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Assessing potential drug-drug interactions between clofazimine and other frequently used agents to treat drug-resistant tuberculosis
Antimicrob Agents Chemother. 2024 Apr 10:e0158323. doi: 10.1128/aac.01583-23. Online ahead of print.ABSTRACTClofazimine is included in drug regimens to treat rifampicin/drug-resistant tuberculosis (DR-TB), but there is little information about its interaction with other drugs in DR-TB regimens. We evaluated the pharmacokinetic interaction between clofazimine and isoniazid, linezolid, levofloxacin, and cycloserine, dosed as terizidone. Newly diagnosed adults with DR-TB at Klerksdorp/Tshepong Hospital, South Africa, were started on the then-standard treatment with clofazimine temporarily excluded for the initial 2 weeks. Pha...
Source: Antimicrobial Agents and Chemotherapy - April 10, 2024 Category: Microbiology Authors: Allan Kengo Firdaus Nabeemeeah Paolo Denti Ryan Sabet Gifty Okyere-Manu Pattamukkil Abraham Lubbe Weisner Modiehi Helen Mosala Sibongile Tshabalala Janine Scholefield Juan Eduardo Resendiz-Galvan Neil A Martinson Ebrahim Variava Source Type: research

Promoting oxygen vacancies utility for tetracycline degradation via peroxymonosulfate activation by reduced Mg-doped Co 3 O 4 : Kinetics and key role of electron transfer pathway
This study showcases an innovative strategy for the rational design of an efficient cobalt-based activator, leveraging electron transfer pathways through PMS activation to degrade antibiotics effectively.PMID:38599451 | DOI:10.1016/j.envres.2024.118892 (Source: Environmental Research)
Source: Environmental Research - April 10, 2024 Category: Environmental Health Authors: Cheng Wang Lian Chang Xiaodan Zhang Hongxiang Chai Yuming Huang Source Type: research

Tackling antibiotic contaminations in wastewater with novel Modified-MOF nanostructures: A study of molecular simulations and DFT calculations
In conclusion, our study highlighted the importance of modeling in developing practical solutions for removing antibiotics as PHCs from wastewater. The insights gained from our calculations can facilitate the design of more effective adsorption materials, ultimately leading to a more hygienic and sustainable ecosystem.PMID:38599447 | DOI:10.1016/j.envres.2024.118856 (Source: Environmental Research)
Source: Environmental Research - April 10, 2024 Category: Environmental Health Authors: Iman Salahshoori Majid Namayandeh Jorabchi Afsaneh Mazaheri Seyedeh Masoomeh Sadat Mirnezami Mahdis Afshar Mahdi Golriz Marcos A L Nobre Source Type: research

Investigations on physiochemical and biomedical properties of Aloe vera - Sterculia gum copolymeric dressings impregnated with antibiotic-anesthetic drugs to enhance wound healing
Int J Biol Macromol. 2024 Apr 5:131363. doi: 10.1016/j.ijbiomac.2024.131363. Online ahead of print.ABSTRACTRecently, various innovative advancements have been made in carbohydrate research to design versatile materials for biomedical applications. The current research focuses on the development of copolymeric hydrogel wound dressings (HWD) using a combination of aloe vera (AV) - sterculia gum (SG) - poly (vinylsulfonic acid) (VSA)-based with the aim to enhancing their efficacy in drug delivery (DD) applications. These hydrogel dressings were encapsulated with levofloxacin and lidocaine to address both microbial infection a...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Diwanshi Sharma Ashima Sharma Ritu Bala Baljit Singh Source Type: research

Efflux pump effects on levofloxacin resistance in Mycobacterium abscessus 
Antimicrob Agents Chemother. 2024 Apr 4:e0134823. doi: 10.1128/aac.01348-23. Online ahead of print.ABSTRACTMycobacterium abscessus (M. abscessus) inherently displays resistance to most antibiotics, with the underlying drug resistance mechanisms remaining largely unexplored. Efflux pump is believed to play an important role in mediating drug resistance. The current study examined the potential of efflux pump inhibitors to reverse levofloxacin (LFX) resistance in M. abscessus. The reference strain of M. abscessus (ATCC19977) and 60 clinical isolates, including 41 M. abscessus subsp. abscessus and 19 M. abscessus subsp. massi...
Source: Antimicrobial Agents and Chemotherapy - April 4, 2024 Category: Microbiology Authors: Tianlu Teng Suting Chen Fengmin Huo Junnan Jia Liping Zhao Guanglu Jiang Fen Wang Naihui Chu Hairong Huang Source Type: research

Influence of microplastics and environmentally persistent free radicals on the ability of biochar components to promote degradation of antibiotics by activated peroxymonosulfate
Environ Pollut. 2024 Apr 2:123827. doi: 10.1016/j.envpol.2024.123827. Online ahead of print.ABSTRACTMicroplastics (MPs) in sludge can affect the ability of biochar-activated peroxymonosulfate (PMS) to degrade antibiotics. In this work, biochar was prepared by mixing sludge and polystyrene (PS) through hydrothermal carbonization (HTC) and high-temperature pyrolysis processes. The resulting biochar was used to activate PMS to degrade ofloxacin (OFX), levofloxacin (LEV), and pefloxacin (PFX). The addition of PS significantly enhanced the ability of biochar/PMS to degrade antibiotics and the levels of environmentally persisten...
Source: Environmental Pollution - April 4, 2024 Category: Environmental Health Authors: Yanzhuo Zhang Rui He Yutai Sun Jing Zhao Xiaozhuan Zhang Jiqin Wang Alexandr V Bildyukevich Source Type: research

