Fight Aging! Newsletter, June 24th 2019
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age.
Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - June 23, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
GORE CARDIOFORM Approved by FDA to Treat Atrial Septal Defects
The GORE CARDIOFORM Septal Occluder has been approved by the FDA to treat ostium secundum atrial septal defects (ASD) via percutaneous closure procedures. In a clinical study of the device in 125 patients with ASD, ranging in age from 2 to 84, all who successfully received the implant maintained the closure when evaluated six months later.
The GORE CARDIOFORM is made of two discs that make contact with the tissue walls on both sides of the opening and, when activated, come together to block the passage of blood between the atria. It was approved by the FDA last year for patent foramen ovale closures, as a way of reducing ...
Source: Medgadget - June 7, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Cardiac Surgery Cardiology Radiology Source Type: blogs
Fight Aging! Newsletter, June 3rd 2019
In conclusion, there is solid evidence that obesity deregulates cellular mechanisms related to nutrient sensing.
Altered Intercellular Communication
It is accepted that aging impacts the organism at the cellular level, but also decreases the capacity of cells of an organism to interact. During aging, there is a decreased communication at the neuronal, neuroendocrine, and endocrine levels. Two of the most compelling examples of impaired communication are inflammaging and immunosenescence. The inflammaging phenotype results in elevated cytokines. These cytokines can accelerate and propagate the aging process. T...
Source: Fight Aging! - June 2, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Review of the State of Stem Cell Therapy for Stroke Patients
The author of this open access review asks whether or not we can consider stem cell therapy to aid recovery from stroke to be a solved problem. Given that clinical trials are underway, is it just a matter of time and we can all agree that viable treatments exist? Unfortunately matters might not be that cut and dried, and recent clinical trials have failed for reasons that can be hypothesized to center around differences in the production of cells for transplantation. Nothing is ever straightforward in biology and medicine. Further, in the long term, why would we ever want medical technologies that only work after the damag...
Source: Fight Aging! - May 28, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Still Negative on Watchman
Many readers have contacted me to ask whether my negative viewson left atrial appendage occlusion with Watchman have changed since 2017.
The short answer is no. My views are even more negative today.
In 2016, I published an editorial on theHeart.org | Medscape Cardiology arguing that this procedure should stop. One of the rebuttals was that it was a blog post, not an academic editorial.
Months later, Andrew Foy, Gerald Naccarelli and I put the same argument into academic-speak and the influential journal Heart Rhythm published it.[1]
I have debated and presented this topic multiple times ...
Source: Dr John M - May 17, 2019 Category: Cardiology Authors: Dr John Source Type: blogs
Imperative Care Gets FDA Clearance for ZOOM Stroke Clot Remover
Imperative Care, a company based in the Silicon Valley area, won FDA clearance for its ZOOM Aspiration System for removing stroke-causing clots. The system is designed to work particularly well with Imperative’s access catheters, which are long and highly flexible devices made to reach deep into the brain.
The ZOOM is comprised of the ZOOM Reperfusion Catheters, which feature a “TRX” tip for easier delivery, ZOOM Aspiration Pump, ZOOM Canister, and the ZOOM Aspiration Tubing. The catheters are available in four different sizes and have a special coating to facilitate their movement through blood vasculatu...
Source: Medgadget - April 30, 2019 Category: Medical Devices Authors: Editors Tags: Neurology Neurosurgery Radiology Source Type: blogs
Kardia Mobile – Smart phone based ECG
Kardia Mobile – Smart phone based ECG
Kardia Mobile (Alivecor, San Francisco, CA, USA) is a smart phone compatible device that allows recording of a single lead ECG [1]. Recently a third sensor has been added to allow 6 lead ECG.
MOBILE-AF trial (Mobile Phones in Cryptogenic Stroke Patients Bringing Single Lead ECGs to Detect Atrial Fibrillation) is evaluating the role of Kardia Mobile in detection of atrial fibrillation in patients with cryptogenic stroke [2]. It is an international multicenter trial of patients with cryptogenic stroke or transient ischemic attacks. Half of the patients will receive the self ECG re...
