Bypassing Causes to Focus on Repairing Damaged Synapses in Alzheimer's Disease
Should we expect an approach focused on repair of synapses in neurodegenerative conditions like Alzheimer's disease, while leaving the causative mechanisms of the condition operating intact, to have a large effect on patient outcomes? Given what is known of the underlying mechanisms of protein aggregation, neuroinflammation, and other problems that ultimately kill neurons, not just damage them, it seems possible that synaptic repair might do well in the early stages of cognitive impairment, but later do little to help as the condition progresses. Regardless, it is interesting to consider to degree to which neural function ...
Source: Fight Aging! - February 9, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chest pain with anterior ST depression: look what happens if you use posterior leads.
Don ' t forget to watch theWebinar: Smith and Pendell Meyers interpret ECGs for OMI or not OMI on Monday Feb 12 at 11 AM U.S. Central time. Register here:https://zoom.us/webinar/register/7617067094184/WN_LMN0vPb1Rz-HZu12K-QuYQWritten by Jesse McLarenA 65 year old
with a history of atrial flutter, CABG and end-stage renal disease on dialysis presented
with 3 days of fluctuating chest pain, which was ongoing at triage. What do you
think? Do you need posterior leads?There ’s atrial
flutter with controlled ventricular response, a non-specific intra-ventricular
conduction delay, borderline right axis, normal R wave...
Source: Dr. Smith's ECG Blog - February 9, 2024 Category: Cardiology Authors: Jesse McLaren Source Type: blogs
Broadening Opportunities for Students in STEM at Brown University and Beyond
Credit: Courtesy of Brown University.
Andrew G. Campbell, Ph.D., a professor of medical science at Brown University in Providence, Rhode Island, and previous dean of the graduate school, is passionate about researching understudied diseases and helping students reach their full potential.
Dr. Campbell’s lab has studied the single-cell organism Trypanosoma brucei (T. brucei), a parasite transmitted through the bite of the tsetse fly, which is only found in specific regions of Africa. In humans, T. brucei causes African Trypanosomiasis, also known as sleeping sickness. Symptoms of this illness include headache, weakne...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Profiles Training Source Type: blogs
Increasing Opportunities in STEM at Brown University and Beyond
Credit: Courtesy of Brown University.
Andrew G. Campbell, Ph.D., a professor of medical science at Brown University in Providence, Rhode Island, and previous dean of the graduate school, is passionate about researching understudied diseases and helping students reach their full potential.
Dr. Campbell’s lab has studied the single-cell organism Trypanosoma brucei (T. brucei), a parasite transmitted through the bite of the tsetse fly, which is only found in specific regions of Africa. In humans, T. brucei causes African Trypanosomiasis, also known as sleeping sickness. Symptoms of this illness include headache, weakne...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 7, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Profiles Training Source Type: blogs
Will Patients Have To Pay For Using AI In Their Healthcare?
This article discussed how the author was asked if she wanted to pay $40 extra for additional AI analysis in mammography. In her case a Manhattan radiology clinic offered an AI analysis of their mammogram for an additional $40, not covered by insurance. This scenario was echoed at a clinic in suburban Baltimore, where patients were similarly offered AI-assisted mammography for a $40 fee. These instances mark the initial real-world applications of AI in patient care but also introduce new factors to the healthcare equation.
To make things more complicated, we can’t look for a single, universal solution here. Heal...
Source: The Medical Futurist - February 6, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI in healthcare AI in medicine Source Type: blogs
The Business Case for a Biosimilar Company to Bring a Copy of Levemir to Market
My readers may recall that in November 2023, I blogged that Novo Nordisk announced it plans to retire (stop making) its first " Lantus killer " known as Levemir (insulin detemir injection) in the U.S. in 2024 (catch my post at https://blog.sstrumello.com/2023/11/novo-nordisk-to-discontinue-levemir-in.html for more). At the time I learned of the announcement, I was on vacation in Amsterdam, so I just made a note of the development and blogged about it a few weeks later upon my return.Like other patients my age, I have endured the company ' s previous insulin " retirements " . Novo Nordisk ' s time-frame for withdr...
