Developmental stage and infection status may affect drug distribution in the prostate of rats

Xenobiotica. 2024 Apr 18:1-13. doi: 10.1080/00498254.2024.2343892. Online ahead of print.ABSTRACTProstate inflammation is often treated with drugs which are ineffective. Antibacterial agents fail to reach the prostate epithelium, and the blood-prostate barrier (BPB) may affect the drug transport process. Factors affecting drug efficacy remain unclear.Rats were categorized into groups A and B, corresponding to adulthood and puberty, respectively. Group C included the model of chronic prostate infection. Dialysates of levofloxacin and cefradine were collected from the prostate gland and jugular vein and evaluated. Pharmacokinetic analysis was conducted.The free concentrations of antimicrobials in the prostate and plasma samples of all groups peaked at 20 min, then gradually decreased. The mean AUC0-tprostate/AUC0-tplasma ratio in the levofloxacin group were 0.86, 0.53, and 0.95, and the mean values of AUC0-∞prostate/AUC0-∞plasma ratio were 0.85, 0.63, and 0.97. The corresponding values in the cefradine group were 0.67, 0.30 and 0.84, and 0.66, 0.31, and 0.85, respectively. The mean values in group B were lower than those in group A, and those in group C were higher than those in group B.The maturity of the prostate may affect the ability of the drug to cross the BPB. Infection may disrupt the BPB, affecting drug permeability.PMID:38634734 | DOI:10.1080/00498254.2024.2343892

Source: Xenobiotica - April 18, 2024 Category: Research Authors: Ziyang Xu Lianzhan Sun Chang Yin Handa Wang Xue Wang Yunyun Yang Zhuo Wang Source Type: research