Room for Innovation in Digital Transformation
Digital Transformation is a huge buzz word in the world of healthcare at the moment. With the pandemic, we had to scramble to find a digital way to do many things in order to stay safe. So in a lot of ways, healthcare has been skyrocketed into the future, but there is still room for improvement. For some organizations, being rushed to find a digital solution has left certain areas unsupported. This rush also means that not all organizations have adopted the same practices that patients have grown to love and are now trying to catch up. So while we have made huge progress in the world of digital transformation, there is sti...
Source: EMR and HIPAA - December 7, 2022 Category: Information Technology Authors: John Lynn Tags: C-Suite Leadership Healthcare IT IT Infrastructure and Dev Ops 4D Path ABOUT Healthcare Alan Stein Amanda Bury Andrew Rickman Angie Franks Bamboo Health Brandon Clark Catalyst Health Group Chris Evanguelidi CloudWave Digital In Source Type: blogs
Reviewing Work on CISD2, a Mammalian Longevity Gene
Few genes have been shown to robustly alter mammalian longevity as a result of altered expression, with data obtained primarily in mice. Klotho is perhaps the most well known and well studied of that small but steadily growing portfolio. The topic of today's open access paper is another of these longevity genes, CISD2. Loss of CISD2 shortens lifespan, while increased expression extends life span in mice. CISD2 is upregulated after exercise, and may act through autophagy, a common factor in many approaches shown to modestly slow aging in laboratory species. Like other approaches to upregulation of autophagy, increased CISD2...
Source: Fight Aging! - December 5, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 5th 2022
In conclusion, the PAAIs examined (i.e. mTOR loss of function, Ghrhr loss of function, intermittent fasting-based version of dietary restriction) often influenced age-sensitive traits in a direct way and not by slowing age-dependent change. Previous studies often failed to include young animals subjected to PAAI to account for age-independent PAAI effects. However, any study not accounting for such age-independent intervention effects will be prone to overestimate the extent to which an intervention delays the effects of aging on the phenotypes studied. This can result in a considerable bias of our view on how modifiable a...
Source: Fight Aging! - December 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Calorie Restriction as a Treatment to Slow Parkinson's Disease
Calorie restriction is known to suppress inflammation to some degree, alongside many other benefits to health that result from the reaction of cells and biological systems to a reduced calorie intake. Since chronic inflammation in brain tissue is implicated in the onset and development of neurodegenerative conditions, this makes calorie restriction a topic of interest in this part of the field. With a few exceptions, that interest largely manifests as research aimed at reproducing some of the metabolic alterations of calorie restriction with small molecule drugs, however, rather than more more rigorously testing calorie re...
Source: Fight Aging! - December 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A woman in her 20s with syncope
Written by Destiny Folk MD, with edits by Meyers, peer reviewed by Smith and GrauerA woman in her late 20s with a past medical history of cervical cancer status post chemotherapy and radiation therapy presented to the emergency department for shortness of breath, chest tightness, and two episodes of syncope.Her initial vital signs revealed a temp of 97.7F, HR 125, RR 20, BP 115/90, and an oxygen saturation of 95% on room air. Upon arrival, she did not appear in acute distress. She was noted to be tachycardic and her heart sounds were distant on physical exam. She had a normal respiratory effort, and her lungs were clear to...
Source: Dr. Smith's ECG Blog - November 28, 2022 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, November 28th 2022
This study explored whether determining the gain or loss of specific taxa represent a more precise metric of healthy/unhealthy aging than summary microbiome statistics, such as diversity and uniqueness. We analyzed microbiome diversity and four measures of microbiome uniqueness in 21,000 gut microbiomes for their relationship with aging and health. We show that diversity and uniqueness measures are not synonymous; uniqueness is not a uniformly desirable feature of the aging microbiome, nor is it an accurate biomarker of healthy aging. Different measures of uniqueness show different associations with diversity and with mark...
Source: Fight Aging! - November 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Year End Charitable Donations to Help Advance Rejuvenation Research
As Giving Tuesday approaches once again, it is time to consider charitable donations for the end of 2022. If your priority is to reduce human suffering in the world, then by far the most cost-effective approach is to support scientific programs that enable the development of rejuvenation therapies. In comparison to the vast and inflated cost of medicine, the scientific research that produces the means to make new medicines is cheap. Given the right infrastructure of advocacy and networking between the scientific community and industry, new scientific results achieved at low cost can inspire a great deal of investment in fu...
Source: Fight Aging! - November 21, 2022 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Danger Alert: A.I. Is Writing Content, But It ’s Lying – Let Us Show You How
There is a growing number of A.I. text generators around the web, offering more or less the same.