Source: Scott's Web Log - January 25, 2024 Category: Endocrinology Tags: 2024 Biosimilar Levemir Novo Nordisk PBM Source Type: blogs
7 Things To Expect From AI In Healthcare This Year
The past year was all about artificial intelligence, with a particular focus on its integration into healthcare in our universe. At The Medical Futurist, we have extensively explored how AI is reshaping the healthcare landscape, outlining what to expect and how to prepare for these transformative changes.
As we move into 2024, it’s time to continue our forward-looking journey. This year promises to be a blend of consolidation and revolution. Some trends we’ve previously identified are beginning to solidify and integrate into the fabric of healthcare systems, while others are just starting to unfold.
In th...
Source: The Medical Futurist - January 25, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF AI AI in medicine artificial intelligence artificial intelligence in healthcare Source Type: blogs
Zombie Viruses of the Permafrost
By KIM BELLARD
We’ve had some cold weather here lately, as has much of the nation. Not necessarily record-breaking, but uncomfortable for millions of people. It’s the kind of weather that causes climate change skeptics to sneer “where’s the global warming now?” This despite 2023 being the warmest year on record — “by far” — and the fact that the ten warmest years since 1850 have all been in the last decade, according to NOAA.
One of the parts of the globe warming the fastest is the Arctic, which is warming four times as fast as the rest of the planet. That sounds like good news if you run a ...
Source: The Health Care Blog - January 24, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Climate Change Kim Bellard Viruses Source Type: blogs
What Will Blood Testing Look Like In The Near Future?
The traditional process of blood draw is familiar to everyone. It typically involves visiting a healthcare facility where a professional, such as a nurse or phlebotomist, draws the blood. Patients then wait for results that are often challenging for non-professionals to interpret.
This analysis aims to explore how this universally recognized procedure has evolved recently and how it is expected to change in the next 5-10 years, especially in the context of digital health.
Initially, blood draw was a purely manual process, requiring skilled professionals for both the drawing and the analysis. The procedure and e...
Source: The Medical Futurist - January 23, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF lab test blood draw Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Parasite Case of the Week 735
This week ' s case features a liver cyst (6 cm in diameter) that was removed and send to the parasitology laboratory for evaluation. The following images were taken by our fabulous Education Specialists, Felicity Norrie. Identification? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - January 17, 2024 Category: Parasitology Source Type: blogs
Suppressing Inflammatory Activity of Supporting Cells in the Brain as a Treatment for ALS
Constant, unresolved inflammatory behavior in the supporting cells of the brain is implicated in the pathology of diverse neurodegenerative conditions. Here, researchers find that dampening this inflammation can help restore function in animal models of amyotrophic lateral sclerosis (ALS). This joins many other conceptually similar demonstrations conducted in the laboratory for a range of different neurodegenerative diseases. It remains to be seen as to how well these anti-inflammatory strategies will perform in human clinical trials.
ALS is caused by the loss of upper motor neurons, located in the brain, and lowe...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Evidence for the Unfolded Protein Response to be Involved in Age-Related Deafness
Researchers have found that deafness-associated gene TMTC4 causes pathology via an excessive increase in the unfolded protein response in sensory hair cells of the inner ear, and loud noise does much the same. This suggests that inhibition of the unfolded protein response in these cells might be a way to slow loss of hearing capacity, or protect against the effects of loud noise and drugs that can harm hair cells. Still, this isn't a path to restoration of hearing capacity. That would require some way to replace lost hair cells and their connections to the brain.
Mutations to the TMTC4 gene trigger a molecular dom...
Source: Fight Aging! - January 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Stress Temporarily Increases Epigenetic Age
This study used DNA methylation (DNAm)-based aging clocks to measure changes in biological age in response to diverse forms of stress. The researchers began with a laboratory experiment known to produce aged physiology in young mice or restore youthful physiology to old mice by surgically joining young, 3-month-old mice with older, 20-month-old mice, which allowed them to share their blood. At the molecular level, they found that the biological age of the young mice increased when measured with most aging clocks. Once the young mice were separated from the old mice and therefore were no longer experiencing the older mouse ...
Source: Fight Aging! - January 11, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
