Testing novel strategies for patients hospitalised with HIV-associated disseminated tuberculosis (NewStrat-TB): protocol for a randomised controlled trial
The objective of the study is to assess the safety and efficacy of both intensified TB treatment (high dose rifampicin plus levofloxacin) and immunomodulation with corticosteroids as interventions to reduce early mortality in hospitalised patients with HIV-associated disseminated TB.MethodsThis is a phase III randomised controlled superiority trial, evaluating two interventions in a 2 × 2 factorial design: (1) high dose rifampicin (35 mg/kg/day) plus levofloxacin added to standard TB treatment for the first 14 days versus standard tuberculosis treatment and (2) adjunctive corticosteroids (prednisone 1.5 mg/kg/day) versus ...
Source: Trials - May 8, 2024 Category: Research Source Type: clinical trials
Efficacy and Safety of Bismuth Quadruple Therapy Containing Cefuroxime and Tetracycline as First-line Therapy for Eradicating Helicobacter Pylori in Patients Allergic to Penicillin
Conditions: Helicobacter Pylori Infection Interventions: Drug: 14-day bismuth quadruple regimen containing cefuroxime and tetracycline; Drug: 14-day bismuth quadruple regimen containing cefuroxime and levofloxacin Sponsors: Qilu Hospital of Shandong University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 8, 2024 Category: Research Source Type: clinical trials
H. Pylori Screen-and-treat Study in a Population of Young Adults
Conditions: Gastric Cancer; H Pylori Infection; H Pylori Eradication; H-pylori Interventions: Drug: Bismuth-based quadruple therapy; Drug: Levofloxacin-based quadruple therapy; Drug: Standard triple therapy; Drug: Levofloxacin-based triple Sponsors: University of Latvia; Clinical Hospital Center Rijeka; Clinical Hospital Centre Zagreb; Beacon Hospital; Wroclaw Medical University; Iuliu Hatieganu University of Medicine and Pharmacy; National Institute of Public Health, Slovenia Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials
Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection
Conditions: Helicobacter Pylori Infection Interventions: Drug: Bismuth Subcitrate; Drug: Esomeprazole; Drug: Metronidazole; Drug: Amoxicillin; Drug: Clarithromycin; Drug: Levofloxacin Sponsors: National Institute of Public Health, Slovenia; Community Healthcare Center dr. Adolf Drolc Maribor (HCM) Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 22, 2024 Category: Research Source Type: clinical trials
Efficacy of a 2-week therapy with levofloxacin concomitant versus a levofloxacin sequential regimen for Helicobacter pylori infection in the Syrian population: a study protocol for randomized controlled trial
DiscussionFor the first time in the Syrian population, this randomized controlled trial will provide objective and accurate evidence about the efficacy of a sequential levofloxacin-based treatment regimen.Trial registrationClinicalTrials.govNCT06065267. Registered on October 3, 2023. Prospective registered. Enrollment of the first participant has not started yet. (Source: Trials)
Source: Trials - January 15, 2024 Category: Research Source Type: clinical trials
Tailored vs. Empirical Helicobacter Pylori Infection Treatment
Conditions: Helicobacter Pylori Infection Interventions: Diagnostic Test: Clarithromycin (mutations in the 23S rRNA gene, A2134G, A2142G and A2142C mutations) and levofloxacin resistance (mutations in the gyrA gene) PCR test; Drug: Empirically H. pylori eradication treatment with bismuth quadruple therapy (Pylera ®); Drug: PPI, amoxicillin 1 g and clarithromycin 500 mg, twice daily, for 10 days; Drug: PPI, amoxicillin 1g and levofloxacin 250 mg, twice daily, for 10 days; Drug: Bismuth quadruple therapy (Pylera®) for 10 days Sponsors: Manuel Coelho da Rocha Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 11, 2024 Category: Research Source Type: clinical trials
Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy
