Distribution and Drug Resistance of Common Pathogens Causing Lower Respiratory Tract Infection in Xinjiang Region
CONCLUSIONS: In patients with lower respiratory tract infection (LRTI) in a hospital in Xinjiang, the most common pathogenic bacteria are gram-negative bacilli, mainly Acinetobacter baumannii and Pseudomonas aeruginosa. Both resistant and non-resistant strains showed sensitivity to amikacin and tigecycline. Additionally, staphylococcus accounted for half of the total number of gram-positive bacteria, among which methicillin-resistant strains were more sensitive to vancomycin and linezolid.PMID:38430170 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Lixia Wang Huan Guo Leyan Qu Guozhen Wang Jianjiang Luo Source Type: research

Distribution and Drug Resistance of Common Pathogens Causing Lower Respiratory Tract Infection in Xinjiang Region
CONCLUSIONS: In patients with lower respiratory tract infection (LRTI) in a hospital in Xinjiang, the most common pathogenic bacteria are gram-negative bacilli, mainly Acinetobacter baumannii and Pseudomonas aeruginosa. Both resistant and non-resistant strains showed sensitivity to amikacin and tigecycline. Additionally, staphylococcus accounted for half of the total number of gram-positive bacteria, among which methicillin-resistant strains were more sensitive to vancomycin and linezolid.PMID:38430170 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Lixia Wang Huan Guo Leyan Qu Guozhen Wang Jianjiang Luo Source Type: research

Distribution and Drug Resistance of Common Pathogens Causing Lower Respiratory Tract Infection in Xinjiang Region
CONCLUSIONS: In patients with lower respiratory tract infection (LRTI) in a hospital in Xinjiang, the most common pathogenic bacteria are gram-negative bacilli, mainly Acinetobacter baumannii and Pseudomonas aeruginosa. Both resistant and non-resistant strains showed sensitivity to amikacin and tigecycline. Additionally, staphylococcus accounted for half of the total number of gram-positive bacteria, among which methicillin-resistant strains were more sensitive to vancomycin and linezolid.PMID:38430170 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Lixia Wang Huan Guo Leyan Qu Guozhen Wang Jianjiang Luo Source Type: research

Distribution and Drug Resistance of Common Pathogens Causing Lower Respiratory Tract Infection in Xinjiang Region
CONCLUSIONS: In patients with lower respiratory tract infection (LRTI) in a hospital in Xinjiang, the most common pathogenic bacteria are gram-negative bacilli, mainly Acinetobacter baumannii and Pseudomonas aeruginosa. Both resistant and non-resistant strains showed sensitivity to amikacin and tigecycline. Additionally, staphylococcus accounted for half of the total number of gram-positive bacteria, among which methicillin-resistant strains were more sensitive to vancomycin and linezolid.PMID:38430170 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Lixia Wang Huan Guo Leyan Qu Guozhen Wang Jianjiang Luo Source Type: research

Merging 3D-printing technology and disposable materials for electrochemical purposes: A sustainable alternative to ensure greener electroanalysis
In this study, we propose a solution to these challenges by creating a simple and versatile electrochemical system that combines 3D-printing technology with recyclable disposable materials, such as graphite from an exhausted battery and a stainless-steel screw. Our results demonstrate a novel strategy for developing electrodes and other laboratory-made devices that align with the principles of sustainability and green chemistry. Furthermore, we provide evidence of the effectiveness of the proposed system in an analytical application involving the simultaneous determination of tert-butylhydroquinone, acetaminophen, and levo...
Source: Talanta - March 1, 2024 Category: Chemistry Authors: Liriana Mara Roveda Vitor Ferreira Ottoni Cl áudio Teodoro de Carvalho Raphael Rodrigues Marcela Zanetti Corazza Magno Aparecido Gon çalves Trindade Source Type: research

