Cerebral T waves in ischemic stroke: what do they mean?
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - December 22, 2017 Category: Internal Medicine Tags: cardiovascular neurology Source Type: blogs
High-Tech Mobile Stroke Units Treat Patients Sooner
A stroke is one of the most time-critical medical emergencies. If not treated quickly, a patient can quickly deteriorate as brain cells die from a lack of oxygen. Doctors aim to begin treating stroke patients within an hour from the onset of symptoms, something that is often difficult to do when relying on conventional ambulances.
To reduce the time to treatment and increase the likelihood of positive clinical outcomes for stroke victims, a dozen hospitals in the U.S. have developed mobile stroke units. The mobile stroke units are state-of-the-art ambulances equipped with all the technology and personnel needed to treat a ...
Source: Medgadget - December 5, 2017 Category: Medical Devices Authors: Scott Jung Tags: Cardiology Emergency Medicine Neurology Public Health Source Type: blogs
Fight Aging! Newsletter, November 13th 2017
In conclusion, we have developed an effective PILs strategy to deliver the AUF1 plasmid to a specific target, and this system may be useful for the development of new anti-aging drugs.
Considering the Evidence for Vascular Amyloidosis as a Cause of Aging
https://www.fightaging.org/archives/2017/11/considering-the-evidence-for-vascular-amyloidosis-as-a-cause-of-aging/
The balance of evidence for the aging of the cardiovascular system suggests the following view. It starts off in the blood vessels, with the accumulation of senescent cells and cross-links. Cross-links directly stiffen these tissues, while...
Source: Fight Aging! - November 12, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Considering the Evidence for Vascular Amyloidosis as a Cause of Aging
The balance of evidence for the aging of the cardiovascular system suggests the following view. It starts off in the blood vessels, with the accumulation of senescent cells and cross-links. Cross-links directly stiffen these tissues, while senescent cells produce inflammation and changes in cell behavior that promote calcification - again leading to stiffness. These and other processes also disrupt the delicate balance of cell signaling responsible for blood vessel constriction and relaxation. All of this combines to degrade the feedback system controlling pressure in the cardiovascular system, and blood pressure rises as ...
Source: Fight Aging! - November 6, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 23rd 2017
In this study, we demonstrate that irrespective of the derivation of CD8+ CD45RA+CD27- T cells, these primed cells exhibit a unique highly inflammatory secretory profile characteristic of the SASP, and we also provide evidence that ADAM28 can be used as a functional marker of senescence in CD8+ T cells. Furthermore, we show that the secretory phenotype in CD8+ CD45RA+CD27- T cells is controlled through p38 MAPK signalling, which contributes to age-associated inflammation.
Patient Paid Clinical Studies are a Good Plan for Rejuvenation Therapies
https://www.fightaging.org/archives/2017/10/patient-paid-clinical-s...
Source: Fight Aging! - October 22, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cardiology MCQ Test 5
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Source: Cardiophile MD - October 22, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Anticoagulation not useful in secondary AF? – New study
Anticoagulation in atrial fibrillation (AF) secondary to acute coronary syndrome, acute pulmonary disease or sepsis may not prevent stroke, but may increase risk of bleeding, says an new study published in JACC Clinical Electrophysiology [1]. The authors retrospectively evaluated a cohort of over 2300 patients aged 65 years or more who were hospitalized with acute coronary syndrome, acute pulmonary disease which included worsening of chronic obstructive pulmonary disease, pneumonia, influenza, pulmonary embolism and pleural effusion or sepsis associated with new onset AF during admission. Over a three year follow up, the...
Source: Cardiophile MD - October 17, 2017 Category: Cardiology Authors: Johnson Francis Tags: Cardiology ECG / Electrophysiology Source Type: blogs
Left Atrial Appendage Closure Does Not Prevent Strokes
Our cautionary left atrial appendage occlusion (Watchman) editorial is now published in a prominent medical journal, called Heart Rhythm. My co-authors are Drs. Andrew Foy and Gerald Naccarelli from Penn State. It was a peer-reviewed version of my previous theheart.org | Medscape Cardiology column.
