An Angiogenesis Hypothesis of Aging
There are many theories of aging, some with a broader scope, focused on the high level or the evolutionary explanation for aging and all of its variations in pace, and others that are more limited, examining just a few aspects of age-related decline and in search of the principle mechanisms that cause that decline. Today's example is one of the more compact theories of aging, restricting itself to considering the creation and maintenance of the network of capillaries that supplies tissues. The oxygen and nutrients carried by blood cannot perfuse far beyond blood vessels, and so every last cubic millimeter of the body must ...
Source: Fight Aging! - June 2, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
“ Beholders ” or patients and families?
LITFL: Life in the Fast Lane Medical Blog
LITFL: Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
This is a guest post by Dr Peter Hutchinson, Professor of Neurosurgery; Dr Angelos Kolias, Clinical Lecturer in Neurosurgery; and Dr David Menon, Professor of Anaesthesia – all at the University of Cambridge and Addenbrooke’s Hospital, Cambridge, UK. It is a response to the recent LITFL post by Dr Alistair Nichol titled RESCUEicp and the Eye of the Beholder.
* beholder
NOUN
literary, archaic
A person who sees or observes someone or something.
We welcome the ongoing dis...
Source: Life in the Fast Lane - May 14, 2017 Category: Emergency Medicine Authors: Chris Nickson Tags: Intensive Care Neurosurgery angelos kolias david menon Decompressive craniectomy peter hutchinson RESCUEicp TBI traumatic brain injury Source Type: blogs
“ Beholders ” or patients and families?
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
This is a guest post by Dr Peter Hutchinson, Professor of Neurosurgery; Dr Angelos Kolias, Clinical Lecturer in Neurosurgery; and Dr David Menon, Professor of Anaesthesia – all at the University of Cambridge and Addenbrooke’s Hospital, Cambridge, UK. It is a response to the recent LITFL post by Dr Alistair Nichol titled RESCUEicp and the Eye of the Beholder.
* beholder
NOUN
literary, archaic
A person who sees or observes someone or something.
We welcome the ongoi...
Source: Life in the Fast Lane - May 14, 2017 Category: Emergency Medicine Authors: Chris Nickson Tags: Intensive Care Neurosurgery angelos kolias david menon Decompressive craniectomy peter hutchinson RESCUEicp TBI traumatic brain injury Source Type: blogs
Fight Aging! Newsletter, May 1st 2017
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation."
In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create molec...
Source: Fight Aging! - April 30, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Mechanism to Link Air Pollution and Cardiovascular Disease
Air pollution is associated with increased mortality and risk of a variety of age-related diseases, but as is often the case in human epidemiological data it isn't all that clear as how much of this is due to direct versus indirect effects. Lesser degrees of air pollution are associated with wealthier regions of the world, for example, and wealth in turn correlates with lower mortality and less age-related disease. That said, there are range of direct mechanisms for air pollution to impact long-term health, some with better accompanying evidence than others, such as the one explored here:
Tiny particles in air pol...
Source: Fight Aging! - April 26, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 17th 2017
This study assessed the prevalence of grey hair in patients with coronary artery disease and whether it was an independent risk marker of disease.
This was a prospective, observational study which included 545 adult men who underwent multi-slice computed tomography (CT) coronary angiography for suspected coronary artery disease. Patients were divided into subgroups according to the presence or absence of coronary artery disease, and the amount of grey/white hair. The amount of grey hair was graded using the hair whitening score: 1 = pure black hair, 2 = black more than white, 3 = black equals white, 4 = white more t...
Source: Fight Aging! - April 16, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Funtabulously Frivolous Friday Five 181
LITFL: Life in the Fast Lane Medical Blog
LITFL: Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 181.
Question 1
Approximately 225 Canadian men drown each year falling overboard, resulting in some unusual safety advice. What are these Canadian men advised not to do while in their boats?
+ Reveal the Funtabulous Answer
expand(document.getElementById('ddet21133365'));expa...
Source: Life in the Fast Lane - March 17, 2017 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five acnestis ballpoint pen cricothyroidotomy drowning feet Foot forearm hickey love bite stroke Tracheostomy Source Type: blogs
Socialized Medicine: From Anecdote to Data
Last night ’s CNN duel between Senators Bernie Sanders and Ted Cruz on the future of Obamacare was pretty illuminating for a recent arrival to the United States, with Senator Sanders’ playbook all-too-familiar to those of us from the UK.Sanders wants a single-payer socialized healthcare system in the United States, just as we have in Britain. Any objection to that is met with the claim that you are “leaving people to die.” The only alternatives on offer, you would think, are the U.S. system as it exists now, or the UK system. Sanders did not once acknowledge that the UK structure, which is free at the point of use,...
