Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research

Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research

Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research

Emerging threats of high biofilm formation and antibiotic resistance in clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates from Pakistan
CONCLUSIONS: Clinical MRSA strains exhibit a substantial potential for biofilm formation, contributing to a resistant phenotype. Routine antibiotic testing in clinical settings that overlook the biofilm aspect may lead to the failure of empiric antibiotic therapy.PMID:38614413 | DOI:10.1016/j.meegid.2024.105592 (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - April 13, 2024 Category: Genetics & Stem Cells Authors: Asad Ali Saba Riaz Source Type: research

Periprosthetic bacterial and fugal infection after total knee arthroplasty with one-stage debridement: a case report
ConclusionsIn addition to the case study, we provide an analysis of the diagnosis and treatment of fungal infection after arthroplasty, especially the efficacy of debridement, antibiotics, and implant retention for a short-term outcome. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - April 13, 2024 Category: General Medicine Source Type: research

Effects of Rifampicin Plus Levofloxacin or Isoniazid on Immune Function of Patients with Pulmonary Tuberculosis
CONCLUSIONS: Compared with rifampicin + isoniazid, rifampicin + levofloxacin had a better clinical effect in the treatment of pulmonary TB and could effectively regulate patients' immune functions and inhibit inflammatory reactions. The current research team recommends that rifampicin + levofloxacin become the preferred treatment for pulmonary TB in the absence of a drug allergy.PMID:38607224 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Feng Lv Nan Tang Source Type: research

Effects of Rifampicin Plus Levofloxacin or Isoniazid on Immune Function of Patients with Pulmonary Tuberculosis
CONCLUSIONS: Compared with rifampicin + isoniazid, rifampicin + levofloxacin had a better clinical effect in the treatment of pulmonary TB and could effectively regulate patients' immune functions and inhibit inflammatory reactions. The current research team recommends that rifampicin + levofloxacin become the preferred treatment for pulmonary TB in the absence of a drug allergy.PMID:38607224 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Feng Lv Nan Tang Source Type: research

Effects of Rifampicin Plus Levofloxacin or Isoniazid on Immune Function of Patients with Pulmonary Tuberculosis
CONCLUSIONS: Compared with rifampicin + isoniazid, rifampicin + levofloxacin had a better clinical effect in the treatment of pulmonary TB and could effectively regulate patients' immune functions and inhibit inflammatory reactions. The current research team recommends that rifampicin + levofloxacin become the preferred treatment for pulmonary TB in the absence of a drug allergy.PMID:38607224 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Feng Lv Nan Tang Source Type: research

Effects of Rifampicin Plus Levofloxacin or Isoniazid on Immune Function of Patients with Pulmonary Tuberculosis
CONCLUSIONS: Compared with rifampicin + isoniazid, rifampicin + levofloxacin had a better clinical effect in the treatment of pulmonary TB and could effectively regulate patients' immune functions and inhibit inflammatory reactions. The current research team recommends that rifampicin + levofloxacin become the preferred treatment for pulmonary TB in the absence of a drug allergy.PMID:38607224 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Feng Lv Nan Tang Source Type: research

Hospital-acquired pneumonia due to Burkholderia cepacia in a thalassemia pregnancy with postoperative eclampsia: A case report
Respir Med Case Rep. 2024 Apr 4;49:102021. doi: 10.1016/j.rmcr.2024.102021. eCollection 2024.ABSTRACTThere are limited case reports on individuals infected with Burkholderia cepacia who do not have typical risk factors, particularly pregnant women with beta-thalassemia. A 34-year-old pregnant female with beta-thalassemia trait and hypertension was admitted to the hospital. The patient was diagnosed with eclampsia and underwent a cesarean section. After two days following the surgery, the patient experienced hospitality-acquired pneumonia. B.cepacia was isolated from blood cultures, and antibiotic susceptibility testing ind...
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Khoa Nguyen-Dang Ngoc Duong-Minh Hanh-Duyen Bui-Thi Source Type: research

