Connecting NANOG Expression with the Response to Methionine Restriction
Calorie restriction is known to slow aging, albeit to a much greater degree in short-lived species than in long-lived species. Finding important mechanisms involved in the beneficial response to calorie restriction continues to be a major focus on the research community, even though it is questionable as to whether this is a good approach to the treatment of aging. A sizable fraction of the response to calorie restriction appears to be mediated by methionine sensing, at least judging by the degree to which reducing methioninine intake can reproduce the benefits of full calorie restriction.
In today's open access pap...
Source: Fight Aging! - February 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 27th 2023
This study tested the hypothesis that ischemic vascular repair in aging by Ang-(1-7) involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells.
Young or Old male mice of age 3-4 and 22-24 months, respectively, received Ang-(1-7) for four weeks. Myelopoiesis was evaluated in the bone marrow (BM) cells by carrying out the colony forming unit (CFU-GM) assay followed by flow cytometry of monocyte-macrophages. Expression of pro-myelopoietic factors and alarmins in the hematopoietic progenitor-enriched BM cells was evaluated. Hindlimb ischemia (HLI) was induced by ...
Source: Fight Aging! - February 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Insufficient Water Intake May Correlate with Increased Arterial Stiffness
As a companion piece to a recent discussion of whether mild dehydration is both quite prevalent and meaningfully impacts aspects of aging, one might look at this study of water consumption and vascular health in hyperuremic individuals. A relationship between lower water intake and arterial stiffness was only significant in women, but nonetheless it is interesting to see data that suggests at least some populations are harming themselves over the long term via too little water intake.
Hyperuricemia is defined as an elevated serum uric acid (sUA) level in the blood and is well-known as an independent risk factor fo...
Source: Fight Aging! - February 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
One of the Many Advantages of AI in Healthcare: Data
In the world of Healthcare, there isn’t much room for making guesses. When you’re in charge of someone’s well being, it is critical that all of your decisions are well thought through and based on data. This is where AI can be very useful to your organization. AI, when applied properly, is very helpful in not only gathering data, but in sharing, analyzing, and storing it.
We reached out to our incredibly talented Healthcare IT Today Community for their comments and insights on the impact AI can have on data. This is what they had to say.
Ben Herzberg, Chief Scientist at Satori
From “where we are sta...
Source: EMR and HIPAA - February 21, 2023 Category: Information Technology Authors: John Lynn Tags: AI/Machine Learning Ambulatory Analytics/Big Data C-Suite Leadership Clinical Health IT Company Healthcare IT Hospital - Health System LTPAC 4medica Artificial Intelligence Ben Herzberg Charlie Clarke Data Driven Healthcare Dr. Source Type: blogs
Lessons From a Ransomware Attack: The Importance of Partnership & Collaboration
The following is a guest article by John Gaede, Director of Information Systems at Sky Lakes Medical Center.
Imagine a rural business is the victim of a cyberattack. A nefarious person or group convinces an unsuspecting employee to open an email promising a bonus. Within 12 hours, every piece of technology connected to that network, and every process needed to conduct daily operations, is paralyzed.
Now imagine that business is a hospital. It serves 80,000 people and it’s the only one within 10,000 square miles. Add to the scenario a global pandemic that is steadily ravaging the nation’s healthcare system. On October...
Source: EMR and HIPAA - February 21, 2023 Category: Information Technology Authors: Guest Author Tags: Health IT Company Healthcare IT Hospital - Health System IT Infrastructure and Dev Ops Security and Privacy 3M 3M Health Information Systems 3M HIS Abbadox Cohesity Cyberattacks Cybersecurity Electromek Diagnostic System FBI’s Source Type: blogs
Thoughts on How to Help Advance Work on the Treatment of Aging
This article lists a variety of types of activity and project that might be undertaken to help to speed up the development of ways to treat aging as a medical condition. If you don't have a background in the life sciences, but nonetheless find human longevity a compelling topic, and would like to work in the field, what can you do? That is a good question, and often asked. There are many options that don't involve working as a scientist in a laboratory, though educating yourself about the science helps a great deal when it comes to picking the better options from the array of choices on the table.
Aging is a set o...