Merging 3D-printing technology and disposable materials for electrochemical purposes: A sustainable alternative to ensure greener electroanalysis
In this study, we propose a solution to these challenges by creating a simple and versatile electrochemical system that combines 3D-printing technology with recyclable disposable materials, such as graphite from an exhausted battery and a stainless-steel screw. Our results demonstrate a novel strategy for developing electrodes and other laboratory-made devices that align with the principles of sustainability and green chemistry. Furthermore, we provide evidence of the effectiveness of the proposed system in an analytical application involving the simultaneous determination of tert-butylhydroquinone, acetaminophen, and levo...
Source: Talanta - March 1, 2024 Category: Chemistry Authors: Liriana Mara Roveda Vitor Ferreira Ottoni Cl áudio Teodoro de Carvalho Raphael Rodrigues Marcela Zanetti Corazza Magno Aparecido Gon çalves Trindade Source Type: research

Inverse opal manganese-doped tungsten trioxide as a high-performance Fenton-like photocatalyst for levofloxacin degradation
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3NJ05798D, PaperNan Jia, Yizhou Wu, Xinxi Zhang, Liang Zhou, Juying Lei, Tan Phong Nguyen, Jinlong Zhang, Yongdi Liu It is crucial to develop high-performance catalysts for the degradation of antibiotic pollutants. In this paper, we reported an inverse opal Mn-doped WO3 (IO Mn-WO3) catalyst to effectively activate peroxymonosulfate... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - February 29, 2024 Category: Chemistry Authors: Nan Jia Source Type: research

Scleritis following intravitreal brolucizumab injection: a case series
ConclusionsIntraocular inflammation following IVBr injection may progress to the posterior segment. Scleritis can occur after IVBr injection, and topical eye drops alone may not be sufficient for initial treatment. Clinicians should consider the possibility of scleritis in patients with worsening inflammation after IVBr injection. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 29, 2024 Category: General Medicine Source Type: research

Efficacy of adding levofloxacin to gemcitabine and nanoparticle-albumin-binding paclitaxel combination therapy in patients with advanced pancreatic cancer: study protocol for a multicenter, randomized phase 2 trial (T-CORE2201)
This study will enroll patients treated with GEM/nabPTX as the first-line chemotherapy for stage IV pancreatic adenocarcinoma.DISCUSSION: GEM/nabPTX is a standard first-line chemotherapy regimen for patients with advanced pancreatic cancer. Recently, the superiority of 5-fluorouracil, liposomal irinotecan, and oxaliplatin combination therapy (NALIRIFOX) to GEM/nabPTX as first-line therapy for pancreatic cancer has been reported. However, the efficacy of NALIRIFOX is inadequate. Based on previous retrospective studies, it is hypothesized that treatment efficacy will improve when levofloxacin is added to GEM/nabPTX therapy. ...
Source: Cancer Control - February 24, 2024 Category: Cancer & Oncology Authors: Hiroo Imai Yasuhiro Sakamoto Shin Takahashi Hiroyuki Shibata Atsushi Sato Kazunori Otsuka Kenji Amagai Masanobu Takahashi Takuhiro Yamaguchi Chikashi Ishioka Source Type: research

Efficacy of adding levofloxacin to gemcitabine and nanoparticle-albumin-binding paclitaxel combination therapy in patients with advanced pancreatic cancer: study protocol for a multicenter, randomized phase 2 trial (T-CORE2201)
Advanced pancreatic cancer is one of the leading causes of cancer-related deaths. For patients with advanced pancreatic cancer, gemcitabine and nanoparticle albumin-binding paclitaxel (nabPTX) combination (GEM... (Source: BMC Cancer)
Source: BMC Cancer - February 24, 2024 Category: Cancer & Oncology Authors: Hiroo Imai, Yasuhiro Sakamoto, Shin Takahashi, Hiroyuki Shibata, Atsushi Sato, Kazunori Otsuka, Kenji Amagai, Masanobu Takahashi, Takuhiro Yamaguchi and Chikashi Ishioka Tags: Study Protocol Source Type: research