Hospital-acquired pneumonia due to Burkholderia cepacia in a thalassemia pregnancy with postoperative eclampsia: A case report
Respir Med Case Rep. 2024 Apr 4;49:102021. doi: 10.1016/j.rmcr.2024.102021. eCollection 2024.ABSTRACTThere are limited case reports on individuals infected with Burkholderia cepacia who do not have typical risk factors, particularly pregnant women with beta-thalassemia. A 34-year-old pregnant female with beta-thalassemia trait and hypertension was admitted to the hospital. The patient was diagnosed with eclampsia and underwent a cesarean section. After two days following the surgery, the patient experienced hospitality-acquired pneumonia. B.cepacia was isolated from blood cultures, and antibiotic susceptibility testing ind...
Source: Respiratory Care - April 11, 2024 Category: Respiratory Medicine Authors: Khoa Nguyen-Dang Ngoc Duong-Minh Hanh-Duyen Bui-Thi Source Type: research

A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses
Infect Genet Evol. 2024 Apr 9:105591. doi: 10.1016/j.meegid.2024.105591. Online ahead of print.ABSTRACTSepsis and multidrug resistance comprise a complex of factors attributable to mortality among intensive care unit (ICU) patients globally. Pathogens implicated in sepsis are diverse, and their virulence and drug resistance remain elusive. From a tertiary care hospital ICU in Uganda, we isolated a Citrobacter freundii strain RSM030 from a patient with sepsis and phenotypically tested it against a panel of 16 antibiotics including imipenem levofloxacin, cotrimoxazole and colistin, among others. We sequenced the organism's g...
Source: Infection, Genetics and Evolution - April 11, 2024 Category: Genetics & Stem Cells Authors: Reuben S Maghembe Maximilian A K Magulye Emmanuel Eilu Simon Sekyanzi Abdalah Makaranga Savannah Mwesigwa Eric Katagirya Source Type: research

A sophisticated virulence repertoire and colistin resistance of Citrobacter freundii ST150 from a patient with sepsis admitted to ICU in a tertiary care hospital in Uganda, East Africa: Insight from genomic and molecular docking analyses
Infect Genet Evol. 2024 Apr 9:105591. doi: 10.1016/j.meegid.2024.105591. Online ahead of print.ABSTRACTSepsis and multidrug resistance comprise a complex of factors attributable to mortality among intensive care unit (ICU) patients globally. Pathogens implicated in sepsis are diverse, and their virulence and drug resistance remain elusive. From a tertiary care hospital ICU in Uganda, we isolated a Citrobacter freundii strain RSM030 from a patient with sepsis and phenotypically tested it against a panel of 16 antibiotics including imipenem levofloxacin, cotrimoxazole and colistin, among others. We sequenced the organism's g...
Source: Infection, Genetics and Evolution - April 11, 2024 Category: Genetics & Stem Cells Authors: Reuben S Maghembe Maximilian A K Magulye Emmanuel Eilu Simon Sekyanzi Abdalah Makaranga Savannah Mwesigwa Eric Katagirya Source Type: research

Promoting oxygen vacancies utility for tetracycline degradation via peroxymonosulfate activation by reduced Mg-doped Co < sub > 3 < /sub > O < sub > 4 < /sub > : Kinetics and key role of electron transfer pathway
This study showcases an innovative strategy for the rational design of an efficient cobalt-based activator, leveraging electron transfer pathways through PMS activation to degrade antibiotics effectively.PMID:38599451 | DOI:10.1016/j.envres.2024.118892 (Source: Environmental Research)
Source: Environmental Research - April 10, 2024 Category: Environmental Health Authors: Cheng Wang Lian Chang Xiaodan Zhang Hongxiang Chai Yuming Huang Source Type: research

Tackling antibiotic contaminations in wastewater with novel Modified-MOF nanostructures: A study of molecular simulations and DFT calculations
In conclusion, our study highlighted the importance of modeling in developing practical solutions for removing antibiotics as PHCs from wastewater. The insights gained from our calculations can facilitate the design of more effective adsorption materials, ultimately leading to a more hygienic and sustainable ecosystem.PMID:38599447 | DOI:10.1016/j.envres.2024.118856 (Source: Environmental Research)
Source: Environmental Research - April 10, 2024 Category: Environmental Health Authors: Iman Salahshoori Majid Namayandeh Jorabchi Afsaneh Mazaheri Seyedeh Masoomeh Sadat Mirnezami Mahdis Afshar Mahdi Golriz Marcos A L Nobre Source Type: research