Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Autoimmune disease flares: stress, grief, and management tips
Autoimmune diseases occur when the immune system mistakenly attacks healthy cells and tissues in the body. More than 80 recognized autoimmune diseases exist, including alopecia areata, rheumatoid arthritis, psoriasis, lupus, multiple sclerosis, celiac disease, scleroderma, and Raynaud’s. These conditions can cause a wide range of symptoms, making management crucial for maintaining a good quality of
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Autoimmune disease flares: stress, grief, and management tips originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 4, 2024 Category: General Medicine Authors: Nancie Wiseman Attwater Tags: Conditions Rheumatology Source Type: blogs
Efferocytosis in the Context of Aging and Age-Related Disease
There is something of a tradition in the aging research community of writing reviews that attempt to summarize everything that is known of a single specific cellular behavior in the context of the panoply of cell and tissue dysfunction observed in aging. Today it is the turn of efferocytosis, the clearance of dying cells and their immediate debris by phagocytes such as macrophages of the innate immune system. It is fairly straightforward to mount an argument to suggest that more efficient efferocytosis is a good thing, as unwanted consequences attend the presence of lingering cell corpses cluttering up tissue. Like autopha...
Source: Fight Aging! - April 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pulmonary Arterial Hypertension: Unraveling Its Impact On Heart And Lungs
Conclusion
Navigating the complexities of Pulmonary Arterial Hypertension (PAH) might seem daunting. However, with the right knowledge and proactive approach, it’s possible to manage the condition and maintain a good quality of life.
PAH, a unique type of high blood pressure affecting the arteries in the lungs, can put extra strain on the heart. Over time, this can lead to heart failure. The condition’s root cause may vary, from genetic factors to other health issues like heart defects, liver disease, or autoimmune diseases. Remember, sometimes the cause remains unknown, resulting in idiopathic pulmonary ...
Source: The EMT Spot - July 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
From diagnosis to digital health advocate: Navigating lupus in the era of technology
It’s been over ten years since my life changed forever. In 2012, I was out to dinner with a friend when I developed a rash across my face. Little did I know, this was an early sign of what would soon be a life-altering discovery; I have lupus. Receiving this diagnosis was both challenging and
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From diagnosis to digital health advocate: Navigating lupus in the era of technology originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 17, 2023 Category: General Medicine Authors: Alyshia Merchant Tags: Conditions Rheumatology Source Type: blogs
A teenager with chest pain, a troponin below the limit of detection, and " benign early repolarization "
Sent by anonymous, written by Pendell MeyersA male in his teens presented with complaints of chest discomfort and dyspnea beginning while exercising but without obvious injury. He immediately stopped exercising and symptoms started to improve. Later that evening he felt recurrent central chest discomfort, shortness of breath, and vomited. Symptoms have been constant since this second episode, and are still present on arrival, which seems to have been less than 1 to 2 hours from onset of symptoms. No similar symptoms in the past. No prior exertional complaints of chest pain, dizziness, lightheadedness, or undue shortness of...
Source: Dr. Smith's ECG Blog - January 9, 2023 Category: Cardiology Authors: Pendell Source Type: blogs
Thrombus, tumor or vegetation?
This question is often faced by the echocardiographer while evaluating a mass detected on the heart valves or cardiac chambers. Usual method is to take it in the clinical context. There could also be non-infective vegetations of marantic endocarditis which are almost impossible to differentiate from infective vegetations. Marantic vegetations can be suspected in the presence of small and multiple vegetations changing from one examination to another, without associated abscess or valve destruction [1]. It may be noted that echocardiography is neither 100% specific nor 100% sensitive for the diagnosis of infective endocardi...
Source: Cardiophile MD - December 15, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Does Surviving The Plague Mean You Will Eventually Contract An Autoimmune Disease?
BY MIKE MAGEE
This Fall, I am teaching a 4-week course on “How Epidemics Have Shaped Our World” at the President’s College at the University of Hartford. It is, of course a timely topic, but also personally unnerving as we complete a third year under the shadow of Covid-19.
Where does one begin on a topic such as this? Yale historian, Frank M. Snowden, in his book “Epidemics and Society: From the Black Death to the Present”, made his intentions obvious. He would begin with the plaque. Why? His answer, “The word ‘plague’ will always be synonymous with ‘terror’”, and especially references:
...