Anaerobic antibiotic coverage in aspiration pneumonia and the associated benefits and harms: A retrospective cohort study
Chest. 2024 Feb 20:S0012-3692(24)00260-5. doi: 10.1016/j.chest.2024.02.025. Online ahead of print.ABSTRACTBACKGROUND: Antibiotics with extended anaerobic coverage are commonly used to treat aspiration pneumonia, which is not recommended by current guidelines.RESEARCH QUESTION: In patients admitted to hospital for community-acquired aspiration pneumonia, is there a difference between antibiotic therapy with limited anaerobic coverage (LAC) versus antibiotic therapy with extended anaerobic coverage (EAC) in terms of in-hospital mortality and risk of Clostridioides difficile colitis?METHODS: We conducted a multicenter retrosp...
Source: Chest - February 22, 2024 Category: Respiratory Medicine Authors: Anthony D Bai Siddhartha Srivastava Genevi ève C Digby Vincent Girard Fahad Razak Amol A Verma Source Type: research

Anaerobic antibiotic coverage in aspiration pneumonia and the associated benefits and harms: A retrospective cohort study
Chest. 2024 Feb 20:S0012-3692(24)00260-5. doi: 10.1016/j.chest.2024.02.025. Online ahead of print.ABSTRACTBACKGROUND: Antibiotics with extended anaerobic coverage are commonly used to treat aspiration pneumonia, which is not recommended by current guidelines.RESEARCH QUESTION: In patients admitted to hospital for community-acquired aspiration pneumonia, is there a difference between antibiotic therapy with limited anaerobic coverage (LAC) versus antibiotic therapy with extended anaerobic coverage (EAC) in terms of in-hospital mortality and risk of Clostridioides difficile colitis?METHODS: We conducted a multicenter retrosp...
Source: Chest - February 22, 2024 Category: Respiratory Medicine Authors: Anthony D Bai Siddhartha Srivastava Genevi ève C Digby Vincent Girard Fahad Razak Amol A Verma Source Type: research

Insight into the electrocatalytic activation of peroxymonosulfate by a Ti/MnO2 anode via one-step electrodeposition approach toward the degradation of levofloxacin
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4NJ00300D, PaperWenzhi Zhang, Hao Zhang, Guohua Dong, Zhuanfang Zhang, Dong-Feng Chai, Ming Zhao, Jinlong Li, Han wu, Xu Hou In this work, Ti/MnO2 anode (denoted as MnO2) is facilely constructed via a one-step electrodeposition method and designed a combined system towards degradation of the refractory Levofloxacin (LFX), in which... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - February 20, 2024 Category: Chemistry Authors: Wenzhi Zhang Source Type: research

Discovery of psoralen as a quorum sensing inhibitor suppresses Pseudomonas aeruginosa virulence
In conclusions, this study identifies the anti-QS and antibiofilm effects of psoralen against P. aeruginosa strains and sheds light on the discovery of anti-pseudomonal drugs among Traditional Chinese Medicines. KEY POINTS: • Psoralen derived from Psoralea corylifolia L. inhibits the virulence-related phenotypes of P. aeruginosa. • Psoralen simultaneously targets the three core regulators of P. aeruginosa QS system and inhibits the expression of a large part of downstream genes. • Psoralen protects C. elegans from P. aeruginosa challenge and enhances the susceptibility of P. aeruginosa to antibiotics.PMID:38372782 | ...
Source: Applied Microbiology and Biotechnology - February 19, 2024 Category: Microbiology Authors: Fulong Wen Yi Wu Yang Yuan Xiting Yang Qiman Ran Xiongyao Gan Yidong Guo Xinrong Wang Yiwen Chu Kelei Zhao Source Type: research

Antibiotic susceptibility and genomic analysis of ciprofloxacin-resistant and ESBLs-producing Escherichia coli in vegetables and their irrigation water and growing soil
In conclusion, our research highlights the widespread presence of CIPRE. coli in irrigation water and thoroughly examines the genetic characteristics of CIPR-ESBLs-producing E. coli strains, underlining the need for ongoing monitoring and management to reduce multidrug-resistant bacteria in vegetables and their environment.PMID:38368793 | DOI:10.1016/j.ijfoodmicro.2024.110629 (Source: International Journal of Food Microbiology)
Source: International Journal of Food Microbiology - February 18, 2024 Category: Food Science Authors: Jiali Sun Jinghan Dai Jin Chen Yuanjie He Li Su Mengqing Gong Mengyuan Cao Kexin Wei Yi You Lisha Liu Li Bai Shenghui Cui Jia Chen Baowei Yang Source Type: research