Source: Fight Aging! - February 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TWiV 985: Bambi ’ s revenge
TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Click arrow to playDownload TWiV 985 (66 MB .mp3, 109 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become […] (Source: virology blog)
Source: virology blog - February 19, 2023 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology coronavirus COVID-19 hemorrhagic fever IPV marburg virus pandemic poliovirus poliovirus essential facility SARS-CoV-2 variant of concern viral viruses white-tailed deer Source Type: blogs
TWiV 985: Bambi ’ s revenge
TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Click arrow to playDownload TWiV 985 (66 MB .mp3, 109 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become … TWiV 985: Bambi’s revenge Read More » (Source: virology blog)
Source: virology blog - February 19, 2023 Category: Virology Authors: Vincent Racaniello Source Type: blogs
Microglial Autophagy in Parkinson's Disease
Autophagy is the name given to a collection of maintenance processes responsible for clearing waste and damaged proteins and structures from the cell. Autophagy is implicated in aging. It is thought to become dysfunctional and less efficient in cells in aging tissues. Further, evidence suggests that improved autophagy is an important mechanisms in the slowing of aging produced by calorie restriction and a range of other interventions tested in laboratory species. Here, researchers discuss the relationship between aging and autophagy specifically in the context of Parkinson's disease and the role of inflammatory microglia i...
Source: Fight Aging! - February 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A New Record for the Longest Lived Laboratory Rat, Resulting from Plasma Dilution
Many more life span studies are carried out in mice rather than rats, so it is not too surprising to see people pushing the record for longest lived rat. The longest lived mice are those in which growth hormone receptor signaling is inhibited, while the longest lived rats are the result of life-long calorie restriction. The group noted here is pursuing a strategy of processing the blood plasma from young animals and then introducing the processed plasma into old animals. A treatment starting in mid-life produced a modest gain in median life span in rats, while the one still surviving rat from the small study group has surp...
Source: Fight Aging! - February 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Path Forward for Healthcare ’s People Matching Problem
The following is a guest article by Rachel Podczervinski MS, RHIA, Vice President of Professional Services at Harris Data Integrity Solutions.
Efforts to identify the right path forward for healthcare’s patient matching problem are gaining a foothold as stakeholders from across the spectrum come together to remove obstacles and implement effective solutions. Most notably, in 2022, efforts by industry organizations like Patient ID Now led to the temporary removal of Section 510 from the U.S. House and Senate Labor, Health and Human Services, Education, and Related Agencies (Labor-HHS) appropriations bills. While it was ul...
Source: EMR and HIPAA - February 15, 2023 Category: Information Technology Authors: Guest Author Tags: C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Interoperability Security and Privacy Telemedicine and Remote Monitoring Black Book Research EHR Electronic Health Records EMPI Enterprise Master Patient Ind Source Type: blogs
Nanowire Assay Detects Brain Tumors from Urine
Researchers at Nagoya University in Japan have developed a nanowire assay that can be used to capture and detect specific extracellular vesicles in a urine sample that indicate the presence of a brain tumor. These extracellular vesicles are naturally excreted in the urine but techniques to capture and analyze them have been complex, requiring different pieces of equipment, until now. This all-in-one assay uses a simple well plate that has been coated with zinc oxide nanowires that extracellular vesicles are attracted to because of their surface electrical charge. Then, the researchers can detect tumor-specific extracellula...
Source: Medgadget - February 14, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Materials Oncology Pathology nagoyacity_univ NagoyaUniv Source Type: blogs
Neural Chip Detects, Suppresses Neurological Symptoms
Researchers at Ecole Polytechnique Fédérale de Lausanne in Switzerland have designed an advanced neural chip that can detect and suppress symptoms from a variety of neurological disorders, including Parkinson’s and epilepsy. The closed-loop neuromodulation system, which the researchers have called NeuralTree, includes soft implantable electrodes, a processor for machine learning, and a 256 channel sensing array. The device is also energy efficient, helping to extend battery life. The technology can spot the signs of upcoming tremors or seizures, for example, and initiate neurostimulation to reduce or avoid the symptoms...
Source: Medgadget - February 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Neurosurgery brain computer interface EPFL Source Type: blogs
Fight Aging! Newsletter, February 6th 2023
In conclusion, our study reveals that aging enhances atherosclerosis via increased inflammation of visceral fat. Our study suggests that future therapies targeting the visceral fat may reduce atherosclerosis diseaseburden in the expanding older population.
Is the Gut a Significant Source of Amyloid-β in Alzheimer's Disease?
https://www.fightaging.org/archives/2023/02/is-the-gut-a-significant-source-of-amyloid-%ce%b2-in-alzheimers-disease/
The early stages of Alzheimer's disease are characterized by rising levels of amyloid-β in the brain and the formation of misfolded amyloid aggregates. It is present...
Source: Fight Aging! - February 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
