Thus, our study sought to fill this gap by investigating SARS-CoV-2 presence in dogs visiting veterinary clinics during the third pandemic peak in eastern Colombia. We collected and analyzed 43 oropharyngeal and rectal swabs using real-time PCR assays targeting the Envelope Gene of SARS-CoV-2. Out of these, two dogs tested positive, indicating an infection rate of 4.7%. Further examination through c...
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Claudia Magaly Sandoval-Ram írez Nathalia Ballesteros Juan Carlos Pinilla Carolina Hern ández Marina Mu ñoz Juan David Ram írez Source Type: research
Considering belimumab during pregnancy: A more viable option over time
CONCLUSIONS: Belimumab may be an option for pregnant women with difficult-to-control lupus. Further research is needed to confirm the absence of association between belimumab and foetal harm.PMID:38594808 | DOI:10.1177/09612033241245549 (Source: Lupus)
Source: Lupus - April 10, 2024 Category: Rheumatology Authors: Paloma Vela-Casasempere Roc ío Caño Alameda Silvia G ómez Sabater Silvia Cortell Aznar Encarnaci ón Pérez Pascual Source Type: research
Automatic classification of immune-mediated glomerular diseases based on multi-modal multi-instance learning
CONCLUSION: This multi- modal multi- instance model based on OM, IM, and TEM images can achieve automatic classification of immune-mediated glomerular diseases with a good classification accuracy.PMID:38597451 | DOI:10.12122/j.issn.1673-4254.2024.03.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: K Long D Weng J Geng Y Lu Z Zhou L Cao Source Type: research
< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research
Considering belimumab during pregnancy: A more viable option over time
CONCLUSIONS: Belimumab may be an option for pregnant women with difficult-to-control lupus. Further research is needed to confirm the absence of association between belimumab and foetal harm.PMID:38594808 | DOI:10.1177/09612033241245549 (Source: Lupus)
Source: Lupus - April 10, 2024 Category: Rheumatology Authors: Paloma Vela-Casasempere Roc ío Caño Alameda Silvia G ómez Sabater Silvia Cortell Aznar Encarnaci ón Pérez Pascual Source Type: research
Automatic classification of immune-mediated glomerular diseases based on multi-modal multi-instance learning
CONCLUSION: This multi- modal multi- instance model based on OM, IM, and TEM images can achieve automatic classification of immune-mediated glomerular diseases with a good classification accuracy.PMID:38597451 | PMC:PMC11006708 | DOI:10.12122/j.issn.1673-4254.2024.03.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: K Long D Weng J Geng Y Lu Z Zhou L Cao Source Type: research
< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | PMC:PMC11006693 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research
Automatic classification of immune-mediated glomerular diseases based on multi-modal multi-instance learning
CONCLUSION: This multi- modal multi- instance model based on OM, IM, and TEM images can achieve automatic classification of immune-mediated glomerular diseases with a good classification accuracy.PMID:38597451 | PMC:PMC11006708 | DOI:10.12122/j.issn.1673-4254.2024.03.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: K Long D Weng J Geng Y Lu Z Zhou L Cao Source Type: research
< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | PMC:PMC11006693 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research
Automatic classification of immune-mediated glomerular diseases based on multi-modal multi-instance learning
CONCLUSION: This multi- modal multi- instance model based on OM, IM, and TEM images can achieve automatic classification of immune-mediated glomerular diseases with a good classification accuracy.PMID:38597451 | PMC:PMC11006708 | DOI:10.12122/j.issn.1673-4254.2024.03.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: K Long D Weng J Geng Y Lu Z Zhou L Cao Source Type: research
< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | PMC:PMC11006693 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research
Automatic classification of immune-mediated glomerular diseases based on multi-modal multi-instance learning
CONCLUSION: This multi- modal multi- instance model based on OM, IM, and TEM images can achieve automatic classification of immune-mediated glomerular diseases with a good classification accuracy.PMID:38597451 | PMC:PMC11006708 | DOI:10.12122/j.issn.1673-4254.2024.03.21 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: K Long D Weng J Geng Y Lu Z Zhou L Cao Source Type: research
< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | PMC:PMC11006693 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research
