A 90-something with acute stroke. She has no chest symptoms. What is the diagnosis?
A 90-something year old woman presented with an acute mild stroke.She had a routine ECG as part of her workup:What do you think?This was shown to me in real time.I thought it had to be an inferior-lateral-posterior OMI. But the patient had no symptoms. Later, she did admit to some vague chest discomfort, but that could be due to the power of suggestion.The one strange thing that I noted at the time is that there is no reciprocal ST depression in aVL. This is extremely unusual in inferior OMI, even if there is simultaneous STE in V5-6.We studied this: In this paper on the importance of lead aVL f...
Source: Dr. Smith's ECG Blog - November 11, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Rate vs Rhythm Control in Atrial Fibrillation
Rate vs rhythm control as a management strategy in atrial fibrillation has been a long standing topic for debate. Though at one look rhythm control would appear to be the ideal strategy, long term adverse effects of the currently available medications for rhythm control is the often cited down side. AFFIRM [1] and RACE [2] trials were the main reason for the debate as they failed to show any benefit for the rhythm control strategy. AF-CHF trial in those with AF and congestive heart failure also failed to show any advantage for the rhythm control strategy [3]. But there have been important criticisms as well [4]. In AFFIRM...
Source: Cardiophile MD - October 26, 2023 Category: Cardiology Authors: Johnson Francis Tags: ECG / Electrophysiology General Cardiology Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Valeric Acid as a Harmful Metabolite Generated by the Aged Gut Microbiome
The balance of microbial populations making up the gut microbiome shifts with age. The research community has developed a good list of contributing causes, ranging from lifestyle changes to aspects of degenerative aging that affect immune function and the state of the intestinal lining, but the degree to which any given contribution is important relative to the others remains a question mark. The immune system is responsible for gardening the gut microbiome, suppressing the population growth of problem microbes, but immune aging likely reduces this activity. In turn, growing populations of problem microbes can help to prov...
Source: Fight Aging! - September 29, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Climbing More Than Five Flights of Stairs Daily Reduces Risk of Heart Disease!
World Heart Day greetings to all. Climbing more than five flights of stairs every day can reduce the risk of atherosclerotic cardiovascular disease by over 20% according to a study using data from the UK Biobank, published in the journal Atherosclerosis [1]. But beware, those who stop climbing has a higher risk than those who never did it! The study had over four hundred and fifty thousands adult participants. Information about climbing stairs, sociodemographic factors and lifestyle factors were collected at baseline and by a resurvey after 5 years. Median follow up period was 12.5 years. Similar results were noted for bo...
Source: Cardiophile MD - September 29, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Repair of the Leaking Blood-Brain Barrier
Researchers here report on an effort to find small molecule drugs that can favorably adjust cell metabolism in the blood-brain barrier, in order to prevent some fraction of the dysfunction and leakage that occurs with age. The blood-brain barrier is a specialized layer of cells that controls the traffic of molecules between the bloodstream and brain tissue. With advancing age, it becomes less effective, allowing unwanted molecules and cells to leak into the brain to provoke chronic inflammation and other issues. Maintaining effectiveness of the blood-brain barrier could push back the onset of neurodegenerative conditions.
...
Source: Fight Aging! - June 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
27 Dangers And Risks Of High Blood Pressure
Conclusion
Despite its silent nature, high blood pressure gradually damages organs over time. The interconnectedness of the circulatory system means that all organs reachable by blood are at risk.
Hypertension can lead to critical complications such as heart enlargement, coronary artery disease, stroke, cognitive decline, erectile dysfunction, kidney disease, proteinuria, vision problems, and vascular damage.
The importance of proactive measures to manage and prevent these adverse effects is emphasized.
Regular blood pressure monitoring, adopting a healthy lifestyle, and working with healthcare professionals ar...
Source: The EMT Spot - June 1, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Dangers And Risks Of High Blood Pressure
Conclusion
Despite its silent nature, high blood pressure gradually damages organs over time. The interconnectedness of the circulatory system means that all organs reachable by blood are at risk.
Hypertension can lead to critical complications such as heart enlargement, coronary artery disease, stroke, cognitive decline, erectile dysfunction, kidney disease, proteinuria, vision problems, and vascular damage.
The importance of proactive measures to manage and prevent these adverse effects is emphasized.
Regular blood pressure monitoring, adopting a healthy lifestyle, and working with healthcare professionals ar...
Source: The EMT Spot - June 1, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rejuvenation of the Gut Microbiome as a Strategy to Improve Late Life Cognitive Function
The aging of the brain is driven by many factors. Animal studies have demonstrated that the composition of the gut microbiome is one such factor. With age, the balance of microbial populations shifts to favor harmful, inflammatory microbes at the expense of helpful microbial species that produce metabolites necessary for tissue function. Chronic inflammation is a feature of many age-related conditions, neurodegenerative conditions particularly, and the aging gut microbiome contributes to that inflammatory state. Further, the microbiome generates metabolites such as butyrate that support neurogenesis, the creation of new ne...
Source: Fight Aging! - May 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Improving Internal Communications Leads to 50% Stroke Workflow Improvement
TigerConnect has seen its customers improve their stroke workflows by more than 50% when staff have access to and embrace the use of communication technology. By delivering the right information to the right person when and where they need it, organizations are able speed up patient care in an area where every second matters.
Healthcare IT Today sat down with Will O’Connor, M.D., Chief Medical Information Officer at TigerConnect, to find out how these results were achieved and why improving internal communications can have such an impact.
Every Second Matters for Stroke Patients
According to the CDC, more than 795,000 pe...
Source: EMR and HIPAA - May 22, 2023 Category: Information Technology Authors: Colin Hung Tags: Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System door-to-needle Healthcare Scene Featured healthcare workflow improvements HIMSS23 provider-to-provider communications Quality of Car Source Type: blogs
Fight Aging! Newsletter, May 8th 2023
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.
Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study
https://www.fightaging.org/archives/2023/05/retinal-cell-reprogramming-restores-vision-in-non-human-primate-study/
Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system...
Source: Fight Aging! - May 7, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