You give a brief of your planned content and maybe some keywordsSet the parameters, like the language, the tone of the text and the creativity levelHit enterVoila, you get your blog post/article/marketing copy/whatever
Isn’t it amazing? Writing a good text takes effort, so outsourcing it to A.I. could save us a ton of time in researching and crafting content.
Before you quickly lay off all your writers, let me show through a few examples of why trusting A.I. with content is dangerous as of now. TLDR spoiler: it ...
Source: The Medical Futurist - November 15, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI AI text generator synthetic media AI in heaalthcare Source Type: blogs
Danger Alert: AI Is Writing Content, But It ’s Lying – Let Us Show You How
There is a growing number of AI text generators around the web, offering more or less the same.
You give a brief of your planned content and maybe some keywordsSet the parameters, like the language, the tone of the text and the creativity levelHit enterVoila, you get your blog post/article/marketing copy/whatever
Isn’t it amazing? Writing a good text takes effort, so outsourcing it to AI could save us a ton of time in researching and crafting content.
Before you quickly lay off all your writers, let me show through a few examples of why trusting A.I. with content is dangerous as of now. TLDR spoiler: it is l...
Source: The Medical Futurist - November 15, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Artificial Intelligence in Medicine AI AI text generator synthetic media AI in heaalthcare Source Type: blogs
Fight Aging! Newsletter, November 14th 2022
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Investigating the Ability of Type 2 Diabetes...
Source: Fight Aging! - November 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Is GHB Anyway?
Let’s face it, there are a whole bunch of street drugs out there that we as EMS caregivers should understand. While we can’t always be expected to identify the exact drug a patient has ingested. We do need to be able to predict a given drugs effect on the body.
We should also be able to take a fair guess at the identity of an ingested drug based on our evaluation of the patient’s physical presentation. GHB is one of those drugs that can be hard to nail down based on the physical signs. But it does leave some clues – if you know what your look for.
What Is It? : A Multi-Receptor Stimulant
GHB is short for ...
Source: The EMT Spot - November 10, 2022 Category: Emergency Medicine Authors: Steve Whitehead Tags: EMT Source Type: blogs
Intent to Reissue MIRA Funding Opportunity Announcement for Early Stage Investigators (R35)
I’m pleased to announce that the funding opportunity announcement (FOA) for the Maximizing Investigators’ Research Award (MIRA) for early stage investigators (ESIs) will be reissued in the spring of 2023. MIRA provides support for a research program in an ESI’s laboratory that falls within the NIGMS mission. For details, see NOT-GM-23-017.
The reissued FOA will essentially be the same as the previous one, with a couple of minor changes:
There will be two application receipt dates per year—February and October.Applications must include a plan for enhancing diverse perspectives, which i...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - November 9, 2022 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Early Stage Investigator MIRA Source Type: blogs
Considering Mitophagy in the Aging Nervous System
Mitophagy is the selective version of autophagy focused on recycling mitochondria. Every cell contains hundreds of mitochondria, their primary responsibility the generation of chemical energy store molecules to power cellular processes. Mitochondria are the descendants of ancient symbiotic bacteria. They lead dynamic lives, replicating like bacteria, passing component parts around, and fusing together. Mitophagy is a quality control mechanism, removing damaged mitochondria in order to prevent cellular dysfunction. A good deal of evidence suggests that age-related declines in mitochondrial function are in large part caused ...
Source: Fight Aging! - November 8, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Sparking Rural Students ’ Interest in STEM
When asked why he leads the NIGMS-supported Science Education Partnership Award (SEPA) program at Dartmouth College in Hannover, New Hampshire, Roger D. Sloboda, Ph.D., the Ira Allen Eastman Professor of Biological Sciences (emeritus), shares a story. Several years ago, he learned of a public-school science teacher in rural New Hampshire who had a very limited budget for classroom equipment. With her annual budget, she’d been able to buy a single stainless-steel laboratory cart. “Next year, I hope to buy a piece of equipment to put on it,” she said. A short time later, Dr. Sloboda attended a scientific meeting and ta...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 8, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education Scientific Process Training Source Type: blogs
Connecting IGF1 Signaling and Cellular Senescence
In this study, we show that TXNIP is vital for the cell fate choice when cells are challenged by various stress signals. Furthermore, prolonged IGF1 treatment leads to the establishment of a premature senescence phenotype characterized by a unique senescence network signature. Combined IGF1/TXNIP-induced premature senescence can be associated with a typical secretory inflammatory phenotype that is mediated by STAT3/IL-1A signaling. Finally, these mechanistic insights might help with the understanding of basic aspects of IGF1-related pathologies in the clinical setting.
Link: https://doi.org/10.3390/cells11203260 ...
Source: Fight Aging! - November 8, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
