GSE261387 Immuno-Oncologic Profiling by Stage-Dependent Transcriptome and Proteome Analyses of Spontaneously Regressing Canine Cutaneous Histiocytoma
Contributors : Alina K Langenhagen ; Alexander F Haake ; Vladimir M Jovanovic ; Sandro Andreotti ; Michael Hummel ; Benjamin-Florian Hempel ; Achim D GruberSeries Type : Expression profiling by high throughput sequencingOrganism : Canis lupus familiarisCanine cutaneous histiocytoma (CCH) is a tumor originating from dermal Langerhans cells, especially affecting young dogs. The common spontaneous regression of CCH makes it an interesting model in comparative oncology research. Previous studies have indicated that anti-tumor immune responses may be involved but details remain speculative to date. Here, we asked which speci...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Canis lupus familiaris Source Type: research
SARS-CoV-2 Mu variant in dogs visiting veterinary clinics during the third pandemic peak in Eastern Colombia
AbstractThe global presence of SARS-CoV-2 in household pets is acknowledged, yet documentation remains scarce, leaving many regions unexplored. Thus, our study sought to fill this gap by investigating SARS-CoV-2 presence in dogs visiting veterinary clinics during the third pandemic peak in eastern Colombia. We collected and analyzed 43 oropharyngeal and rectal swabs using real-time PCR assays targeting the Envelope Gene of SARS-CoV-2. Out of these, two dogs tested positive, indicating an infection rate of 4.7%. Further examination through complete sequencing and phylogenetic analysis revealed the lineage B.1.621 for the SA...
Source: Veterinary Research Communications - April 10, 2024 Category: Veterinary Research Source Type: research
Paradoxical Psoriasis
Cytokine blocking therapies have revolutionized the management of psoriasis and atopic dermatitis but can lead to the development of paradoxic psoriasis (PP). Patients treated with biologics should be closely monitored for the development of PP and other paradoxical eruptions (including inflammatory joint disease, inflammatory bowel disease, eczematous eruptions, lupus like eruptions, sarcoidal eruptions, and others) and occasionally the development of cutaneous T-cell lymphoma. Further understanding the immunologic mechanism of these processes will ultimately drive our understanding of and ability to predict and manage PP...
Source: Dermatologic Clinics - April 10, 2024 Category: Dermatology Authors: Mariam Abdelghaffar, Sita Kottilil, Michael J. Murphy, Jeffrey M. Cohen, William Damsky Source Type: research
Cohort profile: the PERSIAN Dena Cohort Study (PDCS) of non-communicable diseases in Southwest Iran
This study conducted in Dena County is a population-based cohort study as part of the Prospective Epidemiological Research Studies in Iran (PERSIAN). The specific objectives of this study were to estimate the prevalence of region-specific modifiable risk factors and their associations with the incidence of major non-communicable diseases (NCDs).
Participants
This PERSIAN Dena Cohort Study (PDCS) was conducted on 1561 men and 2069 women aged 35–70 years from October 2016 in Dena County, Kohgiluyeh and Boyer-Ahmad Province, Southwest Iran. The overall participation rate was 82.7%.
Findings to date
Out of 3630 partici...
