The 7 Decade History of ChatGPT
By MIKE MAGEE Over the past year, the general popularization of AI orArtificial Intelligence has captured the world’s imagination. Of course, academicians often emphasize historical context. But entrepreneurs tend to agree with Thomas Jefferson who said, “I like dreams of the future better than the history of the past.” This particular dream however is all about language, its standing and significance in human society. Throughout history, language has been a species accelerant, a secret power that has allowed us to dominate and rise quickly (for better or worse) to the position of “masters of the un...
Source: The Health Care Blog - February 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI ChatGPT History of AI Mike Magee Source Type: blogs

Fight Aging! Newsletter, February 19th 2024
This study aimed to explore the metabolic mechanisms and potential biomarkers associated with declining HGS among older adults. We recruited 15 age- and environment-matched inpatients (age, 77-90 years) with low or normal HGS. Liquid chromatography-mass spectrometry (LC-MS) and 16S ribosomal DNA (rDNA) gene sequencing were performed to analyze the metabolome of serum and stool samples and the gut microbiome composition of stool samples. Spearman's correlation analysis was used to identify the potential serum and fecal metabolites associated with HGS. We assessed the levels of serum and fecal metabolites belonging to...
Source: Fight Aging! - February 18, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Current State And Future Of Biohacking
For years at The Medical Futurist, we’ve covered countless digital health devices and technologies, and how they can empower patients in the digital health age. These share the common feature of augmenting the patient experience, and such augmentations can be taken to the next level via biohacking.  In this article, we’ll introduce the biohacking concept, illustrate it with examples of biohackers (you might be one already!) and contemplate its impact on the future of digital health. What is biohacking? As the term itself suggests, “biohacking” generally refers to the act of hacking or modifying biolog...
Source: The Medical Futurist - February 15, 2024 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF implants biohacking grinders Source Type: blogs

Get Ready for Filariae!
Dear Readers, I ' m delighted to announce that March and April areFilariasis Monthscourtesy of Idzi Potters and the Institute of Tropical Medicine in Antwerp! Image by Blaine MathisonYou may want to brush up on your filariae/microfilariae diagnostic skills in preparation. Here are a few resources to help you: World Health Organization Bench Aids for the Diagnosis of Filarial Infections. Available here: https://www.cdc.gov/dpdx/diagnosticprocedures/index.html (see the section on filariasis near the bottom right of the page)CDC DPDx - Laboratory Identification of Parasites of Public Health Concern:Lymphatic fi...
Source: Creepy Dreadful Wonderful Parasites - February 15, 2024 Category: Parasitology Source Type: blogs

What Does an Immunologist Do?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed. Immunology is the study of the immune system, including all the cells, tissues, and organs that work together to protect you from germs. A person who studies immunology is called an immunologist, and there are three types: Researchers, who study the immune system in the laboratory to understand how it works or how it can go awry and find new treatments for immune system-related diseases Doctors, who diagnose and care for patients with diseases related to the immune system, such as ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 12, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Injury and Illness Immunology Miniseries Infectious Diseases Medicines Microbes Research Roundup Source Type: blogs

Considering the Near Future of Senotherapeutics
Senescent cells accumulate with age, and this accumulation drives a sizable fraction of the dysfunction of degenerative aging. While never present in very large numbers, these cells energetically secrete signal molecules that provoke inflammation and tissue remodeling. As noted here, a major theme in the development of senotherapeutic drugs to either selectively destroy senescent cells or broadly suppress the disruptive signaling of senescent cells is the need for greater understanding of the diversity of cellular senescence. Different tissues, different cell types, different origins of the senescent state may all be meani...
Source: Fight Aging! - February 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people. « Back to Top Greater Individual Wealth Correlates with Longer Life Expectancy https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/ Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Bypassing Causes to Focus on Repairing Damaged Synapses in Alzheimer's Disease
Should we expect an approach focused on repair of synapses in neurodegenerative conditions like Alzheimer's disease, while leaving the causative mechanisms of the condition operating intact, to have a large effect on patient outcomes? Given what is known of the underlying mechanisms of protein aggregation, neuroinflammation, and other problems that ultimately kill neurons, not just damage them, it seems possible that synaptic repair might do well in the early stages of cognitive impairment, but later do little to help as the condition progresses. Regardless, it is interesting to consider to degree to which neural function ...
Source: Fight Aging! - February 9, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Chest pain with anterior ST depression: look what happens if you use posterior leads.
Don ' t forget to watch theWebinar: Smith and Pendell Meyers interpret ECGs for OMI or not OMI on Monday Feb 12 at 11 AM U.S. Central time.  Register here:https://zoom.us/webinar/register/7617067094184/WN_LMN0vPb1Rz-HZu12K-QuYQWritten by Jesse McLarenA 65 year old with a history of atrial flutter, CABG and end-stage renal disease on dialysis presented with 3 days of fluctuating chest pain, which was ongoing at triage. What do you think? Do you need posterior leads?There ’s atrial flutter with controlled ventricular response, a non-specific intra-ventricular conduction delay, borderline right axis, normal R wave...
Source: Dr. Smith's ECG Blog - February 9, 2024 Category: Cardiology Authors: Jesse McLaren Source Type: blogs

