Molecular Analysis of Antibiotic Resistance in CarbapenemResistant Pseudomonas aeruginosa Isolates Isolated from Clinical Samples
In this study, it was aimed to investigate the molecular epidemiology of 47 carbapenem resistant P.aeruginosa (CRPA) isolates derived from various clinical samples from the Central Laboratory Bacteriology Unit of Kocaeli University Research and Training Hospital between October 2021 and March 2023. The rates of resistance to the antibiotics, some carbapenemase and virulence genes, conjugative resistance plasmids, integron gene cassette contents and the clonal similarity of the isolates were investigated and then epidemiologically evaluated. In the study, identification of the bacterial isolates and their susceptibility to ...
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: G ülşah Altan Erva Rakici Osman Birol Özgümüş Source Type: research
A Case of Thyroid Gland Abscess Caused by Brucella melitensis
Mikrobiyol Bul. 2024 Apr;58(2):217-223. doi: 10.5578/mb.20249810.ABSTRACTBrucellosis is a zoonotic disease endemic in many developing countries, including Türkiye. Among the species that are pathogenic for humans; Brucella melitensis is isolated from livestock animals like sheep and goats, Brucella abortus from cattle and Brucella suis from pigs. Laboratory diagnosis of infection caused by Brucella species with gram-negative coccobacillus morphology; can be made through characteristic culture features, serological tests and molecular methods. Brucellosis, which has a wide distribution of clinical signs and symptoms; can c...
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: Ilgaz Kazaz Ertu ğrul Yazici İsmail Selçuk Aygar Tu ğrul Hoşbul Source Type: research
Molecular Analysis of Antibiotic Resistance in CarbapenemResistant Pseudomonas aeruginosa Isolates Isolated from Clinical Samples
In this study, it was aimed to investigate the molecular epidemiology of 47 carbapenem resistant P.aeruginosa (CRPA) isolates derived from various clinical samples from the Central Laboratory Bacteriology Unit of Kocaeli University Research and Training Hospital between October 2021 and March 2023. The rates of resistance to the antibiotics, some carbapenemase and virulence genes, conjugative resistance plasmids, integron gene cassette contents and the clonal similarity of the isolates were investigated and then epidemiologically evaluated. In the study, identification of the bacterial isolates and their susceptibility to ...
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: G ülşah Altan Erva Rakici Osman Birol Özgümüş Source Type: research
Ultra-sensitive electrochemical detection of levofloxacin using a binder-free copper and graphene composite
Talanta. 2024 Apr 25;275:126132. doi: 10.1016/j.talanta.2024.126132. Online ahead of print.ABSTRACTGiven the levels of pollution in the aquatic environment and the development of antimicrobial resistance, it is essential to develop sensors, with sensitivity, selectivity, stability, and cost-effectiveness, for the determination of antibiotics. The present article highlights the fabrication of an ultra-sensitive graphene and copper sensor, Gr/Cu, supported on glassy carbon (GCE/Gr/Cu) for the electroanalysis of levofloxacin through a cost-effective electrodeposition method. The sequential electrodeposition of graphene and Cu...
Source: Talanta - April 26, 2024 Category: Chemistry Authors: Tian Yu Palanisamy Rupa Kasturi Carmel B Breslin Source Type: research
Ultra-sensitive electrochemical detection of levofloxacin using a binder-free copper and graphene composite
Talanta. 2024 Apr 25;275:126132. doi: 10.1016/j.talanta.2024.126132. Online ahead of print.ABSTRACTGiven the levels of pollution in the aquatic environment and the development of antimicrobial resistance, it is essential to develop sensors, with sensitivity, selectivity, stability, and cost-effectiveness, for the determination of antibiotics. The present article highlights the fabrication of an ultra-sensitive graphene and copper sensor, Gr/Cu, supported on glassy carbon (GCE/Gr/Cu) for the electroanalysis of levofloxacin through a cost-effective electrodeposition method. The sequential electrodeposition of graphene and Cu...
Source: Talanta - April 26, 2024 Category: Chemistry Authors: Tian Yu Palanisamy Rupa Kasturi Carmel B Breslin Source Type: research
Attuning doped ZnO-based composites for an effective light-driven mineralization of pharmaceuticals via PMS activation
In this study, we investigated the effect of doping ZnO nanoparticles with either copper, gallium or indium on the structure, morphology, photophysical properties and photocatalytic mineralization of pharmaceuticals. Their architecture was further improved through the fabrication of composites, pairing the best performing doped ZnO with either BaFe12O19 or nickel nanoparticles. Their suitability was tested on a complex 60-ppm multi-pollutant solution (tetracycline, levofloxacin and lansoprazole). The activation strategy combined photocatalysis with peroxymonosulfate (PMS) as an environmentally friendly source of highly oxi...
Source: Chemosphere - April 25, 2024 Category: Chemistry Authors: Roger Bujald ón Majdi Benamara Ramzi Dhahri Elvira G ómez Albert Serr à Source Type: research
Attuning doped ZnO-based composites for an effective light-driven mineralization of pharmaceuticals via PMS activation
In this study, we investigated the effect of doping ZnO nanoparticles with either copper, gallium or indium on the structure, morphology, photophysical properties and photocatalytic mineralization of pharmaceuticals. Their architecture was further improved through the fabrication of composites, pairing the best performing doped ZnO with either BaFe12O19 or nickel nanoparticles. Their suitability was tested on a complex 60-ppm multi-pollutant solution (tetracycline, levofloxacin and lansoprazole). The activation strategy combined photocatalysis with peroxymonosulfate (PMS) as an environmentally friendly source of highly oxi...
