Research into the Use of Exercise to Slow Aging is Not as Simple as One Might Think
One might naively think that studying the effects of exercise on human aging is fairly straightforward. This isn't the case, as illustrated by the authors of this commentary. Very little is simple when it comes to making use of existing epidemiological data, or trying to construct studies that shed light on the question of how exactly exercise interacts with aging. It seems very clear that exercise is a good thing, and that most of us should be undertaking more of it, but once down in the weeds, at the detail level, it is all too easy to find large gaps in present knowledge and contradictory or poorly designed studies.
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Source: Fight Aging! - April 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
BusinessWeek Says " Why Cheaper Insulin Today Risks Higher Costs Later " . We should want that!
On April 4, 2023,Bloomberg BusinessWeek magazine published an article entitled " Why Cheaper Insulin Today Risks Higher Costs Later " (seehttps://www.bloomberg.com/news/articles/2023-04-04/cheaper-insulin-from-lilly-and-sanofi-risks-raising-costs-later for the article). Unfortunately, Americans have grown much too accustomed to seeing prescription drug prices being artificially manipulated from behind-the-scenes by entities who rig the system to line their own pockets that today, we instinctively view higher prices in the future as a direct assault. Don ' t play that game!But if the market was working properly to begi...
Source: Scott's Web Log - April 7, 2023 Category: Endocrinology Tags: glucose responsive insulin 2023 Amphastar Biocon bloomberg BusinessWeek Civica insulin prices Lannett Sandoz the Business of Diabetes Source Type: blogs
Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Tradeoff of Working with Short-Lived Laboratory Species
It is cheaper and faster to study aging - and potential approaches to treat aging - in short-lived species. The disadvantage is that much of what is learned and achieved will be irrelevant to aging as it occurs in longer-lived species such as our own. The response to calorie restriction, an upregulation of cellular housekeeping mechanisms that lengthens life, fortunately evolved early on in the development of life, and the biochemistry is surprisingly consistent even across widely divergent species. Thus much can be learned of it in lower animals with short life spans. Unfortunately, it turns out that this class of interve...
Source: Fight Aging! - March 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Non-Canonical Autophagy in Aging
Autophagy is the name given to a complex collection of processes that recycle broken and unwanted proteins and cell structures. Autophagy declines in effectiveness with age, while upregulation of autophagy is a feature of many of the approaches shown to slow aging in laboratory species. The ability of calorie restriction to slow aging appears to depend on autophagy, for example. So far, little meaningful progress has been made towards therapies that can greatly improve on the ability of exercise to improve autophagy, though mTOR inhibitors could be argued to be somewhat better than exercise on this front, given their great...
Source: Fight Aging! - March 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
CRISPR Combined with Glowing Proteins for Viral Detection
Researchers at Eindhoven University of Technology in the Netherlands have developed a sensitive diagnostic test for viral pathogens that is suitable for use in low-resource regions. The test is based on CRISPR proteins that can detect viral genetic material but also incorporates luciferase proteins, which are bioluminescent proteins that are naturally found in fireflies and other creatures. Two CRISPR/Cas proteins are specific for different parts of the viral genome, and when they both bind to target nucleic acid sequences they join together, uniting two fragments of luciferase and initiating a bioluminescent signal. The r...
Source: Medgadget - March 23, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Genetics Medicine Public Health CRISPR TUeindhoven Source Type: blogs
Imagene Profiles Cancer Biomarkers in Real Time
Cancer therapies have proliferated over the past few decades, improving outcomes for many patients. But this variety requires accurate diagnostics and appropriate decision making to choose the optimal course of therapy. The current gold standard of identifying which cancer mutation is present is new generation sequencing (NGS), which provides a comprehensive genetic report, but can take up to six weeks to complete, requires a significant tumor sample size, and can only be done in an advanced laboratory at a high cost.
Imagene, a company headquartered in Tel Aviv, Israel, has developed AI-based image analysis software...
Source: Medgadget - March 22, 2023 Category: Medical Devices Authors: Medgadget Editors Tags: Diagnostics Exclusive Oncology Pathology biomarkers cancer biomarkers molecular profiling Source Type: blogs
Slideshow: Circles of Life
Every year on March 14, many people eat pie in honor of Pi Day. Mathematically speaking, pi (π) is the ratio of a circle’s circumference (the distance around the outside) to its diameter (the length from one side of the circle to the other, straight through the center). That means if you divide the circumference of any circle by its diameter, the solution will always be pi, which is roughly 3.14—hence March 14, or 3/14. But pi is an irrational number, which means that the numbers after the decimal point never end. With the help of computers, mathematicians have determined trillions of digits of pi.
