Fight Aging! Newsletter, February 22nd 2021
In conclusion, long term LRIC could decrease blood pressure and ameliorate vascular remodeling via inflammation regulation.
The Damage of a Heart Attack Causes the Immune System to Overreact
https://www.fightaging.org/archives/2021/02/the-damage-of-a-heart-attack-causes-the-immune-system-to-overreact/
Researchers here note a mechanism that causes T cells of the adaptive immune system to spur chronic inflammation and tissue damage following a heart attack. As the researchers note, not all inflammation is the same. Some is maladaptive, and this is particularly the case in older individuals. The aged immun...
Source: Fight Aging! - February 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Incidence of Stroke is Declining in People Aged 70 and Older
The decline of cardiovascular disease in older people is the result of improved health practices, primarily less smoking, and a focus on lowering blood cholesterol via lifestyle change and drugs such as statins. The formation of fatty plaque in blood vessel walls occurs in later life, the condition known as atherosclerosis. The plaque narrows and weakens blood vessels throughout the body. The rupture of a vessel or disintegration of a plaque followed by a a downstream blockage is the mechanism that causes both stroke and heart attack. Atherosclerosis is a consequence of the mechanisms of aging and their downstream conseque...
Source: Fight Aging! - February 17, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Catheter Stimulates Lymphatic Drainage for Heart Failure Treatment: Interview with Eamon Brady, CEO of WhiteSwell
WhiteSwell, a medtech company based in Galway, Ireland, has developed a catheter system to treat acute decompensated heart failure (ADHF).
ADHF is often treated using diuretics to remove excess fluid, but this doesn’t work for every patient and can have side-effects.
This latest technology consists of a catheter with an impeller pump that is designed to stimulate lymphatic drainage, and thereby aid with decongestion without the need for diuretics. The catheter creates an area of low pressure where the largest lymph vessel, the thoracic duct, connects with the venous system near the heart.
WhiteSwell claims that...
Source: Medgadget - January 19, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Exclusive Radiology Thoracic Surgery Source Type: blogs
Can COVID-19 coronavirus “invade” human brain tissue? (Quick answer: evidence so far is mixed)
Brain scans show lower part of a COVID-19 patient’s brain stem, postmortem. Arrows point to light and dark spots suggesting blood vessel damage, without signs of infection by the coronavirus that causes COVID-19. Credit: National Institute of Neurological Disorders and Stroke, NIH
Taking a Closer Look at COVID-19’s Effects on the Brain (NIH Director’s blog):
While primarily a respiratory disease, COVID-19 can also lead to neurological problems. The first of these symptoms might be the loss of smell and taste, while some people also may later battle headaches, debilitating fatigue, and trouble thinking clearly, someti...
Source: SharpBrains - January 19, 2021 Category: Neuroscience Authors: SharpBrains Tags: Brain/ Mental Health brain fog brain tissue brainstem COVID-19 human-brain neurological neurological problems Neurons NIH Source Type: blogs
A 50 year old man with sudden altered mental status and inferior STE. Would you give lytics? Yes, but not because of the ECG!
DiscussionFlutter waves are well known to mimic ST deviations, as well as to hide true ischemic ST deviations from the interpreter. In many cases of flutter waves mimicking ST deviations, the expert electrocardiographer can see the morphology of the flutter waves as the cause of apparent STE or STD. Likewise, in some cases of ischemia concealed by flutter waves, the ischemia can be seen despite the flutter waves, whereas in other cases the dysrhythmia must be terminated before the ischemia can be clearly distinguished. Even when flutter waves conceal true ST segment deviations, the cause and effect relationship may be...
Source: Dr. Smith's ECG Blog - December 26, 2020 Category: Cardiology Authors: Pendell Source Type: blogs
A 45 year old smoker presents with palpitations, is discharged, and is found dead 2 days later
A 45 year old smoker presented with palpitations. He had no other medical problems. There was no syncope. He was on no medications.Unfortunately, no other information is available, but that is enough to provide an learning point.Here is the EKG:Do you see anything worrisome?There are PVCs, and these might be the cause of the palpitations (whether they are indeed the source of the palpitations could easily be ascertained by asking the patient if the palpitations are still present during the ECG). However, there are wide QS-waves (0.8 ms) in III and aVF, and they have afragmented QRS (extra spike...
