Chest discomfort, Sinus Tachycardia, Q-waves, ST Elevation, and Intermittent Wide Complex Tachycardia. Activate the Cath Lab?
This ECG was texted to me with no other information:Computer Diagnosis:SINUS TACHYCARDIAINCOMPLETE RIGHT BUNDLE BRANCH BLOCK [90+ ms QRS DURATION,TERMINAL R IN V1/V2, 40+ ms S IN I/aVL/V4/V5/V6]LEFT ANTERIOR FASCICULAR BLOCK [QRS AXIS<= -45, QR IN I, RS IN II]ANTEROSEPTAL MYOCARDIAL INFARCTION , PROBABLY RECENT [40+ ms QWAVE IN V1-V4]***ACUTE MI***What do you think? Below is my response.There is sinus tach. There is an incomplete RBBB and LAFB. There are QR-waves in aVL and V2, and a QS-wave in V3. There is ST elevation in V2 and V3, with upright T-waves in V2 and V3. There is reciprocal ST depre...
Source: Dr. Smith's ECG Blog - August 12, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
TIGERTRIEVER XL Cleared in EU to Remove Large Stroke Clots
Israel’s Rapid Medical has won European regulatory clearance to introduce its TIGERTRIEVER XL device for removing large ischemic stroke-causing clots from intracranial vessels. The company calls its line of devices “stentrievers,” as these look and operate similar to stents but can retrieve clots out of the body.
Clot removed from the brain of the first stroke patient treated with Tigertriever XL at Bochum University Hospital
The TIGERTRIEVER XL can be used to remove clots as big as 9 mm in diameter and 53 mm in length, all via a standard 0.02 internal diameter microcatheter. The company’s CE ...
Source: Medgadget - August 4, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Neurology Neurosurgery Radiology Vascular Surgery Source Type: blogs
Fight Aging! Newsletter, July 27th 2020
In this study, we applied a well studied prediction model developed on data from five CpG sites, to increase the practicability of these tests.
We have determined the biological age of the heart, specifically of the right atrium (RA) and left atrium (LA), and of peripheral blood leucocytes, by measuring the mitotic telomere length (TL) and the non-mitotic epigenetic age (DNAmAge). We found that DNAmAge, of both atrial tissues (RA and LA), was younger in respect to the chronological age (-12 years). Furthermore, no significant difference existed between RA and LA, suggesting that, although anatomically diverse and ex...
Source: Fight Aging! - July 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Update: Should candidates to high office should pass a cognitive/ mental fitness test?
Wow, that was a couple of very insightful discussions, via social media no less.
#1. The first one was about whether heads of state and candidates to high office should pass a cognitive/ mental fitness test. Click HERE to read and discuss some of the sharpest comments, such as…
“I wonder what brought this up.”
“Definitely. We routinely screen applicants for a wide range of jobs.”
“Then the balance of political power would shift towards the designers of those tests.”
“That’s what debates are for.”
“Yes, but probably nobody would pass it.”
“No, because if we can’t judge that for ourselves, t...
Source: SharpBrains - July 24, 2020 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology Alzheimer's disease prevention Alzheimers-disease amyloid artificial intelligence Bill Gates brain health brain-teaser cognitive behavioral therapies Source Type: blogs
Survey finds ischaemic stroke and altered mental status as most common neurological complications in severe COVID-19 cases
This study provides valuable and timely data that are urgently needed by clinicians, researchers, and funders to inform immediate steps in COVID-19 neuroscience research and health policy.
The Study in Context:
Neurological Implications of COVID-19 Infections
Three ways to protect your mental health during –and after– COVID-19 (Source: SharpBrains)
Source: SharpBrains - July 1, 2020 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness altered mental state brain hemorrhage brain-damage coronavirus neurological neuropsychiatric psychiatric problems stroke strokes Source Type: blogs
Repost: 63 minutes of ventricular fibrillation, followed by shock. What is going on?
In this study, 5% of VF arrest was due to PE: V fib is initial rhythm in PE in 3 of 60 cases. On the other hand, if the presenting rhythm is PEA, then pulmonary embolism is likely. When there is VF in PE, it is not the initial rhythm, but occurs after prolonged PEA renders the myocardium ischemic.--Another study by Courtney and Kline found that, of cases of arrest that had autopsy and found that a presenting rhythm of VF/VT had an odds ratio of 0.02 for massive pulmonary embolism as the etiology, vs 41.9 for PEA. ===================================MY Comment by KEN ...
Source: Dr. Smith's ECG Blog - June 27, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, June 15th 2020
In this study, we used markers to monitor the formation of SGs in Caenorhabditis elegans. We found that, in addition to acute heat stress, SG formation could also be triggered by dietary changes, such as starvation and dietary restriction (DR). We found that HSF-1 is required for the SG formation in response to acute heat shock and starvation but not DR, whereas the AMPK-eEF2K signaling is required for starvation and DR-induced SG formation but not heat shock. Moreover, our data suggest that this AMPK-eEF2K pathway-mediated SG formation is required for lifespan extension by DR, but dispensable for the longevity by reduced ...