Source: Chemosphere - April 25, 2024 Category: Chemistry Authors: Roger Bujald ón Majdi Benamara Ramzi Dhahri Elvira G ómez Albert Serr à Source Type: research
Attuning doped ZnO-based composites for an effective light-driven mineralization of pharmaceuticals via PMS activation
In this study, we investigated the effect of doping ZnO nanoparticles with either copper, gallium or indium on the structure, morphology, photophysical properties and photocatalytic mineralization of pharmaceuticals. Their architecture was further improved through the fabrication of composites, pairing the best performing doped ZnO with either BaFe12O19 or nickel nanoparticles. Their suitability was tested on a complex 60-ppm multi-pollutant solution (tetracycline, levofloxacin and lansoprazole). The activation strategy combined photocatalysis with peroxymonosulfate (PMS) as an environmentally friendly source of highly oxi...
Source: Chemosphere - April 25, 2024 Category: Chemistry Authors: Roger Bujald ón Majdi Benamara Ramzi Dhahri Elvira G ómez Albert Serr à Source Type: research
Preparation of Zn/Zr-MOFs by microwave-assisted ball milling and adsorption of lomefloxacin hydrochloride and levofloxacin hydrochloride in wastewater
Environ Res. 2024 Apr 20:118941. doi: 10.1016/j.envres.2024.118941. Online ahead of print.ABSTRACTThe Zn/Zr-MOFs were synthesized via microwave-assisted ball milling and subsequently characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The thermal stability of the Zn/Zr-MOFs was evaluated through thermogravimetry (TGA). The results demonstrated the exceptional adsorption properties of the Zn/Zr-MOFs towards Lomefloxacin hydrochloride and Levofloxacin hydrochloride. At a concentration of 30 ppm for Lomefloxacin hydrochloride, the addition of 30...
Source: Environmental Research - April 22, 2024 Category: Environmental Health Authors: Fuhua Wei Jie Gong Qinhui Ren Xiang Yu Yan Wang Hongliang Chen Zhao Liang Source Type: research
Molecular epidemiological and clinical infection characteristics analysis of Ralstonia
ConclusionWe established a sequence typing system with a relatively fine resolution and the PCR assay is a faster and more sensitive method for clinical identification ofRalstonia pickettii. ST9 is the most common sequence types ofRalstonia pickettii. The most common clinical characteristics ofRalstonia pickettii infected patients were cough, sputum, shortness of breath and pulmonary rales. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 19, 2024 Category: Microbiology Source Type: research
Developmental stage and infection status may affect drug distribution in the prostate of rats
Xenobiotica. 2024 Apr 18:1-13. doi: 10.1080/00498254.2024.2343892. Online ahead of print.ABSTRACTProstate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear.Rats were categorized into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacoki...
Source: Xenobiotica - April 18, 2024 Category: Research Authors: Ziyang Xu Lianzhan Sun Chang Yin Handa Wang Xue Wang Yunyun Yang Zhuo Wang Source Type: research
Developmental stage and infection status may affect drug distribution in the prostate of rats
Xenobiotica. 2024 Apr 18:1-13. doi: 10.1080/00498254.2024.2343892. Online ahead of print.ABSTRACTProstate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear.Rats were categorized into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacoki...
Source: Xenobiotica - April 18, 2024 Category: Research Authors: Ziyang Xu Lianzhan Sun Chang Yin Handa Wang Xue Wang Yunyun Yang Zhuo Wang Source Type: research
Viruses, Vol. 16, Pages 627: Trends in and Risk Factors for Drug Resistance in Mycobacterium tuberculosis in HIV-Infected Patients
Zhaoqin Zhu
Yinzhong Shen
Trends in and risk factors for drug resistance in Mycobacterium tuberculosis (M. tuberculosis) in human immunodeficiency virus (HIV)-infected patients with active tuberculosis were analyzed. The clinical data of M. tuberculosis and HIV-coinfected patients treated at the Shanghai Public Health Clinical Center between 2010 and 2022 were collected. The diagnosis of tuberculosis was confirmed by solid or liquid culture. The phenotypic drug susceptibility test was carried out via the proportional method, and the resistance to first-line and second-line drugs was analyzed. Logistic regression an...
Source: Viruses - April 18, 2024 Category: Virology Authors: Xiaoqin Le Xueqin Qian Li Liu Jianjun Sun Wei Song Tangkai Qi Zhenyan Wang Yang Tang Shuibao Xu Junyang Yang Jiangrong Wang Jun Chen Renfang Zhang Zhaoqin Zhu Yinzhong Shen Tags: Article Source Type: research
Challenges in the treatment of pediatric Mycoplasma pneumoniae pneumonia
Conclusion: This report summarizes the clinical significance of macrolide-resistant and refractory MP pneumonia and discusses the efficacy and safety of alternative drugs, with a stepwise approach to the management of MP pneumonia recommended from the viewpoint of clinical practice.What is Known:•Although MP pneumonia is usually a benign self-limited infection with response macrolides as first line therapy,severe life-threatening cases may develop if additional treatment strategies are not effectively implemented.•Macrolide-resistant and refractory MP pneumonia are two conditions that may complicate the clinical cour...
Source: European Journal of Pediatrics - April 18, 2024 Category: Pediatrics Source Type: research
Oral Antibiotics vs IV and Oral Antibiotics for Uncomplicated Appendicitis
This secondary analysis of a randomized clinical trial assesses the 3-year clinical outcomes of oral moxifloxacin vs combined intravenous ertapenem plus oral levofloxacin and metronidazole in patients with uncomplicated acute appendicitis. (Source: JAMA Surgery)
Source: JAMA Surgery - April 17, 2024 Category: Sports Medicine Source Type: research