Broadening Opportunities for Students in STEM at Brown University and Beyond
Credit: Courtesy of Brown University. Andrew G. Campbell, Ph.D., a professor of medical science at Brown University in Providence, Rhode Island, and previous dean of the graduate school, is passionate about researching understudied diseases and helping students reach their full potential. Dr. Campbell’s lab has studied the single-cell organism Trypanosoma brucei (T. brucei), a parasite transmitted through the bite of the tsetse fly, which is only found in specific regions of Africa. In humans, T. brucei causes African Trypanosomiasis, also known as sleeping sickness. Symptoms of this illness include headache, weakne...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Profiles Training Source Type: blogs

Increasing Opportunities in STEM at Brown University and Beyond
Credit: Courtesy of Brown University. Andrew G. Campbell, Ph.D., a professor of medical science at Brown University in Providence, Rhode Island, and previous dean of the graduate school, is passionate about researching understudied diseases and helping students reach their full potential. Dr. Campbell’s lab has studied the single-cell organism Trypanosoma brucei (T. brucei), a parasite transmitted through the bite of the tsetse fly, which is only found in specific regions of Africa. In humans, T. brucei causes African Trypanosomiasis, also known as sleeping sickness. Symptoms of this illness include headache, weakne...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 7, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Profiles Training Source Type: blogs

Will Patients Have To Pay For Using AI In Their Healthcare?
This article discussed how the author was asked if she wanted to pay $40 extra for additional AI analysis in mammography. In her case a Manhattan radiology clinic offered an AI analysis of their mammogram for an additional $40, not covered by insurance. This scenario was echoed at a clinic in suburban Baltimore, where patients were similarly offered AI-assisted mammography for a $40 fee. These instances mark the initial real-world applications of AI in patient care but also introduce new factors to the healthcare equation.  To make things more complicated, we can’t look for a single, universal solution here. Heal...
Source: The Medical Futurist - February 6, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI in healthcare AI in medicine Source Type: blogs

The Business Case for a Biosimilar Company to Bring a Copy of Levemir to Market
My readers may recall that in November 2023, I blogged that Novo Nordisk announced it plans to retire (stop making) its first " Lantus killer " known as Levemir (insulin detemir injection) in the U.S. in 2024 (catch my post at https://blog.sstrumello.com/2023/11/novo-nordisk-to-discontinue-levemir-in.html for more). At the time I learned of the announcement, I was on vacation in Amsterdam, so I just made a note of the development and blogged about it a few weeks later upon my return.Like other patients my age, I have endured the company ' s previous insulin " retirements " . Novo Nordisk ' s time-frame for withdr...
Source: Scott's Web Log - January 25, 2024 Category: Endocrinology Tags: 2024 Biosimilar Levemir Novo Nordisk PBM Source Type: blogs

7 Things To Expect From AI In Healthcare This Year
The past year was all about artificial intelligence, with a particular focus on its integration into healthcare in our universe. At The Medical Futurist, we have extensively explored how AI is reshaping the healthcare landscape, outlining what to expect and how to prepare for these transformative changes. As we move into 2024, it’s time to continue our forward-looking journey. This year promises to be a blend of consolidation and revolution. Some trends we’ve previously identified are beginning to solidify and integrate into the fabric of healthcare systems, while others are just starting to unfold. In th...
Source: The Medical Futurist - January 25, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF AI AI in medicine artificial intelligence artificial intelligence in healthcare Source Type: blogs

Zombie Viruses of the Permafrost
By KIM BELLARD We’ve had some cold weather here lately, as has much of the nation. Not necessarily record-breaking, but uncomfortable for millions of people. It’s the kind of weather that causes climate change skeptics to sneer “where’s the global warming now?” This despite 2023 being the warmest year on record — “by far” — and the fact that the ten warmest years since 1850 have all been in the last decade, according to NOAA. One of the parts of the globe warming the fastest is the Arctic, which is warming four times as fast as the rest of the planet. That sounds like good news if you run a ...
Source: The Health Care Blog - January 24, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Climate Change Kim Bellard Viruses Source Type: blogs