Source: BMJ Open - April 10, 2024 Category: General Medicine Authors: Harooni, J., Joukar, F., Goujani, R., Sikaroudi, M. K., Hatami, A., Zolghadrpour, M.-A., Hejazi, M., Karimi, Z., Rahmanpour, F., Askari Shahid, S., Jowshan, M.-R. Tags: Open access, Epidemiology Source Type: research
Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus
Neuropsychiatric lupus (NPSLE) describes the cognitive, memory, and affective emotional burdens faced by many lupus patients. While NPSLE ’s pathogenesis has not been fully elucidated, clinical imaging studies ... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 10, 2024 Category: Neurology Authors: Joshua Reynolds, Michelle Huang, Yaxi Li, Myriam Meineck, Tamara Moeckel, Julia Weinmann-Menke, Chandra Mohan, Andreas Schwarting and Chaim Putterman Tags: Research Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Percutaneous kidney biopsies in children: a 24-year review in a tertiary center in northern Portugal
CONCLUSIONS: The main indication for KB was NS, which increased over time, justifying the finding of MCD as main histological diagnosis. LN showed an increase in incidence over time, while FSGS cases did not increase.PMID:38591825 | DOI:10.1590/2175-8239-JBN-2023-0143en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Patr ícia Sousa Catarina Br ás Catarina Menezes Ramon Vizcaino Teresa Costa Maria Sameiro Faria Concei ção Mota Source Type: research
Maternal and fetal outcomes in pregnancy complicated by pre-existing lupus nephritis: Insights from a developing country Pakistan
CONCLUSION: The maternal and fetal outcomes in pre-existing LN depend on the disease activity at the time of conception. No correlation was found between International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of LN and adverse disease and pregnancy outcomes.PMID:38594605 | DOI:10.1177/09612033241246642 (Source: Lupus)
Source: Lupus - April 9, 2024 Category: Rheumatology Authors: Tabassum Elahi Saima Ahmed Muhammed Mubarak Ejaz Ahmed Source Type: research
Systemic and Bilateral Severe Ocular Toxoplasmosis Resembling Autoimmune Phenomena: A Case Report
CONCLUSION AND IMPORTANCE: This case underscores the importance of ruling out an infectious etiology in all cases of uveitis. Additionally, it alerts clinicians to the possibility that elevated positive autoantibodies may result from a severe inflammatory reaction caused by pathogens rather than an autoimmune or autoinflammatory disease, particularly in instances of poor treatment response or atypical clinical presentation.PMID:38592492 | DOI:10.1080/09273948.2024.2336605 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Sofia Romero-Santos Daniela Parra-Tanoux Carlos Cifuentes-Gonz ález Juliana Mu ñoz-Ortiz Germ án Mejía-Salgado Alejandra de-la-Torre Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Percutaneous kidney biopsies in children: a 24-year review in a tertiary center in northern Portugal
CONCLUSIONS: The main indication for KB was NS, which increased over time, justifying the finding of MCD as main histological diagnosis. LN showed an increase in incidence over time, while FSGS cases did not increase.PMID:38591825 | DOI:10.1590/2175-8239-JBN-2023-0143en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Patr ícia Sousa Catarina Br ás Catarina Menezes Ramon Vizcaino Teresa Costa Maria Sameiro Faria Concei ção Mota Source Type: research
Maternal and fetal outcomes in pregnancy complicated by pre-existing lupus nephritis: Insights from a developing country Pakistan
CONCLUSION: The maternal and fetal outcomes in pre-existing LN depend on the disease activity at the time of conception. No correlation was found between International Society of Nephrology/Renal Pathology Society (ISN/RPS) classes of LN and adverse disease and pregnancy outcomes.PMID:38594605 | DOI:10.1177/09612033241246642 (Source: Lupus)
Source: Lupus - April 9, 2024 Category: Rheumatology Authors: Tabassum Elahi Saima Ahmed Muhammed Mubarak Ejaz Ahmed Source Type: research
Systemic and Bilateral Severe Ocular Toxoplasmosis Resembling Autoimmune Phenomena: A Case Report
CONCLUSION AND IMPORTANCE: This case underscores the importance of ruling out an infectious etiology in all cases of uveitis. Additionally, it alerts clinicians to the possibility that elevated positive autoantibodies may result from a severe inflammatory reaction caused by pathogens rather than an autoimmune or autoinflammatory disease, particularly in instances of poor treatment response or atypical clinical presentation.PMID:38592492 | DOI:10.1080/09273948.2024.2336605 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 9, 2024 Category: Allergy & Immunology Authors: Sofia Romero-Santos Daniela Parra-Tanoux Carlos Cifuentes-Gonz ález Juliana Mu ñoz-Ortiz Germ án Mejía-Salgado Alejandra de-la-Torre Source Type: research
Percutaneous kidney biopsies in children: a 24-year review in a tertiary center in northern Portugal
CONCLUSIONS: The main indication for KB was NS, which increased over time, justifying the finding of MCD as main histological diagnosis. LN showed an increase in incidence over time, while FSGS cases did not increase.PMID:38591825 | DOI:10.1590/2175-8239-JBN-2023-0143en (Source: Jornal Brasileiro de Nefrologia)
Source: Jornal Brasileiro de Nefrologia - April 9, 2024 Category: Urology & Nephrology Authors: Patr ícia Sousa Catarina Br ás Catarina Menezes Ramon Vizcaino Teresa Costa Maria Sameiro Faria Concei ção Mota Source Type: research