A novel molecularly imprinted electrochemical sensor from poly (3, 4-ethylenedioxythiophene)/chitosan for selective and sensitive detection of levofloxacin
Int J Biol Macromol. 2024 Apr 1:131321. doi: 10.1016/j.ijbiomac.2024.131321. Online ahead of print.ABSTRACTThe improper usage of levofloxacin (LEV) endangers both environmental safety and human public health. Therefore, trace analysis and detection of LEV have extraordinary significance. In this paper, a novel molecularly imprinted polymer (MIP) electrochemical sensor was developed for the specific determination of LEV by electrochemical polymerization of o-phenylenediamine (o-PD) using poly(3,4-ethylenedioxythiophene)/chitosan (PEDOT/CS) with a porous structure and rich functional groups as a carrier and LEV as a template...
Source: International Journal of Biological Macromolecules - April 3, 2024 Category: Biochemistry Authors: Qian Cheng Tursun Abdiryim Ruxangul Jamal Xiong Liu Cong Xue Shuyue Xie Xinsheng Tang Jin Wei Source Type: research

Research on the sustainable effect of ZnS and MoS 2 decorated biochar nanocomposites for removing quinolones from antibiotic-polluted aqueous solutions
Ying-Jie Gan, Yue-hui Wang, Ya-ru Dang, Wen-jie Hao, Zheng-rong Hu, Zhi-wei Zhang, Yu-min Luo, Yan-bo Wu, Ai-jun Song, Zhong-bao Zhao - Volume 77(4) Schematic of the synthesis of ZMMBC and its use as an absorbant for quinolone antibiotics.MoS2 and ZnS modified biochar (ZMMBC) was synthesised by hydrothermal method. The removal potential of pefloxacin (PF), levofloxacin (LF) and norfloxacin (NF) was studied. It only takes 90&nbsp;min for ZMMBC to reach its maximum adsorption capacity. The adsorption behaviour mainly includes complexation, pore filling, &#x003C0;&#x02013;&#x003C0; interactions...
Source: Australian Journal of Chemistry - April 3, 2024 Category: Chemistry Authors: Ying-Jie Gan Yue-hui Wang Ya-ru Dang Wen-jie Hao Zheng-rong Hu Zhi-wei Zhang Yu-min Luo Yan-bo Wu Ai-jun Song Zhong-bao Zhao Source Type: research

Estimation of country-specific tuberculosis resistance antibiograms using pathogen genomics and machine learning
CONCLUSIONS: This is the first attempt at global Mtb antibiogram estimation. DR prevalence in Mtb can be reliably estimated using public WGS and phenotypic resistance prediction for key antibiotics, but public WGS data demonstrates oversampling of isolates with higher resistance levels than MDR. Nevertheless, our results raise concerns about the empiric use of short-course fluoroquinolone regimens for drug-susceptible TB in South Asia and indicate underutilisation of ethionamide in MDR treatment.PMID:38548342 | DOI:10.1136/bmjgh-2023-013532 (Source: Cancer Control)
Source: Cancer Control - March 28, 2024 Category: Cancer & Oncology Authors: Avika Dixit Luca Freschi Roger Vargas Matthias I Gr öschel Maria Nakhoul Sabira Tahseen S M Masud Alam S M Mostofa Kamal Alena Skrahina Ramon P Basilio Dodge R Lim Nazir Ismail Maha R Farhat Source Type: research

The Potentiation Activity of Azithromycin in Combination with Colistin or Levofloxacin Against Pseudomonas aeruginosa Biofilm Infection
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - March 28, 2024 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Insight into the catalytic performances of Fe 0 @chitosan/cellulose green hybrid structure for enhanced photo-Fenton's oxidation of levofloxacin toxic residuals: Pathway and toxicity
Int J Biol Macromol. 2024 Mar 22:130615. doi: 10.1016/j.ijbiomac.2024.130615. Online ahead of print.ABSTRACTA green hybridized structure of Fe0 painted chitosan/cellulose base (Fe0@CS/CF) has been developed using cellulose extracted from sugarcane bagasse along with reduction agents sourced from Khaya senegalensis leaves. The composite was assessed as an affordable, powerful, and multifunctional catalyst for enhancing the degradation of Levofloxacin (LVX) remnants within water supplies via photo-Fenton's interactions. Using a dosage of 0.5 g/L, the Fe0@CS/CF blend demonstrated noteworthy catalytic qualities, resulting in t...
Source: International Journal of Biological Macromolecules - March 27, 2024 Category: Biochemistry Authors: Sarah I Othman Haifa E Alfassam Haifa A Alqhtani Maha A Al-Waili Ahmed A Allam Mostafa R Abukhadra Source Type: research

Emergence of eravacycline heteroresistance in carbapenem-resistant Acinetobacter baumannii isolates in China
In conclusion, this study identified the emergence of eravacycline heteroresistance in CRAB isolates in China, which is associated with high expression of AdeABC and AdeRS. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - March 27, 2024 Category: Microbiology Source Type: research