Anti-U1RNP antibodies are associated with a distinct clinical phenotype and a worse survival in patients with systemic sclerosis

CONCLUSIONS: In SSc patients, anti-U1RNP antibodies are associated with a higher incidence of overlap syndrome, a distinct clinical phenotype, and poorer survival compared to SSc-RNP- and MCTD patients. Our study suggests that SSc-RNP+ patients should be separated from MCTD patients and may constitute an enriched population for progressive lung disease.PMID:38642508 | DOI:10.1016/j.jaut.2024.103220

Source: Journal of Autoimmunity - April 20, 2024 Category: Allergy & Immunology Authors: Kevin Chevalier Guillaume Chassagnon Sarah Leonard-Louis Pascal Cohen Bertrand Dunogue Alexis Regent Benjamin Thoreau Luc Mouthon Benjamin Chaigne Source Type: research