Source: Cato-at-liberty - February 8, 2017 Category: American Health Authors: Ryan Bourne Source Type: blogs
Can These Healthy Lifestyle Changes Prevent Stroke?
This study also assessed how risk factors vary between stroke subtype, throughout the world, and according to age or sex.
Overall, it was established that over 90% of the worldwide risk of stroke can be attributed to only ten risk factors: hypertension, low physical activity, high apolipoprotein (Apo)B/ApoA1 ratio (predictor of coronary heart disease risk), diet, abdominal obesity, psychosocial factors, current smoking, cardiac causes, alcohol consumption, and diabetes. Of these, hypertension was identified as the most important risk factor for stroke.
Some risk factors were shown to be predominantly associated with a subt...
Source: World of Psychology - January 24, 2017 Category: Psychiatry & Psychology Authors: Psych Central Staff Tags: Brain and Behavior Brain Blogger Exercise & Fitness Health-related Publishers Research Self-Help Healthy Lifestyle Changes risk factors for stroke Sara Adaes PhD stroke prevention Source Type: blogs
Research and Reviews in the Fastlane 162
Welcome to the 162nd edition of Research and Reviews in the Fastlane. R&R in the Fastlane is a free resource that harnesses the power of social media to allow some of the best and brightest emergency medicine and critical care clinicians from all over the world tell us what they think is worth reading from the published literature.
This edition contains 5 recommended reads. The R&R Editorial Team includes Jeremy Fried, Nudrat Rashid, Soren Rudolph, Justin Morgenstern and, of course, Chris Nickson. Find more R&R in the Fastlane reviews in the R&R Archive, read more about the R&R project or check o...
Source: Life in the Fast Lane - November 30, 2016 Category: Emergency Medicine Authors: Justin Morgenstern Tags: Clinical Research Education Emergency Medicine R&R in the FASTLANE Toxicology and Toxinology EBM literature recommendations research and reviews Source Type: blogs
Incidence of High Blood Pressure Rises and Spreads, Following Increased Wealth
Rates of obesity and high blood pressure, or hypertension, follow the increases in wealth and comfort that have spread through much of the world over the past 60 years. Regions that are in the process of transitioning from predominantly poor agricultural populations to a level of wealth and mix of occupations that looks much more like Europe or the US, with South Korea as a good example of the full span of such a transition, see rising life expectancy as well as a rising level of lifestyle conditions. High blood pressure drives the development of cardiovascular disease, and is made worse by excess fat tissue and lack of ex...
Source: Fight Aging! - November 29, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Interleukin-1 Receptor Antagonists as a Stroke Treatment
Researchers here investigate a class of drug that blocks interleukin-1 receptor activity, something that has been found to reduce cell death and improve regeneration following stroke. This form of interference in cellular metabolism lowers the level of inflammation, but that may or may not be the most important mechanism in the outcome for stroke patients; it is plausible, but the details remain to be determined conclusively at this point.
The pro-inflammatory cytokine interleukin-1 (IL-1) is a major driver of inflammation, with well documented detrimental effects in multiple preclinical models of systemic inflamm...
Source: Fight Aging! - November 29, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Selection of Recent Regenerative Research
In conclusion, rHDL can promote wound healing and wound angiogenesis, and blood flow recovery in response to ischemia in aged mice. Mechanistically, this is likely to be via an increase in VEGF. This highlights a potential role for HDL in the therapeutic modulation of age-impaired vascular complications. (Source: Fight Aging!)
Source: Fight Aging! - November 19, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
BAG3 as a Target to Reduce Reperfusion Injury in Heart Tissues
There have been a number of life science discoveries of late that might lead to therapies capable of reducing the level of tissue damage caused by structural failures in important blood vessels, the basis for a range of age-related conditions. News of another possible approach arrived recently, and you will find links to the publicity materials and open access paper below. Blood vessel failures cause an interruption of oxygenated blood flow to tissues, and depending on the location in the body and size of the failed vessel, can produce the dramatic symptoms of stroke, heart attack, and so forth. While methods of prevention...
Source: Fight Aging! - November 18, 2016 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Say No to Watchman
Cardiology is on the brink of making a big mistake. We have embraced a new procedure called left atrial appendage isolation.
You may be seeing the ads for a device called Watchman. Like this one>
The appendage-closure idea was a good one: during atrial fibrillation (AF), blood can pool in the left atrial appendage, and this promotes clot formation. (The LA appendage has many nooks and crannies.) So… if we could put a device in there, see image, this would block clots from getting out and causing stroke. Also, once the device has been in for months, the body walls it off and the patient can stop the anticoagulan...
Source: Dr John M - November 10, 2016 Category: Cardiology Authors: Dr John Source Type: blogs
