Case of the Week 724
This week ' s case was generously donated by Dr. Nazia Nagi in New Delhi, India. She saw these ' cute ' little objects (around 15 micrometers long) during her rotation in the Diarrhoeal Laboratory. The patient is a young teenager with diarrhea lasting for 15-17 days. Identification?Saline wet mounts:Iodine wet mount: (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - August 16, 2023 Category: Parasitology Source Type: blogs
Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health."
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Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis?
https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/
Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sustainable Healthcare: Reducing the Energy Burden and Environmental Impact of Caregiving
The following is a guest article by Steve Lazer, Global Healthcare and Life Sciences CTO at Dell Technologies
Healthcare services play a vital role in enhancing human well-being, but it’s essential to recognize that they also leave an environmental footprint contributing to environment-related health threats.
According to a report from the environmental advocacy group Health Care Without Harm, the U.S. healthcare industry is responsible for 7.6 percent of the nation’s total “climate footprint.” While this might seem like a relatively low number, when we are talking about working towards a net ze...
Source: EMR and HIPAA - August 10, 2023 Category: Information Technology Authors: Guest Author Tags: Ambulatory C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System IT Infrastructure and Dev Ops LTPAC Climate Footprint Dell Technologies Emissions Energy Consumption Healthcare Climate Crisis Healthcare Costs Source Type: blogs
In the Long Run, Even Baseline Humans Will Live for a Very, Very Long Time
It is at present somewhat out of style to point out that, yes, obviously, it will be possible in the future to ensure that humans live for a very, very long time. That will be true for even baseline humans lacking all of the various genetic modifications one might propose a future scientific community to be capable of, modifications to introduce the numerous distinct forms of resilience to the mechanisms of mammalian aging exhibited by naked mole-rats, whales, elephants, bats and so forth. Control over aging is a subset of control over molecules and their positions. To be as reductionist as possible, degenerative aging is ...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Donate to Support a Study of Allotopic Expression for the COX2 Mitochondrial Gene
Mitochondria, hundreds to a cell, are evolved descendants of the ancient bacteria that became symbiotic with the first, primitive cells. Mitochondria still behave a great deal like bacteria, in that they fuse together, replicate, carry a small circular genome, the mitochondrial DNA and promiscuously swap component parts. While the primary role of mitochondria is the generation of adenosine triphosphate (ATP), a chemical energy store used to power cell processes, they are also well integrated cellular components in a broader sense, influential in a range of fundamental cellular activities.
Mitochondrial DNA is a lot ...
Source: Fight Aging! - August 7, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Investigating the Secrets of Cancer-Causing Viruses
Credit: Courtesy of Dr. Mandy Muller.
While she was in graduate school, Mandy Muller, Ph.D., became intrigued with viruses that are oncogenic, meaning they can cause cancer. At the time, she was researching human papillomaviruses (HPVs), which can lead to cervical and throat cancer, among other types. Now, as an assistant professor of microbiology at the University of Massachusetts (UMass) Amherst, Dr. Muller studies Kaposi sarcoma-associated herpesvirus (KSHV), which causes the rare AIDS-associated cancer Kaposi sarcoma.
A Continental Change
Dr. Muller has come a long way, both geographically and professionally, s...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - August 1, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Infectious Diseases Microbes Profiles RNA Viruses Source Type: blogs
The Top 10 Health Chatbots
This study from March 2023 reports how an app developed to help patients’ bowel preparation can increase compliance and thus, the number of successful colonoscopies.
In some cases, health chatbots are also able to connect patients with clinicians for diagnosis or treatment, but that is one step further down the line. The general idea is that in the future, these talking or texting smart algorithms might become the first contact point for primary care. Patients will not get in touch with physicians or nurses or any medical professional with every one of their health questions but will turn to chatbots first. If th...
Source: The Medical Futurist - August 1, 2023 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Future of Medicine Healthcare Design List medical Personalized medicine AI technology chatbot digital health chatbots health chatbot Innovation Source Type: blogs
Answer to Case 723
Answer to theParasite Case of the Week 723: mite, not scabies. Given that this mite was found in a fungal culture from skin scrapings, it could very well be a dust mite (Dermatophagoidessp.) as many of you suggested. However, mites are challenging to identify, so genus/species level identification is best left to the acarologists (people who study mites and ticks). The biggest concern here is its location - on a fungal culture in the mycology laboratory. Mites are a terror in the mycology lab. They crawl from plate to plate, contaminating and destroying cultures from patient samples. In most cases, the culture plates ...
Source: Creepy Dreadful Wonderful Parasites - July 31, 2023 Category: Parasitology Source Type: blogs
Bonus Features – July 23, 2023 – Number of people impacted by data breaches up 56% compared to last year, CMS keeps temporary telehealth expansion in 2024 Medicare fee schedule, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Studies
The 2024 Medicare Physician Fee Schedule Proposed Rule from CMS would continue many of the public health emergency telehealth flexibilities, such as an expanded definition of telehealth practitioners, continued...
Source: EMR and HIPAA - July 23, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Health IT Company Healthcare IT Regulations AliveCor American Telemedicine Association Amwell ATA AVIA Black Book Research Bren Webster CenTrak Cerner CMS eClinicalWorks eCW Force Therapeutics Fortified Health Security He Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Late Life Rapamycin Treatment Reverses Diastolic Dysfunction in Mice
Inhibitors of mTOR such as rapamycin are increasingly well studied. This class of drug stimulates cellular stress responses, principally autophagy, and thus produces outcomes that are broadly similar to the long-term improvement of health resulting from calorie restriction, exercise, or other demonstrated means of upregulating autophagy. This results in benefits to health, such as those noted in today's open access paper.
It is one thing to demonstrate that a drug improves measures of autophagy known to decline with age, and note that many of the interventions shown to modestly slow aging in laboratory species are c...
Source: Fight Aging! - July 14, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Microfluidic Chip Aids Tuberculosis Diagnosis
Researchers at the University of London have collaborated with QuantuMDx, a medtech company based in the UK, to develop a microfluidic diagnostic device for tuberculosis. The CAPTURE-XT chip is designed to concentrate and purify Mycobacterium tuberculosis from suspected tuberculosis patients, particularly in areas that lack access to routine diagnostic technologies. The chip uses dielectrophoresis to capture the bacteria based on their dielectric properties, whereas other bacteria and impurities in the sputum sample are washed away. The captured bacteria can be assessed visually, providing a simple yes/no diagnosis, and th...
Source: Medgadget - July 10, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Public Health Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Role of TFEB Upregulation in Approaches Shown to Slow Aging
Most of the varied approaches shown to modestly slow the progression of aging appear to operate through a small number of common mechanisms, largely involving the cellular response to stress. Some of those mechanisms will turn out to be more influential than others, though little progress has been made towards assigning relative importance to the various layers of the exceedingly complex reactions to heat, cold, restriction of nutrients, and other forms of mild stress that can produce beneficial outcomes.
The most compelling evidence to date suggests that improved autophagy is one of the more relevant portions of th...
Source: Fight Aging! - June 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