Source: Fight Aging! - June 14, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeted Interference in the Complement System Improves Recovery from Stroke
The complement system is a part of the innate immune system, and aids in the coordination of the immune response. It promotes inflammation, and in certain circumstances, such as the loss of blood supply to tissue, known as ischemia, it is actively harmful. Following a stroke, the complement system encourages the immune system to attack and destroy neurons and neural connections in the ischemic area, treating them as though they are dead or debris. A sizable fraction of those brain cells could in principle be salvaged if the blood supply is restored quickly enough, but the complement system actively sabotages this goal. Thu...
Source: Fight Aging! - June 10, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Looking through a stack of ECGs for a troponin study.....
And I came across this one while reading EKGs for a high sensitivity troponin study:what do you think?Normally, if one sees STE in aVL with reciprocal STD in III, one would say " Acute OMI " .But I instantly knew it was not.I immediately recognized it as normal, and classified it for the study (blinded) as " normal with normal ST Elevation and " normal ST depression. "More on this ECG:All I know when I see the ECG for this study is that the patient has had at least 2 troponins drawn.I don ' t know whether it is for chest pain, weakness, whatever.I don ' t know for certain why my (our) mind immediately knows that it is norm...
Source: Dr. Smith's ECG Blog - May 6, 2020 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, April 20th 2020
In conclusion, elevated brain amyloid was associated with family history and APOE ε4 allele but not with multiple other previously reported risk factors for AD. Elevated amyloid was associated with lower test performance results and increased reports of subtle recent declines in daily cognitive function. These results support the hypothesis that elevated amyloid represents an early stage in the Alzheimer's continuum.
Blood Metabolites as a Marker of Frailty
https://www.fightaging.org/archives/2020/04/blood-metabolites-as-a-marker-of-frailty/
Frailty in older people is usually diagnosed in a symptomatic...
Source: Fight Aging! - April 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Left ventricular assist device (LVAD)
Left ventricular assist device is used to support the failing left ventricle when it is refractory to guideline directed medical therapy. It can be either a bridge to cardiac transplantation or a destination therapy. In general, cardiac transplantation offers better long term surival compared to LVAD according data available from devices except the most recent.
As per the The Registry of the International Society for Heart and Lung Transplantation: Thirty-fourth Adult Heart Transplantation Report-2017 [1], there were 126,753 pediatric and adult heart transplants between 1982 and June 2015. Median survival was 10.7 years i...
Source: Cardiophile MD - April 16, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiac Surgery LVAD Source Type: blogs
Transplanted Neurons Derived From Induced Pluripotent Stem Cells Restore Function Following Stroke in Rats
Like much of the nervous system, the brain doesn't regenerate well at all. Lost cells remain lost, and lost function is often permanent. One of the most important goals in the field of regenerative medicine is repair of the brain, which might be achieved in the decades ahead via delivery of new neurons that can integrate with existing neural circuits. Far from being a class of therapy only deployed following evident injury such as the aftermath of a stroke, this could take the form of periodic treatments that maintain the brain by repairing the lesser damage and loss of neurons that accumulates in an ongoing fashion over a...
Source: Fight Aging! - April 15, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Left atrial appendage closure devices
Anticoagulation for prevention of stroke is a well established modality of treatment in atrial fibrillation. But a significant number of them have bleeding complications. Hence the option of left atrial appendage closure with multiple types of devices have been developed. Left atrial appendage with its sluggish flow is the most common location for thrombus formation in atrial fibrillation.
Following devices have been used with varying success:
Watchman
Amplatzer Cardiac Plug/Amulet
Lariat suture ligation
Atriclip
PROTECT-AF (Watchman Left Atrial Appendage System for Embolic Protection in Patients With Atrial Fibrillatio...
Source: Cardiophile MD - April 15, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
AF in cryptogenic stroke – Cardiology MCQ – Answer
This study high lights the fact that a 24 hour Holter monitoring grossly underestimates the occurrence of AF in those with cryptogenic stroke. Guidelines recommend a minimum of 72 hour ECG monitoring in patients with transient ischemic attack (TIA) or ischemic stroke to screen for AF [3].
Back to question
Reference
Sanna T, Diener HC, Passman RS, Di Lazzaro V, Bernstein RA, Morillo CA, Rymer MM, Thijs V, Rogers T, Beckers F, Lindborg K, Brachmann J; CRYSTAL AF Investigators. Cryptogenic stroke and underlying atrial fibrillation. N Engl J Med. 2014 Jun 26;370(26):2478-86.
Brachmann J, Morillo CA, Sanna T, Di Lazzaro ...
Source: Cardiophile MD - April 15, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
HATCH score for progression from paroxysmal to persistent AF
HATCH score for prediction of progression from paroxysmal to persistent atrial fibrillation (AF) checks the following: heart failure, age, previous transient ischemic attack or stroke, chronic obstructive pulmonary disease, and hypertension [1]. For the analysis, the authors used over 1200 patients with paroxysmal AF who participated in Euro Heart Survey on AF. Those who had progression of AF after one year of follow up were noted.
The components and weightage given in HATCH score were as follows:
Hypertension: 1
Age 75 years or more: 1
Transient ischemic attack or stroke: 2
Chronic obstructive pulmonary disease: 1
Heart ...
Source: Cardiophile MD - April 14, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