Conditions: Traumatic Brain Injury Interventions: Behavioral: Rehabilitation therapy; Device: Intermittent Oro-esophageal Tube Feeding; Device: Nasogastric tube feeding; Drug: Reserpine; Drug: Levofloxacin Sponsors: The First Affiliated Hospital of Zhengzhou University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 10, 2024 Category: Research Source Type: clinical trials
Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection
Conditions: Prosthetic-joint Infection; Infection Hip; Infection; Knee, Joint Interventions: Drug: Clindamycin; Drug: Rifampicin and levofloxacin Sponsors: Leiden University Medical Center; University Medical Center Groningen; Onze Lieve Vrouwe Gasthuis; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Medical Centre Leeuwarden; Isala; Martini Hospital Groningen; Radboud University Medical Center; Sint Maartenskliniek; Elisabeth-TweeSteden Ziekenhuis; Erasmus Medical Center; Alrijne Hospital; Spaarne Gasthuis; Reinier Haga Orthopedisch Centrum; Tergooi Hospital; Rijnstate Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 15, 2023 Category: Research Source Type: clinical trials
FOVOCIP study: a multicenter randomized trial of fosfomycin versus ciprofloxacin for febrile neutropenia in hematologic patients —efficacy and microbiologic safety
DiscussionThis trial will provide evidence of the efficacy of an alternative drug to ciprofloxacin for febrile neutropenia prevention in high-risk hematological patients. The battery of planned microbiological studies will allow us to evaluate prospectively the microbiological safety of both pharmacological strategies in terms of the selection of MRGNB occurring in each arm. In addition, valuable information on the way in which each drug changes the fecal microbiome of the patients throughout the treatment will be generated.Trial registrationClinical trials NCT05311254, Registered on 5 April 2022,https://clinicaltrials.gov...
Source: Trials - October 27, 2023 Category: Research Source Type: clinical trials
Efficacy of Amoxicillin-Esomeprazole HDDT Compared to Levofloxacin Triple Therapy for H. Pylori Eradication: A RCT
Conditions: Helicobacter Pylori Infection; Helicobacter Pylori Eradication Interventions: Drug: group A : Amoxicillin Esomeprazole HDDT; Drug: group-B : Levofloxacin triple therapy Sponsors: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 18, 2023 Category: Research Source Type: clinical trials
Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis ：Contizolid and Dlamanid Cohort
Conditions: Pulmonary Tuberculosis; Rifampicin-resistant Tuberculosis Interventions: Drug: Bedaquiline; Drug: Delamanid; Drug: Contezolid; Drug: Levofloxacin; Drug: Moxifloxacin; Drug: Clofazimine; Drug: Linezolid; Drug: Cycloserine; Drug: Prothionamide; Drug: Pyrazinamide; Drug: Para-Aminosalicylic Acid; Drug: Ethambutol Sponsors: Beijing Chest Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 13, 2023 Category: Research Source Type: clinical trials
Levofloxacin Concomitant Versus Levofloxacin Sequential
Conditions: Helicobacter Pylori Infection Interventions: Drug: sequential; Drug: Levofloxacin 500Mg Oral Tablet Sponsors: Damascus Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 3, 2023 Category: Research Source Type: clinical trials
D2 Versus D3 Dissection in Laparoscopic Right Hemicolectomy
Conditions: Blood Loss; Intensive Care; Anastomotic Leakage; Lymph Node Disease; Survival; Blood Transfusion Interventions: Procedure: LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (intervention); Drug: Enoxaparin 40 Mg/0.4 mL Injectable Solution; Drug: Levofloxacin 500mg; Procedure: LAPAROSCOPIC RIGHT HEMICOLECTOMY procedure (Conventional) Sponsors: General Committee of Teaching Hospitals and Institutes, Egypt Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
Effectiveness of Single Dose Fosfomycin and Single Dose Levofloxacin as Pre-urodynamic Antibiotic for UTI Prevention
Conditions: Urological System Complication of Procedure; Urinary Tract Infections Interventions: Drug: Fosfomycin 3000 MG; Drug: Levofloxacin 500mg Sponsor: Indonesia University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 30, 2023 Category: Research Source Type: clinical trials