Source: Dr. Smith's ECG Blog - December 14, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
How to recognize a ministroke or stroke — and what to do
If you suddenly experience a strange but fleeting symptom — your arm or face suddenly feels weak or numb — you might be tempted to brush it off, especially if it’s short-lived.
But if those odd, unexplained symptoms last more than a few seconds, they could signal a transient ischemic attack, or TIA. Commonly referred to as a ministroke, a TIA is caused by a temporary lack of blood in part of the brain. Most of the time a blood clot is to blame, and the symptoms resolve quickly because your body’s natural clot-dissolving action restores blood flow. But according to the American Stroke Association (ASA), these events...
Source: Harvard Health Blog - November 10, 2020 Category: Consumer Health News Authors: Julie Corliss Tags: Health Healthy Aging Hypertension and Stroke Neurological conditions Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest.
BMP6 as a Target for Pro-Angiogenic Therapies
https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/
Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a p...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cerebrovascular Disease Prevention as a Priority in Dementia Prevention
Disruption of the blood flow to the brain, either a slow decline in supply due to vascular aging, or following a stroke, is an important contributing factor in the development of dementia. The brain requires a great deal of energy to function, and thus the supply of nutrients and oxygen is even more critical than is the case for other organs. Reductions in that supply have consequences.
Cerebrovascular diseases include a variety of medical conditions that affect the blood vessels of the brain and the cerebral circulation. These include conditions that may cause acute interruption of cerebral circulation and subse...
Source: Fight Aging! - October 23, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results.
Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
ReStore Exosuit Shows Positive Trial Results for Stroke Rehab
Soft exosuits that provide assistive force during movement could be a game changer for patients with mobility issues. Such devices can help enhance rehabilitation and assist patients while they perform everyday tasks. The idea with such technology is that the soft suit feels almost like a piece of clothing and applies force gently and evenly to affect natural movement.
This latest suit, the ReStore exosuit from ReWalk Robotics, has been FDA cleared for use in patients who have experienced a stroke and now have a mobility issue. A recent trial has assessed the ReStore exosuit in terms of safety, feasibility, and reliabil...
Source: Medgadget - September 15, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Neurology Rehab Source Type: blogs
Fight Aging! Newsletter, September 14th 2020
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3.
Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Source: Fight Aging! - September 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Meta-Analysis of the Ability of Exercise to Reduce Age-Related Mortality
The objective of this study was to conduct a systematic review and dose-response meta-analysis of physical activity and mortality in people with selected non-communicable diseases (NCDs). We aimed to define the dose-response relationship between post-diagnosis physical activity and mortality rates for nine NCDs with a high global burden of disease, including low back pain, type 2 diabetes (T2D), osteoarthritis, depressive disorder, chronic obstructive pulmonary disease (COPD), breast cancer, lung cancer, stroke, and ischemic heart disease (IHD).
In total, 28 studies were included in the meta-analysis: 12 for breast ...
Source: Fight Aging! - September 10, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Raised Blood Pressure is So Harmful that Reductions are Beneficial Even Without Addressing Underlying Causes
The raised blood pressure of hypertension causes harm throughout the body, raising mortality risk and accelerating the onset and progression of numerous forms of ultimately fatal age-related disease. It accelerates atherosclerosis, and raises the risk of a fatal rupture of blood vessels weakened by atherosclerotic lesions. It causes pressure damage to delicate tissues throughout the body. It leads to detrimental remodeling of heart tissue and the onset of heart failure. Thus forcing a reduction in blood pressure is quite beneficial in later life, even when it is achieved - as is presently the case - by overriding regulator...
Source: Fight Aging! - September 8, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