Source: Cardiophile MD - April 29, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Fight Aging! Newsletter, April 22nd 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - April 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Selection of Recent Research into the Impact of Diet and Exercise on Aging
It is undeniably the case that both diet and exercise influence the course of aging, though the size of the beneficial effect, even in the case of optimal lifestyle choices, is nowhere near as large as we'd all like it to be. Animal studies show calorie restriction extending maximum life span in mice by up to 40%, as well as lesser effects from various other forms of dietary strategy. Exercise meanwhile doesn't extend life span in mice, but does postpone age-related dysfunction and disease. Unfortunately, the effects on life span due to any of the strategies that are based on the metabolic effects of exercise and reduced c...
Source: Fight Aging! - April 18, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reducing residual cardiovascular risk
Reducing residual cardiovascular risk in patients treated with statins and having hypertriglyceridemia was addressed by Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial (REDUCE-IT) [1].
REDUCE-IT was a double blind placebo controlled multicenter randomized trial. Patients with established cardiovascular disease or diabetes mellitus with other risk factors treated with statins were evaluated. At study inclusion they needed to have fasting triglyceride levels between 135 and 499 mg/dL and LDL cholesterol level 41 to 100 mg/dL.
They were randomized to either 2 g of icosapent ethyl twice daily or...
Source: Cardiophile MD - April 15, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
Epigastric pain radiating to the chest for 18 hours. ECG makes the Dx. Troponin makes the Dx. CT makes the Dx!
I was shown this ECG with no other information:What do you think?Hint: try to see through the artifact!I answered immediately: " High lateral MI with posterior MI. OMI. " (Occlusion Myocardial Infarction)I asked, " Did the patient present with chest pain? "Here is the history:" A middle-aged male complained of about 18 hours of epigastric pain that radiated to the chest. He also had an apparently new facial droop of equal duration. A stroke code was called, NIH stroke scale was only 1, and attention was turned to the chest pain. " BP was 148/83.How did I make this ECG diagnosis?There is subtle STE in aVL ...
Source: Dr. Smith's ECG Blog - March 28, 2019 Category: Cardiology Authors: Steve Smith Source Type: blogs
Snake Bite and Radiology
Discussion-Local manifestations of snake bite are soft-tissue swelling from edema, necrosis, and hemorrhage. Common long-term sequelae of envenomation is soft-tissue atrophy distal to the bite, particularly in the digits.-Systemic signs and symptoms after a venomous snake bite are due to anticoagulant/procoagulant activity or neurotoxicity. Cerebral hypoxia can occur due to hypotensive shock that may accompany some snake bite envenomations. Neuromuscular disorders with damage of the peripheral nervous system can with blockage of synaptic transmission, at either presynaptic or postsynaptic levels.Common neuro...
Source: Sumer's Radiology Site - March 21, 2019 Category: Radiology Authors: Sumer Sethi Source Type: blogs
P wave indices and risk of ischemic stroke
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - March 16, 2019 Category: Internal Medicine Tags: cardiovascular neurology Source Type: blogs
What will you do for this patient transferred to you who is now asymptomatic?
A middle-aged woman with history of hypertension presented to another hospital approximately 2 hours after onset of chest pain and shortness of breath.This ECG was recorded on arrival:What do you think?This is technically a STEMI, with 1.5 mm STE in V1 and 1.5-2.0 mm in V2. The current criteria only require 1mm in V1 and 1.5mm in V2 for a female. However, I think many practitioners might not see this as a clear STEMI, and would instead call this " borderline. " The normal QRS complex with STE and large volume underneath the T-waves in V1-V3 confirm Occlusion MI (OMI). There is not technically STD in V6 and I, however the m...
Source: Dr. Smith's ECG Blog - March 5, 2019 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, February 25th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - February 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