Watchman and other similar devices are plugs that occlude the left atrial appendage in an attempt to reduce the odds of stroke in patients with atrial fibrillation. It was a nice idea but it did NOT work.
The link is here> Percutaneous Left Atrial Appendage Closure is Not Ready for Routine Clinical Use
In the allotted 2500 ...
Source: Dr John M - October 12, 2017 Category: Cardiology Authors: Dr John Source Type: blogs
Inferolateral ST elevation, vomiting, and elevated troponin
Another post written by Pendell Meyers, with edits from Dr. Smith:A male in his late 40s presented with nausea, vomiting, and epigastric abdominal pain of several hours duration. An ECG was recorded from triage:What is your interpretation?The ventricular rate is 160 bpm and regular with narrow complex. Rhythm differential is therefore sinus tachycardia, SVT (AVRT, AVNRT, etc), or atrial flutter. There is clear ST elevation present in V4-V6, as well as II, III, and aVF. No clear reciprocal changes in aVL, however with this distribution you could consider a very rare case in which high lateral STE cancels out reciprocal STD....
Source: Dr. Smith's ECG Blog - October 6, 2017 Category: Cardiology Authors: Pendell Source Type: blogs
Adjusting Neutrophil Behavior to Enhance Stroke Recovery
An emerging theme in regenerative research is the importance of the innate immune system to the mechanisms of tissue maintenance, and researchers have so far found a number of ways in which the behavior of these immune cells might potentially be adjusted in order to enhance healing. The scientific community has made initial strides with macrophages and microglia, shifting the balance of pro-inflammatory versus pro-regenerative cells, and here some of the same high level themes are observed in the response to injury of the innate immune cells known as neutrophils. It matters greatly as to whether these immune cells turn up ...
Source: Fight Aging! - September 21, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Healthy 50-something with new dyspnea on exertion and an interesting ECG
This study was on asymptomatic patients.There are other longitudinal studies which did NOT show increased long term risk. (Source: Dr. Smith's ECG Blog)
Source: Dr. Smith's ECG Blog - July 25, 2017 Category: Cardiology Authors: Steve Smith Source Type: blogs
Fight Aging! Newsletter, July 17th 2017
This study aimed to estimate associations between combined measurements of BMI and waist-to-hip ratio (WHR) with mortality and incident coronary artery disease (CAD). This study followed 130,473 UK Biobank participants aged 60-69 years (baseline 2006-2010) for 8.3 years (n = 2974 deaths). Current smokers and individuals with recent or disease-associated (e.g., from dementia, heart failure, or cancer) weight loss were excluded, yielding a "healthier agers" group.
Ignoring WHR, the risk of mortality for overweight subjects was similar to that for normal-weight subjects. However, among normal-weight subjects, mortalit...
Source: Fight Aging! - July 16, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
This is your brain on alcohol
It’s no secret that alcohol affects our brains, and most moderate drinkers like the way it makes them feel — happier, less stressed, more sociable. Science has verified alcohol’s feel-good effect; PET scans have shown that alcohol releases endorphins (the “pleasure hormones”) which bind to opiate receptors in the brain. Although excessive drinking is linked to an increased risk of dementia, decades of observational studies have indicated that moderate drinking — defined as no more than one drink a day for women and two for men — has few ill effects. (A drink equals 1.5 ounces of 80-proof spirits, 5 ounces of ...
Source: Harvard Health Blog - July 14, 2017 Category: Consumer Health News Authors: Beverly Merz Tags: Addiction Brain and cognitive health Healthy Eating Heart Health Memory Source Type: blogs
Fight Aging! Newsletter, June 19th 2017
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span.
Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - June 18, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 5th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
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Source: Fight Aging! - June 4, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