Source: The Health Care Blog - October 26, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health Autoimmune. Disease Mike Magee Plague Source Type: blogs
What is complete heart block? Cardiology Basics
When natural pacemaker impulses from the sinoatrial node fails to reach the ventricles and activate them, it is known as complete heart block. The block could be at the level of the atrioventricular (AV) node or below that.
Sinus node is a subepicardial structure located in the upper part of right atrium near the orifice of the superior vena cava. Signals from sinus node travel to the AV node through three internodal pathways. They are Wenckebach, Thorel and Bachmann bundles. Bachmann bundle gives a branch to the left atrium also.
AV node is located near the atrioventricular junction in the lower part of right atrium. It ...
Source: Cardiophile MD - October 17, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity.
A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mitochondrial Stress Provokes Inflammation via Fragments of Mitochondrial DNA
A large body of evidence links mitochondrial dysfunction with chronic inflammation. These are both features of aging, but it appears that dysfunctional, stressed mitochondria are a meaningful cause of inflammatory signaling. Mitochondria can generate molecular fragments, such as pieces of mitochondrial DNA, that are recognized as potentially threatening by the innate immune system. These damage-associated molecular patterns are present in much greater amounts in old tissues, and the immune system reacts to them to produce lasting, unresolved inflammation, harmful to tissue function rather than protective.
In today's...
Source: Fight Aging! - October 12, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A man in his 30s with cardiac arrest and STE on the post-ROSC ECG
Conclusions: outpatients with witnessed cardiac arrest and primary PEA carry a high probability of Massive Pulmonary Embolism________________Case Continued:" Initial ROSC EKG showed what appeared to be in atrial fibrillation with inferior ST elevations, depressions in aVL, concerning for STEMI. "He had multiple cardiac arrests with ROSC regained each time. " Endotracheal tube re-intubation was confirmed multiple times, bilateral breath sounds, yet O2 saturation remained in the 50s and 60s. I was able to visualize the ETT on initial intubation pass through the cords however given his continued hypoxemia, I felt it...
Source: Dr. Smith's ECG Blog - October 10, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
3D Printed Light Sensor for Light-Sensitive Disease
At the University of Minnesota a team of researchers has developed a 3D printed light sensing wearable that can help people with light-sensitive diseases, such as lupus, to understand more about the types of light that can exacerbate their symptoms. Many people with lupus are sensitive to light, such as sunlight or even regular indoor light, but they may not know what specific light conditions are likely to cause flare-ups. This new device aims to provide such people with more information, so that they can learn more about their flare-ups and take steps to avoid or reduce them. The technology could lead to more personalize...
Source: Medgadget - September 19, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Dermatology Diagnostics Medicine UMNews Source Type: blogs
Revolutionizing Real-World Data Using Next-Generation Tokenization Technology
The following is a guest article by Josh Schoeller, CEO, Health Care business of LexisNexis® Risk Solutions & Global President, Elsevier Clinical Solutions.
Connecting datasets with unparalleled precision unlocks better health for all
The healthcare industry has widely acknowledged the importance of enabling patient-centered care. We all seem to agree that understanding patients and their unique healthcare journeys provides a more complete picture and increases the chances of positive health outcomes. Real-word data (RWD) can provide this insight, but today’s RWD is incomplete, often restricted to only a fraction of...
Source: EMR and HIPAA - September 13, 2022 Category: Information Technology Authors: Guest Author Tags: Analytics/Big Data C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Interoperability Security and Privacy Elsevier Elsevier Clinical Solutions Healthcare Scene Featured Healthcare Tokenization Healthcare To Source Type: blogs
TORdx LUNG Test for Donor Lung Assessment: Interview with Eric Brouwer, Chief Scientific Officer at SQI Diagnostics
SQI Diagnostics, a medtech company based in Canada, is developing the TORdx LUNG Test. The technology is intended to assist clinicians in assessing donor lungs in their suitability for transplantation. At present, clinicians typically assess donor lungs using qualitative variables, such as donor health and lung size. One of the most important factors, lung inflammation, is difficult to assess, and clinicians will often play it safe and reject an organ if there is any doubt about it.
This means that lungs that might actually be suitable for transplantation are often rejected, further compounding the lack of donor organs....
Source: Medgadget - July 18, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Exclusive Medicine Thoracic Surgery lung transplant sqi diagnostics Source Type: blogs