To celebrate Pi ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Molecular Structures Cellular Imaging Cool Images Microbes Research Organisms Source Type: blogs
Smartphone Photos to Detect Anemia
Researchers at University College London and at the University of Ghana have developed a smartphone-based system that can detect anemia through simple photos taken using the phone’s camera. The technology is intended for use in low- and middle-income countries where access to routine medical diagnostics may be unreliable. The process involves obtaining images of areas of the body which are least pigmented, including the white of the eye, the lower eyelid, and the lip. The app then analyzes the color of the imaged tissue, and as hemoglobin absorbs light in a specific fashion the app can use this information to calcula...
Source: Medgadget - March 9, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Telemedicine anaemia anemia uclnews UCLResearch univofgh Source Type: blogs
AI in Healthcare: A Great Add-on, Not a Replacement
There has been this huge rush to implement AI wherever it can be added. And while nothing is wrong with this, it’s important that we don’t loose sight of AI being a tool and not a replacement. There are so many great things that AI can do, such as data gathering, increased pattern recognition, etc. However, it cannot fully nor successfully replace a human. A human touch is very much still needed, not only to get the AI to function as it should but in order for patients to feel comfortable.
So instead of looking for one or the other, it’s important to look for a balance. For a closer look at this balance w...
Source: EMR and HIPAA - March 9, 2023 Category: Information Technology Authors: John Lynn Tags: AI/Machine Learning C-Suite Leadership Communication and Patient Experience Healthcare IT Adam Cole Advata Archie Mayani Art Papier athenahealth Ben Zaniello Billy Parrish Brian Fugere Cedar Change Healthcare Charlie Clarke C Source Type: blogs
Launching Biomedical Careers for Students Who Are Deaf and Hard of Hearing
Group of RIT U-RISE students, including Bo Allaby (standing second from the right) and Maameyaa Asiamah (kneeling in front) who are interviewed in this post. Credit: Dr. Bonnie Jacob.
Scientists who are deaf and hard of hearing (DHH) are underrepresented at all career stages, especially at the Ph.D. level. To address this, the Undergraduate Research Training Initiative for Student Enhancement (U-RISE) training program for undergraduates who are deaf and hard of hearing at the Rochester Institute of Technology (RIT) in Rochester, New York, has committed to lifting barriers and increasing DHH representation in science.
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Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 8, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
Fight Aging! Newsletter, March 6th 2023
In this study, we develop a rFOXN1 fusion protein that contains the N-terminal of CCR9, FOXN1, and TAT. We show here that, when injected intravenously (i.v.) into aged mice, the rFOXN1 fusion protein can migrate into the thymus and enhance T cell generation in the thymus, resulting in increased number of peripheral T cells. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in the older adult.
Increased miR-181a-5p Expression Improves Neural Stem Cell Activity, Learning, and Memory in Old Mice
https://www.fightaging.org/archives/20...
Source: Fight Aging! - March 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Whoops! AI might have invented 40000 new toxic nerve agents … but probably not
TL:DR – Software used to predict which chemicals in a database have potential as new medicines has been flipped as a warning demonstrating that the same system could be used to predict whether they are highly toxic.
Artificial intelligence, AI, machine learning, language models, neural networks, generative models, algorithms trained on big data. A lovely collection of buzzwords that have been littering grant proposals for years and are now emerging into the real world as apps and websites and citizen science projects. For chemists and pharmaceutical scientists, AI has been a tool to experiment with for a long time. ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 4, 2023 Category: Science Authors: David Bradley Tags: Artificial Intelligence Chemistry Source Type: blogs
Alpha TAU Killing Tumors With Highly Targeted Alpha Radiation
Radiation is commonly employed in hospitals around the world to treat tumors, typically using gamma ray beams of high energy photons, with a relatively long range, that penetrate all the tissues on the way to and from the tumor. This leads to substantial damage to healthy tissues and too often results in poor outcomes. An alpha particle, consisting of two protons and two neutrons bound together and akin to a helium-4 nucleus, is much trickier to work with in medicine because it is extremely powerful, yet has a very short effective range.
Ronen Segal
We recently visited the offices of Alpha TAU, a company based in Jeru...
Source: Medgadget - March 2, 2023 Category: Medical Devices Authors: Medgadget Editors Tags: Exclusive Oncology Radiation Oncology TelAvivUni Source Type: blogs
A ChatGPT glossary
TL:DR – A number of people were reaching Sciencebase searching for the phrase ChatGPT beam search so I asked ChatGPT itself to give me a definition. I then asked it to create a glossary of other common terms associated with Generative pre-trained transformers, GPTs.
ChatGPT, the language model, is essentially an incredibly sophisticated autocomplete program that responds to text prompts by predicting what might come next. It’s worth noting that it’s commonly referred to as artificial intelligence, AI. It is not AI. Here’s its response to my prompt asking it for a definition of ChatGPT beam search:
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Source: David Bradley Sciencebase - Songs, Snaps, Science - March 1, 2023 Category: Science Authors: David Bradley Tags: Artificial Intelligence Source Type: blogs
