Case of the Week 734
Welcome to the first blog post of 2024! I had been particularly busy last year as I was serving as the Interim Chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic. Now that the permanent Department Chair has arrived, I can go back to my ' day job ' of Chair of Clinical Microbiology and Director of the Clinical Parasitology laboratory. I anticipate being able to go back to regular posting again as well. So without further ado, here is our case this week, courtesy of Heather Morris, the Parasitology Technical Specialist in my laboratory. The following objects were found in a concentrated wet prep...
Source: Creepy Dreadful Wonderful Parasites - January 11, 2024 Category: Parasitology Source Type: blogs
The Longevity-Associated Gene INDY as a Target for Treatment of Osteoporosis
INDY is a well-studied longevity-associated gene. Reduced INDY expression extends life in a number of short-lived laboratory species. Here, researchers argue that INDY inhibition could form the basis for osteoporosis treatments. Osteoporosis is the condition resulting from age-related loss of bone density. Bone is constantly remodeled by osteoblasts that build bone extracellular matrix and osteoclasts that destroy it. With advancing age, the activity of osteoclasts steadily outpaces the activity of osteoblasts. This occurs for a variety of reasons, and much of the research into osteoporosis is conducted in search of ways t...
Source: Fight Aging! - January 9, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Three normal high sensitivity troponins over 4 hours with a " normal ECG "
Written byWilly FrickA 46 year old man with a history of type 2 diabetes mellitus presented to urgent care with complaint of " chest burning. " The documentation does not describe any additional details of the history. The following ECG was obtained.ECG 1What do you think?The ECG shows sinus bradycardia but is otherwise normal. There is TWI in lead III, but this can be seen in normal ECGs. No labs were obtained. The patient was given a prescription for albuterol and a referral to cardiology.Smith comment:No patient over 25 years of age with unexplained chest burning should be discharged without a troponin rule out, no matt...
Source: Dr. Smith's ECG Blog - January 5, 2024 Category: Cardiology Authors: Willy Frick Source Type: blogs
Inspiring the Next Generation of Scientists Through CityLab
Credit: CityLab.
“Many of the students we work with don’t have access to a laboratory through their local schools. For them, CityLab is their first exposure to a laboratory environment—these are hugely important moments for these kids,” says Carl Franzblau, Ph.D., the founder of CityLab at Boston University (BU). CityLab was established more than 30 years ago as a science education outreach program for precollege students and teachers through a partnership between the Chobanian & Avedisian School of Medicine and the Wheelock College of Education & Human Development at BU.
“Since our first Science Edu...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 3, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology STEM Education SEPA Training Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Existing Geroprotective Drugs May Not Interact Well with Exercise
The big disadvantage of the geroprotective approach to aging, which is essentially to undertake the long-term use of supplements and small molecule drugs to alter metabolism in ways that slow aging over years and decades, is that distinct supplements and small molecules and adjustments tend to combine in unexpected ways. Short of testing every combination in laboratory species, something that Brian Kennedy's team has been working on, one can never know the outcome of combining a treatment. Based on presentations and interviews given by Kennedy in the last few years, the result of combining two geroprotectors that individua...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Seeking Success in Science Through NIH-Funded Training
Credit: Courtesy of Hasset Nurelegne.
“What’s great about a career in research is that there are so many paths you can take. I get so excited for the future when I think about all the open doors ahead of me,” says Hasset Nurelegne, a senior at Emory University in Atlanta, Georgia. Hasset is majoring in neuroscience and behavioral biology (NBB) as well as English.
Since her first year on campus, Hasset has been an active participant in an NIGMS-funded program at Emory that aims to develop a diverse pool of scientists, the Initiative for Maximizing Student Development (IMSD) (which is now just for graduate student...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 20, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
Healthy Data Management: How IT Assists Healthcare Institutions
The following is a guest article by Natalie Tkachenko, Healthcare Software Solutions Consultant at NIX
To obtain test results today, there’s no need to visit the hospital. Simply open a mobile app and download the report to your smartphone. Doctors remotely manage patient data without being tied to a specific medical facility. They also handle large volumes of data effortlessly within their hospitals. This became possible thanks to electronic health records, telemedicine, and cloud solutions. However, along with advancements, challenges in digital healthcare are increasing. Let’s discuss how to tackle them and ...
Source: EMR and HIPAA - December 15, 2023 Category: Information Technology Authors: Guest Author Tags: Analytics/Big Data C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Regulations Security and Privacy AI Amazon Web Services AWS Blockchain Cloud Storage Cybersecurity Data Management Digital Healthcar Source Type: blogs
Top 6 Medical Trends To Watch for 2024
This study also reported a weight reduction of 4.0 kilograms and a 10.8-millimeter reduction in systolic blood pressure among patients.
This segment is becoming significant in market terms as well: the market for DTx was valued at USD 5.53 billion in 2022 and is expected to grow to USD 28.66 billion by 2030. The increased prevalence of chronic conditions, as the result of our longer lives, fuels this growth as conditions like diabetes or hypertension can be more efficiently managed with a combination of traditional medicine and DTx.
While these apps are available in a large number of medical specialties, channe...
Source: The Medical Futurist - December 14, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Source Type: blogs
RSNA Panel Emphasizes Link Between Radiology and Quadruple Aim
A panel of radiology experts at RSNA23 put the spotlight on the important role radiology plays in achieving the quadruple aim. The panelists unanimously agreed that radiologists have a significant impact on a patient’s care journey and population health.
At the 2023 RSNA Conference in Chicago, PocketHealth hosted a lunch and learn event on Day 1. This special event featured a panel of radiology and data sharing experts:
Rishi Nayyar – Co-Founder & CEO at PocketHealth (moderator)
Aimee Langan – Director, Diagnostic Imaging and Laboratory Services at William Osler Health System
Ajay Kohli, MD, MBA – ...
Source: EMR and HIPAA - December 12, 2023 Category: Information Technology Authors: Colin Hung Tags: Health IT Company Healthcare IT HIM Hospital - Health System Interoperability Aimee Langan Ajay Kohli Frank Manole Image Exchange PocketHealth Population Health Quadruple Aim Radiology Radiology IT Raleigh Radiology Ram Chada Source Type: blogs
Aranscia Acquires YouScript from Invitae
Aranscia, a global provider of diagnostics software, services, and testing solutions, and Invitae Corporation, a leading medical genetics company, today announced that Aranscia has acquired select assets of the YouScript personalized medication management platform from Invitae Corporation in an all-cash transaction. YouScript is a widely recognized leader in providing actionable, real-time medication risk and pharmacogenomics (PGx) insights that enable healthcare providers and organizations to build, deliver, and scale comprehensive personalized medication management programs. YouScript’s foundational peer-reviewed resea...
Source: EMR and HIPAA - December 11, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 2bPrecise AccessDX Laboratory Aranscia Health IT Acquisitions Healthcare M&A Invitae Corporation Joe Spinelli Kristine Ashcraft SinguLab YouScript Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
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Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Progressing Towards Regulatory Approval of Veterinary Therapies Targeting Aging
Veterinary medicine is typically less impeded by FDA regulatory costs than human medicine. A cynic would note that the publicity-related incentives operating on FDA staff and leadership are quite different in these two cases, with a great deal more attention given by the media to matters regarding human medicine. With the relative costs being what they are, a number of entrepreneurs in the longevity industry chose to work towards veterinary therapies targeting mechanisms of aging. One of those companies, Loyal, here reports on progress towards the FDA essentially agreeing to a regulatory framework for therapies targeting a...
Source: Fight Aging! - December 8, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
